Patents Represented by Attorney Donald J. Barrack
  • Patent number: 5001148
    Abstract: Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, has been found in compounds of the formula ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from:(1) alkyl,(2) substituted alkyl in which one or more substituents are selected from(a) halogen,(b) hydroxyl,(c) alkoxy,(d) alkoxycarbonyl,(e) acyloxy,(f) cycloalkyl,(g) phenyl,(h) substituted phenyl in which one or more substituents are X or Y,(i) alkyl-S(O).sub.n,(j) cycloalkyl-S(O).sub.n,(k) phenyl-S(O).sub.n,(l) substituted phenyl-S(O).sub.n in which one or more substituents are X or Y, and(m) oxo,(3) alkoxy,(4) alkenyl,(5) cycloalkyl,(6) substituted cycloalkyl in which one or more substituents are selected from(a) alkyl,(b) substituted alkyl in which one or more substituents are selected from(i) halogen,(ii) hydroxy,(iii) alkoxy,(iv) alkoxycarbonyl(v) acyloxy(vi) phenyl(vii) substituted phenyl in which one or more substituents are X and Y,(viii) alkyl-S(O).sub.n,(ix) cycloalkyl-S(O).sub.
    Type: Grant
    Filed: June 7, 1989
    Date of Patent: March 19, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jeffrey O. Saunders, Eric M. Gordon
  • Patent number: 4978762
    Abstract: A new process for preparing [1S-[1.alpha.,2.alpha.(Z),-3.alpha.,4.alpha.]]-7-[3-[[[ (1-oxoheptyl)amino]acetyl]amino]-methyl]-7-oxabicyclo[2,2,1]hept-2-yl]-5-h eptenoic acid. New intermediates are also described. [1S-(1.alpha.,2.alpha.(Z),3.alpha.,4.alpha.]]-7-[3-[[[[(1-oxoheptyl)-amino ]acetyl]amino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid is useful in the treatment of thrombotic disease.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: December 18, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: David Kronenthal
  • Patent number: 4973747
    Abstract: A process has now been discovered by which an intermediate in preparation of antibiotics ##STR1## may be directly derived from the substrate ##STR2## by treatment with aqueous solutions of MHCO.sub.3 and MOH, wherein: R.sup.1, R.sup.2 and R.sup.3 are each independently alkyl, alkenyl, alkynyl, substituted alkyl, substituted alkenyl, substituted alkynyl, aryl, or substituted aryl;M is alkali metal (such as Na, Li, or K); andX is halogen.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: November 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Janak Singh, Richard H. Mueller
  • Patent number: 4963671
    Abstract: This process enables preparation of the preferred (+)-threo enantiomer by resolution of its racemic mixture of a compound of the formula ##STR1## wherein Y.sup.1 and Y.sup.2 are each independently lower alkyl and R.sup.1 is hydrogen or lower alkyl. The compound is treated with a chiral acid (tartaric aicd preferred) in an organic solvent (ethanol preferred) to yield the (+)-threo enantiomer, which is then recovered from the reaction mixture. This enantiomer may then be used to produce the preferred (+)-cis enantiomer of certain benzothiazepine cardiovascular agents.
    Type: Grant
    Filed: November 20, 1989
    Date of Patent: October 16, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John Krapcho
  • Patent number: 4959470
    Abstract: Componds having the formula ##STR1## and pharmaceutically acceptable salts thereof, exhibit antibacterial activity wherein R is ##STR2##
    Type: Grant
    Filed: August 17, 1988
    Date of Patent: September 25, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • Patent number: 4939253
    Abstract: Antibiotic activity is exhibited by .beta.-lactams having an ##STR1## substituent (and analogs thereof) in the 1-position and an acylamino substituent in the 3-position.
    Type: Grant
    Filed: July 21, 1983
    Date of Patent: July 3, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Henner Straub
  • Patent number: 4931045
    Abstract: A two-part ostomy coupling has a first part which is a flat annulus having inner and outer peripheral walls. With the annulus these walls define a shallow channel. The coupling has a second part formed by a second flat annulus with radially inner and outer rims formed by respective flexible peripheral elements of plastics material. The first and second parts are constructed so that the second part is a push fit into the shallow channel defined by the first part. An annular member having a flexible resilient strip extending inwardly from its radially inner edge and an element extending from its radially outer edge which can engage under a rim portion of the said outer peripheral wall. Alternatively, the second part may be an annular member having a flexible resilient strip extending outwardly from its radially outer edge and an element extending from its radially inner edge which can engage under a rim portion of the said inner peripheral wall.
    Type: Grant
    Filed: July 5, 1988
    Date of Patent: June 5, 1990
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Peter L. Steer
  • Patent number: 4925216
    Abstract: Apparatus for attaching a catheter to a bag includes a pair of coupling rings for trapping a part of the bag wall between them. A cutter having a blade of circular or closed loop form makes a cut in the trapped wall and an elastomeric member for gripping a catheter is connectable to the cutter or to one of the rings. The catheter is inserted in the elastomeric member and through the rings, the member serving as a gaiter.
    Type: Grant
    Filed: March 31, 1988
    Date of Patent: May 15, 1990
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Peter L. Steer
  • Patent number: 4918075
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## its pharmaceutically acceptable salts thereof wherein R.sub.2 and R.sub.3 are independently hydrogen, --PO.sub.3 H.sub.2 or ##STR2## and R.sub.1 is either a purine, pyrimidine or an analog thereof.
    Type: Grant
    Filed: December 20, 1988
    Date of Patent: April 17, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert Zahler, Glenn A. Jacobs
  • Patent number: 4917692
    Abstract: A faecal incontinence bag having flexible front and rear walls secured together around their periphery. The front wall has a hole therein for entry of matter discharged by the wearer. The hole is surrounded by an adhesive pad of skin-compatible water-resistant material secured to the external surface of the front wall surrounding the hole. The pad is generally heart-shaped so that when in position on the wearer the concave portion of the heart-shaped pad is towards the front of the wearer.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: April 17, 1990
    Assignee: E. R. Squibb and Sons, Inc.
    Inventors: Peter L. Steer, Ronald A. Plass
  • Patent number: 4909478
    Abstract: A drainage tap can be readily fixed in a face-to-face manner to the wall of a plastics drainage bag and is easily operated by a user. The tap has a body and a valve member therein, and the latter is held within the body by engagement of an external rib on the valve member in a slot which extends into a flange of the body.
    Type: Grant
    Filed: March 8, 1988
    Date of Patent: March 20, 1990
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Peter L. Steer
  • Patent number: 4904764
    Abstract: 4-Diazo-3-methoxy-2,5-cyclohexandien-1-one, and pharmaceutically acceptable salts thereof, are antibiotics having antibacterial activity against a variety of gram positive and gram negative bacteria, particularly against anaerobic bacteria. The compound can be prepared by culturing aerobically Penicillium funiculosum A.T.C.C. No. 20783 in a culture medium containing assimilable sources of carbohydrates and nitrogen.
    Type: Grant
    Filed: December 12, 1985
    Date of Patent: February 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph O'Sullivan, Pushpa Singh
  • Patent number: 4904775
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof and possessing antibacterial activity, and intermediates to compounds of formula I having the formula
    Type: Grant
    Filed: May 16, 1988
    Date of Patent: February 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, Peter H. Ermann
  • Patent number: 4892530
    Abstract: An ostomy appliance intended for attachment to a peristomal area of a wearer includes a pad of medical-grade skin-attachable adhesive material, a first coupling element secured thereto, the element having a medically-extending flange attached to a surface of the pad and an upstanding rib of closed loop form constructed to couple with a couterpart (second) coupling element on a bag or pouch. An inner chute member is located radially within and adjacent to the first coupling element, the chute member having a substantially cylindrical wall covering the whole of the radially inner surface of the first coupling element. At one of its ends, the chute has a radially outwardly extending flange positioned so that it traps the chute member in position when the two coupling elements are coupled together.
    Type: Grant
    Filed: December 28, 1987
    Date of Patent: January 9, 1990
    Assignee: Edward Weck Incorporated
    Inventor: Peter L. Steer
  • Patent number: 4890608
    Abstract: An attachment assembly is disclosed for attaching an article such as a wound cover or a prosthesis to human skin. The article attached may be, for example, a cover or dressing over a wound or a fistula or other lesion, it may be an eye patch or a breast prosthesis for use after masectomy or it may be a pouch to cover the genital region. The attachment assembly comprises a body-attachable pad of skin-compatible adhesive material and a series of double-sided adhesive layers thereon, which layers are constructed and arranged to be manually peeled off one-by-one when desired in order to expose a fresh adhesive surface to which the article is then attached.
    Type: Grant
    Filed: June 4, 1986
    Date of Patent: January 2, 1990
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Peter L. Steer
  • Patent number: 4888424
    Abstract: Hypotensive activity is exhibited by compounds having the formulas ##STR1##
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: December 19, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, David Floyd, Ving G. Lee
  • Patent number: 4887894
    Abstract: An improved beam deflector having a first ball element attached to a second ball element with the first ball element mounted in a movable socket, movable about a single axis only through the first ball element. The second ball element is mounted in a fixed socket and is rotatable about a single axis only through the second ball element. The fixed socket is fixed to the housing of the beam deflector. Rotational movement is limited by the spacing between opposing flat surfaces of the movable and fixed sockets. The movable socket is remotely movable in response to movement of a control rod which is coupled to the movable socket through a universally movable third ball and socket arrangement.
    Type: Grant
    Filed: February 6, 1989
    Date of Patent: December 19, 1989
    Assignee: Edward Weck Incorporated
    Inventors: Boris Gluzerman, Nicholas Lakatos, Paul W. Hensler
  • Patent number: 4885292
    Abstract: Compounds of the formula ##STR1## are disclosed wherein R.sub.1 is N-heterocyclic moiety. These compounds intervene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.
    Type: Grant
    Filed: June 29, 1989
    Date of Patent: December 5, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Harold N. Weller, III
  • Patent number: 4885363
    Abstract: Metal-chelating liquids having the formula ##STR1## wherein Y is oxygen or ##STR2## R.sub.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: December 5, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael F. Tweedle, Glen T. Gaughan, James T. Hagan
  • Patent number: 4883477
    Abstract: An ostomy appliance has four annular parts. The first part is attachable to the body of the wearer. It is also attachable to the third part by a second part which comprises a rotatable locking ring. The third part is attachable to the fourth part in a push fit manner and the ostomy bag is connected to the fourth part.
    Type: Grant
    Filed: April 15, 1988
    Date of Patent: November 28, 1989
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Peter L. Steer