Abstract: The present invention relates to nucleic acid molecules comprising a nucleic acid sequence coding for the ?- and the ?-chain of the human follicle stimulating hormone (FSH), respectively, which has been modified with respect to the codon usage in CHO cells. The present invention further relates to a recombinant nucleic acid molecule comprising such nucleic acid sequences and host cells containing such recombinant nucleic acid molecules, as well as their use in the production of recombinant human FSH. Finally, the present invention also relates to a method for producing host cells expressing human follicle stimulating hormone by transfecting cells in suspension culture under serum-free conditions with the recombinant nucleic acid molecule of the present invention.

Abstract: A communications cable having a plurality of twisted wire pairs each having a substantially uniform twist rate along the cable. An elongated shielding separator is positioned between the twisted wire pairs and physically separates them from one another. The shielding separator has a plurality of electrically non-conductive separator sections positioned between the twisted wire pairs and a plurality of electrically conductive separator sections arranged in an alternating pattern with the non-conductive separator sections along the shielding separator. Each of the conductive separator sections has one of a predetermined number of section lengths and is arranged along the shielding separator such that the conductive separator sections are substantially aperiodic with the twist rates of the twisted wire pairs. Optionally, the cable includes a continuous or discontinuous outer cable shielding system enclosing the discontinuous shielding separator and the plurality of twisted wire pairs.

Abstract: Data in less than all of the pages of a non-volatile memory block are updated by programming the new data in unused pages of either the same or another block. In order to prevent having to copy unchanged pages of data into the new block, or to program flags into superceded pages of data, the pages of new data are identified by the same logical address as the pages of data which they superceded and a time stamp is added to note when each page was written. When reading the data, the most recent pages of data are used and the older superceded pages of data are ignored. This technique is also applied to metablocks that include one block from each of several different units of a memory array, by directing all page updates to a single unused block in one of the units.

Abstract: A lock and key mechanism reduces exposure to lock picking by including an extension into a key slot to receive and conceal tapered end portions of key pins. The only portions of key pins exposed in a key slot are cylindrical portions that are difficult to move from a resting position. A key includes a beveled leading edge and a spring-loaded pin activation element at the leading edge of the key. As the key is inserted into the key slot, the spring-loaded pin activation element is compressed to permit entry into the key slot. As the pin activation element reaches a pin, an aperture in the extension allows the spring-loaded pin activation element to move toward the key pin and move the key pin from its resting position. In this activated position, the tapered end portion of the key pin is exposed for further activation by the beveled leading edge of the key. The process is repeated until the pin activation element engages and activates each successive key pin and allows full insertion of the key.

Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

Abstract: In certain aspects, the preproghrelin gene, but not the ghrelin receptor (GHS-R1a) is required for normal integration of thermoregulation and sleep in mice. Particular aspects provide methods for modulation of thermoregulation and other ghrelin-mediated conditions (e.g., reduction of appetite or food intake, reduction of body weight or treatment of obesity, reduction of body temperature or induction of hypothermia, etc.), comprising administration of an inhibitor of ghrelin expression, and including, e.g., siRNA inhibition for treatment of obesity and for modulation of thermoregulation (e.g., induction of hypothermia in surgical settings benefiting from same). Additionally provided are methods for reducing body temperature or induction of hypothermia, comprising administration to a mammalian subject in need thereof an amount of an anti-obestatin antibody agent sufficient to reduce body temperature or induce hypothermia. Further methods comprise administration of a ghrelin peptide antagonist.

Abstract: A reel with a rotatable spool. The reel includes a motor coupled to a drive shaft and configured to rotate the drive shaft in a first direction and a second direction opposite the first direction. A drive assembly is disposed on the drive shaft and rotation of the drive shaft in the first direction moves the drive assembly along the drive shaft and into engagement with the spool. Rotation of the drive shaft in the second direction moves the drive assembly along the drive shaft and out of engagement with the spool. When the drive assembly is engaged with the spool, the drive assembly rotates the spool in a windup direction. When the drive assembly is out of engagement with the spool, the spool may be rotated manually in an unwind direction without encountering resistance from the motor.

Abstract: Embodiments of the invention relate to the new soybean variety designated G00-3209 as well as the seeds, plants and derivatives of the new soybean variety G00-3209. Also provided are tissue cultures of the new soybean variety G00-3209 and the plants regenerated therefrom. Additional embodiments of the invention are directed to methods for producing soybean plants by crossing the new soybean variety G00-3209 with itself or another soybean variety and plants produced by such methods.

Abstract: Techniques and corresponding circuitry are presented for the detection of broken wordlines in a memory array. In an exemplary embodiment, a program operation of the memory circuit is performed on a first plurality of memory cells along a word-line, where the programming operation includes a series of alternating programming pulses and verify operations, with the memory cells individually locking out from further programming pulses as verified. The determination of whether the word-line is defective based on the number of programming pulses for the memory cells of a first subset of the first plurality to verify as programmed relative to the number of programming pulses for the memory cells of a second subset of the first plurality to verify as programmed, where the first and second subsets each contain multiple memory cells and are not the same.

Abstract: A group of memory cells is programmed respectively to their target states in parallel using a multiple-pass programming method in which the programming voltages in the multiple passes are correlated. Each programming pass employs a programming voltage in the form of a staircase pulse train with a common step size, and each successive pass has the staircase pulse train offset from that of the previous pass by a predetermined offset level. The predetermined offset level is less than the common step size and may be less than or equal to the predetermined offset level of the previous pass. Thus, the same programming resolution can be achieved over multiple passes using fewer programming pulses than conventional method where each successive pass uses a programming staircase pulse train with a finer step size. The multiple pass programming serves to tighten the distribution of the programmed thresholds while reducing the overall number of programming pulses.

Abstract: A method for collecting transcripts each storing an order in which portions of an application file were accessed by the file when the file was executed on one of a plurality of computing devices. The method includes receiving requests to download the file from directing processes each executing on a different one of the computing devices, and in response to those requests, downloading the file to the computing devices and instructing the directing processes to profile usage of the file. Then, transcripts created by the directing processes are received therefrom. A streaming model may be created based on the transcripts received. The file may be divided into a plurality of smaller files based on the streaming model. The streaming model may be used to download the file by downloading at least a portion of the smaller files using a conventional download protocol without using a specialized streaming protocol.

Abstract: One or more sense amplifiers for sensing the conduction current of non-volatile memory is controlled by signals that are timed by a reference sense amplifier having similar characteristics and operating conditions. In one aspect, a sensing period is determined by when the reference sense amplifier sensing a reference current detects an expected state. In another aspect, an integration period for an amplified output is determined by when the reference sense amplifier outputs an expected state. When these determined timings are used to control the one or more sense amplifiers, environment and systemic variations are tracked.

Abstract: A memory device and a method thereof allow programming and sensing a plurality of memory cells in parallel in order to minimize errors caused by coupling from fields of neighboring cells and to improve performance. The memory device and method have the plurality of memory cells linked by the same word line and a read/write circuit is coupled to each memory cells in a contiguous manner. Thus, a memory cell and its neighbors are programmed together and the field environment for each memory cell relative to its neighbors during programming and subsequent reading is less varying. This improves performance and reduces errors caused by coupling from fields of neighboring cells, as compared to conventional architectures and methods in which cells on even columns are programmed independently of cells in odd columns.

Abstract: In sensing a page of nonvolatile memory cells with a corresponding group of sense modules in parallel, as each high current cell is identified, it is locked out from further sensing while others in the page continued to be sensed. The sense module involved in the locked out is then in a lockout mode and becomes inactive. A noise source from the sense module becomes significant when in the lockout mode. The noise is liable to interfere with the sensing of neighboring cells by coupling through its bit line to neighboring ones. The noise can also couple through the common source line of the page to affect the accuracy of ongoing sensing of the cells in the page. Improved sense modules and method isolate the noise from the lockout sense module from affecting the other sense modules still active in sensing memory cell in the page.

Abstract: A non-volatile memory device and power-saving techniques capable of reading and writing a large number of memory cells with multiple read/write circuits in parallel has features to reduce power consumption during sensing, which is included in read, and program/verify operations. A sensing verify operation includes one or more sensing cycles relative to one or more demarcation threshold voltages to determine a memory state. In one aspect, coupling of the memory cells to their bit lines are delayed during a precharge operation in order to reduce the cells' currents working against the precharge. In another aspect, a power-consuming precharge period is minimized by preemptively starting the sensing in a multi-pass sensing operation. High current cells not detected as a result of the premature sensing will be detected in a subsequent pass.

Abstract: In a non-volatile memory storage system such as a flash EEPROM system, a controller switches the manner in which data sectors are mapped into blocks and metablocks of the memory in response to host programming and controller data consolidation patterns, in order to improve performance and reduce wear. Data are programmed into the memory with different degrees of parallelism.

Abstract: A memory card that adapts its operation according to the application to which it applied or the conditions under which it is operated. This allows the card to dynamical self optimize. In a first set of embodiments, the card uses host profiling where it will learn about the host during host-card interactions and the card's controller will optimize its algorithms accordingly. In another set of embodiments, the host and card will report to one another their capabilities for a quality of service negotiation. A further set of embodiments allows the storage device to memorize access sequences issued by the host under various predefined conditions, such as host reset or a power on boot sequence. The storage device can use this information to optimize operation for the expected commands. On deviation from an expected sequence, the device would memorize the new command sequence and save it, thus operating in a self-adaptive manner.

Abstract: A wireless communication device includes conventional components to permit a network communication link to be established with a wireless communication network. In addition, the wireless communication device includes a non-network transceiver that detects the presence of a wireless access point. When two such equipped devices come within proximity of the access point, a non-network wireless communication link is established. The two devices exchange portions of profile data which is analyzed to determine if a match exists. If a match occurs, a contact notification is generated. This permits the wireless communication device to act as an auto-detecting social network device that detects the proximity of other devices whose owners have a profile that matches the stored user preference data. Subsequent communication may occur in a conventional manner using the wireless network communication channels and web applications may also be used to gain additional information.