Patents Represented by Attorney, Agent or Law Firm Ellen K. Park
  • Scopularin
    Patent number: 5294725
    Abstract: A novel antibiotic substance, Scopularin, is prepared by cultivation of a strain of the microorganism, Scopulariopsis, A.T.C.C. No. 20,914. This compound and its alcohol derivative have also been found to have cytochrome P450 inhibition activity.
    Type: Grant
    Filed: January 31, 1989
    Date of Patent: March 15, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald R. Kirsch, Joseph O'Sullivan, Douglas W. Phillipson
  • Heteroaryl derivatives of monocyclic beta-lactam antibiotics
    Patent number: 5290929
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: March 1, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Joseph E. Sundeen, Henner Straub, Peter Ermann, Uwe D. Treuner, Kent Amsberry, Michael Fakes, Sailesh A. Varia
  • Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
    Patent number: 5276168
    Abstract: A new method for the treatment of ischemic conditions and arrhythmia is disclosed. The method uses compounds of the formula ##STR1## wherein A can be --CH.sub.2 --, --O--, --NR.sub.9 --, --S--, --SO--, --SO.sub.2 --; X can be oxygen or sulfur; Y can be --NR.sub.8, --O--, --S--, --CH.sub.2 -- and the R groups are as defined herein. Novel compounds within the definition of formula I are also disclosed.
    Type: Grant
    Filed: June 19, 1992
    Date of Patent: January 4, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Intramolecular arbuzov process for the preparation of intermediates useful in the preparation of phosphorus containing HMG-COA reductase inhibitors
    Patent number: 5274155
    Abstract: A process for the preparation of compounds of formula ##STR1## and pharmaceutically acceptable salts thereof; wherein X is --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C-- or --CH.sub.2 O-- (where O is linked to Z); Z is a hydrophobic anchor R.sub.1 is hydrogen, alkyl, cycloalkyl or aryl; comprising the steps of:(A) reacting a compound of formula ##STR2## with a compound of formula ##STR3## or a compound of formula ##STR4## in the presence of an amine base or an alkali metal hydride in an organic solvent to form a compound having the formula ##STR5## (B) heating the compound of formula IX at a temperature of from about 100.degree. C. to about 200.degree. C., to form a compound of formula ##STR6## and (C) quenching the compounds of formula VIII with an acid provides the compounds of formula I.
    Type: Grant
    Filed: December 7, 1992
    Date of Patent: December 28, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John K. Thottathil, David Kronenthal
  • 4-methoxy-5-methyl-pyran-3-ol natural products and derivatives thereof
    Patent number: 5270334
    Abstract: Novel antibiotic substances, including novel natural products, having the general formula ##STR1## wherein R.sub.1 and R.sub.2 are as defined herein, are disclosed. These compounds have been found to be cytochrome P450 inhibitors.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: December 14, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph O'Sullivan, Douglas W. Phillipson, Henner Straub, Peter H. Ermann
  • Substituted pyran derivatives having antiinfective activity
    Patent number: 5266593
    Abstract: Novel antibiotic substances, having the general formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as defined herein.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: November 30, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter Ermann, Henner Straub, Uwe D. Treuner, Jakob-Matthias Drossard
  • Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
    Patent number: 5262532
    Abstract: Porphyrin-complex compounds useful as contrast agents in magnetic resonance imaging (MRI) having the formula ##STR1## where Y is a transition metal such as Fe.sup.III, Cr.sup.III, Mn.sup.III, Mn.sup.II and Cu.sup.II, X is a biologically well-tolerated metal complexing anion such as Cl.sup.-, CF.sub.3 SO.sub.3 or CF.sub.3 COO.sup.- and R is a nonionic water solubilizing moiety.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: November 16, 1993
    Assignee: E.R. Squibb & Sons, Inc.
    Inventors: Michael F. Tweedle, Lon J. Wilson, Joseph E. Bradshaw, Daniel W. Lee
  • Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
    Patent number: 5262419
    Abstract: Ulcerative conditions of the gastro-intestinal tract, e.g., antiinflammatory-drug-induced ulcers, are treated or prevented by the administration of a potassium channel activator. Methods and combination products are also disclosed for the treatment of inflammatory conditions without causing ulceration of the gastrointestinal tract.
    Type: Grant
    Filed: June 11, 1992
    Date of Patent: November 16, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: A. K. Gunnar Aberg, Martin L. Ogletree, Eugene H. O'Keefe
  • Acyl amidine and acyl guanidine substituted biphenyl derivatives
    Patent number: 5256695
    Abstract: Novel compounds are disclosed having the formula ##STR1## where A is ##STR2## and wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: October 26, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Heteroaryl derivatives of monocyclic beta-lactam antibiotics
    Patent number: 5250691
    Abstract: Compounds having the formula ##STR1## exhibiting antibacterial activity.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: October 5, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Henner Straub, Jakob-Matthias Drossard
  • Aminoalkylphosphonic acid esters of natural 4-methoxy-5-methyl-pyran-3-ol and derivatives thereof
    Patent number: 5248790
    Abstract: Antibiotic substances having the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: September 28, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • Oxadiazinone substituted indole and benzimidazole derivatives
    Patent number: 5236916
    Abstract: Novel compounds having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Michael A. Poss
  • Substitute indole and benzimidazole derivatives
    Patent number: 5234923
    Abstract: Novel compounds are disclosed having the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: August 10, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael A. Poss, Karnail S. Atwal
  • Indole and benzimidazole-substituted dihydropyrimidine derivatives
    Patent number: 5212177
    Abstract: Novel compounds having the formula ##STR1## and its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, an antihypertensive agents.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: May 18, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael A. Poss, Karnail S. Atwal
  • Substituted imidazole phosphonic and phosphinic acid derivatives
    Patent number: 5208234
    Abstract: Novel compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: May 4, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Indole- and benzimidazole-substituted imidazole derivatives
    Patent number: 5208235
    Abstract: Novel compounds having the formula ##STR1## where X R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore for example, as antihypertensive agents.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: May 4, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
    Patent number: 5190942
    Abstract: Novel compounds are disclosed having the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: April 22, 1991
    Date of Patent: March 2, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Acyl amidine and acyl, guanidine substituted biphenyl derivatives
    Patent number: 5177097
    Abstract: Novel compounds are disclosed having the formula ##STR1## and wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: July 24, 1991
    Date of Patent: January 5, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Michael A. Poss
  • Enzymatic resolution process
    Patent number: 5177006
    Abstract: A novel enzymatic resolution process for preparing resolved compounds of the formula ##STR1## with improved yields and high optical purity is disclosed. Compounds of formula I' are useful, for example, as intermediates for the preparation of physiologically active compounds, e.g. captopril, zofenopril and endopeptidase inhibitor.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: January 5, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jeffrey M. Howell, Ramesh N. Patel, Laszlo J. Szarka
  • Method for solubilizing membrane receptor proteins
    Patent number: 5151502
    Abstract: A process for solubilizing membrane receptor proteins which includes exposing an outer membrane having the desired protein to an oxidizing agent, treating the membrane with a detergent and treating with an inhibitory material lowering agent. This method maintains the activity of the membrane proteins after solubilization.
    Type: Grant
    Filed: April 30, 1991
    Date of Patent: September 29, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Maria L. Webb, Hossain Monshizadegan