Patents Represented by Attorney Gerald D. Sharkin
  • Patent number: 4916125
    Abstract: A method of treating migraine in a subject in need of such treatment comprising administering to said subject a therapeutically effective amount of a phosphonic acid.
    Type: Grant
    Filed: July 11, 1989
    Date of Patent: April 10, 1990
    Assignee: Sandoz Ltd.
    Inventors: Paul L. Herrling, Julian A. Gray
  • Patent number: 4916175
    Abstract: Compounds are provided which are useful as light stabilizers for polymeric materials and which have the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are organic radicals, R.sub.3 and R.sub.15 are hydrogen or organic radicals and R is hydrogen, oxygen or an organic radical.
    Type: Grant
    Filed: November 5, 1987
    Date of Patent: April 10, 1990
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 4915741
    Abstract: The fluidizing or water-retention effect of plasticizers and superplasticizers in cement is increased when the cement has been treated with water before the mixing step, so that it retains from 0.1 to 10% by weight of water.
    Type: Grant
    Filed: November 5, 1986
    Date of Patent: April 10, 1990
    Assignee: Sandoz Ltd.
    Inventors: Stefano Biagini, Mario Collepardi
  • Patent number: 4913705
    Abstract: A mixed fabric of hydroxy group-containing fibers and cyano and/or carboxy group-containing fibers, the hydroxy group-containing fibers having been dyed with a reactive dye, is aftertreated with a product of reacting a mono- or polyfunctional amine having one or more primary, secondary and/or tertiary amino groups with cyanamide, dicyandiamide guanidine or bis-guanidine, said product containing at least one reactive hydrogen atom linked to a nitrogen atom, and is then dyed with a basic dye.
    Type: Grant
    Filed: September 2, 1988
    Date of Patent: April 3, 1990
    Assignee: Sandoz Ltd.
    Inventors: Bernhard Schlick, Claudio Artico
  • Patent number: 4914096
    Abstract: The invention discloses certain 6-aryl-substituted-4H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,4]diazepines useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, PAF-mediated bronchoconstriction and extravasation, PAF-induced hypotension, PAF-induced ischemic bowel disease and PAF-mediated, endotoxin induced lung injury, for controlling hyperreactive airways and for protecting against endotoxin-induced hypotension and death.
    Type: Grant
    Filed: March 31, 1989
    Date of Patent: April 3, 1990
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventors: William J. Houlihan, Seung H. Cheon
  • Patent number: 4912114
    Abstract: Compounds of formula I ##STR1## wherein X and Y each denotes hydrogen or together denote -0-,R.sub.1 denotes allyl optionally substituted by 1 to 3 alkyl groups, the substituent or substituents having in total a maximum of 3 carbon atoms, cyclopropyl-methyl or 3-furylmethyl,R.sub.2 denotes hydrogen, alkyl with 1 to 10 C-atoms, cycloalkyl with 5 or 6 carbon atoms, optionally substituted phenyl or optionally substituted phenyl-alkyl with 7 to 12 C-atoms,R.sub.3 denotes hydrogen, alkyl with 1 to 10 C-atoms or phenyl,R.sub.4 denotes hydrogen, OH, NR.sub.6 R.sub.7, NHCOR, NHSO.sub.2 R' or NHCOOR",R.sub.6 and R.sub.7, independently of one another, denote hydrogen or alkyl with 1 to 3 C-atoms,R denotes alkyl with 1 to 6 C-atoms, phenyl or --A--COOR",A denotes alkylene or alkenylene each with 2 to 4 C-atoms,R' denotes alkyl with 1 to 6 C-atoms or phenyl,R" denotes methyl or ethyland wherein either R.sub.3 is in the .alpha.-positionand R.sub.4 is in the .beta.-position, or R.sub.3 is in the .beta.position and R.sub.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: March 27, 1990
    Assignee: Sandoz Ltd.
    Inventor: Laszlo Revesz
  • Patent number: 4910193
    Abstract: Use of a mono or dicyclic carboxylic or heterocyclic carboxylic acid ester or amide of an alcohol or amine nitrogen as a ring atom in free base form or in acid addition or quaternary ammonium salt form as a 5-HT.sub.3 antagonist in the manufacture of a medicament suitable for the treatment of serotonin induced gastrointestinal disturbances.
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: March 20, 1990
    Assignee: Sandoz Ltd.
    Inventor: Karl-Heinz Buchheit
  • Patent number: 4910207
    Abstract: The dicarboxylic, heterocyclic and substituted benzoic acid alkylene bridged piperidyl amides and esters are serotonin M antagonists.
    Type: Grant
    Filed: November 15, 1988
    Date of Patent: March 20, 1990
    Inventors: Peter Donatsch, Gunter Engel, Bruno Hugi, Brian P. Richardson, Paul A. Stadler, deceased, by Hildegard R. Stadler, heir, by Brigitte M. Stadler, heir, by Sigrid A. Stadler, heir, by Gerald Breuleux, legal representative
  • Patent number: 4910206
    Abstract: The invention discloses certain 5-hetero or aryl-substituted-imidazo[2,1-a]isoquinolines useful as platelet activating factor (PAF) receptor antagonists, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-mediated bronchoconstriction and extravassation and PAF-mediated, endotoxin-induced lung injury, and for controlling hyperreactive airways induced by PAF or allergin. In addition, the invention discloses the use of a select group of said compounds as anti-tumor agents.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: March 20, 1990
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventor: William J. Houlihan
  • Patent number: 4900812
    Abstract: Compounds of the formula ##STR1## and water-soluble salts thereof each cation of which is independently a non-chromophoric cation, whereinMe is cobalt, copper or nickel,Pc is the phthalocyanine radical,each R.sub.1 and R.sub.2 is independently hydrogen or C.sub.1-6 alkyl,each R.sub.4 is independently hydrogen, halo, hydroxy, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, carboxy or sulfo,each R.sub.6 is hydrogen, cyano, carbamoyl or ##STR2## wherein An .crclbar. is a non-chromophoric anion,each R.sub.7 is hydrogen, C.sub.1-4 alkyl, C.sub.5-6 cycloalkyl, phenyl, benzyl, phenylethyl or carboxy,each W is linear or branched C.sub.2-6 alkylene; linear or branched C.sub.3-6 alkylene monosubstituted by hydroxy; linear or branched C.sub.2-6 alkylene interrupted by ##STR3## wherein R.sub.11 is linear or branched C.sub.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: February 13, 1990
    Assignee: Sandoz Ltd.
    Inventors: Helmut A. Moser, Roland Wald
  • Patent number: 4898928
    Abstract: Water-soluble polyacetal or polyketal having the formula ##STR1## wherein R.sub.1, and R.sub.2 are aliphatic, cycloaliphatic or aromatic groups, for ketals; R.sub.1 is hydrogen and R.sub.2 is aliphatic, cycloaliphatic, or aromatic groups for acetals; R.sub.3 and R.sub.4 are also aliphatic, alkoxy, cycloaliphatic or aromatic groups X represents groups as (CH.sub.2).sub.n, O(CH.sub.2).sub.N O or ##STR2## that connect the pendant unsaturation to the aliphatic, cycloaliphatic or aromatic R.sup.4 groups, the ratio of a to b is 0.5 to 10, and n is 10-100.
    Type: Grant
    Filed: March 7, 1988
    Date of Patent: February 6, 1990
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventors: Jorge Heller, Donald W. H. Penhale, Steve Y. Ng
  • Patent number: 4897427
    Abstract: The invention relates to a method of combatting pruning wound diseases in plants employing a compound of the formula ##STR1## wherein X is H or Cl and R is butyl, 1-cyclopropyl-ethyl or 1-cyclopropyl-1-methylethyl, or associations of a compound of the formula with appropriate fungicides.The invention comprises also hydrophobic compositions for combatting pruning wound diseases, comprising an effective amount of an appropriate fungicide and/or bactericide in an oily, thixotropic, hydrophobic non-phytotoxic medium.
    Type: Grant
    Filed: January 14, 1988
    Date of Patent: January 30, 1990
    Assignee: Sandoz Ltd.
    Inventors: Marc Barnavon, Philippe Dutruel, Rene Ravaux
  • Patent number: 4894065
    Abstract: The invention refers to a mixture of anionic dyestuffs having a skitteriness value at pH5 of 3-4 and a combinability value at pH5 of 4-5 and to a process for dyeing a fibre material comprising wool with such a mixture of dyestuffs. These mixtures of anionic dyestuffs give surface and fibre level dyeings.
    Type: Grant
    Filed: March 3, 1988
    Date of Patent: January 16, 1990
    Assignee: Sandoz Ltd.
    Inventors: Oskar Annen, Wolfgang Beck, Josef Frauenknecht
  • Patent number: 4892879
    Abstract: Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents.
    Type: Grant
    Filed: February 2, 1988
    Date of Patent: January 9, 1990
    Assignee: Sandoz Pharm. Corp.
    Inventor: Dieter Sorg
  • Patent number: 4892941
    Abstract: Disclosed are tetraphenyl porphyrins which are beta-substituted by fluoro or chloro and/or bear electronegative substituents on the phenyl including one or two water solubilizing substituents. The new porphorins are particularly suitable as catalysts in a variety of oxidative reactions and methods.
    Type: Grant
    Filed: April 15, 1988
    Date of Patent: January 9, 1990
    Inventors: David H. Dolphin, Taku Nakano, Thomas K. Kirk, Tilak P. Wijesekera, Roberta L. Farrell, Theodore E. Maione
  • Patent number: 4891396
    Abstract: A compound of formula I ##STR1## in which R.sub.1 is selected from C.sub.9-32 alkyl, C.sub.9-32 alkenyl, C.sub.9-32 alkoxy, --CO--R.sub.4 and --(CH.sub.2).sub.1-6 --COOC.sub.6-18 alkyl, where R.sub.4 is C.sub.8-31 alkyl, C.sub.8-31 alkenyl or C.sub.8-31 alkoxy; the alkyl group of each significance of R.sub.1 being uninterrupted or interrupted by one --O--, --S-- --SO.sub.2 -- group and being unsubstituted or substituted by --N(R.sub.5).sub.2, OH or halogen, where each R.sub.5, independently, is selected from hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl and C.sub.1-6 alkoxy;R.sub.2 has a significance of R.sub.1 independently, of R.sub.1 or is --COOH hydrogen, hydroxyC.sub.1-6 alkyl, hydroxyC.sub.1-6 alkoxy, --COOC.sub.1-6 alkyl, OCOC.sub.1-6 alkoxy; Cl, Br, I, OH, C.sub.1-8 alkyl, C.sub.1-8 alkoxy or C.sub.2-8 alkenyl; andR.sub.3 is C.sub.1-6 alkyl, Cl, Br, I, OH, COOH, hydroxyC.sub.1-6 alkyl, C.sub.2-6 alkenyl, hydroxyC.sub.1-6 alkoxy, COOC.sub.1-6 alkyl, --OCOC.sub.1-6 alkoxy or C.sub.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: January 2, 1990
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Helmut Bohnke
  • Patent number: 4889535
    Abstract: Compounds of the formula ##STR1## and mixtures thereof, wherien p1 R.sub.1 is hydrogen, chloro or bromo, p1 R.sub.2 is hydrogen, chloro, bromo or nitro, p1 R.sub.3 is hydrogen, chloro, bromo, nitro or --SCN, p1 R.sub.4 is hydrogen, chloro or bromo, p1 R.sub.5 is hydrogen or C.sub.1-4 alkyl, and p1 R.sub.5 is C.sub.8-14 alkyl,with the provisos that (i) at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is other than hydrogen, (ii) when R.sub.3 is nitro or --SCN, R.sub.2 is other than nitro, and (iii) when two or more of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are halo, then R.sub.3 is one of those halos, are useful as disperse dyes for dyeing substrates such as synthetic and semi-synthetic, hydrophobic, high molecular weight organic materials.
    Type: Grant
    Filed: March 13, 1987
    Date of Patent: December 26, 1989
    Assignee: Sandoz Ltd.
    Inventor: Beat Henzi
  • Patent number: 4889945
    Abstract: The invention relates to phosphoric acid partial esters derived from a block ethoxylated and propoxylated C.sub.9-16 aliphatic alcohol. These phosphoric acid partial esters are useful as wetting agents, especially in the pre-treatment of cellulosic textile materials.
    Type: Grant
    Filed: April 6, 1989
    Date of Patent: December 26, 1989
    Assignee: Sandoz Ltd.
    Inventor: Achim Wiedemann
  • Patent number: 4885325
    Abstract: A quaternized aminoamide-modified wax obtainable by amidating, with a polyamine containing a single primary amino group, a carboxy group-containing, oxidized hydrocarbon wax which may be partially saponified, and quaternizing at least one amino group of the resulting aminoamide-modified wax, optionally in admixture with a non-oxidized paraffin wax may be applied, preferably in the form of an aqueous dispersion containing a dispersing agent, to a fibrous substrate to improve its workability in mechanical processes.
    Type: Grant
    Filed: April 26, 1988
    Date of Patent: December 5, 1989
    Assignee: Sandoz Ltd.
    Inventors: Bernard Danner, Eckart Schleusener
  • Patent number: D306670
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: March 20, 1990
    Assignee: Sandoz Ltd.
    Inventors: Terrence G. Pfleuger, Lawrence E. Morrison, Gary C. Planty