Abstract: A structure consisting of well-ordered semiconductor structures embedded in a binder material which maintains the ordering and orientation of the semiconductor structures. Methods for forming such a structure include forming the semiconductor structures on a substrate, casting a binder material onto the substrate to embed the semiconductor structures in the binder material, and separating the binder material from the substrate at the substrate. These methods provide for the retention of the orientation and order of highly ordered semiconductor structures in the separated binder material.

Abstract: This disclosure relates to the design and fabrication of micro-electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields for wireless data and power transfer.

Abstract: A wavelength conversion material with an omni-directional reflector is utilized to enhance the optical efficiency of an illumination system. Light guides with restricted output apertures, micro-element plates and optical elements are utilized to enhance the brightness of delivered light through light recycling. In addition, micro-element plates may be used to provide control over the spatial distribution of light in terms of intensity and angle. Efficient and compact illumination systems are also disclosed.

Abstract: An optical system includes optical devices that each have a top side and a bottom side between lateral sides. A first one of the devices has one or more first waveguides immobilized on a first base. The first device having a first via that defines an optical path that extends from the top side of the first device to the bottom side of the first device. A second one of the devices has a second waveguide immobilized on a second base. An optical fiber has a fiber facet immobilized relative to the first device and aligned with the first via. The first device is between the fiber facet and the second device. The first device, the second device and the optical fiber are arranged such that a light signal exchanged between the optical fiber and the second waveguide travels through the first via.

Abstract: Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3.

Abstract: The battery system includes a battery pack having a plurality of power sources arranged in parallel groups that are connected in series. Each parallel group includes a plurality of power sources connected in parallel. Each power source includes a battery. The system also includes electronics configured to repeatedly charge the battery pack according to a charging protocol. The charging protocol is configured such that the voltage of any one battery in the battery pack does not exceed its maximum operational voltage after failure of a battery in the battery pack.

Abstract: A microelectromechanical systems (MEMS) and integrated circuit (IC) based biosensor capable of sensing or detecting various ionic molecules and macromelecules (DNA, RNA or protein). The MEMS based biosensor utilizes a hybridization and enzyme amplification scheme and an electrochemical detection scheme for sensitivity improvement and system miniaturization. The biosensor or biosensors are incorporated on a single substrate. Preferably, the biosensor system includes at least two electrodes. The electrodes includes a working electrode, a reference electrode and a counter (auxiliary) electrode. The biosensor or biosensors also provide an apparatus and method for confinement of reagent and/or solution in the biosensor or biosensors using surface tension at small scale. The confinement system provides controlled contacts between the reagent(s) and/or solution(s) with the components (i.e., electrodes) of the biosensor or biosensors using controllable surface properties and surface tension forces.

Abstract: The battery includes a cover assembly on a battery case. The cover assembly includes a battery cover coupled with an electrically insulating flap of material. The battery can include a first electrical connector that provides electrical communication between a terminal in the cover and one or more first electrodes in the battery. The first connector is at least partially positioned between a first region of the flap and a second region of the flap. The battery can also includes a second electrical connector that provides electrical communication between the cover and one or more second electrodes in the battery. The second connector passes between the flap and the case such that a portion of the flap is between the first connector and the second connector.

Abstract: A method of forming a light sensor array includes tuning a resistance level of a plurality of resistors. The resistors are included in a light sensor array for use with a positron emissision tomography (PET) scanner system. The light sensor array includes detection circuits that each includes one of the resistors connected in series with an avalanche photodiode.

Abstract: The optical device includes a waveguide and a light sensor on a base. The light sensor includes a light-absorbing medium configured to receive a light signal from the waveguide. The light sensor also includes field sources for generating an electrical field in the light-absorbing medium. The field sources are configured so the electrical field is substantially parallel to the base.

Abstract: The feedthrough assembly includes an insulating sleeve positioned between a ferrule and a pin such that the ferrule is electrically insulated from the pin. The feedthrough assembly also includes a compression collar compressing the ferrule and insulating sleeve against the pin. The compression can be sufficient to form a seal between the ferrule and the insulating sleeve and/or between the insulating sleeve and the pin.

Abstract: The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects.

Abstract: A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for identifying a molecule having a biological activity.

Abstract: The optical device includes a plurality of waveguides and an optical grating. A first portion of the waveguides act as input waveguide configured to carry a light beam that includes multiple light signals to the optical grating. The optical grating is configured to demultiplex the light signals. A second portion of the waveguides act as output waveguides configured to carry the demultiplexed light signals away from the optical grating. A method of forming the optical device includes sequentially forming the waveguides and the optical grating while a single mask defines the location of the waveguides and the optical grating.

Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

Abstract: Systems and method of managing map data on electronic devices such as portable electronic devices include systems and methods of preloading map data, managing map data storage, sharing point of interest or pushpin data with other electronic devices, and displaying map data.

Abstract: The disclosure relates, in general, to treatment of fatty liver disorders comprising administering compositions comprising cysteamine products. The disclosure provides administration of enterically coated cysteamine compositions to treat fatty liver disorders, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: Provided is a method for screening for effective agents for the treatment of cancer which method comprises selecting a putative agent that is likely to disrupt a function mediated by a critical normal gene product, which function is required for the successful division and continued cell survival of cancer cells, and which function is not required for the successful division and continued cell survival of control cells, treating a cancer cell sample and a control cell sample with a purative agent and determining the cytotoxic effect of, and/or the growth inhibitory effect of the putative agent on these samples, and identifying an effective agent as an agent which is more cytotoxic to, and/or more inhibiting to the growth of the cancer cell sample than the control cell sample. This invention further provides an effective agent identified by this screening method and a method of treating a cancer patient with such an agent.

Abstract: A mobile communication system employs moving base stations moving in the direction of flow of traffic moving along a roadway. The moving base station communicates with fixed radio ports connected to a gateway office. A plurality of moving base stations are spaced apart on a closed loop and move with the flow of traffic along one roadway on one leg of the loop and with a flow of traffic on another roadway in another leg of the loop. The moving base stations communicate with a plurality of fixed radio ports connected by a signal transmission link to a gateway office which, in turn, is connected to the wire line network. The moving base stations are each provided with a pair of directional antennas with one antenna directed toward the flow of traffic and another antenna directed to the fixed radio ports.

Abstract: Provided are methods and compositions for treating autism spectrum disorders by administering an antioxidant or agent that stabilize or enhance expression of altered neuroligins. An aspect of the disclosure includes site-specific delivery of the antioxidant to the endoplasmic reticulum (ER) to reverse incorrect disulfide binding of the protein neuroligin. Also disclosed is a method of targeting the antioxidant to neuroligin by using the calcium binding or other recognition site of neuroligin to bind the antioxidant. The antioxidant can be cysteamine linked to a molecule which binds to a binding site.