Patents Represented by Attorney Frederick H. Weinfeldt
  • Patent number: 4246259
    Abstract: Higher alkyl diaryl sulfonium salts, e.g., octadecyldiphenylsulfonium tetrafluoroborate, are useful as anti-obesity agents.
    Type: Grant
    Filed: February 7, 1979
    Date of Patent: January 20, 1981
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4233292
    Abstract: Cyclopropyl alkyl arylsulfonium salts, e.g., cyclopropyl n-propyl phenylsulfonium tetrafluoroborate, are useful as pharmaceutical agents.
    Type: Grant
    Filed: February 7, 1979
    Date of Patent: November 11, 1980
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4229463
    Abstract: Mono- or poly-unsaturated fatty acid hydrazides, e.g. cis,-9-octadecenoic acid, 2-(o-methylphenyl)-hydrazide are useful as pharmaceutical agents and are obtainable by reacting a derivative, e.g. mixed anhydride, of a long chain unsaturated carboxylic acid with an appropriate hydrazine compound.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: October 21, 1980
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4228105
    Abstract: A process for the production of compounds of formula I, ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms,R.sub.2 is hydrogen, fluorine, chlorine or bromine, andR.sub.3 is bromine, iodine, isobutyl, tert. butyl, cyclohexyl, cyclohexenyl; or phenyl, optionally substituted by fluorine, chlorine, bromine or alkoxy of 1 to 4 carbon atoms; or a radical of formula II, ##STR2## in which either R.sub.4 and R.sub.5 are the same or different and each signifies alkyl of 1 to 3 carbon atoms,orR.sub.4 and R.sub.5 together signify the radical --(CH.sub.2).sub.n --, in which n is 4 or 5, the radical --CH.sub.2 --CH.sub.2 --0--CH.sub.2 --CH.sub.2 --, the radical --CH.sub.2 --CH.dbd.CH--CH.sub.2 --, or the radical --CH.sub.2 --CH.sub.2 --N(R.sub.6)--CH.sub.2 --CH.sub.2 --, in which R.sub.6 is hydrogen or alkyl of 1 to 3 carbon atoms. Hydroxyketone and hydroxy imine intermediates are also disclosed.The compounds of formula I are known to exhibit anti-inflammatory activity.
    Type: Grant
    Filed: November 27, 1978
    Date of Patent: October 14, 1980
    Assignee: Sandoz Ltd.
    Inventor: Rudiger Jeck
  • Patent number: 4221797
    Abstract: The compounds are amino- or cyano-bearing dihydroquinolines, which have either of the combinations of (a) 2-amino, 3-carboxylic and 4-oxo functions, or (b) 2-oxo, 3-cyano and 4-hydroxy functions, and may be optionally substituted at 1 or 2 of the 5, 6, 7 or 8 positions, eg 1-allyl-2-amino-1,4-dihydro-6,7-dimethoxy-4-oxo-quinoline-3-carboxylic acid ethyl ester, and 1-allyl 3-cyano-1,2-dihydro-4-hydroxy-6,7-dimethoxy-2-oxo-quinoline. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: September 9, 1980
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • Patent number: 4214889
    Abstract: 2-amino-4H-3,1 benzoxazines, eg 6-chloro 2-dimethylamino-4H, 3,1-benzoxazine, are useful as herbicides. The compounds may be prepared by reacting an amine with a 2-halomethylphenyl isocyanate.
    Type: Grant
    Filed: April 16, 1979
    Date of Patent: July 29, 1980
    Assignee: Sandoz, Inc.
    Inventors: Stewart W. Myers, Homer K. Spencer
  • Patent number: 4201785
    Abstract: Cyclopropanyl-group-bearing-hydrazides, e.g. cis-2-octyl-cyclopropanoctanoic acid, 2-(o-methylphenyl)-hydrazide, are useful as pharmaceutical agents and are obtainable by reacting a derivative, e.g. mixed anhydride, of a cyclopropanyl-group bearing-long chain carboxylic acid with an appropriate hydrazine.
    Type: Grant
    Filed: April 4, 1979
    Date of Patent: May 6, 1980
    Assignee: Sandoz Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4194002
    Abstract: Long chain fatty acid amides of styryl hexahydroindolinols in which the amido portions have ethyleneically unsaturated positions or cyclopropanyl rings, eg 1-(1-oxo-9-cis-octadecenyl)-(3aRS, 4RS, 7aRS)-4-(Z)-(3,4-dimethoxy)-styryl-hexahydro-4-indolinol, are useful as cholesterol ester-reducing agents and are obtainable by reacting corresponding long chain carboxylic acids (or derivatives thereof) with appropriate 4-styryl-4-hexahydroindolinols.
    Type: Grant
    Filed: March 29, 1978
    Date of Patent: March 18, 1980
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4185118
    Abstract: Unsaturated fatty acid amides of benzocycloalkylamines, eg. N-(1-indanyl)-cis,cis-9,12-octadecadienylamide, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain unsaturated carboxylic acid with an appropriate benzocycloalkylamine.
    Type: Grant
    Filed: January 12, 1979
    Date of Patent: January 22, 1980
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4164407
    Abstract: 2-amino-4H-3,1 benzoxazines, e.g. 6-chloro 2-dimethylamino-4H, 3,1-benzoxazine, are useful as herbicides. The compounds may be prepared by reacting an amine with a 2-halomethylphenyl isocyanate.
    Type: Grant
    Filed: October 7, 1977
    Date of Patent: August 14, 1979
    Assignee: Sandoz, Inc.
    Inventors: Stewart W. Myers, Homer K. Spencer
  • Patent number: 4129658
    Abstract: The present invention provides compounds of formula I, ##STR1## wherein R.sub.1 and R.sub.2 are, independently, hydrogen, fluorine, chlorine, trifuoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, andR.sub.3 is hydrogen, or alkoxy of 1 to 4 carbon atoms, with the proviso that when R.sub.3 is alkoxy then at least one of R.sub.1 and R.sub.2 is alkoxy, orR.sub.1 and R.sub.2 are bound to adjacent ring carbon atoms and are together --(CH.sub.2).sub.m --, wherein m is 3 or 4, --CH.dbd.CH--CH.dbd.CH--, or --O--CH.sub.2 --X--, wherein X is --O-- or --CH.sub.2 --, andR.sub.3 is hydrogen, fluorine, chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms,Useful as hypolipidemic agents and anti-arrhythmics.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: December 12, 1978
    Assignee: Sandoz Ltd.
    Inventor: Richard Berthold
  • Patent number: 4127658
    Abstract: Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenylyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.
    Type: Grant
    Filed: March 23, 1978
    Date of Patent: November 28, 1978
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • Patent number: 4117137
    Abstract: 2-Amino-3-pyridyl (or phenyl) nitromethylketones are prepared eg by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido [2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with the carbanion resulting from the reaction of nitromethane with a porton abstracting agent. The compounds are useful as anti-allergic agents.
    Type: Grant
    Filed: July 6, 1977
    Date of Patent: September 26, 1978
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4112117
    Abstract: Alpha-cyano-o-anisidino derivatives, e.g., alpha-cyano-o-acetanisidide, are useful as hypolipidemic agents. The compounds are obtainable by reacting an appropriate 2-amidophenol with a haloalkylnitrile.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: September 5, 1978
    Assignee: Sandoz, Inc.
    Inventors: Paul L. Anderson, Thomas F. Oglia
  • Patent number: 4100300
    Abstract: Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: July 11, 1978
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • Patent number: 4098908
    Abstract: Phenoxyphenyl pyridyl carbinols and ketones, e.g., p-phenoxyphenyl-nicotinyl ketone, are useful as pharmaceutical agents. The ketones are obtainable by oxidation of corresponding phenoxyphenyl pyridyl carbinols.
    Type: Grant
    Filed: June 28, 1976
    Date of Patent: July 4, 1978
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4089908
    Abstract: The compounds are 1-aryl-1-alknyl-1-(t-butyl)-substituted methanols, e.g. 3-(2'-naphthyl)-4,4-dimethyl-pent-1-yn-3-ol, are useful as hypolipidemic agents, and are prepared by reacting a 4-aryl-pivalophenone with a metallo-alkynyl reagent under Grignard reaction conditions.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: May 16, 1978
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4081476
    Abstract: The compounds are 1-aryl-1-lower alkyl-substituted-1-buten-3-ols, butan-3-ols, and acylation products thereof, e.g., (p-biphenylyl)-2-penten-4-ol and are useful as pharmaceuticals.
    Type: Grant
    Filed: November 19, 1975
    Date of Patent: March 28, 1978
    Assignee: Sandoz, Inc.
    Inventors: Paul L. Anderson, Darryl A. Brittain
  • Patent number: 4073936
    Abstract: The compounds are 4-aryl substituted buta-2,3-dienoic acids and esters thereof which may also be lower alkyl-substituted at any of the 2- and 4- positions, e.g., 4-(p-methoxyphenyl)-2-methyl-buta-2,3-dienoic acid. The compounds are useful as pharmaceuticals, e.g., as antiinflammatory agents and hypolipidemic agents.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: February 14, 1978
    Assignee: Sandoz, Inc.
    Inventors: Eugene E. Galantay, Faizulla G. Kathawala
  • Patent number: 4064246
    Abstract: Hydroxymethyl-substituted-2(1H)-quinazolinones, e.g., 7-hydroxymethyl-1-isopropyl-4-phenyl-2(1H)-quinazolinone, are useful as anti-inflammatory agents.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: December 20, 1977
    Assignee: Sandoz, Inc.
    Inventor: Eugene A. Papp