Abstract: Topical pharmaceutical compositions containing a specific 6-amino-1,2-dihydro-1-hydroxy-2-iminopyrimidine component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C.sub.3 -C.sub.4 diol or C.sub.3 -C.sub.6 triol and isocetyl alcohol polar lipid compound. The vehicle provides marked transepidermal and percutaneous delivery of the iminopyrimidine compound. These compositions, when applied topically, act to stimulate the growth of mammalian hair on the body.
Type:
Grant
Filed:
November 20, 1990
Date of Patent:
August 20, 1991
Assignee:
The Procter & Gamble Company
Inventors:
Gerald B. Kasting, Ellen R. Massaro, Ronald L. Smith, William E. Snyder
Abstract: Processes for dehusking psyllium seeds to obtain high yields of high purity psyllium seed husk. These processes comprise milling intact psyllium seeds in a mill which causes the husk to be fragmented by collision under conditions whereby the husk is fractured and separated from the non-husk portion of the psyllium seed without substantial breakage and size reduction of the non-husk portion. Preferred milling utilizes impact speeds within the range of from about 5 m/sec to about 40 m/sec.
Abstract: Mixtures of tartrate disuccinate and tartrate monosuccinate enriched in the disuccinate species are prepared by reacting isomerically pure D- or L-tartaric acid with maleic anhydride in the presence of sodium hydroxide and calcium hydroxide.
Abstract: Tartrate monosuccinate and tartrate disuccinate compounds of the formulae HO(CHCOOX)CH(COOX)OCH(COOX)CH.sub.2 COOX and CH.sub.2 (COOX)CH(COOX)O(CH[COOX]).sub.2 OCH(COOX)CH.sub.2 COOX are used in combination with various polymers to provide anticalculus and antiplaque effects on teeth. Oral care compositions such as dentifrices, mouthwashes, and the like, are provided. Use of the tartate-succinates and polymers in combination with other oral car ingredients such as fluoride, pyrophosphate and antibacterials is also described.
Abstract: Tartrate monosuccinate and tartrate disuccinate compounds of the formulas HO(CHCOOX)CH(COOX)OCH(COOX)CH.sub.2 COOX and CH.sub.2 (COOX)CH-(COOX)O(CH[COOX]).sub.2 OCH(COOX)CH.sub.2 COOX are used to provide anticalculus benefits on teeth. Oral care composition such as dentifrices, mouthwashes, and the like, are provided. Use of the tartrate-succinates in combination with other oral care ingredients such as fluoride, pyrophosphate and antibactrials is also described.
Type:
Grant
Filed:
June 26, 1990
Date of Patent:
May 14, 1991
Assignee:
The Procter & Gamble Company
Inventors:
John J. Parran, Jr., Margaret M. Coyle-Rees, John T. Rotruck, Richard J. Sunberg
Abstract: Microbially-stable liquid pharmaceutical suspensions for oral administration comprising a bismuth-containing pharmaceutical agent, benzoic acid, sorbic acid, a suspension system and water, and wherein said compositions have a pH within the range of from about 3.0 to about 5.5. These compositions are efficacious, and have good aesthetics and good storage stability.
Type:
Grant
Filed:
March 17, 1989
Date of Patent:
May 7, 1991
Assignee:
The Procter & Gamble Company
Inventors:
Laura L. Stentz, Jerry R. Maney, Thomas E. Sox
Abstract: Disclosed are facial cleansing compositions in the form of an oil-in-water emulsion which contain specific surfactants with an HLB above about 10 in combination with specific polyalphaolefins and specific carboxylic copolymers which provide improved cleansing efficacy as well as improved rinsability and improved skin feel (such as a nongreasy feeling).
Type:
Grant
Filed:
October 11, 1989
Date of Patent:
April 30, 1991
Assignee:
Richardson-Vicks, Inc.
Inventors:
Susan L. Ciotti, Eric G. Spengler, George E. Deckner
Abstract: The present invention relates to oral hygiene compositions having improved anticalculus activity containing a mixture of a sodium and potassium pyrophosphate salt and a polyacrylic acid or salt thereof or copolymers of acrylic acid and another monomer or mixtures thereof and an effective amount of a water soluble fluoride salt in a pharmaceutically acceptable carrier to provide enhanced anticalculus benefits.
Abstract: This disclosure relates to a novel composition for making and using psyllium high fiber food products useful as a dietary aid. In particular, the compositions contain a dry blend of high fiber food product base which may be incorporated into a psyllium fiber drink mix or extended psyllium fiber bar or puff.
Abstract: An oral hygiene compositions possessing antiplaque and antigingivitis properties containing stannous fluoride stabilized with stannous gluconate in an orally acceptable carrier at pH of from about 3.0% about 4.79 and said composition is substantially free of a calcium ion source.
Type:
Grant
Filed:
September 13, 1989
Date of Patent:
April 2, 1991
Assignee:
The Procter & Gamble Company
Inventors:
Satyanarayana Majeti, Christopher B. Guay, Mark M. Crisanti
Abstract: Disclosed are oral pharmaceutical preparations which comprise a pharmacologically active drug bound to small particles of an ion-exchange resin to provide a drug-resin complex having a drug content above a specified value. The drug-resin complex is subsequently coated with a water-permeable diffusion barrier coating that is insoluble in gastrointestinal fluids thereby providing a controllable sustained release of drug under conditions encountered in the gastrointestinal tract.
Type:
Grant
Filed:
November 2, 1988
Date of Patent:
February 26, 1991
Assignee:
Richardson-Vicks, Inc.
Inventors:
William J. Kelleher, Anthony E. Carpanzano
Abstract: Toothpaste compositions containing pyrophosphate or phosphonic acid salt and 3 pyridylmethanol, which compositions are effective against calculus.
Abstract: Oral compositions containing a cationic antimicrobial agent and benzoic acid and phthalic acid or salts of these acids, which compositions are effective against plaque and gingivitis, are disclosed. Also disclosed are methods for reducing plaque and gingivitis.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
February 19, 1991
Assignee:
The Procter & Gamble Company
Inventors:
Duane L. Charbonneau, Mark D. Evans, Lincoln D. Germain, Martin S. Robin
Abstract: This disclosure relates to drug-polymer matrix compositions comprising an active ingredient having an amine or amido group and a pharmaceutically acceptable copolymer having a plurality of carboxylic acid and ester groups wherein the matrix dissociates in a media having a pH of less than 4, thereby releasing the active ingredient into the media.
Abstract: Oral compositions containing a linear polymer polyelectrolyte, a soluble fluoride ion source and a strontium ion source are described herein.