Patents Represented by Attorney, Agent or Law Firm Fish & Richardson P.C., P.A.
  • Canola oil with reduced linolenic acid
    Patent number: 6680396
    Abstract: A canola line has been stabilized to produce seeds having an &agr;-linolenic acid content of less than that of generic canola oil, more preferably less than or equal to about 7% &agr;-linolenic acid relative to total fatty acid content of said seed and a total glucosinolate content of less than 18 &mgr;mol/g of defatted meal, more preferably less than or equal to about 15 &mgr;mol/g of defatted meal. This canola line has reduced sulfur content of less than or equal to 3.0 ppm, improved sensory characteristics and increased oxidative stability.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: January 20, 2004
    Assignee: Cargill Incorporated
    Inventors: Lorin R. DeBonte, Willie H.-T. Loh, Zhegong Fan
  • Methods and compositions for inhibiting the proliferation of prostate cancer cells
    Patent number: 6680342
    Abstract: The invention provides for methods of monitoring the proliferation of cultured prostate cancer cells in the presence of quercetin, methods of treating an individual with prostate cancer or at risk of developing prostate cancer, and methods of reducing the risk of recurrence of prostate cancer in an individual who had previously been treated for prostate cancer. Methods of the invention further include treating an individual with benign prostatic hyperplasia (BPH) with quercetin as well as methods of screening for compounds that inhibit the proliferation of prostate cancer cells. The invention provides for compositions and articles of manufacture containing quercetin in particular formulations, and quercetin with a second compound that also exerts an effect on the androgen receptor.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: January 20, 2004
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Charles Young, Nianzeng Xing
  • Diagnostic imaging contrast agents with extended blood retention
    Patent number: 6676929
    Abstract: The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: January 13, 2004
    Assignee: Epix Medical, Inc.
    Inventors: Thomas J. McMurry, Hironao Sijiki, Daniel M. Scott, Randall B. Lauffer
  • Tissue ablation device and methods of using
    Patent number: 6669693
    Abstract: The invention provides for a tissue ablation device and methods of using such a tissue ablation device for treating cardiac arrhythmias.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: December 30, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Paul Friedman
  • Cryo balloon for atrial ablation
    Patent number: 6666858
    Abstract: The present invention pertains generally to the field of cryo balloon therapy and the use of cryo balloon therapy catheters to generate cold-induced lesions. The present invention includes a cryo balloon therapy apparatus, comprising a catheter having a proximal and a distal end, a cooling member disposed at the distal end of the catheter, a pull cord coupled to the cooling member, and a sheath that couples the pull cord and the catheter. A method for causing cold-induced necrosis is also disclosed.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: December 23, 2003
    Assignee: SciMed Life Systems, Inc.
    Inventor: Daniel M. Lafontaine
  • Pathogenic Tau mutations in transgenic mice
    Patent number: 6664443
    Abstract: Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau pathology also are described.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: December 16, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Michael L. Hutton, Jada M. Lewis, Eileen M. McGowan
  • Bioprosthetic heart valves
    Patent number: 6660260
    Abstract: The invention provides methods and materials related to heart valves and the treatment of valvular heart disease. Specifically, the invention provides non-murine heart valve cells and heart valve cusps as well as methods for making heart valves. The invention also provides methods and materials for (1) slowing heart valve degeneration, thrombosis, and calcification, (2) treating carcinoid heart disease, (3) identifying inhibitors of heart valve degeneration, thrombosis, and calcification, and (4) determining the safety of drugs.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: December 9, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Nalini M. Rajamannan
  • Brachytherapy seed applicators
    Patent number: 6656107
    Abstract: The invention features brachytherapy applicators for delivering radioactive seeds to a patient. Specifically, the invention provides brachytherapy applicators in which a seed magazine is removably held within a chuck by a magazine retaining structure. The magazine retaining structures described herein are designed such that a seed magazine can be readily inserted into or removed from a brachytherapy applicator. In addition, magazine retaining structures are designed such that they will not become jammed, even when blood cells or other particles enter the applicator during a brachytherapy procedure and become lodged near the seed magazine and the magazine retaining structure.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: December 2, 2003
    Assignee: Mentor Corporation
    Inventors: Laust Pedersen, Jerry R. Barber
  • Methods and compositions for inhibiting the proliferation of prostate cancer cells
    Patent number: 6656969
    Abstract: The invention provides for methods of monitoring the proliferation of cultured prostate cancer cells in the presence of omega-3 fatty acids, methods of treating an individual with prostate cancer or at risk of developing prostate cancer, and methods of reducing the risk of recurrence of prostate cancer in an individual who had previously been treated for prostate cancer. Methods of the invention further include treating an individual with benign prostatic hyperplasia (BPH) with omega-3 fatty acids as well as methods of screening for compounds that inhibit the proliferation of prostate cancer cells. The invention provides for compositions and articles of manufacture containing omega-3 fatty acids in particular formulations, and omega-3 fatty acids with a second compound that also exerts an effect on the androgen receptor.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: December 2, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Charles Young
  • Ostomy bags
    Patent number: 6652496
    Abstract: An wc-disposable ostomy bag has a pouch of alkali-disposable material and an adhesive flange in two parts. One part is an inner ring permanently bonded with the pouch around its opening. The other part forms the major part of the flange and is an outer ring attached with the pouch by a temporary, manually-separable bond. The outer ring can be disposed of separately from the pouch and inner ring, which are placed in a wc to which an alkali has been added. The small size of the inner ring enables it to be flushed away.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: November 25, 2003
    Assignee: Mentor Medical Limited
    Inventor: Timothy Bateman
  • Plants, seeds and oils having an elevated total monounsaturated fatty acid content
    Patent number: 6649782
    Abstract: Plants, seeds and oils having a total long chain monounsaturated content of at least about 82% and an erucic acid content of at least about 15% are described. Methods for producing plants having the profiled fatty acid content are also described.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: November 18, 2003
    Assignee: Cargill, Incorporated
    Inventors: Dharma R. Kodali, Zhegong Fan, Lorin R. DeBonte
  • Cryoplasty device and method
    Patent number: 6648878
    Abstract: A cryoplasty catheter and method for preventing or slowing reclosure of a lesion following angioplasty. The cryoplasty catheter includes a shaft having proximal and distal ends and a dilatation balloon disposed at the distal end. An intake lumen and exhaust lumen are defined by the shaft to deliver coolant to the balloon and to exhaust or drain coolant from the balloon. The method in accordance with the present invention includes cooling a lesion to aid in remodeling the lesion through dilatation and/or freezing a portion of the lesion adjacent the dilatation balloon to kill cells within the lesion to prevent or retard restenosis.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: November 18, 2003
    Assignee: SciMed Life Systems, Inc.
    Inventor: Daniel M. Lafontaine
  • High gain amplifier circuits and their applications
    Patent number: 6650184
    Abstract: A high gain amplifier circuit includes two differential transistor pairs and a current generator coupled to each differential pair to control tail current. Each differential transistor pair has a first transistor and a second transistor and an output node for each. Bias terminals of the first transistors serve as inputs for the amplifier circuit. The output node of each first transistor serves as an output for the amplifier circuit and is respectively coupled to the bias terminal of the second transistor of the same differential pair. The amplifier circuit has applications in a comparator circuit that also has a load circuit, which may have active components or only passive components. The amplifier circuit may also be used as a sense amplifier in a receiver of a communications system.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: November 18, 2003
    Assignee: Intel Corporation
    Inventor: James E. Jaussi
  • Methods of reducing &bgr;-amyloid polypeptides
    Patent number: 6649196
    Abstract: The invention features methods of reducing the level of a &bgr;-amyloid (A&bgr;) polypeptide using an Cimicifuga extract. The invention also features methods of producing an active fraction from an extract of Cimicifuga. The invention further features a composition containing an active fraction of a Cimicifuga extract and an article of manufacture containing such a composition.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: November 18, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Christopher B. Eckman, Debra Yager, Sharie Haugabook, Abdul Fauq
  • Solid phase synthesis
    Patent number: 6646118
    Abstract: The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: November 11, 2003
    Assignee: Quiatech AB
    Inventors: Marek Kwiatkowski, Mats Nilsson, Ulf Landegren
  • Synthases
    Patent number: 6645762
    Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: November 11, 2003
    Assignees: The Salk Institute for Biological Studies, The University of Kentucky Research Foundation
    Inventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
  • Compounds for protecting hydroxyls and methods for their use
    Patent number: 6639088
    Abstract: A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compounds can also be used for chemically synthesizing oligonucleotides and for sequencing nucleic acid compounds.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: October 28, 2003
    Assignee: Quiatech AB
    Inventor: Marek Kwiatkowski
  • Method for treating urinary incontinence in women and implantable device intended to correct urinary incontinence
    Patent number: 6638211
    Abstract: The invention relates to a method and device for treating urinary incontinence in women.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: October 28, 2003
    Assignee: Mentor Corporation
    Inventors: Patrice Suslian, Emmanuel Delorme
  • Brachytherapy medical devices
    Patent number: 6639237
    Abstract: The invention relates to brachytherapy devices, methods for making brachytherapy devices, and methods for using brachytherapy devices. For example, the invention provides brachytherapy devices such as staging-sterilization devices and insert devices that can be used in various brachytherapy procedures.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: October 28, 2003
    Assignee: Mentor Corporation
    Inventors: Laust Pedersen, Jerry Barber, Ronald Crouther, Dennis Femrite, Scott Henderson, Charles Pitman, Martin T. Steele, Sr.
  • Methods and materials for diagnosing unstable angina
    Patent number: 6635433
    Abstract: The invention provides methods and materials for diagnosing an angina condition in a patient. Specifically, the invention provides methods and materials for classifying an angina condition as either stable or unstable. In addition, the invention provides methods and materials for determining an individual's predisposition to have a stable or unstable angina condition. The invention also provides kits for classifying an angina condition as either stable or unstable as well as kits for determining an individual's predisposition to have a stable or unstable angina condition.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: October 21, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Jorg J. Goronzy, Cornelia M. Weyand, Giovanna Liuzzo