Abstract: The power pack includes a plurality of parallel groups. Each parallel group includes a plurality of electrical power sources connected in parallel. The pack also includes a plurality of series groups. Each series group connects in series one of the power sources from each of the parallel groups. The pack also includes a series balancing circuit configured to balance the voltage of the power sources in one of the series groups such that one or more power sources in the series group recharges one or more other power sources in the same series group.

Abstract: Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively using atmospheric dioxygen as an oxidant. Mutant 9-10A-A328V hydroxylates octane primarily at the 2-position to form S-2-octanol (40% ee). Another mutant, 1-12G, hydroxylates alkanes larger than hexane primarily at the 2-position, but forms R-2-alcohols (40-55% ee). These biocatalysts are highly active for alkane substrates and support thousands of product turnovers. These regio- and enantio-selectivities are retained in whole-cell biotransformations with E. coli, where the engineered P450s can be expressed at high levels and the expensive cofactor is supplied endogenously.

Abstract: The optical device includes a waveguide on a base. The device also includes a modulator on the base. The modulator includes an electro-absorption medium configured to receive a light signal from the waveguide. The modulator also includes field sources for generating an electrical field in the electro-absorption medium. The electro-absorption medium is a medium in which the Franz-Keldysh effect occurs in response to the formation of the electrical field in the electro-absorption medium. The field sources are configured so the electrical field is substantially parallel to the base.

Abstract: The cartridge can include a mixing component for mixing different solutions so as to form a product solution. A mixture of different solutions can be transported into the mixing component where they combine to form a product solution. The mixing component includes a plurality of variable volume reservoirs in liquid communication with one another. The product solution can be repeatedly transported from one of the variable volume reservoirs to another of the variable volume reservoirs until the desired degree of mixing is achieved. Once the desired degree of mixing is achieved, the product solution can be transported directly to a product chamber within the cartridge or can be treated further before being transported to the product chamber.

Abstract: The chip includes electrodes on a substrate. The electrodes include a working electrode, a reference electrode, and a counter electrode. The reference electrode is constructed so as to not have an intrinsic potential. A self-assembly monolayer is positioned on the reference electrode. The self-assembly monolayer includes spacers and active probes. The active probes are configured to have a higher affinity for a capture probe than the spacers have for the capture probe.

Abstract: The sensor includes an optical waveguide defined in a light-transmitting medium. The waveguide includes a sensing portion and an non-sensing portion. The light-transmitting medium included in the sensing portion has defects that provide the light-transmitting medium with a deep band gap level between a valence band of the light-transmitting medium and a conduction band of the light-transmitting medium. The deep band gap level is configured such that the waveguide guiding light signals through the light-transmitting medium in the sensing portion causes free carriers to be generated in the light-transmitting medium. A detector is configured to detect the free carriers in the sensing region of the waveguide.

Abstract: The invention provides dBHD-based compositions and dBHD analog compositions, and pharmaceutical compositions comprising them, e.g., in the form of liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these dBHD analogs are used to inhibit a dysfunctional stem cell and/or a cancer (tumor) stem cell.

Abstract: An optical device includes a light-transmitting medium on a base. The light-transmitting medium at least partially defines a free propagation region through which light signals travel. A reflective grating is positioned such that light signals can travel through the free propagation region and be received by the optical grating. The optical grating is configured to reflect the received light signal back into the free propagation region. The optical grating reflects the light signals such that light signals associated with different wavelengths separate as the light signals travel through the free propagation region. The portion of the light-transmitting medium that defines the free propagation region has a facet through with the light signals are transmitted. The grating includes a buffer layer between the facet and a reflecting layer that is configured to reflect the light signals received by the grating.

Abstract: Solid and hollow cylindrical nanopillars with nanoscale diameters are provided. Also provides is a method of making such nanopillars using electron beam lithography followed by the electroplating.

Abstract: An isolated caveolin containing vesicle comprising a caveolin protein and at least one lipid, wherein at least about 30% of the at least one lipid is selected from phosphatidylethanolamine and phosphatidylglycerol is disclosed. Also disclosed is a method of making an isolated caveolin containing vesicle, an isolated caveolin containing vesicle comprising a recombinant caveolin protein, an isolated caveolin containing delivery vesicle, a method of making an isolated caveolin containing delivery vesicle and a method of treatment of a disease or condition by delivery of a molecule using the isolated caveolin containing delivery vesicle.

Abstract: In a climate control system for buildings, a number of renewable energy sources (photovoltaic and/or eolic, geothermal and the like) are utilized to obtain a flux of constant temperature fluid to be circulated into radiating pipes placed in continuous spaces or gaps defined in the perimeter walls and floors of said buildings. A desired variable flux of air is made to circulate in said spaces or gaps, to be heated or coiled by said radiating pipes. One said flux of air reaches the desired temperature, its circulation is stopped, to obtain a thermal insulating layer of air, in thermal equilibrium with the rooms to be air conditioned. In the matters of civil, trade, industrial, and also prefabricated buildings endowed with elevated features in heat-sound insulation, it has been utilized a particular simple method for the realization of system of hollow spaces or gaps situated between the outer and inner surface of the building, mainly based on the laying of a series of panels; i.e. thin metal sheets, located.

Abstract: The disclosure provides fusion polypeptides and constructs useful in delivering anionically charged nucleic acid molecules including diagnostics and therapeutics to a cell or subject. The fusion constructs include a protein transduction domain and a nucleic acid binding domain, or a protein transduction domain and a nucleic acid that is coated with one or more nucleic acid binding domains sufficient to neutralize an anionic charge on the nucleic acid. Also provided are methods of treating disease and disorders such as cell proliferative disorders.

Abstract: The disclosure relates, in general, to treatment of fatty liver disorders comprising administering compositions comprising cysteamine products. The disclosure provides administration of enterically coated cysteamine compositions to treat fatty liver disorders, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: The disclosure provides methods and compositions useful for treating claudin-4 associated disorders including cell proliferative disorders. The disclosure also provide claudin-family binding peptides useful in the methods of the disclosure.

Abstract: The disclosure provides methods, systems and kits for cellular and subcellular identification in a rapid, throughput manner.

Abstract: A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for identifying a molecule having a biological activity.

Abstract: The disclosure relates to vehicle navigation systems. More specifically, the disclosure relates to vehicle navigation systems that utilize fuel use and emissions criteria as a parameter to determine directions between two locations.

Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

Abstract: The optical device includes a waveguide and a light sensor on a base. The light sensor includes a ridge extending from slab regions positioned on opposing sides of the ridge. The ridge includes a multiplication layer and an absorption layer. The absorption layer is positioned to receive at least a portion of the light signal from the waveguide. Additionally, the absorption layer generates a hole and electron pair in response to receiving a photon of the light signal. The multiplication layer is positioned to receive the electron generated in the absorption layer and to generate additional electrons in response to receiving the electron.

Abstract: The present invention relates to a cell comprising an Endoplasmic Reticulum (ER) stress element operably linked to a reporter element and an exogenous gene encoding a protein that induces ER stress. Methods of screening using the modified cell, constructs used in the modified cell, the candidate agents identified by the screen and uses thereof are also part of the invention.