Patents Represented by Attorney, Agent or Law Firm Fennemore Craig, P.C.
-
Patent number: 7351830Abstract: Selective phosphorylation of phenpanstatin (3a) with tetrabutylammonium dihydrogen phosphate and dicyclohexyl-carbodiimide in pyridine followed by cation exchange chromatographic procedures was found to provide an efficient mute to a new series (3b-3d) of promising 3,4-O-cyclic phosphate prodrugs designated phenpanstatin phosphates. Application of analogous reaction conditions to pancratistatin (1a) led to a mixture of monophosphate derivatives where sodium paancratistatin 4-O-phosphate (4a) was isolated and the structure confirmed by x-ray craxtallography. Modification of the reaction conditions allowed direct phosphorylation of pancratistatin followed by cation exchange chromatography to afford sodium pancratistatin 3,4-O-cyclic phosphate (5b) which was selected for preclinical development.Type: GrantFiled: June 18, 2004Date of Patent: April 1, 2008Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State UniversityInventors: George R. Pettit, Noeleen Melody
-
Patent number: 7337574Abstract: A firearm frame which is adapted to be disposed in operative relationship as a component part of a firearm, the firearm having disposed in operative relationships each with one or more of the others, a barrel, a receiver, and at least one firing mechanism; wherein the barrel and receiver form operative parts of a movable assembly and the at least one firing mechanism is disposed in a substantially stationary operative relationship therewith; the firearm frame including at least one elongated support structure discrete from the barrel and receiver, the elongated support structure being adapted to directly support the movable assembly in an operative movable relationship therewith; whereby at least one of the barrel and receiver is in direct contact with and movable on the elongated support structure; and, a firing mechanism support structure connected to the at least one elongated support structure, the firing mechanism support structure being adapted to have the firing mechanism connected thereto; the firearmType: GrantFiled: September 9, 2004Date of Patent: March 4, 2008Assignee: Battelle Energy Alliance, LLCInventors: David L. Crandall, Richard W. Watson
-
Patent number: 7317020Abstract: Cribrostatin 6, a dark blue cancer cell growth inhibiting constituent of the Republic of Maldives marine sponge Cribrochalina sp. has been isolated, and its structure (shown below) elucidated, based on a combination of RMS, high field (500 MHz, HMBC, and GOESY experiments) 15N, 1H- and 13C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.Type: GrantFiled: February 19, 2004Date of Patent: January 8, 2008Assignee: Arizona Board of Regents, a body corporate of the State of ArizonaInventors: George R. Pettit, John C. Knight
-
Patent number: 7279466Abstract: Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugs”.Type: GrantFiled: February 27, 2006Date of Patent: October 9, 2007Assignee: Arizona Board of RegentsInventors: George R. Pettit, Monte R. Rhodes
-
Patent number: 7259369Abstract: Ion mobility spectrometer apparatus may include an ion interface that is operable to hold positive and negative ions and to simultaneously release positive and negative ions through respective positive and negative ion ports. A first drift chamber is operatively associated with the positive ion port of the ion interface and encloses an electric field therein. A first ion detector operatively associated with the first drift chamber detects positive ions from the first drift chamber. A second drift chamber is operatively associated with the negative ion port of the ion interface and encloses an electric field therein. A second ion detector operatively associated with the second drift chamber detects negative ions from said second drift chamber.Type: GrantFiled: August 22, 2005Date of Patent: August 21, 2007Assignee: Battelle Energy Alliance, LLCInventors: Jill R. Scott, David A. Dahl, Carla J. Miller, Paul L. Tremblay, Timothy R. McJunkin
-
Patent number: 7249072Abstract: A computer system for managing property tax information for a plurality of real estate parcels includes a data storage device, an output device and a processor. The processor maintains in the storage device a database of property tax data including a plurality of parcel records, each parcel record including a parcel identifier for each parcel of the plurality of real estate parcels, a tax year identifier for identifying the tax year applicable to each parcel, a state identifier for identifying the state in which each parcel is located and a jurisdiction identifier for identifying a jurisdiction within the state in which the parcel is located. The processor also maintains in the storage device a plurality of templates.Type: GrantFiled: March 19, 2001Date of Patent: July 24, 2007Assignee: Eproperty Tax, Inc.Inventors: Richard D. Nearhood, Roger Sabin, James A. Subach, J. Scot Crismon, J. Todd Parker
-
Patent number: 7231011Abstract: Non-destructive testing apparatus according to one embodiment of the invention comprises a photon source. The photon source produces photons having predetermined energies and directs the photons toward a specimen being tested. The photons from the photon source result in the creation of positrons within the specimen being tested. A detector positioned adjacent the specimen being tested detects gamma rays produced by annihilation of positrons with electrons. A data processing system operatively associated with the detector produces output data indicative of a lattice characteristic of the specimen being tested.Type: GrantFiled: August 17, 2001Date of Patent: June 12, 2007Assignee: Battelle Energy Alliance, LLCInventor: Douglas W. Akers
-
Patent number: 7225574Abstract: A forwardly movable assembly for a firearm, the forwardly movable assembly adapted to be disposed in operative relationship relative to the other operative parts of a firearm, the firearm having in operative relationship each with one or more of the others: a barrel, a receiver, and at least one firing mechanism; the forwardly movable assembly comprising: the barrel and the receiver operatively connected with each other; a movable hand support structure to which at least one of the barrel and the receiver is connected, the barrel being movable therewith, the movable hand support structure being adapted to be gripped by an operator of the firearm; the forwardly movable assembly being adapted to be moved forward by an operator upon gripping the movable hand support structure and manually maneuvering the hand support structure forwardly; and, as the forwardly movable assembly is moved forwardly, the firing mechanism is completely disengaged therefrom and held substantially stationary relative thereto.Type: GrantFiled: September 9, 2004Date of Patent: June 5, 2007Assignee: Battelle Energy Alliance, LLCInventors: David L. Crandall, Richard W. Watson
-
Patent number: 7223747Abstract: The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.Type: GrantFiled: September 24, 2004Date of Patent: May 29, 2007Assignee: Arizona Board of Regents Acting for and on Behalf of Arizona State UniversityInventors: George R. Pettit, Mathew D. Minardi, Heidi J. Rosenberg
-
Patent number: 7191603Abstract: Gaseous fluid production apparatus according to one embodiment of the invention includes a fluid container containing fluid in substantially the liquid state. A first fluid line is connected to the fluid container so that it receives from the fluid container a first fluid stream substantially in the liquid state. A gas generator is also connected to the fluid container so that it receives from the fluid container a second fluid stream substantially in the liquid state. A product discharge manifold is connected to the gas generator and to the first fluid line. A control means is operatively associated with the first fluid line and the product discharge manifold for controlling at least one parameter of the first fluid stream. A second control means is operatively associated with the gas generator and the product discharge manifold for controlling at least one parameter of the second fluid stream.Type: GrantFiled: October 14, 2005Date of Patent: March 20, 2007Assignee: Climax Molybdenum CompanyInventor: Joel A. Taube
-
Patent number: 7192467Abstract: Novel forms of molybdenum metal, and apparatus and methods for production thereof. Novel forms of molybdenum metal are preferably characterized by a surface area of substantially about 2.1 m2/g to substantially about 4.1 m2/g. Novel forms of molybdenum metal are also preferably characterized by a relatively uniform size.Type: GrantFiled: November 20, 2003Date of Patent: March 20, 2007Assignee: Climax Engineered Materials, LLCInventors: Mohamed Khan, Joel Taube, Loyal M. Johnson, Jr.
-
Patent number: 7125664Abstract: There is provided a method for identifying genes that regulate the expression of other genes, by placing a sample containing genetic material in a section of a grid, silencing expression of at least one predetermined gene in the sample, grown in the section of the grid, so that in each section of the grid at least one predetermined gene is silenced, determining the amount of genetic material of interest is present in each section of the grid, and identifying the sections of the grid in which the silencing was maximal thereby identifying genes that regulate the expression of other genes and the genes of interest identified by the method. Also provided by the present invention is a kit for performing the above method, the kit having a grid for holding a sample, inactivating agents for inactivating genetic material in the sample, and a measuring device for measuring the inactivation of the genetic material.Type: GrantFiled: June 20, 2002Date of Patent: October 24, 2006Inventor: Dahlia Minc-Golomb
-
Patent number: 7078552Abstract: The present invention relates to the syntheses and structural elucidation of Combretastatin A1-Phosphate Prodrugs and Combretastatin B1-Phosphate Prodrugs and the utilization of those prodrugs in the treatment of neoplastic diseases. The prodrugs described herein have the structure: Combretastin A-1 Phosphate Prodrug (I) and Combretastin B-1 Phosphate Prodrug (II).Type: GrantFiled: April 27, 2001Date of Patent: July 18, 2006Assignee: Arizona Board of RegentsInventors: George R. Pettit, John W. Lippert, III
-
Patent number: 7018987Abstract: The present invention relates to novel water-soluble, stable derivatives of combretastatin A-4, and novel synthesis methods therefore. The combretastatin A-4 prodrugs described herein appear to be useful in the treatment of neoplastic disease.Type: GrantFiled: January 8, 1999Date of Patent: March 28, 2006Assignee: Arizona Broad of Regents acting for and on behalf of Arizona State UniversityInventors: George R. Pettit, Monie R. Rhodes
-
Patent number: 6998413Abstract: Yungamycin A has been demonstrated to have unexpected in vivo anticancer activity. New compounds Yungamycin B and C are also disclosed, and have been demonstrated to be specific for DT-diaphorase, as well as to have in vivo anticancer activity.Type: GrantFiled: January 26, 2000Date of Patent: February 14, 2006Assignee: Arizona Board of Regents acting for and on behalf of Arizona State UniversityInventor: Edward B. Skibo
-
Patent number: 6949647Abstract: (+)-Narciclasine (2), available in quantity from certain Amaryllidaceae species or by total synthesis, is employed in for a ten step synthetic conversion (3.6% overall yield) to natural (+)-pancratistatin (1a). The key procedures involve the epoxidation of natural (+)-narciclasine (2) to an epoxide (6), reduction of the epoxide (6) to diol (8), formation of cyclic sulfate (12) and its ring opening with cesium benzoate followed by saponification of the benzoate to afford (+)-pancratistatin (1a).Type: GrantFiled: December 20, 2001Date of Patent: September 27, 2005Assignee: Arizona Board of RegentsInventors: George R. Pettit, Noeleen Melody
-
Patent number: 6943194Abstract: A newly discovered antineoplastic compound denominated “phenstatin” is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was converted to the sodium phosphate prodrug (3d) by a dibenzylphosphite phosphorylation and subsequent hydrogenolysis sequence 3b?3c?3d. Phenstatin (3b) was found to be a potent inhibitor of tubulin polymerization and the binding of colchicine to tubulin comparable to combretastatin A-4 (1b).Type: GrantFiled: January 9, 1999Date of Patent: September 13, 2005Assignee: Arizona Board of Regents, acting for and on behalf of Arizona State UniversityInventors: George R. Pettit, Brian Toki
-
Patent number: 6777578Abstract: The benzophenone derivative of combretastatin A-1, designated “hydroxyphenstatin”, was synthesized by compiling a protected bromobenzene and a benzaldehyde to form a benzhydrol which was subsequently oxidized to the ketone. Hydroxyphenstatin was converted to a sodium phosphate prodrug by dibenzyl phosphite phosphorylation and subsequent benzyl cleavage: Hydroxyphenstatin and the prodrugs thereof were found to be a potent inhibitor of tubulin polymerization and to demonstrate surprisingly effective antineoplastic activity against a series of human cancer cells and murine P388 lymphocytic leukemia cells.Type: GrantFiled: April 24, 2003Date of Patent: August 17, 2004Assignee: Arizona Board of RegentsInventors: George R. Pettit, Matthew P. Grealish
-
Patent number: D573827Type: GrantFiled: December 7, 2007Date of Patent: July 29, 2008Assignee: Taggart Enterprises Inc.Inventors: Terry Taggart, Charlie Dittrick, Angel Preciado, Doug Wathen, Carlos Babb, Eric Sanchez
-
Patent number: D574051Type: GrantFiled: November 14, 2007Date of Patent: July 29, 2008Assignee: Taggart Enterprises Inc.Inventors: Terry Taggart, Charlie Dittrick, Angel Preciado, Doug Wathen, Carlos Babb, Eric Sanchez