Abstract: A non-hydrogenated canola oil having superior oxidative stability and fry stability useful for food applications is disclosed, as well as seeds, plant lines and progeny thereof from which the oil is derived.
Abstract: The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it contact mucus in an amount, at a frequency, and for a duration effective to prevent, reduce, or eliminate non-invasive fungus-induced rhinosinusitis. This invention also provides methods and materials for diagnosing non-invasive fungus-induced rhinosinusitis and culturing non-invasive fungus from a mammalian mucus sample as well as specific antifungal formulations and medical devices for treating and preventing non-invasive fungus-induced rhinosinusitis. In addition, the invention provides methods and materials for treating and preventing other non-invasive fungus-induced mucositis conditions such as chronic otitis media, chronic colitis, and Crohn's disease. Further, the invention involves methods and materials for treating and preventing chronic asthma symptoms.
Type:
Grant
Filed:
May 25, 2001
Date of Patent:
April 29, 2003
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: A method for reducing atherosclerotic plaques includes administering an effective amount of at least one fatty acid composition to an animal, said fatty acid composition having a carbon chain of at least 16 carbons in length, and wherein at least one pair of double bonds are in a conjugated position. Such a method and article of manufactures facilitating these methods may be useful for reducing atherosclerotic plaques in humans.
Abstract: The invention provides methods and materials for diagnosing a rheumatoid arthritis condition in a patient. Specifically, the invention provides methods and materials for classifying a rheumatoid arthritis condition as diffuse, follicular, or granulomatous. In addition, the invention provides methods and materials for determining if an individual suffering from a rheumatoid arthritis condition will develop severe disease.
Type:
Grant
Filed:
September 1, 1999
Date of Patent:
April 29, 2003
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: A method is provided for improved visualization of vascular structures contained within magnetic resonance angiograms, particularly steady-state contrast-enhanced magnetic resonance angiograms. The disclosed methods include manipulating the relative enhancement levels of the arterial and venous blood pools images with respect to each other and to the surrounding anatomy. This manipulation is meant to optimize visualization of one or both of the individual blood pools without the necessity of completely obscuring or removing the supporting information given by presentation of the other blood pool and/or the surrounding anatomy.
Type:
Grant
Filed:
February 7, 2001
Date of Patent:
April 15, 2003
Assignee:
Epix Medical, Inc.
Inventors:
Robert M. Stefancik, Randy J. Earnest, Robert M. Weisskoff
Abstract: A substantially pure complex including IGFIIE polypeptide and IGFBP2 polypeptide is described. Methods for treating an osteoporosis patient and targeting a compound to the skeletal extracellular matrix of a patient are also described.
Type:
Grant
Filed:
October 27, 1999
Date of Patent:
April 15, 2003
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Sundeep Khosla, Cheryl A. Conover, Francis J. Ballard, Peter M. Tapley
Abstract: A novel apparatus for generating temperature gradients is described. The apparatus includes a semiconductive wafer and electrical connectors attached to, preferably, one of the edges of the wafer. Methods for transferring the temperature gradients to strata are described. The temperature gradients on the strata can be used for analyses of molecules, particularly biological macromolecules. The present invention also includes improved methods for determining the thermal stability of binding complexes.
Type:
Grant
Filed:
August 1, 2000
Date of Patent:
April 8, 2003
Assignee:
Regents of the University of Minnesota
Inventors:
Martin Blumenfeld, Mark Fisher, Fred Williamson, Gregory T. Cibuzar, Brian G. Van Ness
Abstract: Fatty acid desaturase 5′ regulatory elements are described, as well as nucleic acid constructs and transgenic plants that include these regulatory elements. Also described are fatty acid desaturase 3′ untranslated regions.
Abstract: The present invention involves a method for slowing heart valve degeneration in which an inhibitor of hydroxymethylglutaryl CoA reductase is administered.
Type:
Grant
Filed:
December 21, 2001
Date of Patent:
March 18, 2003
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: The present invention relates generally to mu3 opiate receptors, cannabinoid receptors, and estrogen surface receptors (ESRs). Specifically, the invention provides methods and materials for identifying mu3 opiate receptor agonists and antagonists, cannabinoid receptor agonists and antagonists, and ESR agonists and antagonists. In addition, the invention provides an isolated nucleic acid molecule that encodes a mu3 opioid receptor, and an isolated mu3 opioid receptor polypeptide. Further, the invention provides methods and materials for treating cancers, inflammatory conditions, sepsis conditions, viral infections, and cardiovascular diseases.
Abstract: Devices and methods for detecting vulnerable plaque within a blood vessel are disclosed. A catheter in accordance with the present invention includes an elongate shaft having a proximal end, a distal end, and an outer surface. At least one temperature sensor is disposed proximate to the distal end of the elongate shaft. In one preferred embodiment, the at least one temperature sensor is adapted to contact an inner surface of the blood vessel. In another preferred embodiment, at least one temperature sensor is disposed within a channel defined by a body member that is disposed about the elongate shaft.
Type:
Grant
Filed:
February 13, 2001
Date of Patent:
February 4, 2003
Assignee:
SciMed Life Systems, Inc.
Inventors:
Jaydeep Y. Kokate, Eric M. DoBrava, Marwane S. Berrada, Scott Kimmel, Suzana Prstic, Michael F. Hoey, Avram Bar-Cohen, Paul A. Iaizzo
Abstract: Provided is a transgenic non-human eukaryotic animal whose germ cells and somatic cells contain the amyloid precursor protein sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage. In mice, an age-related CNS disorder characterized by agitation, neophobia, seizures, inactivity, diminished cerebral glucose utilization, cortico-limbic gliosis, and death, develops. An acceleration of this disorder occurs in transgenic mice expressing human and mouse Alzheimer amyloid precursor proteins (APP) produced using a hamster prion protein gene-derived cosmid vector that confers position-independent, copy number-dependent expression. In transgenic mice the disorder develops in direct relationship to brain levels of transgenic APP, but mutant APP confers the phenotype at lower levels of expression than wild-type APP. The disorder occurs in the absence of extracellular amyloid deposition, indicating that some pathogenic activities of APP are dissociated from amyloid formation.
Type:
Grant
Filed:
March 2, 1999
Date of Patent:
January 21, 2003
Assignees:
Regents of the University of Minnesota, Johns Hopkins University
Inventors:
Karen Hsiao, David R. Borchelt, Sangram S. Sisodia
Abstract: Methods for isolating taxol and derivatives thereof with high purity are described. The methods include a supercritical fluid and a cosolvent extraction step, a liquid—liquid separation step, and a column chromatography step. An apparatus for isolating Taxol and derivatives thereof that allows the method steps to be performed online also is described.
Type:
Grant
Filed:
February 23, 2001
Date of Patent:
January 7, 2003
Assignee:
Hanwha Chemical Corporation
Inventors:
Jin Woong Kim, Young Hae Choi, Ki Pung Yoo, Min Jeong Noh, Joo Hee Han
Abstract: A clutch including an output hub on an output frame, an input shaft on an input frame, wherein the input shaft rotates within a bore in the output hub. An input hub is attached on an end of the input shaft, and a spring engages the input hub and the output hub. A locking spring clamp attaches the spring to the input hub. The input frame and the output frame are adjacent to one another on a side of the clutch opposite the input hub. An electronic control system for the clutch is also described that makes possible the use of the apparatus for electromechanical joint control in an orthotic or prosthetic device.
Type:
Grant
Filed:
April 7, 2000
Date of Patent:
December 31, 2002
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
Type:
Grant
Filed:
January 12, 2001
Date of Patent:
December 31, 2002
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Cheryl A. Conover, Antonio Bayes-Genis, Robert S. Schwartz
Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.
Type:
Grant
Filed:
June 22, 2001
Date of Patent:
December 17, 2002
Assignees:
University of Kentucky Research Foundation, The Salk Institute for Biological Studies
Inventors:
Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
Abstract: A stent includes a first stent section, a second stent section, and at least one connecting member. The connecting member has a first end attached to the first stent section, a second end attached to the second stent section and a physically separable portion.
Type:
Grant
Filed:
April 14, 2000
Date of Patent:
November 26, 2002
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Allan R. Camrud, David R. Holmes, Jr., Robert S. Schwartz
Abstract: The invention relates to a genetically modified bacteriophage, pseudovirion or phagemid capable of entering a host cell by binding of its artificial ligand to an artificial receptor present on said host cell. The invention relates also to the use of the genetically modified bacteriophage, pseudovirion or phagemid and of the host cell to screen sequence libraries, including antibody library.
Type:
Grant
Filed:
November 3, 1999
Date of Patent:
November 12, 2002
Assignee:
Vlaams Interuniversitair Institutuut voor Biotechnologie
VZW
Inventors:
Serge Muyldermans, Jan Steyaert, Karen Silence, Els Torreele
Abstract: Biopolymers and biopolymer blends, including block copolymers, prepared via enzyme-mediated catalysis preferably in a microorganism host in which the reaction conditions are selected to produce biopolymers and biopolymer blends having particular chemical compositions and microstructures.
Type:
Grant
Filed:
September 9, 1999
Date of Patent:
November 12, 2002
Assignee:
Regents of the University of Minnesota
Inventors:
Friedrich Srienc, Aaron S. Kelley, Nikolaos Mantzaris
Abstract: A new and distinct Chrysanthemum plant named 92-296-25 is provided. This new cultivar was the result of a unique cross between Dendranthema×grandiflora and F1 progeny of a cross between Dendranthema weyrichii and Dendranthema×grandiflora.