Abstract: The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.
Type:
Grant
Filed:
January 28, 2008
Date of Patent:
March 24, 2009
Assignee:
Arizona Board of Regents, a state corporate of the State of Arizona, acting for and on behalf of Arizona State University
Inventors:
George R. Pettit, Mathew D. Minardi, Heidi J. Rosenberg
Abstract: Use of urease-inhibiting amounts of calcium polysulfide, potassium polysulfide, calcium thiosulfate, magnesium thiosulfate, and blends thereof, in combination with urea-containing fertilizer to significantly reduce potential losses of nitrogen due to ammonia volatilization.
Type:
Grant
Filed:
February 22, 2005
Date of Patent:
February 24, 2009
Assignee:
Tessenderlo Kerley, Inc.
Inventors:
Michael Massoud Hojjatie, John Garland Clapp, Thomas David Fairweather, Constance Lynn Frank Lockhart
Abstract: A preparation comprising the carotenoids phytoene and phytofluene in an amount which, in combination, is effective in preventing various kinds of damage resulting from oxidation and exposure to UV light is provided. The preparation is essentially colorless and may be used as a topical cosmetic or pharmaceutical preparation as well as an additive in food preparations. In addition, a method for producing substantive amounts of phytoene and phytofluene from carotenoid producing organisms is described as well.
Abstract: Efficient and effective fuel combustion catalyst delivery apparatus is disclosed. A fuel combustion catalyst delivery apparatus may include a receptacle containing a material such as a liquid. The liquid may include one or more catalytic materials. The apparatus may further include a vibration pump configured to convert the liquid to an aerosol to be delivered into an intake air of a combustion zone, a pressure equalizer configured to maintain the pressure level of the receptacle at about the same pressure level as that of the intake air of the combustion zone, and a liquid delivery device configured to deliver the liquid to the vibration pump. The apparatus may further include an electronic control module and a mounting bracket or a docking station. The electronic control module may be used to control the vibration pump.
Type:
Grant
Filed:
December 5, 2005
Date of Patent:
January 27, 2009
Assignee:
Emissions Technology, Inc.
Inventors:
Emmett Manuel Cunningham, George M. Malouf, Russ Webster
Abstract: A dormant preparation (DC) is provided which is capable of inhibiting proliferation of various kinds of cells. The preparation comprises an extract which is obtained from cells or tissue originating in an organism capable of entering a phase of dormancy in at least one of its parts and comprises at least one substance which induces or maintains the state of dormancy in the organism from which the cells or tissue are derived. The DC may be used for a variety of indications including human medicine and cosmetics, plant growth control and food preservation.
Abstract: A method for producing a metal powder product involves: Providing a supply of a precursor metal powder; combining the precursor metal powder with a liquid to form a slurry; feeding the slurry into a pulsating stream of hot gas; and recovering the metal powder product.
Abstract: The present invention provides prodrugs derived from the sparingly soluble anticancer isocarbostyril narciclasine, a component of various Narcissus species, said prodrugs having potential for use against animal and human cancers. Also disclosed is an efficient procedure for the synthetic conversion of narciclasine to several more soluble cyclic phosphate compounds, including “narcistatin”.
Abstract: The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 0.001 to <0.0001 ?g/ml) murine and human cancer cell growth inhibitors, denominated herein as irciniastatin A and irciniastatin B. Both were isolated (10-3 to 10-4% yields) by cancer cell line bioassay-guided techniques and named irciniastatins A (1) and B (2). Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR (principally APT, HMQC, HMBC and ROESY) revealed unusual structures 1 and 2.
Type:
Grant
Filed:
November 17, 2004
Date of Patent:
October 21, 2008
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University
Abstract: Molybdenum oxide nano-particles. The nano-particles may be made by vaporizing the precursor material to produce a vapor; directing the vapor into an isolation chamber; contacting the vapor contained in the isolation chamber with a quench fluid stream to precipitate nano-particles; and removing the nano-particles from the isolation chamber.
Type:
Grant
Filed:
January 11, 2006
Date of Patent:
October 21, 2008
Assignee:
Cyprus Amax Minerals Company
Inventors:
Mohamed H. Khan, James A. Cole, Joel A. Taube
Abstract: One aspect of the invention is embodied in a number of machine-readable media having stored thereon sequences of instructions which, when executed by a machine, cause the machine to perform a number of actions. The actions include, for each of a plurality of image space coordinates of a camera image, retrieving 1) a corresponding camera position, and 2) corresponding object space coordinates on an object surface that is represented by the camera image. Then, for each of a plurality of height surfaces (chosen with respect to the object surface), a grid coordinate defined by an intersection between the height surface, and a line extending between the camera position and the object space coordinates, is determined. The determined grid coordinates are then associated with their corresponding image space coordinates. Finally, coefficients for a rational polynomial camera model are estimated by fitting rational polynomials to at least the grid coordinates and image space coordinates.
Type:
Grant
Filed:
May 18, 2004
Date of Patent:
September 2, 2008
Assignee:
Orbimage SI OPCO Inc.
Inventors:
James Anthony Lutes, Jacek Franciszek Grodecki
Abstract: Method for producing nano-particles from a precursor material. One embodiment of the method comprises vaporizing the precursor material to produce a vapor, directing the vapor into an isolation chamber, contacting the vapor contained in the isolation chamber with a quench fluid stream, the quench fluid stream cooling the vapor to produce the nano-particles, and removing the nano-particles from the isolation chamber.
Type:
Grant
Filed:
August 20, 2002
Date of Patent:
August 19, 2008
Assignee:
Cyprus Amax Minerals Company
Inventors:
Mohamed H. Khan, James A. Cole, Joel A. Taube