Abstract: Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, has been found in compounds of the formula ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from:(1) alkyl,(2) substituted alkyl in which one or more substituents are selected from(a) halogen,(b) hydroxyl,(c) alkoxy,(d) alkoxycarbonyl,(e) acyloxy,(f) cycloalkyl,(g) phenyl,(h) substituted phenyl in which one or more substituents are X or Y,(i) alkyl-S(O).sub.n,(j) cycloalkyl-S(O).sub.n,(k) phenyl-S(O).sub.n,(l) substituted phenyl-S(O).sub.n in which one or more substituents are X or Y, and(m) oxo,(3) alkoxy,(4) alkenyl,(5) cycloalkyl,(6) substituted cycloalkyl in which one or more substituents are selected from(a) alkyl,(b) substituted alkyl in which one or more substituents are selected from(i) halogen,(ii) hydroxy,(iii) alkoxy,(iv) alkoxycarbonyl(v) acyloxy(vi) phenyl(vii) substituted phenyl in which one or more substituents are X and Y,(viii) alkyl-S(O).sub.n,(ix) cycloalkyl-S(O).sub.

Abstract: A new process for preparing [1S-[1.alpha.,2.alpha.(Z),-3.alpha.,4.alpha.]]-7-[3-[[[ (1-oxoheptyl)amino]acetyl]amino]-methyl]-7-oxabicyclo[2,2,1]hept-2-yl]-5-h eptenoic acid. New intermediates are also described. [1S-(1.alpha.,2.alpha.(Z),3.alpha.,4.alpha.]]-7-[3-[[[[(1-oxoheptyl)-amino ]acetyl]amino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid is useful in the treatment of thrombotic disease.

Abstract: A process has now been discovered by which an intermediate in preparation of antibiotics ##STR1## may be directly derived from the substrate ##STR2## by treatment with aqueous solutions of MHCO.sub.3 and MOH, wherein: R.sup.1, R.sup.2 and R.sup.3 are each independently alkyl, alkenyl, alkynyl, substituted alkyl, substituted alkenyl, substituted alkynyl, aryl, or substituted aryl;M is alkali metal (such as Na, Li, or K); andX is halogen.

Abstract: This process enables preparation of the preferred (+)-threo enantiomer by resolution of its racemic mixture of a compound of the formula ##STR1## wherein Y.sup.1 and Y.sup.2 are each independently lower alkyl and R.sup.1 is hydrogen or lower alkyl. The compound is treated with a chiral acid (tartaric aicd preferred) in an organic solvent (ethanol preferred) to yield the (+)-threo enantiomer, which is then recovered from the reaction mixture. This enantiomer may then be used to produce the preferred (+)-cis enantiomer of certain benzothiazepine cardiovascular agents.

Abstract: Componds having the formula ##STR1## and pharmaceutically acceptable salts thereof, exhibit antibacterial activity wherein R is ##STR2##

Abstract: Antibiotic activity is exhibited by .beta.-lactams having an ##STR1## substituent (and analogs thereof) in the 1-position and an acylamino substituent in the 3-position.

Abstract: A two-part ostomy coupling has a first part which is a flat annulus having inner and outer peripheral walls. With the annulus these walls define a shallow channel. The coupling has a second part formed by a second flat annulus with radially inner and outer rims formed by respective flexible peripheral elements of plastics material. The first and second parts are constructed so that the second part is a push fit into the shallow channel defined by the first part. An annular member having a flexible resilient strip extending inwardly from its radially inner edge and an element extending from its radially outer edge which can engage under a rim portion of the said outer peripheral wall. Alternatively, the second part may be an annular member having a flexible resilient strip extending outwardly from its radially outer edge and an element extending from its radially inner edge which can engage under a rim portion of the said inner peripheral wall.

Abstract: Apparatus for attaching a catheter to a bag includes a pair of coupling rings for trapping a part of the bag wall between them. A cutter having a blade of circular or closed loop form makes a cut in the trapped wall and an elastomeric member for gripping a catheter is connectable to the cutter or to one of the rings. The catheter is inserted in the elastomeric member and through the rings, the member serving as a gaiter.

Abstract: A faecal incontinence bag having flexible front and rear walls secured together around their periphery. The front wall has a hole therein for entry of matter discharged by the wearer. The hole is surrounded by an adhesive pad of skin-compatible water-resistant material secured to the external surface of the front wall surrounding the hole. The pad is generally heart-shaped so that when in position on the wearer the concave portion of the heart-shaped pad is towards the front of the wearer.

Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## its pharmaceutically acceptable salts thereof wherein R.sub.2 and R.sub.3 are independently hydrogen, --PO.sub.3 H.sub.2 or ##STR2## and R.sub.1 is either a purine, pyrimidine or an analog thereof.

Abstract: A drainage tap can be readily fixed in a face-to-face manner to the wall of a plastics drainage bag and is easily operated by a user. The tap has a body and a valve member therein, and the latter is held within the body by engagement of an external rib on the valve member in a slot which extends into a flange of the body.

Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof and possessing antibacterial activity, and intermediates to compounds of formula I having the formula

Abstract: 4-Diazo-3-methoxy-2,5-cyclohexandien-1-one, and pharmaceutically acceptable salts thereof, are antibiotics having antibacterial activity against a variety of gram positive and gram negative bacteria, particularly against anaerobic bacteria. The compound can be prepared by culturing aerobically Penicillium funiculosum A.T.C.C. No. 20783 in a culture medium containing assimilable sources of carbohydrates and nitrogen.

Abstract: An ostomy appliance intended for attachment to a peristomal area of a wearer includes a pad of medical-grade skin-attachable adhesive material, a first coupling element secured thereto, the element having a medically-extending flange attached to a surface of the pad and an upstanding rib of closed loop form constructed to couple with a couterpart (second) coupling element on a bag or pouch. An inner chute member is located radially within and adjacent to the first coupling element, the chute member having a substantially cylindrical wall covering the whole of the radially inner surface of the first coupling element. At one of its ends, the chute has a radially outwardly extending flange positioned so that it traps the chute member in position when the two coupling elements are coupled together.

Abstract: An attachment assembly is disclosed for attaching an article such as a wound cover or a prosthesis to human skin. The article attached may be, for example, a cover or dressing over a wound or a fistula or other lesion, it may be an eye patch or a breast prosthesis for use after masectomy or it may be a pouch to cover the genital region. The attachment assembly comprises a body-attachable pad of skin-compatible adhesive material and a series of double-sided adhesive layers thereon, which layers are constructed and arranged to be manually peeled off one-by-one when desired in order to expose a fresh adhesive surface to which the article is then attached.

Abstract: Hypotensive activity is exhibited by compounds having the formulas ##STR1##

Abstract: An improved beam deflector having a first ball element attached to a second ball element with the first ball element mounted in a movable socket, movable about a single axis only through the first ball element. The second ball element is mounted in a fixed socket and is rotatable about a single axis only through the second ball element. The fixed socket is fixed to the housing of the beam deflector. Rotational movement is limited by the spacing between opposing flat surfaces of the movable and fixed sockets. The movable socket is remotely movable in response to movement of a control rod which is coupled to the movable socket through a universally movable third ball and socket arrangement.

Abstract: Compounds of the formula ##STR1## are disclosed wherein R.sub.1 is N-heterocyclic moiety. These compounds intervene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.

Abstract: Metal-chelating liquids having the formula ##STR1## wherein Y is oxygen or ##STR2## R.sub.

Abstract: An ostomy appliance has four annular parts. The first part is attachable to the body of the wearer. It is also attachable to the third part by a second part which comprises a rotatable locking ring. The third part is attachable to the fourth part in a push fit manner and the ostomy bag is connected to the fourth part.