Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistaminic, antitussive, antiinflammatory, sedative, and diuretic properties.
Type:
Grant
Filed:
August 31, 1976
Date of Patent:
August 29, 1978
Assignee:
Warner-Lambert Company
Inventors:
Peter Stoss, Gerhard Satzinger, Manfred Herrmann
Abstract: This invention relates to novel compounds of the pyrido-[2,1-b]quinazolin-one series and their methods of preparation. These compounds have utility as antiallergy agents.
Abstract: The present invention is concerned with new dibenzylglycolic acid derivatives and with the preparation thereof. These derivatives show an extraordinary anti-hypertensive and antisecretory profile.
Type:
Grant
Filed:
March 15, 1977
Date of Patent:
August 1, 1978
Assignee:
Warner-Lambert Company
Inventors:
Wolf-Dieter Vigelius, Gerhard Satzinger, Manfred Herrmann
Abstract: The present invention relates to novel benzo(b)thiophene derivatives of the general formula: ##STR1## wherein Y represents a hydrogen or halogen atom; A represents a hydrogen atom or a phenyl group which may be substituted with a halogen atom or a lower alkoxy group; B represents a radical of the formula OR' or NR.sup.2 R.sup.3, wherein R' is an alkyl radical of 1 to 5 carbon atoms which may be substituted with hydroxy, lower alkoxy, phenyl or phenoxy groups or a cycloalkyl or phenyl group which may be substituted by lower alkoxy or halogen atoms; R.sup.2 and R.sup.3, which may be identical or different, represent, if identical, hydrogen, alkyl radicals of 1 to 5 carbon atoms which may be substituted by hydroxy, lower alkoxy, phenoxy, di-lower alkylamino, or phenyl groups; or, if R.sup.2 is hydrogen, R.sup.
Type:
Grant
Filed:
April 8, 1977
Date of Patent:
April 4, 1978
Assignee:
Warner-Lambert Company
Inventors:
Peter Johannes Stoss, Manfred Franz Reinhold Herrmann, Gerhard Satzinger
Abstract: Disclosed are novel benzo[g]Pyrido[2,1-b]-quinazolinones which are active as anti-allergy agents and thus have utility in the treatment of allergic reactions such as bronchial asthma.
Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistominic, antitussive, antiinflammatory, sedative, and diuretic properties.
Abstract: The present invention is concerned with new dibenzylglycolic acid derivatives and with the preparation thereof. These derivatives show an extraordinary anti-hypertensive and antisecretory profile.
Type:
Grant
Filed:
June 16, 1976
Date of Patent:
February 28, 1978
Assignee:
Warner-Lambert Company
Inventors:
Wolf-Dieter Vigelius, Gerhard Satzinger, Manfred Herrmann
Abstract: This invention relates to substituted indolobenzoxazepines which act as central nervous system depressants and as such are useful as tranquillizers.
Abstract: The present invention relates to 8-(1H-tetrazol-5-yl)-11H-pyrido[2,1-b]quinazolin-11-ones having the following structure: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, alkyl, alkyloxy, halogen, hydroxy and methylenedioxy; R.sub.3 is carboxamido, cyano or 5-tetrazolyl groupings and the pharmaceutically acceptable salts of acids and bases thereof.These compounds exhibit anti-allergic properties and are useful as anti-asthmatic agents.
Abstract: The invention relates to 1-phenyl-4-amino-cyclohex-2-ene-1-carboxylic-acid-esters of the general formula I ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and may be H, alkyl, hydroxyalkyl, alkenyl, preferably with 1 to 4 C-atoms, aralkyl which may be bonded to each other, in which connection the heterocyclic system formed may be substituted further by the OH- group and where attachment takes place by an oxygen or a nitrogen atom, if desired, which in its turn carries an H, alkyl with 1 to 4 C-atoms, aryl which may be substituted by chlorine, preferably in 3 or 4-position, and by methoxy, preferably in 2 or 4-position, acyl, preferably alkanoyl with 1 to 4 C-atoms, and aroyl, or aralkyl, and R.sub.3 represents an alkyl radical with 1 to 4 C-atoms, the salts thereof and quarternary ammonium compounds, and a process for their preparation. These compounds have analgesic and neuroleptic properties.
Type:
Grant
Filed:
November 22, 1974
Date of Patent:
December 6, 1977
Assignee:
Warner-Lambert Company
Inventors:
Gerhard Satzinger, Manfred Franz Herrmann
Abstract: The present invention relates to novel benzo(b)thiophene derivatives of the general formula: ##STR1## wherein Y represents a hydrogen or halogen atom; A represents a hydrogen atom or a phenyl group which may be substituted with a halogen atom or a lower alkoxy group; B represents a radical of the formula OR' or NR.sup.2 R.sup.3, wherein R' is an alkyl radical of 1 to 5 carbons which may be substituted with hydroxy, lower alkoxy, phenyl or phenoxy groups or a cycloalkyl or phenyl group which may be substituted by lower alkoxy or halogen atoms; R.sup.2 and R.sup.3, which may be identical or different, represent, if identical, hydrogen, alkyl radicals of 1 to 5 carbon atoms which may be substituted by hydroxy, lower alkoxy, phenoxy, di-lower alkylamino, or phenyl groups; or, if R.sup.2 is hydrogen, R.sup.
Type:
Grant
Filed:
May 28, 1976
Date of Patent:
November 1, 1977
Assignee:
Warner-Lambert Company
Inventors:
Peter Johannes Stoss, Manfred Franz Reinhold Herrmann, Gerhard Satzinger
Abstract: Processes for the production of the compounds of the formula: ##STR1## are disclosed. In the above formula, R.sub.1 is aryl which may be substituted or unsubstituted; R.sub.2 is hydrogen, alkyl, aryl, aralkyl, alkoxy, halogen, cyano, nitro, trifluoromethyl and the like.These compounds are prepared by the following reaction schemes: ##STR2## These compounds are useful as anti-inflammatory agents.
Abstract: The present invention relates to novel thiazolidinone acetic acid derivatives and their preparation. These derivatives show diuretic properties when used as pharmaceuticals.
Type:
Grant
Filed:
March 18, 1976
Date of Patent:
August 9, 1977
Assignee:
Warner-Lambert Company
Inventors:
Gerhard Satzinger, Manfred Herrmann, Karl-Otto Vollmer
Abstract: The present invention relates to novel thiazolidinone acetic acid derivatives and their preparation. These derivatives show diuretic properties when used as pharmaceuticals.
Type:
Grant
Filed:
March 18, 1976
Date of Patent:
August 2, 1977
Assignee:
Warner-Lambert Company
Inventors:
Gerhard Satzinger, Manfred Herrmann, Karl-Otto Vollmer
Abstract: The present invention is concerned with novel tricyclic sulphoximides and with the preparation thereof. This family of compounds has been found to possess antihistominic, antitussive, antiinflammatory, sedative, and diuretic properties.