Abstract: A recapping device is provided for use with medical devices including all hollow and solid medical needles of the type used for entry into the body and into closed intravenous and intraarterial systems for access, sampling, and injection of medications, and are withdrawn after use. The recapping device includes a hollow sleeve encircling a portion of the needle and having a distal end aperture adapted to permit the sleeve to slide between a first position on the medical device wherein the needle is exposed to enable use of the needle, and a second position characterized by the distal end of the needle being contained within the distal end capped hollow sleeve, and the device may optionally contain a housing for a free-floating fenestrated disk, which, upon movement of the device to its second position wherein the tip of the needle exits the distal end aperture, shifts position to provide an obstruction at that aperture.

Abstract: A method of oxidizing olefins or alkanes by contacting with oxygen and a catalyst composition of the formula:Ru.sub.3 O[OCO(CF.sub.2).sub.y CF.sub.3 ].sub.6 LWherein: Ru are reuthenium atoms having a formal oxidation state of +2 or +3,L is a neutral or anionic ligand,Y is an integer from 0 to 6, andx is an integer from 1 to 3; and an anion.

Abstract: A high temperature sensor for use with an induced vibration dynamic touch sensor system comprising a pad element adapted for sliding contact with an object so as to induce vibrations in the pad, a mechanical coupling means comprising a stiff, substantially straight member for coupling the pad to a transducer assembly, the transducer assembly for converting the vibrations into electrical signals. The electrical signals are processed to produce a normalized spectral signature characteristic of the size and shape of the object, and the sizes and shapes and nature of its surface features. A pattern vector is extracted from the spectral signature and subjected to discriminant analysis to classify and recognize the object.

Abstract: A method and apparatus for scientific analysis of a sample under low temperature vacuum conditions uses a vacuum chamber with a conveyor belt disposed therein. One end of the conveyor belt is a cool end in thermal contact with the cold stage of a refrigerator, whereas the other end of the conveyor belt is a warm end spaced from the refrigerator. A septum allows injection of a sample into the vacuum chamber on top of the conveyor belt for spectroscopic or other analysis. The sample freezes on the conveyor belt at the cold end. One or more windows in the vacuum chamber housing allow spectroscopic analysis of the sample. Following the spectroscopic analysis, the conveyor belt may be moved such that the sample moves toward the warm end of the conveyor belt where upon it evaporates, thereby cleaning the conveyor belt.

Abstract: The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable salts thereof, wherein D is the residue of a centrally acting primary, secondary or tertiary amine and ##STR2## is an unsubstituted or substituted dihydropyridyl, dihydroquinolyl or dihydroisoquinolyl radical. The corresponding ionic pyridinium, quinolinium and isoquinolinium salts ##STR3## wherein X.sup.- is the anion of a non-toxic pharmaceutically acceptable acid, are also disclosed.

Abstract: An improved system for removing cells from bone marrow wherein the cells are bound by monoclonal antibodies conjugated to magnetic particles, the system comprising a chamber provided with inlets and outlets for flowing through the chamber a liquid sample containing the bone marrow and magnetic conjugated antibodies bound to the cells and a magnetic field source associated with the chamber wherein the improvement comprises a non-uniform magnetic field in an ascending gradient from the inlet to the outlet.

Abstract: Proteinaceous, antigenic factor derived from a group C Streptococcus which is receptor for the Fc region of IgG, a method for its preparation and immunoassay and antigen detection methods employing the receptor.

Abstract: The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are:(a) compounds of the formula[D--DHC] (I)wherein [D] is a centrally acting drug species, and [DHC] is the reduced, biooxidizable, blood-brain barrier penetrating lipoidal form of a dihydropyridine.revreaction.pyridinium salt redox carrier, with the proviso that when [DHC] is ##STR1## wherein R is lower alkyl or benzyl and [D] is a drug species containing a single NH.sub.2 or OH functional group, the single OH group when present being a primary or secondary OH group, said drug species being linked directly through said NH.sub.

Abstract: For sterilizing a tight enclosure (10) equipped with a ventilation and filtration circuit (14), said enclosure is isolated and the internal relative humidity level is lowered by means of an assembly (50) incorporating a drying cartridge (54). The sterilizing agent (46) is then introduced through a closed circuit (30) until a relative humidity level close to the dew point is obtained. The sterilizing agent is kept in the enclosure for a given contact time, before scavenging said agent by means of the ventilation and filtration circuit (14).

Abstract: A space switch is disclosed which comprises an array (10) of cells (11, 13) which are interconnected with one another. The cells have a transmission gate (11) and a latch (13) for allowing a signal to pass from an input into the cell to an output from the cell. A column selector (12) and a row selector (14) are provided for selecting an appropriate one of the cells (11, 13) so that any one input to the array of cells can be coupled to any output of the cells.

Abstract: A device for determining a flow rate of liquid discharged from a plurality of discharges comprising a plurality of collectors for the discharged liquid connected by a manifold having a plurality of inlet lines attached to the discharges and a single outlet line; a receptacle having at least a first and a second compartment, each of which has a predetermined fixed volume adapted to hold the liquid and each having a volume indicator associated with at least one liquid level in each of the compartments; a connector for the outlet line of the manifold to the receptacle and an attachment for selectively directing the liquid from the outlet line into each of the compartments.

Abstract: Beta-agonist carbostyril derivatives having the formula ##STR1## wherein X may be the ortho, meta or para position and is selected from the group consisting of halogen, amino and substituted and unsubstituted lower alkanoylamino having from 1 to 6 carbon atoms and pharmaceutically acceptable salts and complexes thereof.

Abstract: A composition and method for enhancing permeability of topical drugs wherein the agent which enhances the permeability of the drug is selected from the group consisting of (1) a choline ester having the formula:[CH.sub.3 (CH.sub.2).sub.n --COOCH.sub.2 CH.sub.2 N.sup.+ (CH.sub.3).sub.3 ]X.sup.- or[CH.sub.3 (CH.sub.2).sub.m CH.dbd.CH(CH.sub.2).sub.n --COOCH.sub.2 CH.sub.2 N.sup.+ (CH.sub.3).sub.3 ]X.sup.-wherein m and n are integers in the range of from 0 to 30 and X.sup.- is a pharmaceutically acceptable anion and (2) a mixture of the choline ester and an acid having the formula:CH.sub.3 (CH.sub.2).sub.n --COOH orCH.sub.3 (CH.sub.2).sub.m CH.dbd.CH(CH.sub.2).sub.n --COOHor a pharmaceutically acceptable salt thereof.

Abstract: A gasket seal for use in ultra-high vacuum systems is provided which comprises two rigid flanges disposed in opposite facing relation to each other, the flanges having a gasket inserted therebetween when the gasket seal is made up into its operating position. The gasket has at least one integral handle in the form of at least one wire adapted to extend from the gasket through a leak check groove of one of the flanges, the wire being used to handle the gasket and to clip the gasket to one of the flanges where desired prior to making up the joint. The wire may also be used as a conductor of heat to deliver heat to the portion of the system under vacuum, and the gasket may further have feedthrough means or a section having mounting holes for support structures extending inwardly of the flanges.

Abstract: A method and composition for the stimulation of appetite in human or non-human vertebrate animals comprising the administration to the brain to the animal, an effective appetite stimulating amount of NPY or a pharmaceutically acceptable derivative, analog, salt or complex thereof.

Abstract: The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine.revreaction.pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. These new amino acids contain a redox system appended directly or via an alkylene bridge to the carbon atom adjacent to the carboxyl carbon and may be incorporated into a peptide chain at a variety of positions, including non-terminal positions.

Abstract: Ruthenium trifluoroalkyl carboxylates are disclosed.

Abstract: A type II, Proteinaceous, antigenic factor derived from a Group A streptococcus which is a receptior for the Fc region of human Ig G3 and which exhibits a major diffuse protein band on polyacrylamide gel electrophoresis and which has a molecular weight of about 38,000 daltons.

Abstract: A heat transfer system comprising a pair of zones positioned at respective locations of differing temperatures between which heat is transferred; a first element one surface of which conducts heat; a second element, one end of which communicated with one of the pair of zones and the other end of which communicates with the other of the pair of zones and one surface of which conducts heat and is slidably engaged with the heat-conducting surface of the first element and means for establishing oscillatory movement of the second element between the pair of zones such that the heat-conducting surface thereof slidably engages the heat-conducting surface of the first element and such that the ends thereof do not communicate with the other of the pair of zones.

Abstract: A brain-specific dopaminergic response is elicited in a patient in need of such treatment, e.g., a patient afflicted with Parkinson's disease of hyperprolactinemia, by administering thereto a therapeutically effective amount of preferably catechol protected dopamine tethered to a reduced, blood-brain barrier penetrating lipoidal form [D-DHC] of a dihydropyridine.revreaction.pyridinium salt type redox carrier, e.g., 1,4-dihydrotrigonelline. Oxidation of the dihydropyridine carrier moiety in vivo to the ionic pyridinium salt type dopamine/carrier entity [D-QC].sup.+ prevents elimination thereof from the brain, while elimination from the general circulation is accelerated, resulting in significant and prolongedly sustained brain-specific dopaminergic activity.