Patents Represented by Attorney Everet F. Smith

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  • Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-di benzo [b,d]pyran-9-ones and intermediates therefor
    Patent number: 4115403
    Abstract: Reaction of a 5-substituted resorcinol with a ketal of 4-(1-hydroxy-1-methylethyl)-3-cyclohexen-1-one in the presence of a suitable catalyst effects condensation to provide substantially exclusively a cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibe nzo-[b,d]pyran-9-one.
    Type: Grant
    Filed: July 12, 1977
    Date of Patent: September 19, 1978
    Assignee: Eli Lilly and Company
    Inventors: William B. Blanchard, Charles W. Ryan
  • Alkoxycarbonyl-ethylthio-azetidinones and process for their preparation
    Patent number: 4115383
    Abstract: 2-Sulfinyl (or thio)-.alpha.-isopropenyl (or isopropylidene)-3-amido(or imido)-4-oxo-1-azetidineacetic acids and esters are prepared directly or indirectly from the reaction of a penicillin sulfoxide ester with an ester of acrylic acid. These compounds are active antimicrobial agents or are intermediates to active antimicrobial compounds.
    Type: Grant
    Filed: March 24, 1976
    Date of Patent: September 19, 1978
    Assignee: Eli Lilly and Company
    Inventor: Robin D. G. Cooper
  • Novel fluoroalkoxyphenyl-substituted nitrogen heterocycles
    Patent number: 4110099
    Abstract: There is disclosed a class of fluoroalkoxyphenyl-substituted nitrogen-containing heterocycles which are useful as herbicides, plant fungicides, and plant growth regulators. Internodal elongation of plants is inhibited by treatment with compounds of this invention.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: August 29, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert Lee Benefiel, Eriks Viktors Krumkalns
  • Ring-substituted N-(2,2-difluoroalkanoyl)-o-phenylenediamine compounds
    Patent number: 4108631
    Abstract: Ring-substituted N-(2,2-difluoroalkanoyl)-o-phenylenediamine compounds useful as herbicides and as insecticides; and combinations of these compounds with known herbicides.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: August 22, 1978
    Assignee: Eli Lilly and Company
    Inventor: George O. P. O'Doherty
  • Method of preparing stable sterile ampoules of crystalline cephalosporins for parenteral administration
    Patent number: 4104391
    Abstract: Sterile, essentially crystalline cephalosporins for parenteral administration are prepared by a freeze-drying process wherein, after rapidly cooling a solution of such cephalosporins to at least -15.degree. C. in no more than 3 hours, the frozen solution is held between about <0.degree. C. and about -10.degree. C. until the nucleation of the cephalosporin is substantially complete before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.
    Type: Grant
    Filed: February 9, 1977
    Date of Patent: August 1, 1978
    Assignee: Eli Lilly and Company
    Inventor: Michael D. Cise
  • Novel 3-(oxygenated alkyl)-1,9-dihydroxy and 1-hydroxy-9-keto dibenzo[b,d]p y
    Patent number: 4104282
    Abstract: 1-Hydroxy-9-keto-3-alkyl-dibenzo[b,d]pyrans or 1,9-dihydroxy-3-alkyl-dibenzo[b,d]pyrans are oxygenated on the penultimate carbon of the alkyl side chain by fermentation with a strain of the micro-organism Bacillus cereus.
    Type: Grant
    Filed: August 8, 1977
    Date of Patent: August 1, 1978
    Assignee: Eli Lilly and Company
    Inventors: David S. Fukuda, Bernard J. Abbott, Robert A. Archer
  • 2,5 OR 2,6-Disubstituted benzoxazoles
    Patent number: 4100168
    Abstract: Benzoxazoles substituted in the 2-position with sulfhydryl or halogen and substituted in the 5- or 6-position with an acetic or propionic acid group or a salt or ester thereof or a nitrile convertible thereto useful as intermediates in the preparation of 5- or 6-Substituted benzoxazole propionic or acetic acid derivatives, substituted in the 2-position of the oxazole nucleus by a group of the formula AR.sup.4 wherein A is --CH.sub.2 --, --CO--, --CHOR--, or --NR--, wherein R is hydrogen, C.sub.1-6 alkyl or C.sub.2-7 acyl, and R.sup.4 is optionally substituted phenyl, useful as non-steroidal, non-narcotic, analgesic, antipyretic and anti-inflammatory agents.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: July 11, 1978
    Assignee: Lilly Industries Ltd.
    Inventors: David William Dunwell, Delme Evans, Terence Alan Hicks
  • 3-Substituted propanoic acid derivatives
    Patent number: 4100350
    Abstract: The invention provides 3-(2-formyl-3-hydroxy-5-oxocyclopent-1-enyl)-p ropanoic acid and derivatives thereof having anti-thrombotic activity coupled with low toxicity. Also provided is a method for preparing such compounds by subjecting a 3-[3-hydroxy-5-oxo-2-(.beta.-styryl)cyclopent-1-enyl]-propanoic acid or derivative thereof to oxidative cleavage.
    Type: Grant
    Filed: March 2, 1977
    Date of Patent: July 11, 1978
    Assignee: Lilly Industries Ltd.
    Inventors: William Dawson, Michael John Foulis, Norman James Albert Gutteridge, Colin William Smith
  • Ergoline chlorination process
    Patent number: 4098790
    Abstract: Ergolines are chlorinated with SO.sub.2 Cl.sub.2 /BF.sub.3 .multidot.etherate, preferentially in the 2 position.
    Type: Grant
    Filed: September 15, 1976
    Date of Patent: July 4, 1978
    Assignee: Eli Lilly and Company
    Inventor: Nicholas J. Bach
  • Method for treating arrhythmia
    Patent number: 4098890
    Abstract: Cardiac arrhythmia is treated orally or parenterally with diarylalkylamines and diarylalkenylamines.
    Type: Grant
    Filed: May 27, 1976
    Date of Patent: July 4, 1978
    Assignee: Eli Lilly and Company
    Inventor: Bryan B. Molloy
  • Process for preparing cepham compounds
    Patent number: 4093800
    Abstract: A novel 4-(2'-benzothiazolyldithio)-3-imidoazetidin-2-one of the formula ##STR1## in which X is chloro or bromo and R.sub.2 is methylene or oxygen is ring-closed to the corresponding 3-exomethylenecepham or 3-"oxo" cepham by treatment with sodium or potassium iodide at a temperature of from about 40.degree. C. to about 80.degree. C.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: June 6, 1978
    Assignee: Eli Lilly and Company
    Inventor: Stjepan Kukolja
  • Cyclohexenyl resorcinol derivatives
    Patent number: 4092344
    Abstract: Novel 1-hydroxy-3-alkyl-6,7,8,9,10,11-hexahydrodibenz[b,d]oxepins are prepared from cyclohexenyl resorcinol derivatives and are useful as central nervous system depressants.
    Type: Grant
    Filed: January 24, 1977
    Date of Patent: May 30, 1978
    Assignee: Eli Lilly and Company
    Inventor: Ken Matsumoto
  • N-pentafluoropropionyl and n-heptafluorobutyryl proline
    Patent number: 4091029
    Abstract: An N-perfluoroacyl-L-.alpha.-amino acid is converted to the corresponding acid halide which is useful as a resolving agent for the resolution of racemic amines.
    Type: Grant
    Filed: April 14, 1976
    Date of Patent: May 23, 1978
    Assignee: Eli Lilly and Company
    Inventor: Rex W. Souter
  • Stabilized nitroglycerin tablets
    Patent number: 4091091
    Abstract: A pharmaceutical preparation is described which comprises nitroglycerin tablets stabilized against the migration of the active agent from tablet to tablet when such tablets are in contact with each other.A method is provided for stabilizing such nitroglycerin tablets.
    Type: Grant
    Filed: November 8, 1973
    Date of Patent: May 23, 1978
    Assignee: Eli Lilly and Company
    Inventor: Paul Meredith Terrill
  • Automated sample changer for nuclear magnetic resonance spectrometer
    Patent number: 4091323
    Abstract: An automated sample changer, controlled by gas fluidic circuitry, integrated with a Nuclear Magnetic Resonance (NMR) spectrometer provides a means for sequentially transferring samples to and from such spectrometer without an attendant to control such transfer. Such a changer comprises a means for holding a series of samples, a robot arm cooperating with such holding means and disposed in alignment with the sample receiving tube of an NMR spectrometer, a gas fluidic circuit to sense the required action, and a second gas fluidic circuit integrated therewith to provide the energy to make the transfer.
    Type: Grant
    Filed: October 6, 1976
    Date of Patent: May 23, 1978
    Assignee: Eli Lilly and Company
    Inventor: Paul W. Landis
  • Dinitroanilines for the control of phytopathogens
    Patent number: 4091096
    Abstract: It has been discovered that fungal foliar phytopathogens may be controlled by the use of a broad class of 2,6-dinitroanilines. The fungicidally-effective compounds may bear a broad range of substituent groups on the anilino nitrogen and in the 3- and 4-positions of the benzene ring.
    Type: Grant
    Filed: August 31, 1976
    Date of Patent: May 23, 1978
    Assignee: Eli Lilly and Company
    Inventors: James R. Beck, Joseph A. Yahner
  • Acylamino triazoles as antiasthmatic agents
    Patent number: 4089962
    Abstract: 1,2,3-triazoles and 1,2,4-triazoles having an N-substituted acylamino substituent are prepared by alkylating N-unsubstituted acylamino triazoles or acylating N-substituted amino triazoles. The N-substituted acylamino triazoles are useful as anti-allergy drugs. Pharmaceutical formulations containing acylamino triazoles and a method of treating allergic conditions utilizing such compounds are provided.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: May 16, 1978
    Assignee: Lilly Industries Limited
    Inventors: Roger Garrick Harrison, William Boffey Jamieson, William James Ross, John Christopher Saunders
  • Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs
    Patent number: 4088777
    Abstract: Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: May 9, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Archer, Louis Lemberger
  • Substituted 2-anilinobenzoxazoles used as immunosuppressive agents
    Patent number: 4088770
    Abstract: Compositions comprising certain 2-(substituted anilino)benzoxazoles, such as 2-[4-bromo-3-(trifluoromethyl)anilino]benzoxazole, and methods for using same as immunosuppressive agents, antifertility agents, for the prophylaxis of Marek's disease in chickens and as herbicides.
    Type: Grant
    Filed: November 28, 1973
    Date of Patent: May 9, 1978
    Assignee: Eli Lilly and Company
    Inventor: Charles J. Paget, Jr.
  • N-heterocyclic ureas as immune regulants
    Patent number: 4088768
    Abstract: Benzimidazolyl, benzothiazolyl and benzoxazolyl ureas and thioureas are employed as immune regulatory agents, as agents capable of altering the immune response in mammals.
    Type: Grant
    Filed: January 21, 1976
    Date of Patent: May 9, 1978
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Paget, John L. Sands