Patents Represented by Attorney George M. Yahwak
  • Patent number: 4002665
    Abstract: The present invention relates to a process for 3r-N-Monomethylamino-4 cis-phenyl-4 trans-ethoxycarbonyl-cyclohexene and its N-substitution products which are generally useful as analgesics.
    Type: Grant
    Filed: August 14, 1973
    Date of Patent: January 11, 1977
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Gustav Hechtfischer
  • Patent number: 4001417
    Abstract: The present invention relates to novel thiazolidinone acetic acid derivatives and their preparation. These derivatives show diuretic properties when used as pharmaceuticals.
    Type: Grant
    Filed: October 6, 1975
    Date of Patent: January 4, 1977
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Manfred Herrmann, Karl-Otto Vollmer
  • Patent number: 4001142
    Abstract: Disclosed are a stable, non-protein, buffered control material for monitoring the reliability of blood gas instruments in the acid, normal, and alkaline ranges.
    Type: Grant
    Filed: July 25, 1975
    Date of Patent: January 4, 1977
    Assignee: Warner-Lambert Company
    Inventor: James E. Turner
  • Patent number: 3995372
    Abstract: This invention relates to a method for installing a friction lock retaining pin into a tooth through the use of ultrasonic vibrations and an apparatus by which conventional ultrasonic dental scalers may be adapted for use in this method.
    Type: Grant
    Filed: January 14, 1975
    Date of Patent: December 7, 1976
    Inventor: Joseph A. Rapuano
  • Patent number: 3992376
    Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistaminic, antitussive, antiinflammatory, sedative, and diuretic properties.
    Type: Grant
    Filed: August 12, 1974
    Date of Patent: November 16, 1976
    Assignee: Warner-Lambert Company
    Inventors: Peter Stoss, Gerhard Satzinger, Manfred Herrmann
  • Patent number: 3991196
    Abstract: A substituted benzopyranopyridine of the formula ##SPC1##Which is active as a bronchodilator agent.
    Type: Grant
    Filed: May 13, 1975
    Date of Patent: November 9, 1976
    Assignee: Warner-Lambert Company
    Inventors: Richard E. Brown, Chester Puchalski, John Shavel, Jr.
  • Patent number: 3991181
    Abstract: The preparation of a stroma-free hemoglobin free of plasma proteins and useful as a plasma extender is disclosed.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: November 9, 1976
    Assignee: Warner-Lambert Company
    Inventor: John Doczi
  • Patent number: 3991064
    Abstract: This invention relates to novel substituted benzo[c][2,7]naphthyridines and their preparation. The compounds of this invention are active as bronchodilators.
    Type: Grant
    Filed: January 17, 1975
    Date of Patent: November 9, 1976
    Assignee: Warner-Lambert Company
    Inventors: Richard E. Brown, Chester Puchalski, John Shavel, Jr.
  • Patent number: 3989044
    Abstract: A prefilled syringe having a barrel to hold a liquid medium is disclosed. The rear end of the barrel is sealed by means of a rubber diaphragm whereas the front end of the syringe is sealed by a stopper and a novel needle hub assembly whereby the integrity of the liquid medium remains static until the assembly is activated and the stopper pierced.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: November 2, 1976
    Assignee: Warner-Lambert Company
    Inventor: Eugene J. Meierhoefer
  • Patent number: 3989836
    Abstract: Novel 2-hydroxy-phenyl-1-oxa-4-azaspiroalkane derivatives, the preparation thereof, and pharmaceutical compositions containing these 2-hydroxyphenyl-1-oxa-4-azaspiroalkane derivatives are disclosed. These derivatives possess unexpectedly valuable thereapeutic properties which make them outstandingly useful for the treatment of cardiovascular circulatory insufficiencies and hypotonic states.
    Type: Grant
    Filed: March 10, 1975
    Date of Patent: November 2, 1976
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Manfred Herrmann
  • Patent number: 3989714
    Abstract: The present invention discloses 3-phenylhydroindoles having the formula: ##SPC1##Wherein R.sub.1 may be hydrogen, lower alkyl, phenyl or may be absent; R.sub.2 may be hydrogen, hydroxy, lower alkyl or absent; or where R.sub.1 is absent R.sub.2 may be CH.sub.3.sup.+ I.sup.- or O; and R.sub.3 and R.sub.4 may be hydrogen, hydroxy or lower alkoxy. The compounds possess anti-viral activity.
    Type: Grant
    Filed: October 21, 1974
    Date of Patent: November 2, 1976
    Assignee: Warner-Lambert Company
    Inventors: Sylvester Klutchko, Arch Christian Sonntag, John Shavel, Jr.
  • Patent number: 3984546
    Abstract: Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1##In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.
    Type: Grant
    Filed: October 15, 1975
    Date of Patent: October 5, 1976
    Assignee: Warner-Lambert Company
    Inventors: Richard E. Brown, John Shavel, Jr.
  • Patent number: 3983110
    Abstract: Disclosed is a novel substituted benzopyranopyridine which is active as a bronchodilator agent.
    Type: Grant
    Filed: July 25, 1975
    Date of Patent: September 28, 1976
    Assignee: Warner-Lambert Company
    Inventors: Richard E. Brown, Chester Puchalski, John Shavel, Jr.
  • Patent number: 3983089
    Abstract: The present invention relates to novel 1-(aryl)-2-(arylalkyl)-3-(or-4-)-[4'-(substituted alkyl-)-piperazino-1']-butanols-2, and butenes-1 showing antimicrobial action, to their pharmaceutically acceptable salts, and to the process of manufacture thereof.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: September 28, 1976
    Assignee: Warner-Lambert Company
    Inventors: Wolf-Dieter Vigelius, Spyridon Marinis
  • Patent number: 3978109
    Abstract: The present invention relates to a process for 3r-N-Monomethylamino-4 cis-phenyl-4 trans-ethoxycarbonyl-cyclohexene and its N-substitution products which are generally useful as analgesics.
    Type: Grant
    Filed: August 9, 1973
    Date of Patent: August 31, 1976
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Gustav Hechtfischer
  • Patent number: 3973016
    Abstract: The present invention relates to a method for reducing blood pressue in a hypertensive mammal by the administration of a novel hydroxypyrimidine of the formula: ##SPC1##Wherein R.sub.1 is -CH.sub.3 or -NH.sub.2 ; and R.sub.
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: August 3, 1976
    Assignee: Warner-Lambert Company
    Inventors: Glenn C. Morrison, Wiaczeslaw A. Cetenko
  • Patent number: 3971814
    Abstract: The present invention relates to novel benzo(b)thiophene derivatives of the general formula: ##SPC1##Wherein Y represents a hydrogen or halogen atom; A represents a hydrogen atom or a phenyl group which may be substituted with a halogen atom or a lower alkoxy group; B represents a radical of the formula OR' or NR.sup.2 R.sup.3, wherein R' is an alkyl radical of 1 to 5 carbons which may be substituted with hydroxy, lower alkoxy, phenyl or phenoxy groups or a cycloalkyl or phenyl group which may be substituted by lower alkoxy or halogen atoms; R.sup.2 and R.sup.3, which may be identical or different, represent, if identical, hydrogen, alkyl radicals of 1 to 5 carbon atoms which may be substituted by hydroxy, lower alkoxy, phenoxy, di-lower alkylamino, or phenyl groups; or, if R.sup.2 is hydrogen, R.sup.
    Type: Grant
    Filed: April 9, 1975
    Date of Patent: July 27, 1976
    Assignee: Warner-Lambert Company
    Inventors: Peter Johannes Stoss, Manfred Franz Reinhold Herrmann, Gerhard Satzinger
  • Patent number: 3971794
    Abstract: The present invention relates to novel thiazolidinone acetic acid derivatives and their preparation. These derivatives show diuretic properties when used as pharmaceuticals.
    Type: Grant
    Filed: February 27, 1975
    Date of Patent: July 27, 1976
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Manfred Herrmann, Karl-Otto Vollmer
  • Patent number: 3966779
    Abstract: The present invention relates to new thymol derivatives with strong sympatholytic effect and low toxicity and to a process for their preparation.These novel thymol derivatives have the following general formula: ##SPC1##Wherein R is an alkyl group of 4 to 11 carbon atoms or an alkoxy group R'--O-- wherein R' is an alkyl group of 3 to 10 carbon atoms, and their pharmaceutically acceptable salts.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: June 29, 1976
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Manfred Franz Herrmann
  • Patent number: 3965905
    Abstract: The present invention relates to an improved intravaginal catamenial tampon which is comprised of a plurality of individual small absorbent masses attached at intervals along a string.
    Type: Grant
    Filed: September 24, 1975
    Date of Patent: June 29, 1976
    Assignee: Warner-Lambert Company
    Inventors: Daniel Schoenholz, Myron S. Weinberg