Abstract: The reticulocyte content present in a specimen of red blood cells is quantitatively measured based upon the selective immunoreactivity of the reticulocyte portion of the specimen with a reticulocyte-specific antibody which is immunoreactive with proteinaceous material associated with reticulocytes but not associated with mature red blood cells. Such immunoreactive proteinaceous material may be transferrin, transferrin receptor, transcobalamin II, or transcobalamin II receptor. Various procedures are described for quantitating such selective immunoreactivity, including fluorescent and radioactive detection techniques employing direct or indirect fluorescent or radioactive labeling of the reticulocyte-specific antibody.

Abstract: Concentrations of non-ionic species in aqueous media are measured as a function of potentiometric or polarographic response, employing a membrane electrode selective for the non-ionic species being measured. The electrode comprises a conductive substrate and a membrane formed as a layer on the conductive substrate and adapted for interfacing with the aqueous medium. The membrane is composed of a polymeric matrix having dispersed or dissolved therein an anion exchange material and a water-insoluble salt of the non-ionic species being measured. The electrode is particularly suitable for use as an implantable glucose sensor for continuous in vivo monitoring of glucose concentration in the blood or interstitial fluid.

Abstract: Amorphous chalcogenide films substantially free from particulate and microstructure are formed on a substrate from solution. The solution contains a glass-forming chalcogenide compound dissolved in a non-aqueous vaporizable solvent, such as a low molecular weight amine, and is substantially free from particulate or crystallizable material. Film formation is effected by coating the solution onto the substrate in a non-vacuumized environment, and thereafter evaporating the solvent from the coating. The procedure is particularly useful in forming amorphous chalcogenide resists for photolithographic applications.

Abstract: A method for forming a plurality of optical surfaces on an optical lens precursor, desirably a "soft" contact lens button or blank, to yield a lens adapted for proximate or intimate contact with an eyeball and defined by at least one posterior surface, an edge and at least one anterior surface, is comprised of forming a precision lens precursor, assembling the precursor in a microsurface generating apparatus, ultra-precisely forming the curves or geometry comprising the posterior surface and a portion of the edge to yield a semi-finished lens, blocking the semi-finished lens on an adhesively coated lens block fixture having an ultra-precisely preformed face for intimate precision mating with the posterior surface of the semi-finished lens, reassembling the semi-finished lens/fixture in the microsurface generating apparatus, ultra-precisely forming the curves or geometry comprising the anterior surface and another portion of the edge, and demounting a finished, ultra-precision lens from the blocking fixture.

Abstract: 1,4-Diazabicyclo[2.2.2]octane (DABCO) has been shown to extend the lifetime of several organic laser dyes in nitrogen laser pumped and flashlamp pumped dye lasers. With 0.010M DABCO, average power output in coumarin dye lasers remains at better than 90% of initial power at least three times longer than without DABCO.

Abstract: Vitamin-containing multicomponent compositions are assayed to determine the extent of conversion of the vitamin to one or more analogues thereof due to interaction between the vitamin and the other components of the composition, employing a radioactive labeled form of the vitamin. The assay is useful for quality control in the manufacture of multivitamin and multivitamin-mineral formulations and vitamin-supplemented foods intended for human or animal ingestion.

Abstract: Novel heterogeneous catalysts consist essentially of an anion exchange resin to which is bound ionically an anionic metal carbonyl species having the general formula M.sub.n (CO).sub.m (X).sub.p.sup.z- where M is a transition metal such as for example rhodium, cobalt, ruthenium, osmium, iridium, or iron; X is an anion, for example halide, hydride, or alkyl; n ranges from 1 to 12; m ranges from 1 to 34; p ranges from 0 to 2n+1; and z is an integer charge ranging from 1 to 5. The catalyst in which M is rhodium, m=2, p=2, n=1,and z=1 is highly effective for the carbonylation of alcohols to acids and esters. Many of these anionic species have utility in the hydroformylation of olefins.

Abstract: Milbemycin and avermectin macrolides are synthesized by the cyclized linking of separately synthesized northern and southern hemisphere intermediates. The northern hemisphere intermediate is a spiroketal alkenyl aldehyde, and the southern hemisphere intermediate is an aryl alkenyl phosphine oxide anion.

Abstract: The present invention relates to the reduction of the fibrinogen concentration in cryoprecipitate fraction formed during the fractionation of blood. This zinc-mediated decrease of fibrinogen increases the ratio of Factor VIII to total protein content.

Abstract: Concentrations of large organic cationic species in aqueous solution are measured as a function of potentiometric response, employing a cation-selective electrode having a high degree of selectivity for large organic cationic species with respect to both smaller organic cationic species and inorganic cationic species. The electrode is formed with a cation-selective membrane component composed of a polymeric matrix having dispersed or dissolved therein a cation exchange material whose counter-anion is a high molecular weight alkyl or alkaryl sulfonate or sulphate. By proper choice of the cationic moiety of the cation exchange material, the electrode may be made selective for a variety of large organic cationic species, including a number of such species which are of pharmaceutical or clinical interest, thereby enabling potentiometric assays for such species.

Abstract: A compond parabolic concentrator with a V-shaped cavity is provided in which an optical receiver is emplaced. The cavity redirects all energy entering between the receiver and the cavity structure onto the receiver, if the optical receiver is emplaced a distance from the cavity not greater than 0.27 r (where r is the radius of the receiver).

Abstract: Lower aliphatic carboxylic acids of from 1 to 6 carbon atoms or salts thereof are prepared by culturing the microorganism Eubacterium limosum in a nutrient medium containing at least one member of the group consisting of carbon monoxide and a mixture of hydrogen and carbon oxide under substantially anaerobic conditions.

Abstract: Disclosed are novel benzo[g]Pyrido[2,1-b]-quinazolinones which are active as anti-allergy agents and thus have utility in the treatment of allergic reactions such as bronchial asthma.

Abstract: This invention relates to a single use container package especially adapted for use as a pharmaceutical delivery system. It is a two unit package comprising a liquid containing bottle and an open ended pharmaceutical capsule.

Abstract: The present invention is concerned with new and novel 4-hydroxyaporphine derivatives and with the preparation thereof.

Abstract: Disclosed are novel substituted benzopyranopyridines which are active as bronchodilators.

Abstract: Disclosed are substituted 1,2-benzoxathin-2,2-dioxide, and methods for their manufacture. These compounds show antiinflammatory activity.

Abstract: This invention relates to substituted indolobenzoxazepines which act as central nervous system depressants and as such are useful as tranquillizers.

Abstract: 2-(4-Pyrimidinyl)thioacetamides are disclosed that have been found useful in the treatment of gastric hyperacidity.

Abstract: An assembly for use as a solid phase support for immunoassay procedures.