Abstract: Disclosed is a method of reducing crosslinking in gelatin capsules wherein an amino acid and a carboxylic acid are incorporated into the capsule fill, as well as filled gelatin capsules that utilize the disclosed method. The inventive method is especially useful for pharmaceutical formulations which include hydrochlorothiazide, triamterene, gemfibrozil, chloramphenicol, etodolac, piroxicam, nifedipine, tetracycline, diphenhydramine, hydroflumethiazide and rifampin, or a combination thereof as active ingredient.

Abstract: The invention relates to a new process for the depletion of 7-amino-3-?(E)-1-propen-1-yl!-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-?(Z)-1-propen-1-yl!-3-cephem-4-carboxylic acid and 7-amino-3-?(E)-1-propen-1-yl!-3-cephem-4 carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-?(Z/E)-1-propen-1-yl!-3-cephem-4-carboxylic acid or by adsorption chromatography.

Abstract: A p-toluenesulphonic acid salt of 7-?2-(2-aminothiazol-4-yl)-2-(Z)-hydroximino-acetamido!-3-N,N-dimethylcarb amoyloxymethyl-3-cephem-4-carboxylic acid (isopropoxycarbonyloxy)ethylester, e.g. of formula ##STR1## its use in the production of other salts and a pharmaceutical composition containing it.

Abstract: Cephalosporin derivatives of formula ##STR1## wherein R.sub.1 signifies hydrogen or a silyl protecting group, processes for their production and their use as intermediate products.

Abstract: This application relates to a process for preparing quinacridones whereby the corresponding dihydroquinacridone is oxidized by subjecting a paste containing the dihydroquinacridone and an oxidizing agent to a high shear force mixing step.

Abstract: There is described a liquid preparation comprising:a) 10 to 40 % by weight of the fluorescent whitening agent having the formula: ##STR1## wherein M is hydrogen, an alkali metal, ammonium or magnesium; b) 10 to 85% by weight of polyethylene glycol having a mean molecular weight in the range of from 150 to 500;c) 0 to 75% by weight of water; andd) 0 to 20% by weight of one or more auxiliary compounds; each based on the total weight of the liquid preparation.The new formulation is suitable for the fluorescent whitening of paper or detergents, and is stable over a wide range of temperature.

Abstract: A process for the production of cefotaxime in acetone/water and its use in the production of a sodium salt of cefotaxime and a crystalline sodium salt of cefotaxime in the form of rounded agglomerates and in the form of needles.

Abstract: The invention relates to a process for determing lumnescence with a planar dielectric optical sensor platform which consists of a transparent substrate to which a thin transparent waveguiding layer is applied, which sensor platform is provided with a coupling grating for the input-coupling of the excitation light and the refractive index of the substrate is lower than the refractive index of the waveguiding layer, by briging a liquid sample as superstrate into contact with the layer, and measuring the luminescence produced by substances having luminescence properties in the sample, or by substances having luminescence properties immobilized on the layer, optoelectronically. The invention also relates to the use of the process in quantitative affinity sensing and to the use thereof for the quantitative determination of luminescent constituents in optically turbid solutions, and to sensor platform for carrying out the process.

Abstract: Pyrrolopyrrole derivatives of the formula (I) ##STR1## wherein QA is a quinacridone radical are disclosed. The inventive pyrrolopyrrole derivatives show excellent rheology enhancing properties for pigment dispersions, especially those containing quinacridones, DPPs and their solid solution pigments.

Abstract: The present invention relates to pyrrolopyrrole derivatives of the formula (I) ##STR1## wherein A and B are identical or different aryl radicals, and DPP is a diaryldiketopyrrolopyrrole radical; which diketopyrrolopyrrole derivative is substituted by from 0 to 6 moles of --SO.sub.3 M per mole of the pyrrolopyrrole derivative; wherein M is hydrogen or a metal or ammonium cation. The pyrrolopyrrole derivatives of formula I are useful as rheology-improving agents for pigment dispersions.

Abstract: Dialkyl succinylsuccinates are prepared in a pure form and in high yield by reacting an alkali metal alcoholate with an excess of dialkyl succinate under anhydrous conditions followed by isolation of the di(alkali metal) salt of the dialkyl succinylsuccinate and then neutralization of the salt with acid. The resulting dialkyl succinylsuccinate is isolated or used without isolation as an intermediate in the production of quinacridone pigments. The disclosed process provides for high yields and reduced organic waste compared with known processes.

Abstract: In the optical detection device (1), the excitation light guide (11) and the emission light guide (12) form a structural unit having the end face (14) facing the fluorescence changer (4). The end face (14) physically corresponds substantially to one of the boundary surfaces of the two light guides (11, 12). As a result, the detection device (1) can be separated in a simple manner into an optical part and a mechanical part which are in optical contact only by way of the end face (14). All of the elements in the optical light path are connected in a mechanically stable manner by means of the index-matching medium 20, as a result of which the light between the light source (10) and the photoelectric sensor (13) propagates only in media having a comparable refractive index. The light source (10) is preferably a light-emitting diode.

Abstract: A device for combined bioaffinity assay and electrophoretic separation is provided, which comprises a capillary system having two stages, a first stage in which bioaffinity interactions of analyte molecules and molecular recognition elements are performed, and a second stage, in which electrophoretic separation of the analyte molecules and subsequent detection of the separated species is accomplished. Within the first capillary stage the molecular recognition elements are attached and immobilized to the inside capillary wall, for example, by adsorption or by covalent binding to the capillary material. The method for combined bioaffinity assay and electrophoretic separation comprises flowing an analyte through a capillary system having two stages. In a first capillary stage the analyte molecules are captured by respective molecular recognition elements present in that stage.

Abstract: A compound of formula ##STR1## where R.sup.1 and R.sup.2 are independently a C.sub.1 -C.sub.10 aliphatic radical, or R.sup.1 is a C.sub.1 -C.sub.10 aliphatic radical and R.sup.2 is a C.sub.6 -C.sub.10 aromatic radical, and R.sup.3 is a C.sub.1 -C.sub.8 aliphatic radical, a C.sub.3 -C.sub.8 cycloaliphatic radical, a C.sub.6 -C.sub.15 aromatic radical or a C.sub.7 -C.sub.13 araliphatic radical, provided that R.sup.3 is not methyl when R.sup.1 and R.sup.2 are each methyl, that R.sup.3 is not ethyl when R.sup.1 and R.sup.2 are each methyl and that R.sup.2 is not p-aminophenyl when R.sup.1 is methyl and R.sup.3 is ethyl with an organic compound having at least one group reactive with a P--H bond.

Abstract: The invention relates to a new economical and simple process, using a new intermediate compound, for the production of 3'-substituted 7-amino-3-propenyl-4-cephem-carboxylic acid derivatives of formula ##STR1## wherein R is hydrogen, a negative charge or a silyl protecting group, R.sub.o is hydrogen or methoxy, R.sub.1 is hydrogen or a silyl protecting group and X is the radical of a nucleophile, and their acid addition salts.

Abstract: The cationic or basic dyes of formulae (1) and (2) cited in claim 1 are particularly suitable for dyeing paper.These dyes dye paper in a yellow, orange or brown shade having good fastness properties.

Abstract: A dinucleotide analogue of formula ##STR1## where B.sup.1 and B.sup.2 are each independently a monovalent nucleoside base radical;R.sup.1 is R.sup.1.sub.a or Z;R.sup.1.sub.a, R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, halogen or hydroxy;R.sup.5 is R.sup.5.sub.a or Z;R.sup.6 is hydrogen or R.sup.6.sub.a ;R.sup.7 is hydrogen, alkyl-N,N-dialkylphosphoramidyl or R.sup.7.sub.a, R.sup.8 is R.sup.8.sub.a or Z, or the indicated R.sup.7 O and R.sup.8 together denote an isopropylidenedioxy group;R.sup.5.sub.a and R.sup.8.sub.a are each independently hydrogen, halogen, hydroxy, --OR.sup.10, --OCOR.sup.10 or silyloxy substituted by three C.sub.1 -C.sub.5 hydrocarbyl groups;R.sup.6.sub.a and R.sup.7.sub.a are each independently a C.sub.1 -C.sub.10 aliphatic radical, a C.sub.6 -C.sub.15 aromatic radical, a C.sub.7 -C.sub.30 araliphatic radical, --COR.sup.11, --SO.sub.2 R.sup.11 or silyl substituted by three C.sub.1 -C.sub.15 hydrocarbyl groups;R.sup.9 is hydrogen, a C.sub.1 -C.sub.

Abstract: The disclosure describes pigment compositions containing an organic pigment and a transparent filler having a mean particle size less than 10 .mu.m and a narrow particle size distribution; as well as methods of preparing the pigment compositions. The pigment compositions are useful for pigmenting high-molecular-weight organic materials; especially coating compositions, curable ink systems, plastics, as well as for use in laser marking applications.

Abstract: The disclosure relates to the use of conditioned organic pigments as stir-in pigments in various applications. The conditioned pigments are prepared by wet-milling a pigment crude to a particle size of 0.1 to 9 .mu.m and a specific surface area in the range of from 6 to 35 m.sup.2 /g.

Abstract: Heat-stable, red pigment compositions comprising a physical mixture of 1,4-diketo-3,6-di(4-biphenylyl)-pyrrolo [3,4 c]-pyrrole and a 2,9-dichloroquinacridone pigments, processes for preparing the pigment compositions and the use of the compositions for pigmenting high-molecular-weight organic materials are disclosed.