Patents Represented by Attorney David Prashker
  • Patent number: 5141925
    Abstract: The present invention provides a method for the prophylactic and/or therapeutic treatment of living animals susceptible to infection by at least one parasite able to cause Coccidiosis. The methodology utilizes the ability of each genus and species of infectious parasite as producing its own unique, biochemically distinct, specific lectin composition in vivo as part of the normal life cycle. The method of treatment administers a composition comprising at least one sugar to the living animal, this sugar comprising compound being able to bind selectively with the specific lectin composition of the parasite in vivo. Use of this method causes a loss of parasite infectivity and a subsequent excretion of the infectious parasite into the environment at large.
    Type: Grant
    Filed: April 23, 1990
    Date of Patent: August 25, 1992
    Assignee: Trustees of Tufts College
    Inventors: Joseph Alroy, Miercio E. A. Pereira
  • Patent number: 5139493
    Abstract: The present invention provides a closed, fluid-modulating receiving system for the conveyance, modulation, and collection of fluid matter from its source. The receiving system may be employed under both in vivo and inanimate use conditions for the collection and disposal of fluids which may be infectious, hazardous, or toxic in and of themselves.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: August 18, 1992
    Assignee: Beth Israel Hospital Assoc., Inc.
    Inventor: John D. Hogan
  • Patent number: 5135792
    Abstract: A disposable, self-enveloping and self-containing on-demand superabsorbent composite is provided which is easily transportable, durable, and can be prepared in both sterile and non-sterile formats. The disposable composite provides a fluid absorbing capacity via fibers able to absorb not less than 15 times their own weight in fluid and preferably are able to absorb at least 50 times their own weight in fluid and other liquid wastes. The composite can be prepared in various formats and styles for use in both hospitals, ambulances, emergency medical personnel, and by morticians and funeral directors as well.
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: August 4, 1992
    Assignee: Beth Israel Hospital Assoc., Inc.
    Inventor: John D. Hogan
  • Patent number: 5135849
    Abstract: The present invention provides general protocols by which a substance may be identified and characterized as an androgen agonist and/or an androgen antagonist. The described protocols are in-vitro methods which utilize androgen dependent cells in culture and a medium comprising an inhibitor endogenous to the sera of humans and animals which is able to prevent the proliferation of these cultured cells in-vitro. The methodology is rapid, reproducible, and accurate; and provides the major advantage of being able to test large numbers of unevaluated substances for their androgen agonistic and/or antagonistic properties as primary properties or secondary side-effects.
    Type: Grant
    Filed: April 18, 1989
    Date of Patent: August 4, 1992
    Assignee: Trustees of Tufts College
    Inventors: Ana M. Soto, Carlos Sonnenschein
  • Patent number: 5131582
    Abstract: A unique class of adhesive alloys and bonding methods for their use are provided which enable the user to join non-conductive materials to themselves or to electrically conductive materials. The bonding alloys have enhanced wetting properties and a melting point less than 100.degree. C. in all instances. The bonding alloys are unusual and advantageous in that they create an intimate, direct, and enduring contact between the materials while minimizing mechanical and chemical stresses.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: July 21, 1992
    Assignee: Trustees of Boston University
    Inventors: Alvaro Kaplan, George O. Zimmerman
  • Patent number: 5116633
    Abstract: Simple and effective methods for dramatically reducing the cholesterol content and saturated fat content of red meat and fowl are provided. The processing employs a heated unsaturated oil to solubilize the saturated fat and cholesterol of fragmented meat and then employs an aqueous fluid to separate and remove the extracting oil from the oil processed meat. The invention not only includes methods for such processing, but also provides meat having markedly reduced saturated fat, markedly increased unsaturated fat, reduced total fat, and reduced cholesterol content; an aqueous meat flavoring and stock agent; and an oil containing concentrated amounts of cholesterol and saturated fat which may be employed for food in which cholesterol and saturated fat are not a concern or for non-food uses.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: May 26, 1992
    Assignee: Trustees of Boston University
    Inventor: Donald M. Small
  • Patent number: 5114864
    Abstract: An improved fiber optic sensor, sensing apparatus, and methods for making optical determinations are provided. The fiber optic sensor employs a fiber optic strand to convey light energy and at least one polymer matrix comprising a fluid erodible, continuous release polymer and a releasable reagent formulation able to react with a molecule or analyte of interest. The optic sensors and sensor construction has been demonstrated to be accurate, precise, and of long duration.
    Type: Grant
    Filed: September 19, 1989
    Date of Patent: May 19, 1992
    Assignee: Trustees of Tufts College
    Inventor: David R. Walt
  • Patent number: 5098656
    Abstract: A unique class of bonding alloys and methods for their use are provided which enable the user to electrically join superconductive materials to themselves, to normal conductive materials, or to semi-conductors. The bonding alloys have enhanced wetting properties and a melting point less than 100.degree. C. in all instances. The bonding alloys are unusual and advantageous in that they create an intimate, direct, mechanical and electrical contact between the superconductive material and any other electrical conductor while minimizing mechanical and chemical stresses and avoiding alterations to the superconductive material itself.
    Type: Grant
    Filed: August 1, 1990
    Date of Patent: March 24, 1992
    Assignee: Trustees of Boston University
    Inventors: George O. Zimmerman, Alvaro Kaplan
  • Patent number: 5098899
    Abstract: A novel and effective treatment of psoriatic arthritis is provided using biologically active forms of vitamin D analogues and metabolites, and preferrably 1,25-dihydroxy vitamin D.sub.3. The administration of vitamin D analogues and metabolites may be made orally, topically, or parenterally. Substitive improvements in both the arthritic condition and skin lesions result after approximately two month's treatment when effective dosages are provided and maintained.
    Type: Grant
    Filed: December 14, 1990
    Date of Patent: March 24, 1992
    Assignee: Trustees of Boston University
    Inventors: Lawrence Gilbert, Michael F. Holick
  • Patent number: 5064821
    Abstract: The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs 13-(substituted mercapto) derivatives of tetracycline in combination with other tetracycline-type antibiotics as a synergistic combination of compositions to be administered simultaneously or concurrently. The concomittantly administered compositions effectively overcome the tetracycline resistant mechanisms present such that the cell is effectively converted from a tetracycline-resistant state to a tetracycline-sensitive state. The combination also effects a synergistic bacteriocidal activity against susceptible and resistant cells.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: November 12, 1991
    Assignee: Trustees of Tufts College
    Inventor: Stuart B. Levy
  • Patent number: 5054290
    Abstract: A portable and disposable, superabsorbent carrying container is provided which allows the user to obtain refrigeration on-demand for its contents. The container has a superabsorbent fibrous lining which absorbs not less than 15 times its own weight of fluids. In addition, the carrying container is able to provide refrigeration for the contents held within the internal volume of the container without the need for large mechanical refrigeration units or the use of previously frozen ice packs and the like.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: October 8, 1991
    Assignee: Beth Israel Hospital Assoc.
    Inventor: John D. Hogan
  • Patent number: 5031634
    Abstract: A unique adjustable biopsy needle-guide device is provided which allows it to be inserted accurately at a selected anatomic site; to be secured in an engaged position; to be disengaged on-demand into a moveable form; and to be repositioned at will. The guide device comprises a cannula with multiple wires and sliding member elements as a preassembled unit which can be sterilized and conveniently stored until required for use by the physician. The needle-guide serves as a guide-post for the surgeon to remove small or deep seated lesions or for precise placement of biopsy needles at the target site.
    Type: Grant
    Filed: January 19, 1990
    Date of Patent: July 16, 1991
    Assignee: Beth Israel Hospital Assoc., Inc.
    Inventor: Morris Simon
  • Patent number: 4997818
    Abstract: A therapeutic method for specifically treating terminal deoxynucleotidyl transferase-positive neoplastic disease within living subjects is provided which is uniquely effective and selective. The therapeutic method comprises administering an effective concentration of a therapeutic composition to the subject, the therapeutic composition comprising a nitrogenous heterocyclic base selected from the group consisting of purines and purine derivatives and pyrimidines and pyrimidine derivatives; and a dideoxy-pentose monosaccharide moiety.
    Type: Grant
    Filed: September 21, 1989
    Date of Patent: March 5, 1991
    Assignee: The University Hospital
    Inventors: Ronald P. McCaffrey, Zachary Spigelman
  • Patent number: 4997854
    Abstract: A class of anti-fibrotic agents and methods for their use as effective inhibitor substrate analogues of lysyl oxidase in-situ are provided. The inhibitory substrate analogues comprise adjacently positioned diamine compositions which may be employed in-vivo to therapeutically treat a wide variety of different pathological fibrotic diseases, disorders, and abnormalities.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: March 5, 1991
    Assignee: Trustees of Boston University
    Inventors: Herbert M. Kagan, Stephen N. Gacheru
  • Patent number: 4980040
    Abstract: A method is provided for the photopromoted solid-catalyzed decomposition of oxides of nitrogen such as nitric oxide which are major pollutants of air and the environment at large. By this method, oxides of nitrogen are decomposed into molecular nitrogen and molecular oxygen by reactive passage over a solid metal oxide catalyst at an elevated temperature under irradiation at wavelengths absorbable by the catalyst. In this manner, the major oxides of nitrogen pollutants originating in the exhaust gases produced by automobile engines, jet engines used in the propulsion of aircraft, gas-turbine power generators, and the combustion of fossil fuels generally are controlled and eliminated.
    Type: Grant
    Filed: June 26, 1989
    Date of Patent: December 25, 1990
    Assignee: Trustees of Boston University
    Inventors: Norman N. Lichtin, Kallambella M. Vijayakumar, Junchang Dong
  • Patent number: 4980185
    Abstract: A method for reducing the cholesterol content and saturated fat content of red meat and fowl is provided. The processing employs a heated unsaturated oil to solubilize the saturated fat and cholesterol of fragmented meat and then employs an aqueous fluid to separate and remove the extracting oil from the oil processed meat. The invention not only includes methods for such processing, but also provides meat having markedly reduced saturated fat, reduced total fat, and reduced cholesterol content; an aqueous meat flavoring and stock agent; and an oil containing concentrated amounts of cholesterol and saturated fat which may be employed for food in which cholesterol and saturated fat are not a concern or for non-food uses.
    Type: Grant
    Filed: July 18, 1989
    Date of Patent: December 25, 1990
    Assignee: Trustees of Boston University
    Inventor: Donald M. Small
  • Patent number: 4966142
    Abstract: A unique class of bonding alloys and methods for their use are provided which enable the user to electrically join superconductive materials to themselves, to normal conductive materials, or to semi-conductors. The bonding alloys have enhanced wetting properties and a melting point less than 100.degree. C. in all instances. The bonding alloys are unusual and advantageous in that they create an intimate, direct, mechanical and electrical contact between the superconductive material and any other electrical conductor while minimizing mechanical and chemical stresses and avoiding alterations to the superconductive material itself.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: October 30, 1990
    Assignee: Trustees of Boston University
    Inventors: George O. Zimmerman, Alvaro Kaplan
  • Patent number: 4952513
    Abstract: The present invention provides a general assay methodology suitable for the detection of organic analytes which are neither aldehydes nor ketones and for inorganic substances. The methodology utilizes prepared sensitized films of derivatizing agents and specific developer solutions for the selective and controlled formation of light scattering crystals whose presence serves as a qualitative and/or quantitative measure of the individual analyte of interest in the sample.
    Type: Grant
    Filed: October 24, 1988
    Date of Patent: August 28, 1990
    Assignee: Crystal Diagnostics, Inc.
    Inventor: Martin Koocher
  • Patent number: 4946603
    Abstract: A unique blood filter matrix material is provided which is able to effectively separate whole blood into cellular and noncellular constituents, especially when the whole blood volume is 0.5 milliliters or less. The filter matrix presents an overall negative surface electrical charge to the whole blood and utilizes a mechanism of action to rapidly separate cells from plasma or serum.
    Type: Grant
    Filed: November 17, 1988
    Date of Patent: August 7, 1990
    Assignee: Crystal Diagnostics, Inc.
    Inventors: James A. Laugharn, Denis Hammerton, Timothy W. Towle
  • Patent number: D312582
    Type: Grant
    Filed: June 1, 1987
    Date of Patent: December 4, 1990
    Inventor: Morris Simon