Patents Represented by Attorney Denis A. Polyn

Find this attorney in the Justia Lawyer Directory

  • Novel 15-substituted prostanoic acids and esters
    Patent number: 4046787
    Abstract: This disclosure describes compounds of the class of 15-substituted-9-keto(or 9-hydroxy)prostanoic acids and the esters and cationic salts thereof, useful as inhibitors of gastric acid secretion.
    Type: Grant
    Filed: October 24, 1975
    Date of Patent: September 6, 1977
    Assignee: American Cyanamid Company
    Inventors: Robert Eugene Schaub, Martin Joseph Weiss
  • 11-(4-Piperidyl)dibenzo-diazepines
    Patent number: 4045445
    Abstract: The compounds, 11-(4-piperidyl)-5H-dibenzo[b,e] [1,4]diazepines, intermediates and methods of preparation thereof are described. They are useful as neuroleptic agents.
    Type: Grant
    Filed: December 14, 1975
    Date of Patent: August 30, 1977
    Assignee: American Cyanamid Company
    Inventors: Robert Allis Hardy, Jr., Nicanor Quinones Quinones
  • Derivatives of 9-oxo-13-trans-prostenoic acid esters
    Patent number: 4044043
    Abstract: This disclosure describes homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenoic acid and of 9-hydroxy-13-trans-prostenoic acid, having antimicrobial activity and prostaglandin-like hypotensive activity.
    Type: Grant
    Filed: May 5, 1975
    Date of Patent: August 23, 1977
    Assignee: American Cyanamid Company
    Inventors: Karel Francis Bernady, Middleton Brawner Floyd, Jr., John Frank Poletto, Robert Eugene Schaub, Martin Joseph Weiss
  • 13-Hydroxy-15-deoxy-prostaglandins
    Patent number: 4039574
    Abstract: This disclosure describes 13-hydroxy-15-deoxy-prostaglandins which exhibit multiple biological responses even at low doses.
    Type: Grant
    Filed: September 25, 1975
    Date of Patent: August 2, 1977
    Assignee: American Cyanamid Company
    Inventor: Allan Wissner
  • Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
    Patent number: 4038315
    Abstract: This disclosure describes a process for the recovery of 7-dimethylamino-6-demethyl-6-deoxytetracycline from an aqueous solution thereof by means of a calcium chloride complex of 7-dimethylamino-6-demethyl-6-deoxy-tetracycline hydrochloride.
    Type: Grant
    Filed: May 11, 1972
    Date of Patent: July 26, 1977
    Assignee: American Cyanamid Company
    Inventor: Martin Tobkes
  • 2,5-Dihydro-2,5-dialkoxyfuran derivatives
    Patent number: 4021452
    Abstract: This disclosure describes novel 2,5-dihydro-2,5-dialkoxyfuran derivatives useful as intermediates for the preparation of the natural prostaglandins and their congeners.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: May 3, 1977
    Assignee: American Cyanamid Company
    Inventor: Middleton Brawner Floyd, Jr.
  • Sustained release forms of certain oxazepines for parenteral administration
    Patent number: 4016273
    Abstract: A sustained release depot form of the free base or pamoate salt of 2-chloro-11-(1-piperazinyl)-dibenz[b,f][1,4]-oxazepine or 2-chloro-11-(4-methyl-1-piperazinyl)-dibenz[b,f]-[1,4]oxazepine in an injectable oil for parenteral administration.
    Type: Grant
    Filed: July 16, 1975
    Date of Patent: April 5, 1977
    Assignee: American Cyanamid Company
    Inventors: George Madison Sieger, James Elwood Krueger, Arnold Curtis Osterberg, David Henry Tedeschi
  • Substituted benzodiazepin-10-ones in treating pain and depression
    Patent number: 4007272
    Abstract: 9-Aminoalkyl-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-ones having anti-depressant and analgesic activity and which are intermediates for other compounds having central nervous system activity.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: February 8, 1977
    Assignee: American Cyanamid Company
    Inventor: Sidney Robert Safir
  • 1-Alkoximino-2-(.omega.-substituted alkyl)-2-cyclopentenes
    Patent number: 4006179
    Abstract: This disclosure describes certain 1-alkoximino-2-(.omega.-substituted-alkyl)-2-cyclopentenes useful as intermediates for the preparation of homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenoic acid and of 9-hydroxy-13-trans-prostenoic acid which have antimicrobial activity and prostaglandin-like hypotensive activity.
    Type: Grant
    Filed: February 24, 1975
    Date of Patent: February 1, 1977
    Assignee: American Cyanamid Company
    Inventors: Karel Francis Bernady, John Frank Poletto, Martin Joseph Weiss
  • Substituted tetrahydro-oxybenzothienylurea compounds as growth promoting agents for animals
    Patent number: 3998959
    Abstract: This invention relates to novel substituted 4,5,6,7-tetrahydro-7-oxybenzo[b]thien-4-ylurea compounds and a process for the preparation thereof. The compounds of this invention are useful as herbicidal agents and animal growth regulants.
    Type: Grant
    Filed: October 17, 1975
    Date of Patent: December 21, 1976
    Assignee: American Cyanamid Company
    Inventors: Goro Asato, Terence James Bentley
  • 4,5,6,7-Tetra hydro-7-oxobenzo(B)thien-4-yl isocyanate and isothiocyanate
    Patent number: 3994924
    Abstract: The present invention relates to 4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl isocyanate and isothiocyanate, which are novel and useful intermediates for the preparation of 4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-ylurea and thiourea compounds which are animal growth promoters.The present invention also relates to methods of preparation for the above-identified thienyl isocyanates and isothiocyanates.
    Type: Grant
    Filed: November 4, 1975
    Date of Patent: November 30, 1976
    Assignee: American Cyanamid Company
    Inventor: Goro Asato
  • 1,2,3,4-Tetrahydro-4-oxo-1-naphthylisocyanate
    Patent number: 3993677
    Abstract: This invention relates to 1,2,3,4-tetrahydro-4-oxo-1-naphthylisocyanate and- isothiocyanate and to methods of preparation of said compounds.The compounds of the present invention are useful as intermediates for the preparation of 1,2,3,4-tetrahydro-4-oxo(oxy)-1-naphthylurea and- thiourea compounds and certain derivatives thereof. The naphthylurea and thiourea compounds are animal growth regulators and herbicides.
    Type: Grant
    Filed: November 3, 1975
    Date of Patent: November 23, 1976
    Assignee: American Cyanamid Company
    Inventor: Goro Asato
  • Substituted aminochlorobenzylamino guanidine compounds
    Patent number: 3992446
    Abstract: The preparation of 1-amino-3-(4- and 3,4-substituted benzylideneamino)guanidine and the acid addition salts thereof, and their use as intermediates in the preparation of 1,3-bis-(4- and 3,4-substituted benzylideneamino)guanidines and their acid addition salts.The final compounds prepared from the present intermediates have antiprotozoal activity particularly against coccidiosis and malaria.
    Type: Grant
    Filed: May 1, 1975
    Date of Patent: November 16, 1976
    Assignee: American Cyanamid Company
    Inventor: Andrew Stephen Tomcufcik
  • Method of using benzopyrans as antiparasitic agents
    Patent number: 3991204
    Abstract: This invention relates to a method for the control of helminths in homothermic domestic and farm animals by administering to said animals on anthelmintically effective amount of a benzopyran compound.
    Type: Grant
    Filed: June 17, 1975
    Date of Patent: November 9, 1976
    Assignee: American Cyanamid Company
    Inventor: John Anthony Pankavich
  • Method of using 6-substituted amino phenyl-2,3,5,6-tetra-hydro[2,1-b]thiazoles for controlling gastrointestinal nematodes
    Patent number: 3989835
    Abstract: The preparation of compounds of the type 6-(mono substituted phenyl)-5,6-dihydro or 2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles and the pharmaceutically acceptable salts thereof, is described. The use of said compounds for treating helminthiasis in warm-blooded animals is also described.
    Type: Grant
    Filed: November 7, 1974
    Date of Patent: November 2, 1976
    Assignee: American Cyanamid Company
    Inventors: Larry Dean Spicer, John James Hand
  • Antibacterial antibiotics AM31.alpha., AM31.beta. and AM31.gamma.
    Patent number: 3987029
    Abstract: This disclosure describes a novel class of antibiotics, three of which have been designed AM31.alpha., AM31.beta., and AM31.gamma. and are produced in a microbiological fermentation under controlled conditions using a new strain of Streptoverticillium netropsis.
    Type: Grant
    Filed: March 19, 1975
    Date of Patent: October 19, 1976
    Assignee: American Cyanamid Company
    Inventors: Jane Parsons Kirby, Donald Bruce Borders
  • 1,2,3,11A-Tetrahydro-10-methyl-5H-pyrrolo[2,1-c][1,4]ben zodiazepin-5,11(10H)-diones
    Patent number: 3985732
    Abstract: The compounds 1,2,3,11a-tetrahydro-10-methyl-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5,11(10 H)-dione and 7-fluoro-1,2,3,11a-tetrahydro-10-methyl-5H-pyrrolo[2,1-c][1,4]benzodiazepi n-5,11(10H)-dione in the form of their dextrorotatory isomers and as racemic mixtures, their method of preparation and method of use are described. The compounds in their different forms are useful in treating anxiety in warm-blooded animals.
    Type: Grant
    Filed: July 31, 1975
    Date of Patent: October 12, 1976
    Assignee: American Cyanamid Company
    Inventor: William Blythe Wright, Jr.
  • Para-fluorobenzoylpropyl-N-heterocyclic substituted quaternary salts
    Patent number: 3985754
    Abstract: This invention resides in the field of p-fluorobenzoylpropyl-N-heterocyclic substituted quaternary salts useful as intermediates in the preparation of 1-p-fluorophenyl-4-N-heterocyclic-1-butanols, 1-p-fluorophenyl-4-N-heterocyclic-1-butanol esters and p-fluoro-.gamma.-heterocyclic butyrophenones having neuroleptic and analgesic activity. The butanols, butanol esters and butyrophenones from the subject matter of our concurrently filed and co-pending application Ser. No. 575,846, filed May 8, 1975, incorporated herein by reference.
    Type: Grant
    Filed: May 8, 1975
    Date of Patent: October 12, 1976
    Assignee: American Cyanamid Company
    Inventors: Corris Mabelle Hofmann, Sidney Robert Safir
  • Substituted benzodiazepines and method of use
    Patent number: 3984562
    Abstract: Aminoacyl derivatives of 2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c] [1,4]benzodiazepines in the form of their racemic mixtures, optical isomers and salts, their method of preparation and method of use are described. The compounds are useful in treating anxiety in warm-blooded animals.
    Type: Grant
    Filed: February 24, 1975
    Date of Patent: October 5, 1976
    Assignee: American Cyanamid Company
    Inventor: William Blythe Wright, Jr.
  • Purification of robenidine hydrochloride
    Patent number: 3980705
    Abstract: A superior grade of 1,3-bis(4-chlorobenzylideneamino)-guanidine hydrochloride is obtained by dispersing crude material in a suitable solvent, slowly adding to the dispersion an amount of base at least equivalent to the number of moles of 1,2,3-tris(4-chlorobenzylideneamino)guanidine hydrochloride present in said crude 1,3-bis(4-chlorobenzylideneamino)guanidine hydrochloride, separating the purified 1,3-bis(4-chlorobenzylideneamino)guandidine hydrochloride therefrom, and washing and drying the same.
    Type: Grant
    Filed: May 19, 1975
    Date of Patent: September 14, 1976
    Assignee: American Cyanamid Company
    Inventors: Don Wesley Long, Robert Arthur Ralston