Abstract: The present invention relates to a process for 3r-N-Monomethylamino-4 cis-phenyl-4 trans-ethoxycarbonyl-cyclohexene and its N-substitution products which are generally useful as analgesics.
Abstract: The present invention relates to novel thiazolidinone acetic acid derivatives and their preparation. These derivatives show diuretic properties when used as pharmaceuticals.
Type:
Grant
Filed:
October 6, 1975
Date of Patent:
January 4, 1977
Assignee:
Warner-Lambert Company
Inventors:
Gerhard Satzinger, Manfred Herrmann, Karl-Otto Vollmer
Abstract: Disclosed are a stable, non-protein, buffered control material for monitoring the reliability of blood gas instruments in the acid, normal, and alkaline ranges.
Abstract: This invention relates to a method for installing a friction lock retaining pin into a tooth through the use of ultrasonic vibrations and an apparatus by which conventional ultrasonic dental scalers may be adapted for use in this method.
Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistaminic, antitussive, antiinflammatory, sedative, and diuretic properties.
Type:
Grant
Filed:
August 12, 1974
Date of Patent:
November 16, 1976
Assignee:
Warner-Lambert Company
Inventors:
Peter Stoss, Gerhard Satzinger, Manfred Herrmann
Abstract: This invention relates to novel substituted benzo[c][2,7]naphthyridines and their preparation. The compounds of this invention are active as bronchodilators.
Type:
Grant
Filed:
January 17, 1975
Date of Patent:
November 9, 1976
Assignee:
Warner-Lambert Company
Inventors:
Richard E. Brown, Chester Puchalski, John Shavel, Jr.
Abstract: A prefilled syringe having a barrel to hold a liquid medium is disclosed. The rear end of the barrel is sealed by means of a rubber diaphragm whereas the front end of the syringe is sealed by a stopper and a novel needle hub assembly whereby the integrity of the liquid medium remains static until the assembly is activated and the stopper pierced.
Abstract: Novel 2-hydroxy-phenyl-1-oxa-4-azaspiroalkane derivatives, the preparation thereof, and pharmaceutical compositions containing these 2-hydroxyphenyl-1-oxa-4-azaspiroalkane derivatives are disclosed. These derivatives possess unexpectedly valuable thereapeutic properties which make them outstandingly useful for the treatment of cardiovascular circulatory insufficiencies and hypotonic states.
Abstract: The present invention discloses 3-phenylhydroindoles having the formula: ##SPC1##Wherein R.sub.1 may be hydrogen, lower alkyl, phenyl or may be absent; R.sub.2 may be hydrogen, hydroxy, lower alkyl or absent; or where R.sub.1 is absent R.sub.2 may be CH.sub.3.sup.+ I.sup.- or O; and R.sub.3 and R.sub.4 may be hydrogen, hydroxy or lower alkoxy. The compounds possess anti-viral activity.
Type:
Grant
Filed:
October 21, 1974
Date of Patent:
November 2, 1976
Assignee:
Warner-Lambert Company
Inventors:
Sylvester Klutchko, Arch Christian Sonntag, John Shavel, Jr.
Abstract: Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1##In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.
Abstract: The present invention relates to novel 1-(aryl)-2-(arylalkyl)-3-(or-4-)-[4'-(substituted alkyl-)-piperazino-1']-butanols-2, and butenes-1 showing antimicrobial action, to their pharmaceutically acceptable salts, and to the process of manufacture thereof.
Abstract: The present invention relates to a process for 3r-N-Monomethylamino-4 cis-phenyl-4 trans-ethoxycarbonyl-cyclohexene and its N-substitution products which are generally useful as analgesics.
Abstract: The present invention relates to a method for reducing blood pressue in a hypertensive mammal by the administration of a novel hydroxypyrimidine of the formula: ##SPC1##Wherein R.sub.1 is -CH.sub.3 or -NH.sub.2 ; and R.sub.
Type:
Grant
Filed:
August 5, 1974
Date of Patent:
August 3, 1976
Assignee:
Warner-Lambert Company
Inventors:
Glenn C. Morrison, Wiaczeslaw A. Cetenko
Abstract: The present invention relates to novel benzo(b)thiophene derivatives of the general formula: ##SPC1##Wherein Y represents a hydrogen or halogen atom; A represents a hydrogen atom or a phenyl group which may be substituted with a halogen atom or a lower alkoxy group; B represents a radical of the formula OR' or NR.sup.2 R.sup.3, wherein R' is an alkyl radical of 1 to 5 carbons which may be substituted with hydroxy, lower alkoxy, phenyl or phenoxy groups or a cycloalkyl or phenyl group which may be substituted by lower alkoxy or halogen atoms; R.sup.2 and R.sup.3, which may be identical or different, represent, if identical, hydrogen, alkyl radicals of 1 to 5 carbon atoms which may be substituted by hydroxy, lower alkoxy, phenoxy, di-lower alkylamino, or phenyl groups; or, if R.sup.2 is hydrogen, R.sup.
Type:
Grant
Filed:
April 9, 1975
Date of Patent:
July 27, 1976
Assignee:
Warner-Lambert Company
Inventors:
Peter Johannes Stoss, Manfred Franz Reinhold Herrmann, Gerhard Satzinger
Abstract: The present invention relates to novel thiazolidinone acetic acid derivatives and their preparation. These derivatives show diuretic properties when used as pharmaceuticals.
Type:
Grant
Filed:
February 27, 1975
Date of Patent:
July 27, 1976
Assignee:
Warner-Lambert Company
Inventors:
Gerhard Satzinger, Manfred Herrmann, Karl-Otto Vollmer
Abstract: The present invention relates to new thymol derivatives with strong sympatholytic effect and low toxicity and to a process for their preparation.These novel thymol derivatives have the following general formula: ##SPC1##Wherein R is an alkyl group of 4 to 11 carbon atoms or an alkoxy group R'--O-- wherein R' is an alkyl group of 3 to 10 carbon atoms, and their pharmaceutically acceptable salts.
Type:
Grant
Filed:
November 29, 1974
Date of Patent:
June 29, 1976
Assignee:
Warner-Lambert Company
Inventors:
Gerhard Satzinger, Manfred Franz Herrmann
Abstract: The present invention relates to an improved intravaginal catamenial tampon which is comprised of a plurality of individual small absorbent masses attached at intervals along a string.