Patents Represented by Attorney Everet F. Smith

Find this attorney in the Justia Lawyer Directory

  • Novel contraceptive method
    Patent number: 4171358
    Abstract: Progestational agents administered daily to female mammals during the follicular phase only of the cycle prevents uterine development associated with implantation in the luteal phase, thereby preventing conception.
    Type: Grant
    Filed: April 19, 1976
    Date of Patent: October 16, 1979
    Assignee: Eli Lilly and Company
    Inventor: Larry J. Black
  • N-heterocyclic ureas as immune regulants
    Patent number: 4171364
    Abstract: Benzimidazolyl, benzothiazolyl and benzoxazolyl ureas and thioureas are employed as immune regulatory agents, as agents capable of altering the immune response in mammals.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: October 16, 1979
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Paget, John L. Sands
  • Acylamino derivatives
    Patent number: 4166818
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucelus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: September 4, 1979
    Assignee: Lilly Industries Limited
    Inventors: William J. Ross, John P. Verge, William R. N. Williamson
  • Acylaminopyrazoles
    Patent number: 4166123
    Abstract: Acylamino pyrazolyl compounds of the formula: ##STR1## wherein Ar represents an optionally substituted pyrazolyl group, the acylamino group --NR.sup.1 COR.sup.2 being attached to a carbon atom of the pyrazolyl ring, which have anti-allergic activity, methods of making the compounds and pharmaceutical formulations containing the compounds.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: August 28, 1979
    Assignee: Lilly Industries Limited
    Inventors: Roger G. Harrison, William B. Jamieson, William J. Ross, John C. Saunders
  • Process for preparing sulfinyl chlorides from penicillin sulfoxides
    Patent number: 4165316
    Abstract: A penicillin sulfoxide ester is reacted with an N-chloro halogenating agent at a temperature of from about 75.degree. C. to about 135.degree. C. and in the presence of an alkylene oxide and calcium oxide to produce a 2-chlorosulfinylazetidin-4-one intermediate. The intermediate, upon separation from the alkylene oxide, calcium oxide, and any conversion products of both the alkylene oxide and calcium oxide, can be treated with stannic chloride to produce a 3-exomethylenecepham sulfoxide.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: August 21, 1979
    Assignee: Eli Lilly and Company
    Inventor: Ta-Sen Chou
  • Sulfinyl halides and their preparation from penicillin sulfoxides
    Patent number: 4165315
    Abstract: A penicillin sulfoxide ester is reacted with an N-chloro halogenating agent at a temperature of from about 75.degree. C. to about 135.degree. C. to produce a novel 2-chlorosulfinylazetidin-4-one intermediate. The intermediate can be treated with stannic chloride to produce a 3-exomethylenecepham sulfoxide.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: August 21, 1979
    Assignee: Eli Lilly and Company
    Inventor: Stjepan Kukolja
  • Acylamino-1,2,4-oxadiazole or thiadiazole derivatives as anti-hypersensitivity agents
    Patent number: 4163048
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds having anti-allergy activity.
    Type: Grant
    Filed: June 13, 1977
    Date of Patent: July 31, 1979
    Assignee: Lilly Industries Limited
    Inventors: William J. Ross, John P. Verge, William R. N. Williamson
  • Method of preparation of 3-methylenecephams
    Patent number: 4159266
    Abstract: Penicillin sulfoxide derived azetidinone sulfinyl chlorides and related sulfinic acid derivatives are cyclized to 3-methylenecephams by reaction with Friedel-Crafts catalysts or metathetic cation forming agents.
    Type: Grant
    Filed: May 13, 1977
    Date of Patent: June 26, 1979
    Assignee: Eli Lilly and Company
    Inventor: Stjepan Kukolja
  • Acylamino derivatives
    Patent number: 4158659
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
    Type: Grant
    Filed: October 7, 1977
    Date of Patent: June 19, 1979
    Assignee: Lilly Industries Limited
    Inventors: William J. Ross, John P. Verge, William R. N. Williamson
  • Dinitroanilines for control of soil-borne phytopathogens
    Patent number: 4156722
    Abstract: A class of 2,6-dinitroanilines having a broad range of substituent groups on the anilino nitrogen and in the 3- and 4-positions of the phenyl ring are used for the protection of plants against soil-borne phytopathogens of the genus Phytophthora.
    Type: Grant
    Filed: October 13, 1977
    Date of Patent: May 29, 1979
    Assignee: Eli Lilly and Company
    Inventor: James D. Froyd
  • N-Heterocyclic ureas as immune regulants
    Patent number: 4153709
    Abstract: Benzimidazolyl, benzothiazolyl and benzoxazolyl ureas and thioureas are employed as immune regulatory agents, as agents capable of altering the immune response in mammals.
    Type: Grant
    Filed: October 20, 1977
    Date of Patent: May 8, 1979
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Paget, John L. Sands
  • Certain acylamino-oxa (or thia) diazoles in treatment of hypersensitivity conditions
    Patent number: 4152442
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
    Type: Grant
    Filed: June 22, 1977
    Date of Patent: May 1, 1979
    Assignee: Lilly Industries Limited
    Inventors: William J. Ross, John P. Verge, William R. N. Williamson
  • Cyclopentone propanoic acid compounds
    Patent number: 4151199
    Abstract: Propanoic acid derivatives of the formula: ##STR1## where R.sup.1 is a C.sub.1-8 alkyl group optionally substituted by hydroxyl or --COOH and R.sup.2 is hydrogen or a protecting group, are useful as anti-thrombotic agents.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: April 24, 1979
    Assignee: Lilly Industries Limited
    Inventors: William Dawson, Michael J. Foulis, Norman J. A. Gutteridge, Colin W. Smith
  • N-Substituted-acylamino-oxazoles as antiasthma agents
    Patent number: 4150143
    Abstract: Oxazoles which are substituted in the 2,4 or 5-position with an N-substituted-acylamino group have anti-allergic activity. Methods of making such compounds, pharmaceutical compositions containing the active compounds of the invention and methods of treating asthma utilizing such compounds are provided.
    Type: Grant
    Filed: March 21, 1977
    Date of Patent: April 17, 1979
    Assignee: Lilly Industries Limited
    Inventors: Martin C. Neville, John P. Verge
  • Process and intermediates for preparing cephalosporin antibiotics
    Patent number: 4148817
    Abstract: The silylated and enamine protected D-3- or 4-hydroxyphenylglycine as the sodium salt of the formula ##STR1## wherein A is methyl or ethyl, are crystalline intermediates useful in a new process for the acylation of heterocyclic-thiomethyl-substituted cephalosporin nuclei, e.g. 7-amino-3-(5-methyl-1,3,4-thiadiazole-2-ylthiomethyl)-3-cephem-4-carboxyli c acid and 7-amino-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylic acid.
    Type: Grant
    Filed: March 25, 1976
    Date of Patent: April 10, 1979
    Assignee: Eli Lilly and Company
    Inventor: Ian G. Wright
  • 3-Nitropyrazole derivatives
    Patent number: 4145554
    Abstract: Novel 1,4-disubstituted-3-nitropyrazoles having antimicrobial, parasiticidal, and herbicidal activity are prepared by a reaction sequence of which the individual steps are conventional. The new 3-nitropyrazoles are characterized by a 1-substituent and a usually carbonyl-containing 4-substituent. The novel 3(5)-nitro-4-pyrazolecarbonitrile is obtained as an intermediate in the preparation of the biologically-active compounds. Preferred compounds are 1-alkyl or -alkenyl-4-pyrazolecarboxamides and carbonitriles. The new compounds are particularly useful for the control of bacterial animal diseases.
    Type: Grant
    Filed: October 13, 1977
    Date of Patent: March 20, 1979
    Assignee: Eli Lilly and Company
    Inventors: Reuben G. Jones, Norman H. Terando
  • 3-Carbamyloxymethyl-cephalosporins
    Patent number: 4145538
    Abstract: The present invention is directed to 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid: ##STR1## and to precursors and derivatives. The compound, its precursors, and its derivatives exhibit antibacterial activity, which, in the instance of certain of the derivatives, is of an enhanced degree.
    Type: Grant
    Filed: September 7, 1977
    Date of Patent: March 20, 1979
    Assignee: Eli Lilly and Company
    Inventor: Ramakrishnan Nagarajan
  • (Phenoxyphenyl) alkyl acetates, propionates, and carbamates
    Patent number: 4145557
    Abstract: Novel 3-phenoxyphenylalkyl amines and the amides, alcohols, tetrazoles, and carbamates related thereto as well as novel intermediates useful in the preparation of such compounds. The compounds of this invention are useful as anti-inflammatory, analgesic, and antipyretic agents.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: March 20, 1979
    Assignee: Eli Lilly and Company
    Inventor: Winston S. Marshall
  • Cephalexin tablets
    Patent number: 4143129
    Abstract: A small tablet containing over 90% by weight of an orally active cephalosporin such as cephalexin and which utilizes as a binder polyvinyl pyrrolidone having a number average molecular weight of from 500,000 to 1,500,000.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: March 6, 1979
    Assignee: Lilly Industries Limited
    Inventor: Richard Marsden
  • 2-Sulfinyl and 2-sulfonyl oxazoles
    Patent number: 4143047
    Abstract: Oxazoles having a sulfinyl or sulfonyl substituent at the 2-position are provided. Such compounds readily react with an alkali metal salt of a secondary amide in a method of making 2-acylamino oxazole derivatives having anti-allergic activity.
    Type: Grant
    Filed: September 26, 1977
    Date of Patent: March 6, 1979
    Assignee: Lilly Industries Limited
    Inventor: Roger G. Harrison