Abstract: Catheter assembly (100) having at least one lumen (150 or 160) and joined to hub (106). While the lumen inner diameter(s) remain constant from distal end (144) of the catheter (140) to proximal end (142), the outer catheter diameter increases proximate the hub (106) providing increased resistance to kinking during connection and disconnection from medical apparatus. The increased proximal catheter diameter preferably is sufficiently large to plug the proximal end of an introducer sheath through which the catheter is inserted during patient placement, to plug the proximal sheath end and minimize blood aspiration therethrough, and later serves to fill the vascular insertion upon complete catheter insertion after removal of the introducer sheath again to minimize blood aspiration through the vascular incision. The catheter may have two lumens (150,160) or more, joined to respective extension tubes in hub (106). The two lumens may each have a respective inner diameter of between about 0.020 in and 0.025 in.

Abstract: Described herein is, for example, a battery or capacitor over voltage (overcharge) and under-voltage protection circuit, that, for example, is adapted to not draw current from the battery or capacitor to be charged unless charge energy is detected and to not charge an energy storage device when an over-charge condition is sensed. The protection circuit may, for example, not be turned on unless an over voltage condition is present. Incoming energy to the system can be shunted to ground via a shunt load of various types including resistive loads and active components such as a zener diode. In some embodiments, no switching of the inbound power is required. Within limits, no regulation of inbound power is needed. When inbound power is sufficient to charge the battery or capacitor, regulation can occur via the applied shunt regulator if overcharge voltage conditions exist. Either type of charge source, voltage or current, can be used to provide charge energy.

Abstract: Methods and systems for identifying device models or accounts exhibiting outlying behavior are disclosed. For a method of identifying a device model exhibiting outlying behavior, a processor may receive a color impression count, a monochrome impression count and either a device model for each of a plurality of devices. A proportion of color revenue may be determined for each device based on the color impression count and the monochrome impression count. The processor may determine, for each device model, a distribution of the proportion of color revenue for the one or more devices having the device model and may automatically identify one or more distributions of the proportion of color revenue exhibiting outlying behavior. Each distribution is associated with a device model.

Abstract: Assays for identifying novel compounds for inhibiting eEF2 kinase and consequence peptides employed therein.

Abstract: Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.

Abstract: Embodiments of containers such as bowls can include in outer shell, and an inner shell positioned at least in part within the outer shell. The inner shell can be formed from a material such as stainless steel. The outer shell can be formed from a material such as plastic. An anti-slip provision, such as a strip of elastomeric or other material, can be mounted on the outer shell.

Abstract: A scratch-off document may include a substrate bearing a toner image and a scratch-off layer covering the printed content. The scratch-off layer may include a mass of a first solid ink and a mass of a second solid ink printed over the first solid ink in a distraction pattern. The toner image is formed of a toner that adheres to the substrate, while the scratch-off layer is made of a wax-based or other solid ink that may be removed from the substrate by scratching without removing the toner image. The distraction pattern includes varying pile heights that distract a viewer from any pile height variations that may exist in the toner image.

Abstract: A method of maintaining a locking fluid in an implanted catheter including positioning a catheter assembly in a patient, the catheter assembly including a first lumen having a closed first distal end and a first proximal end, and a second lumen having a closed second distal end and a second proximal end and injecting the locking fluid into the first and second proximal ends at a low pressure such that the locking fluid enters each lumen without opening the respective closed distal end. A method of withdrawing the locking fluid is also provided.

Abstract: A vascular guidewire introducer device (10) having a needle (52), a bulb (16), and a valve subassembly (100) through which a guidewire (14) is insertable for vascular guidewire insertion into a blood vessel (12) of a patient. The valve subassembly (100) includes a proximal fitting (102), a proximal cap (106), and a valve arrangement (104) disposed within a valve seat (118) defined by one of the fitting and the cap. The valve arrangement includes distal and proximal disc-shaped valve members (122,126) having centered slits (124,128) therethrough, and a spacer (130) disposed between the valve members. A method is disclosed for precisely centering the slits of the valve members during assembly and for retaining the valve members in their precisely centered positions in the valve seat. The valve arrangement permits use with a wide range of guidewire diameters.

Abstract: This application relates to pharmacologically-active vanilloid compounds which are useful for the treatment of various anti-inflammatory states characterized by inhibition of FAAH, such as, Alzheimer's dementia, Parkinson's disease, depression, pain, rheumatoid arthritis, pathophysiology of mood disorders, multiple sclerosis, and inflammation, or antagonism of TRPV1, such as, for example, Huntington's disease, hypertension, arthritis, allergic airway inflammation, Crohn's disease, ulcerative colitis, and neuropathic pain.

Abstract: A catheter assembly (10) having an outer catheter (12) and an inner catheter (14) extending coaxially through the outer catheter, and a hub (16). The inner catheter (14) is axially movable within and with respect to the outer catheter (14) by use of an actuator assembly (130) such that the catheter assembly has an opened condition permitting fluid communication with vasculature of a patient, and a closed condition preventing fluid communication with the vasculature of the patient. The opened condition permits the intended use of the catheter assembly such as for hemodialysis of the patient. In the closed condition, locking solution may be maintained in the catheter assembly and later removed therefrom, with essentially no locking solution leaving the catheter assembly or entering the patient. The actuator assembly (130) is secured to a proximal end portion (128) of the inner catheter (14) as it protrudes proximally from the hub (16), where it is accessible to the practitioner.

Abstract: A clamshell case for enclosing a helicopter includes a base for supporting said helicopter, a first side section attached by a first hinge to one edge of the base, a second side section attached by a second hinge to the other edge of the base, and a drive system for rotating said side sections towards each other to substantially enclose said helicopter and substantially completely protect it from the weather and other damage.

Abstract: A stable, phase-pure magnesium-substituted crystalline hydroxyapatite containing from about 2.0 to about 29 wt % magnesium, wherein at least 75 wt % of the magnesium content is substituted for calcium ions in the hydroxyapatite lattice structure.

Abstract: An electronic device may include a keypad having a plurality of predefined key areas and a light guide that may be used to illuminate the key areas. The light guide may include a capacitive sensing grid to sense user contact relative to the keypad.

Abstract: A multi-output switch includes a dipole magnet configured to move from a central position to either a first position or a second position and a Hall Effect sensor having a first sensitive area with a first output and a second sensitive area with a second output, wherein the sensor is relatively positioned such that when the magnet is in the central position, the first output and second output read off, when the magnet is in the first position the first sensitive area is activated and the first output reads on, and when the magnet is in the second position the second sensitive area is activated and the second output reads on. The switch may further include a magnet holder configured to house the magnet and define a pathway of movement for the magnet.

Abstract: An apparatus for diagnosing a patient includes a catheter having a tip. The apparatus includes a bioptome disposed in proximity to the tip to obtain a tissue sample of the patient. The apparatus includes a radiodetector disposed in proximity to the tip to detect radiation in the patient. A method for diagnosing a patient includes the steps of moving a tip of a catheter to a desired location in a blood vessel of the patient determined by radiation detected by a radiodetector disposed in proximity to the tip. There is the step of obtaining a tissue sample of the patient with a bioptome disposed in proximity to the tip.

Abstract: Disclosed are various embodiments of methods, systems, devices and components for reducing power consumption in an LCD display that is backlit by LEDs. The various embodiments typically require the use of an array of backlighting LEDs disposed beneath and configured to emit light in the direction of an overlying LCD or LCD panel. In such an array, some LEDs are operated or driven at a first brightness, while other LEDs are operated or driven at a second brightness that is different from the first brightness, or at no brightness at all (i.e., such LEDs are turned off). LED brightnesses and therefore backlighting brightnesses over different portions of display or screen are varied and determined in accordance with the portion of display or screen that a user or processor has selected for viewing (“the area of interest”).

Abstract: A system for forming a foldable printed substrate includes a creasing system that applies a plurality of creases to the substrate along a first axis. It also applies a plurality of creases to the substrate along a second axis that is angled with respect to the first axis. Each creases is applied in a manner that does not ablate the substrate. The system also may include a cutting system to yield a foldable substrate such as a carton, sleeve, or box. It also may include a printing system to generate a printed, foldable substrate.

Abstract: Methods and systems for determining print revenue behavior for an account are disclosed. A computing device may determine a print revenue for an account for each of a plurality of time periods. The computing device may select a best fit model from a plurality of models based on the print revenue for the account for the plurality of time periods. The computing device may determine a risk level associated with the account based on a best fit model. The risk level may be based on a difference between the best fit model and the print revenue for the account for each of time period.

Abstract: A measuring device is used in conjunction with a programmable controller for monitoring electrolyte levels in the battery. According to one implementation, the measuring device is located in a battery and is configured to detect when the electrolyte level in the battery falls below a particular level. The controller is in electrical communication with the electrolyte detection device. The controller is configured to: (i) receive a signal from the electrolyte level detection device indicating when the electrolyte level in the battery has fallen below the particular level; (ii) introduce a wait-period after the signal is received; and (iii) enable an indicator to indicate that the electrolyte level in the battery should be refilled when the wait-period expires.