Patents Represented by Attorney Gerald D. Sharkin
  • Patent number: 5002702
    Abstract: A composition, for stabilizing a polymeric material, (hereinafter defined as a stabilizing composition) comprising(a) a thiophosphate compound; and(b) an organo tin compound.
    Type: Grant
    Filed: July 8, 1988
    Date of Patent: March 26, 1991
    Assignee: Sandoz Ltd.
    Inventors: Rainer Wolf, Jean-Paul Kehrli
  • Patent number: 5002586
    Abstract: A process for the dyeing or printing of leather with anionic metal complex dyes wherein the metal complex dyes are metal complexes of metallizable monoazo dyes or metallizable monoazomethine dyes or both metallizable monoazo and monoazo methine dyes and before the application of the dye or after the application of the dye or both before and after the application of the dye the leather is treated with a product (P) or a mixture of products (P) or an acid addition product thereof, product (P) being a polymer obtainable by reaction of(.alpha.) a mono-functional or poly-functional amine containing one or more amino groups of the group consisting of primary, secondary and tertiary amino groupswith(.beta.) cyanamide, dicyanodiamide, guanidine or biguanide or a mixture in which up to 50 mole percent of the cyanamide, dicyanodiamide, guanidine or biguanide are replaced by a di-carboxylic acid or a mono- or diester thereofwith cleavage of ammonia or a further reaction product thereof with reactant(.gamma.
    Type: Grant
    Filed: August 5, 1988
    Date of Patent: March 26, 1991
    Assignee: Sandoz Ltd.
    Inventors: Michel Dien, Willi Egli
  • Patent number: 5001255
    Abstract: Compounds of the formula ##STR1## the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
    Type: Grant
    Filed: July 1, 1988
    Date of Patent: March 19, 1991
    Assignee: Sandoz Pharm. Corp.
    Inventors: Faizulla G. Kathawala, Sompong Wattanasin
  • Patent number: 5001226
    Abstract: Compounds of the formula ##STR1## 1:1 and 1:2 metal complexes thereof, salts of such compounds and metal complexes and mixture thereof, whereineach of B.sub.1 and B.sub.2 is independently hydroxy or amino,each D is independently ##STR2## wherein R is hydrogen, C.sub.1-4 alkyl, C.sub.5-6 cycloalkyl, phenyl, benzyl or phenylethyl,R.sub.1 is hydrogen, cyano, --COOR.sub.4, --CONR.sub.5 R.sub.6, --SO.sub.2 NR.sub.5 R.sub.6, ##STR3## wherein each R.sub.3 is independently hydrogen, C.sub.1-4 alkyl, --NR.sub.5 R.sub.6 or --CONR.sub.5 R.sub.6,R.sub.4 is C.sub.1-6 alkyl or phenyl(C.sub.1-3 alkyl),R.sub.7 is C.sub.1-4 alkyl,R.sub.8 is hydrogen or C.sub.1-4 alkyl, andR.sub.9 is --S--, --O-- or --NR.sub.5 --,R.sub.2 is hydrogen, hydroxy or C.sub.1-4 alkoxy,R.sub.2a is hydrogen, C.sub.1-4 alkyl or halo,M is hydrogen; C.sub.1-8 alkyl; (C.sub.1-4 alkoxy)C.sub.1-4 alkyl; C.sub.2-4 hydroxyalkyl; C.sub.5-6 cycloalkyl; C.sub.5-6 cycloalkyl substituted by 1 to 3 C.sub.1-4 alkyls; phenyl(C.sub.1-3 alkyl); phenyl (C.sub.
    Type: Grant
    Filed: December 19, 1989
    Date of Patent: March 19, 1991
    Assignee: Sandoz Ltd.
    Inventors: Helmut A. Moser, Roland Wald
  • Patent number: 5000874
    Abstract: Concentrated aqueous compositions containing(a) a hydroxy- or amino-alkanephosphonic acid(b) a polyaminocarboxylic acid(c) glucoheptonic acid and optionally(d) magnesium chloride, -sulfate and/or -acetateare eminently suitable as stabilizing additives for peroxide-containing alkaline liquors which are employed in the bleach of cellulosic fibrous material.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: March 19, 1991
    Assignee: Sandoz Ltd.
    Inventor: Achim Wiedemann
  • Patent number: 5001133
    Abstract: The substituted benzoic acid heterocyclic amides and esters are serotonin M antagonists. Included are compounds of the formula Iq ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, Z' and R.sub.8 ' have various definitions.
    Type: Grant
    Filed: November 4, 1988
    Date of Patent: March 19, 1991
    Assignee: Sandoz Ltd.
    Inventors: Brian P. Richardson, Gunter Engel, Rudolf K. A. Giger, Andrea Vasella
  • Patent number: 4992211
    Abstract: The invention relates to novel alkylene oxide-containing amphoteric compounds and to their use as surface active agents. The novel amphoteric compounds are especially useful in the cosmetics and toiletries areas, e.g., as surfactants in shampoo compositions.
    Type: Grant
    Filed: November 21, 1989
    Date of Patent: February 12, 1991
    Assignee: Sandoz Ltd.
    Inventor: Robert V. Casciani
  • Patent number: 4992428
    Abstract: The invention discloses certain 5-aryl-substituted,2,3-dihydro-imidazo[1,2-a]furo- and thieno pyridines useful as PAF receptor antagonists and for treating tumors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-mediated bronchoconstriction and extravasation, for controlling hyperreactive airways, for protecting against endotoxin-induced hypotension and death and for treating tumors.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: February 12, 1991
    Assignee: Sandoz Pharm. Corp.
    Inventors: William J. Houlihan, Seung H. Cheon
  • Patent number: 4992078
    Abstract: Improved sulfur dye dispersions are obtained by subjecting an aqueous suspension of oxidized sulfur dye particles to membrane separation. The oxidized sulfur dye is obtained by controlled aeration whereby the content of sulfides, polysulfur and inorganic salts is significantly decreased.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: February 12, 1991
    Assignee: Sandoz Ltd.
    Inventor: Laszlo A. Meszaros
  • Patent number: 4988789
    Abstract: An improved process for preparing glycine hydrochloride in a high purity and high yield employing water as the solvent.
    Type: Grant
    Filed: January 5, 1990
    Date of Patent: January 29, 1991
    Assignee: Sandoz Ltd.
    Inventor: Jerome Linder
  • Patent number: 4988512
    Abstract: Solid nasal inserts of calcitonin and other peptides have particularly interesting drug absorption profiles.
    Type: Grant
    Filed: September 18, 1989
    Date of Patent: January 29, 1991
    Assignee: Sandoz Ltd.
    Inventor: Moise Azria
  • Patent number: 4980359
    Abstract: Compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is hydrogen and R.sub.3 is hydrogen or C.sub.1-4 alkyl, or R.sub.2 and R.sub.3 together represent an additional bond as indicated by the dotted line; R.sub.4 is hydrogen, C.sub.1-4 alkyl or phenyl; R.sub.5 is methoxy or ethoxy; R.sub.6 is hydrogen, hydroxy, C.sub.1-4 alkoxy, hydroxy-(C.sub.2-4 alkoxy) or (C.sub.1-4 alkoxy)-(C.sub.2-4 alkoxy); R.sub.7 and R.sub.8 are each independently C.sub.1-4 alkoxy or (C.sub.1-4 alkoxy)-(C.sub.2-4 alkoxy); and R.sub.9 is hydrogen or halogen,in free form or pharmaceutically acceptable salt form, have pharmaceutical utility, in particular as bronchodilators, eosinophil accumulation and/or activation inhibiting agents and in the treatment of prophylactic treatment of obstructive or inflammatory airways diseases.
    Type: Grant
    Filed: April 10, 1990
    Date of Patent: December 25, 1990
    Assignee: Sandoz Ltd.
    Inventors: Klaus Hasspacher, Reto Naef
  • Patent number: 4980087
    Abstract: The invention relates to novel ether sulfates based on a mixture of branched 1-decanols and to their use as surface active agents. The novel ether sulfates are especially useful as the essential surfactant component in shampoo compositions, which compositions exhibit good foaming properties with little or no irritation potential.
    Type: Grant
    Filed: September 20, 1989
    Date of Patent: December 25, 1990
    Assignee: Sandoz Ltd.
    Inventors: Anthony Latella, Robert V. Casciani
  • Patent number: 4977176
    Abstract: Pilocarpine derivatives of formula I, ##STR1## wherein R.sub.1 to R.sub.5 are as defined in the description, are useful in the treatment of senile dementia, Alzheimer's disease, confusional conditions in the elderly, myasthenia gravis, schizophrenia, mania or glaucoma.
    Type: Grant
    Filed: April 11, 1989
    Date of Patent: December 11, 1990
    Assignee: Sandoz Ltd.
    Inventors: Rene Amstutz, Georg Bolliger, Gideon Shapiro
  • Patent number: 4977227
    Abstract: This invention provides a cement dispersant of a lignosulfonic acid graft copolymer, obtained by a redox free radical reaction of lignosulfonic acid or its salts with one or more acrylic or vinylic monomers containing functional groups, in an aqueous solution in the presence of a radical initiator, e.g, redox catalyst. The lignosulfonic acid graft copolymer has a molecular weight distribution of from 5.times.10.sup.2 to 5.times.10.sup.6.
    Type: Grant
    Filed: November 28, 1988
    Date of Patent: December 11, 1990
    Assignee: Sandoz Ltd.
    Inventors: Shin'ichi Negami, Hiroshi Nomachi, Toru Nemoto, Yoshio Tanaka, Akira Ohta
  • Patent number: 4973767
    Abstract: The invention provides a process for the preparation of a compound of the general formula (I): ##STR1## wherein X, Y and R.sup.1 to R.sup.7 are as defined. In the process, the olefinic analog of the compound of general formula (I) is treated with a halogen-bearing compound in the presence of metallic zinc.
    Type: Grant
    Filed: December 12, 1988
    Date of Patent: November 27, 1990
    Assignee: Sandoz Ltd.
    Inventors: Patrick J. Crowley, Christopher J. Urch, Paul A. Worthington
  • Patent number: 4973427
    Abstract: Process for the fatting and hydrophobizing of tanned leather and pelts, wherein the tanned leather or pelt is fatted with an aqueous dispersion containing a natural optionally chemically modified leather fatting agent and a surface-active phosphoric acid partial ester and optionally a nonionic and/or an anionic carboxy group and/or sulfo group containing surfactant and subsequently treating the fatted leather or pelt in aqueous medium with a plyvalent metal cation; the treated substrates and the dispersions suitable for carrying out the process.
    Type: Grant
    Filed: April 7, 1988
    Date of Patent: November 27, 1990
    Assignee: Sandoz Ltd.
    Inventors: Werner Amati, Markus Badertscher
  • Patent number: 4973704
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-7 cycloalkyl or ##STR2## wherein R.sub.5, R.sub.6 and R.sub.7 are as defined below, R.sub.2 is C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-7 cycloalkyl or ##STR3## wherein R.sub.8, R.sub.9 and R.sub.10 are as defined below, R.sub.3 is hydrogen, C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-7 cycloalkyl or ##STR4## wherein R.sub.11, R.sub.12 and R.sub.13 are as defined below, R.sub.4 is hydrogen, C.sub.1-6 alkyl not containing an asymmetric carbon atom, C.sub.3-7 cycloalkyl or ##STR5## wherein R.sub.14, R.sub.15 and R.sub.16 are as defined below, X is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CH.dbd.CH--CH.sub.2 --or --CH.sub.2 --CH.dbd.CH--, wherein m is 0, 1, 2 or 3, andZ is ##STR6## wherein R.sub.17 is hydrogen or C.sub.1-3 alkyl, andR.sub.18 is hydrogen, R.sub.19 or M,whereinR.sub.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: November 27, 1990
    Assignee: Sandoz Pharm. Corp.
    Inventor: James R. Wareing
  • Patent number: D312321
    Type: Grant
    Filed: July 7, 1988
    Date of Patent: November 20, 1990
    Assignee: Sandoz Pharm. Corp.
    Inventor: Nicholas Calandrillo
  • Patent number: D312322
    Type: Grant
    Filed: July 7, 1988
    Date of Patent: November 20, 1990
    Assignee: Sandoz Pharm. Corp.
    Inventor: Nicholas Calandrillo