Abstract: The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are:(a) compounds of the formula[D--DHC] (I)wherein [D] is a centrally acting drug species, and [DHC] is the reduced, biooxidizable, blood-brain barrier penetrating lipoidal form of a dihydropyridine .revreaction. pyridinium salt redox carrier, with the proviso that when [DHC] is ##STR1## wherein R is lower alkyl or benzyl and [D] is a drug species containing a single NH.sub.2 or OH functional group, the single OH group when present being a primary or secondary OH group, said drug species being linked directly through said NH.sub.

Abstract: Novel magnetically responsive hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide and particulate magnetically responsive material in an organic solvent solution of a high molecular weight polymer to form a stabilized dispersion of microspheres and cross-linking said microspheres with a polyfunctional cross-linking agent.

Abstract: A method of passivating a Group III-V compound surface by exposing the surface to a compound A-B, wherein A is an element having a heat of oxide formation greater than the heats of oxide formation of Group III and V elements and B is an element: S, Se, Te or Po.

Abstract: The invention provides a method for treating sexual dysfunction in male mammals using a compound of the formula[E--DHC] (I)or a non-toxic pharmaceutically acceptable salt thereof, wherein [E] is an estrogen and [DHC] is the reduced, biooxidizable, blood-brain barrier-penetrating, lipoidal form of a dihydropridine.revreaction.pyridinium salt redox carrier. Compositions for use in the subject method are also disclosed. A preferred compound for use in the method and compositions is an estradiol derivative, namely, 17.beta.-[(1-methyl-1,4-dihydro-3-pyridinyl)carbonyloxy]estra-1,3,5(10)-tr ien-3-ol.

Abstract: Cardiac conditions such as blockages in arteries caused by plaque build-up are treated intravascularly with laser radiation using an optical fiber having a heat conducting end cap on its distal end. A spherical lens within the end cap focuses a small portion of the laser energy directly into the plaque which is in contact with the tip of the end cap and disperses the remaining energy into the end cap for heating it up. The direct laser energy vaporizes part of the plaque so that the end cap can be easily forced through the blockage, and the tissue in contact with the heated end cap is burned away. A diffuser catheter for the ablation of electrical conduction tissue in the heart employs spaced electrodes for detecting the presence of the conduction tissue, and directs laser energy outwardly through the side of the catheter for vaporizing the tissue.

Abstract: A method of beneficiating a phosphate ore containing apatite and dolomite impurities consisting of reagentizing a sample of the ore with an aqueous solution containing a cationic collector and sodium chloride and subjecting the ore to flotation to float the apatite fraction.

Abstract: A composition and method for the regulation of the growth and mortality of cockroaches based on the administration thereto of allopurinol.

Abstract: Method and composition for repair of periodontal osseous defects based on particulate bioactive and biocompatible glass.

Abstract: The present invention relates to pharmaceutical products containing a mixture of benzoic acid, phenol and an alkali fluoride, in an aqueous or aqueous-alcohol solution, optionally in the presence of other usual additives for pharmaceutical preparations, in liquid or semi-liquid form, for the control of diseases in the human caused by herpes virus, and to methods for the topical treatment with these products of herpes simplex efflorescences in the human.

Abstract: Catalysts for the preparation of alkyl halides produced by reacting (1) transition metal carbonyl complex capable of oxidatively adding H.sub.2 or HCl and (2) a Lewis acid from the group consisting of aluminum halides, antimony halides and mixtures thereof, with an adsorbent solid containing surface hydroxyl groups, in a solvent.

Abstract: The present invention is predicated on the discovery that mixtures of solutes and/or particulates of differing masses dissolved or suspended in a liquid media can be separated at high differential flow rates by an enhanced diffusion technique involving the oscillation of the liquid media containing the solutes and/or particulates within one or more ducts or capillaries in the presence of axial concentration gradients.

Abstract: N-methylamino derivatives of biologically active substances which have enhanced delivery across topical membranes and pharmaceutical compositions adapted for topical administration containing same.

Abstract: A trailing edge flap assembly for an aircraft wing includes at its rearward end upper and lower surfaces terminating in a trailing edge portion. The assembly has a flap (15) is located in a stowed position during normal flight. A mounting beam (18) is located to the lower surface (12) of the wing, extending rearwardly thereof and below the flap (15). A carriage (23) is in rolling engagement with longitudinal guideways (53) on the mounting beam (18). To actuate the flap (15), at or about the rearward extremity of the mounting beam (18), there is provided an actuator mounting bracket (21), a rotary actuator (52), and lever arms (27, 28) assocaited with the actuator about a common substantially transverse axis of rotation. The lever arms (27, 28) extend upwardly and terminate adjacent the undersurface of the flap (15), in a pivotal attachment (22) forwardly extending actuator links (25, 26) pivotally interconnecting the lever arms (27, 28) and the carriage (23).

Abstract: A composition comprising a crystalline aluminosilicate zeolite having entrapped therein as an ion pair an anionic material having the formula ML.sub.n.sup.-n+m, wherein M is a metal, L is an anionic ligand, which coordinates more strongly to M than to the surface of said zeolite, n is the number of ligands bound to the metal ion and is an integer from 1 to 6, and m is the oxidation state of the metal.

Abstract: The invention provides compounds of the formulaD--DHC].sub.n (I)and the nontoxic pharmaceutically acceptable salt thereof, wherein D is the residue of a centrally acting drug containing at least one reactive functional group selected from the group consisting of amino, hydroxyl, mercapto, carboxyl, amide and imide, said residue being characterized by the absence of a hydrogen atom from at least one of said reactive functional groups in said drug; n is a positive integer equal to the number of said functional groups from which a hydrogen atom is absent; and [DHC] is the reduced, biooxidizable, blood-brain barrier penetratring lipoidal form of a dihydropyridine.revreaction.pyridinium salt redox carrier, said carrier comprising a bivalent radical of the formula ##STR1## wherein the alkylene group can be straight or branched and can contain 1 to 3 carbon atoms; R.sub.

Abstract: The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are:(a) compounds of the formula[D--DHC] (I)wherein [D] is a centrally acting drug species, and [DHC] is the reduced, biooxidizable, blood-brain barrier penetrating lipoidal form of a dihydropyridine.revreaction.pyridinium salt redox carrier, with the proviso that when [DHC] is ##STR1## wherein R is lower alkyl or benzyl and [D] is a drug species containing a single NH.sub.2 or OH functional group, the single OH group when present being a primary or secondary OH group, said drug species being linked directly through said NH.sub.

Abstract: Improved heart valve assembly 1(FIG. 4) includes: Sewing ring 2 made preferably of woven/knitted fabric of carbon/carbon coated polyester/polytetra-fluoroethylene;Metallic valve housing 3, with external groove accommodating sewing ring, with flat lugs 3a on one side and lug 3b having hook 3c on the other side, said housing being preferably made of "Stellite", titanium or alloys of titanium with aluminum, vanadium or palladium or of stainless steel or cobalt based alloys optionally with coating of boron nitride, titanium nitride or diamond and;Valve occluder disc 4 made of Agate, polyacetal homopolymer, synthetic sapphire, synthetic ruby, corundum or ceramics like alumina, tungsten carbide, titanium carbide or their mixture or of metals like aluminum, titanium, steel or cobalt-chromium-tungsten alloy having coating of one or more of said ceramics, and tapered surface 4a with depression/groove 4c therein held by hook 3c on its less pronounced depression 4d as seen in FIG. 5 more clearly.

Abstract: The present invention relates a fastening element for the connection of two sheets or plates (herein termed sheets) arranged at a selectable angle in relation to each other along their abutting edges using two gripping jaws able to be centrally connected with each other by means of a screw, said jaws having wings of different length and forming two bearing sockets, in each of which there are rotatable cylindrical gripping rollers provided with an axial gripping groove and consisting of elastic material.The purpose of the invention is to provide an improved form of such a fastening element remedying the defects of known devices and making it possible to set sheets at a predetermined included angle in a single manner. In this respect it should be possible for the gripping rollers to be slipped onto the sheets easily in the non-screwed tight condition and to prevent the gripping rollers from falling out during assembly.

Abstract: A tubular acoustic projector for underwater use consists of a ceramic, piezo-electric transducer (21A, 21B) contained in a coaxial, electrically-conductive cylindrical housing (10) whose side wall (11) is thin enough to vibrate with the transducers (21A, 21B). The side wall (11) maintains the transducer under a radial compressive pre-load so as to avoid ceramic failure due to tensile stress. The side wall is sufficiently thermally conductive to dissipate the heat generated in the transducer, in use, to prevent failure of the transducer under the effects of heat. Electrical isolation of the inner and outer surfaces of the transducer is achieved by filling the housing with an insulating liquid.

Abstract: The present invention embodies a composition particularly adapted for use as an ophthalmic viscosurgical material for use in the anterior chamber of the eye consisting essentially of an aqueous solution preferably having a near physiological pH and osmolarity and containing at least about 1.5%, by weight, of a water soluble physiologically acceptable derivative of carboxymethylcellulose having a molecular weight greater than 500,000 and a degree of substitution (DS) greater than about 0.4, the aqueous solution having a viscosity greater than about 10,000 centipoises.The invention further embodies an improved ophthalmic viscosurgical procedure wherein the anterior chamber of the eye is filled with a space-filling corneal endothelium and ocular tissue protective surgical material, the improvement comprising the utilization of an ophthalmic surgical material having the above described composition.