Abstract: Haloperidol analogs that conforms to the structural formulae: wherein: R is H, or —(CH2)n—OH, n is an integer from 0 to 2, and A is a heterocyclic bridging group, consisting essentially of carbon and at least one nitrogen atom, which effectively maintains the distance between the moieties connected thereby such that the compound (1) is incapable of metabolizing to BCPP+ like species, (2) has an affinity for the D2 receptor subtype of 15<D2<250 and (3) functions as a dopamine receptor antagonist, or the structural formulae: wherein: R1 is H, or —(CH2)n—OH, n is an integer from 0 to 2, B is an aza- or diaza-bicyclo group, which effectively maintains the distance between the moieties connected thereby such that the compound is incapable of metabolizing to BCPP+ like species; and Z is —CH— or N; and pharmaceutically acceptable salts, esters, derivatives, metal complexes, conjugates and prodrugs thereof.

Abstract: A method and composition for treating irritable bowel syndrome in a subject in need of such treatment, utilizing an amount of a polyamine having the formula: 1) R—NH—(CH2)a—NH—(CH2)bH—(CH2)c—NH2, 2) CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)d—NH—(CH2)e—C6H5—CF3, 3) R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R and 4) PIP—(CH2)aNH—(CH2)b—NH—(CH2)c—PIP, wherein: R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of the alkyl chains may optionally be interrupted by at least one etheric oxygen atom, PIP is piperidine and a, b, c, d, and e may be the same or different and are integers from 1-10 effective to treat irritable bowel syndrome.

Abstract: Disclosed are compounds having the formula: where R1=H, C1-C6 alkyl, cycloalkyl, R2=H, C1-C6 alkyl, cycloalkyl W=CnH2n-m—NH (n=1-6, m=0, 2, or 4), Z=CONR8(CH2)n, CONR8(CH2)nCO, P(CH3)OCHR8OCOR9, SO2, SO2(CH2)n, SO2(CH2)nCO, SO2NR8(CH2)n, SO2NR8(CH2)nCO, n=1-4 R4=H, (CH2)nOH, (CH2)nOCOR10, (CH2)nNR10R11, (CH2)nCONR10R11, n=0-4 R5=H, (CH2)nNR12R13, n=0-4 R6=H, (CH2)nNR14R15, n=0-4 R7=H, C1-C6 alkyl, cycloalkyl; R8=H, C1-C6 alkyl, cycloalkyl; R9=H, C1-C6 alkyl, cycloalkyl; R10=H, C1-C6 alkyl, cycloalkyl; R11=H, C1-C6 alkyl, cycloalkyl; R12=H, C1-C6 alkyl, cycloalkyl; R13=H, C1-C6 alkyl, cycloalkyl; R14=H, C1-C6 alkyl, cycloalkyl; R15=H, C1-C6 alkyl, cycloalkyl Dashed lines: optional; conformational constraint by (CH2)n, n=1-3, R′=H or O(═) as well as pharmaceuticals c

Abstract: A mixture comprising a cross-linkable thermosetting resin and a fluorocarbon additive which is curable to form a thermoset resin composition having a gradient concentration of the fluorocarbon additive through a cross-section thereof.

Abstract: A continuous method using gaseous carbon dioxide or a pressurized flow of liquefied carbon dioxide is described to reduce microbial and/or enzymatic activity in a liquid product. The carbon dioxide is combined with a pressurized flow of the liquid product, or the mixture is pressurized after the mixture is formed. The pressure and temperature in the flow regions are maintained at a level which is sufficient to keep the carbon dioxide in a continuous liquid state, but which does not freeze the liquid product. The pressurized mixture of the carbon dioxide and liquid product flows through a reaction zone for a sufficient time to reduce harmful microorganisms and/or inactivate enzymes and then enters one or more expansion stages wherein the pressure of the mixture flow is sufficiently decreased to vaporize the carbon dioxide for separation from the liquid product. If necessary, heat is applied in at least one of the expansion stages to prevent a freezing of the mixture.

Abstract: The invention comprises a method and apparatus for generating a synthetic echocardiographic image. The method comprises first obtaining, for a plurality of pathologically similar reference hearts, a reference echocardiographic image of each reference heart at end-systole and at end-diastole. Next, the coupled epicardial and endocardial borders are identified in each echocardiographic image. An epicardial/endocardial border pair is then modeled from the identified borders. The method then locates a plurality of predetermined features in the reference echocardiographic images. The predetermined features are then located in the subject echocardiographic image from the location of the predetermined features in the reference echocardiographic images. The modeled epicardial/endocardial border pair is then mapped onto the subject echocardiographic image relative to the location of the predetermined features in the subject echocardiographic image.

Abstract: A method for quantitatively analyzing digital images of approximately elliptical body organs, and in particular, echocardiographic images is provided. In particular, methods are disclosed for obtaining short-axis apical four-chamber views of a heart, and particularly for obtaining high-quality automated images of particular regions of the heart muscle, as viewed along its long axis.

Abstract: An improved method and composition for preventing damage to tissue and/or organs during surgery and during harvesting, implanting, manufacture and manipulation of bioprostheses therefrom. Tissue surfaces and surgical articles involved in the surgery and bioprostheses are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue and/or organs during surgery. The composition comprises a solution of a polymeric material having a molecular weight of about 50,000 D or above having a concentration of from about 0.01% to about 15% by weight.

Abstract: A composition in unit dosage form for the inhibition, prevention or treatment of inflammatory bowel disease comprising an effective amount of a compound having the formula: and a pharmaceutically acceptable carrier therefor.

Abstract: A method and composition for treating irritable bowel syndrome in a subject in need of such treatment, utilizing an amount of a polyamine having the formula: RNH—(CH2)aNH(CH2)bNH(CH2)cNH2,  1) CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)d—NH—(CH2)e—C6H5—CF3,  2) R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R and  3) PIP—(CH2)aNH—(CH2)b—NH—(CH2)c—PIP,  4) wherein: R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of the alkyl chains may optionally be interrupted by at least one etheric oxygen atom, PIP is piperidine and a, b, c, d, and e may be the same or different and are integers from 1-10 effective to treat irritable bowel syndrome.

Abstract: A method for planning an intensity modulated radiation therapy system comprising outlining a 3D target volume, providing relative radiation intensities of the 3D, a) selecting specific beam directions for the system to use and b) optimizing the system using an arcing paradigm; back-projecting the given intensities to the selected beam entry portals; sub-dividing each entry portal into discrete dose elements; applying thereto a cost function that scores the goodness of the plan by positively rewarding doses in selected regions and negatively rewarding doses in protected regions, and adjusting the weights of each of the dose elements to increase the overall score.

Abstract: New derivatives of platinum (II) complex are herein provided, which are liposoluble and applicable as antimicrobial agents and anticancer agents specific to the affected parts of patients and selectively transferred to the parts if they are used in combination with a contrast medium such as lipiodol, the derivatives being represented by the following general formula: (wherein R1 and R2 may be identical or different with each other and represent an ammine optionally substituted with an organic substituent and they may be bonded together through a bivalent organic group and R3 is a saturated or unsaturated higher fatty acid, these derivatives being prepared by nitrifying a cis-dichloro-di-(substituted or unsubstituted)-ammine platinum (II) and then reacting the resulting aqua type product with a corresponding alkali metal salt of higher fatty acid.

Abstract: A computer controlled system for guiding the needle device, such as a biopsy needle, by reference to a single mode medical imaging system employing any one of computed tomography imaging (CTI) equipment, magnetic resonance imaging equipment (MRI), fluoroscopic imaging equipment, or 3D ultrasound system, or alternatively, by reference to a multi-modal imaging system, which includes any combination of the aforementioned systems. The 3D ultrasound system includes a combination of an ultrasound probe and both passive and active infrared tracking systems so that the combined system enables a real time image display of the entire region of interest without probe movement.

Abstract: A composition of matter formed by melt-blending certain thermoplastic polymers and from about 1.0 to about 7.5 wt. % of a fluorocarbon additive, the additive having a lower by surface energy than that of the polymer; the blending resulting in a cooled admixture having a concentration of fluorocarbon additive through a cross-section of the solid composition lower in the interior thereof and higher at the surfaces thereof.

Abstract: A method of providing Web access to data using dynamic generation of Web pages by a mainframe computer connected to a Web server. The mainframe computer has legacy programs, legacy data, and legacy subroutines on it (Legacy means existing information systems which may not be specifically adapted to Web access). A Web control program on the mainframe marries file definition objects and page definition objects to generate Web pages and allow a Web user to access legacy data stored in databases on the mainframe. A state key is generated by the mainframe upon a user inputting identification data and the state key is then incorporated into the Web page generated by the Web control program. By receiving the state key back from the user, the Web control program determines the extent of access allowed to a particular user without the user having to reenter identification data. The Web control program allows one to manage and change the appearance of Web pages.

Abstract: Disclosed is a self plugging blind rivet for securing together apertured members, the rivet comprising a tubular shell having a tail end face at one end and a preformed radially enlarged bead at the other end, and a stem that extends through the shell and has a stem head adjacent the tail end face of the shell and a breakneck located away from the stem head, in which the region of the stem shank on the stem head side of the breakneck has a plurality of depressions formed therein extending to the breakneck, the corresponding region of the shell substantially filling the depressions in a region adjacent the stem head and progressively less towards the breakneck whereby, in use and under axial compression loading of the shell, the shell preferentially buckles in the region adjacent the member remote from the preformed head to form a blind head in contact with the member so as to clamp together the apertured members.

Abstract: Polyamines having the formula: wherein R1 and R2 are alkyl, aralkyl or aryl having up to 10 carbon atoms; and a and b may be the same or different and are integers from 1 to 8; or a salt thereof with a pharmaceutically acceptable acid. Anti-neoplastic, anti-diarrheal, anti-peristaltic, gastro-intestinal anti-spasmodic, anti-viral, anti-retroviral, anti-psoriasis and insecticidal compositions comprising biologically effective amounts of the above-described amines and biologically acceptable carriers therefor are also disclosed, as well as methods of treatment, administration or application of biologically effective amounts of the polyamines of the invention. Also disclosed are methods for preparing the polyamines of the invention.

Abstract: An improved method and composition for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue during surgery. The composition comprises a solution of a polymeric material having a molecular weight of about 500,000 or above having a concentration of from about 0.01 to about 15%, by weight.

Abstract: A method and composition for treating irritable bowel syndrome in a subject in need of such treatment, utilizing an amount of a polyamine having the formula: R—NH—(CH2)a—NH—(CH2)bH—(CH2)c—NH2,  1) CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)dNH—(CH2)e—C6H5—CF3,  2) R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R  3) and PIP—(CH2)a—NH—(CH2)b—NH—(CH2)c—PIP,  4) wherein: R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of the alkyl chains may optionally be interrupted by at least one etheric oxygen atom, PIP is piperidine and a, b, c, d, and e may be the same or different and are integers from 1-10 effective to treat irritable bowel syndrome.

Abstract: Anti-diarrheal, anti-secretory, nitric oxide agonist, nitric oxide synthase activating or gastrointestinal anti-spasmodic compounds of the formula:  R1—N1H—(CH2)3—N2H—(C2)3—N3H—(CH2)4—N4H—(CH2)3—N5H—(CH2)3—N6H—R6  (II); or wherein: R1 and R6 may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms; R2-R5 may be the same or different and are H, R1 or R6; R7 is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; and n is an integer from 3 to 6, inclusive; or (IV) a salt thereof with a pharmaceutically acceptable acid; and a pharmaceutically acceptable carrier therefor. Methods of treatment utilizing the composition are also disclosed.