Patents Represented by Attorney Everet F. Smith

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  • Acylamino derivatives
    Patent number: 4088773
    Abstract: Acylamino pyrrole compounds having anti-allergic activity, methods of making the compounds and pharmaceutical formulations containing the compounds.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: May 9, 1978
    Assignee: Lilly Industries Limited
    Inventors: Delme Evans, Michael R. J. Jolley, William J. Ross, Brian P. Swann
  • 5' Acetoxy vinblastine 4' bis-sulfite
    Patent number: 4087429
    Abstract: Vincaleukoblastine (VLB, vinblastine) is reacted with thionyl chloride to form a bis-sulfite ester which is converted to various 5'-oxygenated derivatives.
    Type: Grant
    Filed: October 20, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Allen S. Katner, Gerald E. Gutowski, Jean C. Miller
  • Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs
    Patent number: 4087545
    Abstract: Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as antiemetic drugs.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Archer, Louis Lemberger
  • Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs
    Patent number: 4087546
    Abstract: Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Archer, Louis Lemberger
  • 1H-imidazo(4,5-b)pyridine compounds
    Patent number: 4087432
    Abstract: Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.
    Type: Grant
    Filed: September 8, 1975
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: George O. P. O'Doherty, Kenneth H. Fuhr
  • 5-(Tertiary alkyl) resorcinol preparation and intermediates therefor
    Patent number: 4087410
    Abstract: 2,6-Dimethoxyphenol reacts with a tertiary carbinol in the presence of an acid to provide exclusively a 1-hydroxy-2,6-dimethoxy-4-tertiary alkyl)benzene, which when reacted with a halogenated disubstituted phosphite affords a 2,6-dimethoxy-4-tertiary alkyl)phenyl disubstituted phosphate. Reduction of the phenyl phosphate derivative by reaction with an alkali metal affords a 1-(tertiary alkyl)-3,5-dimethoxybenzene, which upon reaction with a demethylating agent provides a 5-(tertiary alkyl)resorcinol.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Samuel J. Dominianni, Charles W. Ryan
  • Somatostatin analogs and intermediates thereto
    Patent number: 4087390
    Abstract: The tetradecapeptides ##STR1## in which Y is L-Asn or L-Ala are described along with corresponding non-toxic pharmaceutically-acceptable acid addition salts as well as intermediates useful in the synthesis of the tetradecapeptides. These tetradecapeptides as well as their pharmaceutically-acceptable acid addition salts exhibit various activities including inhibition of the release of gastric acid.
    Type: Grant
    Filed: February 2, 1977
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventor: James E. Shields
  • Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma
    Patent number: 4087547
    Abstract: Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones in treatment of glaucoma.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Archer, Louis Lemberger
  • Antifungal antibiotics
    Patent number: 4087603
    Abstract: 5'-Deoxy-5'-(3'-aminopiperidin-2-one-6-yl)adenosine and 5'-deoxy-5'-(1-amino-4-ureido-4-carboxyamidobutyl)-adenosine and the pharmaceutically acceptable acid addition salts thereof are antifungal antibiotics active vs. systemic infections produced by culturing Streptomyces griseolus NRRL 3739 and are isolated from the broth and obtained pure via chromatography over cationic resin.
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Ramakrishnan Nagarajan
  • 2-Phenyl-5-benzoxazolylalkanoic acid purification process
    Patent number: 4087437
    Abstract: Crude preparations of 2-phenyl-5-benzoxazolylalkanoic acids are purified by forming the ammonium salt thereof in an organic solvent and thermally reconverting the separated ammonium salt to the acid. Gaseous ammonia is a by-product.
    Type: Grant
    Filed: September 7, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventor: Erwin A. Stephan
  • Animal cage
    Patent number: 4085705
    Abstract: A ventilated animal cage system is provided in which a plurality of animal cages are removably suspended on shelves of a portable rack. Each shelf is hollow to form an air duct that is in communication with the cages suspended therefrom, thus minimizing the possibility of cross-contamination between animals in the cages and personnel in the laboratory room.
    Type: Grant
    Filed: September 17, 1976
    Date of Patent: April 25, 1978
    Assignee: Eli Lilly and Company
    Inventors: Thomas M. Gland, Robert C. A. Frederickson
  • Method of increasing feed utilization
    Patent number: 4085224
    Abstract: Antibiotic A-28086 complex, comprising microbiologically active, structurally related factors A, B, and D, produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 5758. Individual factors A, B, and D are separated and isolated by chromatography. The A-28086 antibiotics are antibacterial, antifungal, antiviral, anti-PPLO, anticoccidial, insecticidal and acaricidal agents and also increase feed-utilization efficiency in ruminants.
    Type: Grant
    Filed: September 2, 1976
    Date of Patent: April 18, 1978
    Assignee: Eli Lilly and Company
    Inventors: David H. Berg, Robert L. Hamill, Marvin M. Hoehn
  • Antibiotic A-35512 for increasing feed utilization efficiency in an animal
    Patent number: 4083964
    Abstract: Antibiotic A-35512 complex, comprising microbiologically active, related factors A, B, C, E and H, is produced by submerged aerobic fermentation of Streptomyces candidus NRRL 8156. The individual A-35512 factors are separated and isolated by chromatography. The A-35512 antibiotics are antibacterial and growth-promoting agents and increase feed-utilization efficiency in animals. In addition, A-35512 factor B is useful in the treatment of dental caries and acne.
    Type: Grant
    Filed: September 13, 1976
    Date of Patent: April 11, 1978
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Calvin E. Higgens
  • Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas
    Patent number: 4083977
    Abstract: Novel 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas, active as insecticides, and methods for their use as insecticides.
    Type: Grant
    Filed: November 18, 1976
    Date of Patent: April 11, 1978
    Assignee: Eli Lilly and Company
    Inventor: John Louis Miesel
  • Coccidiocidal combinations
    Patent number: 4083962
    Abstract: Synergistic coccidiocidal combinations comprise two ionophorous fermentation-derived coccidiocides, each of which is administered to poultry in a concentration too low to produce satisfactory coccidiocidal effect alone. Preferred combinations include monensin and A204, monensin and lasalocid, and monensin and A28086.
    Type: Grant
    Filed: March 14, 1977
    Date of Patent: April 11, 1978
    Assignee: Eli Lilly and Company
    Inventor: Larry R. McDougald
  • Acylamino derivatives
    Patent number: 4082771
    Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 5-membered ring containing a single heteroatom, which may be oxygen, or sulphur, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: April 4, 1978
    Assignee: Lilly Industries Limited
    Inventors: Delme Evans, Michael Ralph John Jolley, William James Ross, Brian Picton Swann
  • Process for preparing n-chlorophthalimide
    Patent number: 4082766
    Abstract: N-Chlorophthalimide is prepared by contacting an alkali metal salt of phthalimide with chlorine under substantially non-aqueous conditions in the presence of a halogenated aliphatic hydrocarbon and at a temperature of from about -10.degree. C. to about +40.degree. C.
    Type: Grant
    Filed: May 27, 1976
    Date of Patent: April 4, 1978
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, James R. Burgtorf
  • 1H-Imidazo(4,5-b)pyridine derivatives
    Patent number: 4082534
    Abstract: Ethers and esters of 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds, useful as herbicides.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: April 4, 1978
    Assignee: Eli Lilly and Company
    Inventor: George O. P. Doherty
  • Methylenedioxybenzene -- improved method of preparation
    Patent number: 4082774
    Abstract: Methylenation of catechol by reaction with a methylene dihalide under alkaline conditions is improved by adding the pre-formed catechol dianion in a heated protic alkaline medium to a solution of methylene dihalide in dimethyl sulfoxide.
    Type: Grant
    Filed: July 11, 1974
    Date of Patent: April 4, 1978
    Assignee: Eli Lilly and Company
    Inventor: John A. Kirby
  • Penniclavine acetonide
    Patent number: 4082753
    Abstract: Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.
    Type: Grant
    Filed: June 17, 1977
    Date of Patent: April 4, 1978
    Assignee: Eli Lilly and Company
    Inventors: Edmund C. Kornfeld, Nicholas J. Bach