Abstract: A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.

Abstract: This invention relates to iodonium salts, acetal copolymers and polymer binders comprising functional groups capable of undergoing cationic or radical polymerization, their method of preparation and their use in the preparation of coating solutions and coatings. This invention also relates to coatings containing the iodonium salts, acetal copolymers and/or polymer binders and to negative working lithographic printing plates comprising these coatings.

Abstract: A stabilized thylakoid membrane formulation comprising thylakoid membranes in a buffered solution and liposomes, wherein the formulation has a ratio of chlorophyll/liposomes of at least about 10:1. The invention further comprises a method for detecting or quantifying the presence of toxic molecules in a fluid sample, comprising obtaining a stabilized thylakoids membranes formulation; and assessing the photosynthetic efficiency of the thylakoid membranes formulation in the presence of said sample, whereby the molecules are detected when the photosynthetic efficiency is measurably different in the presence versus in the absence of the sample. The present invention also comprises kits using the stabilized thylakoid membranes formulation for detecting and/or quantifying the toxic molecule in a fluid sample.

Abstract: An implement comprises a first member, at least a second member secured at one end of the first member; and at least one piece of material overlapping a junction between the first member and the second member. The implement is made by securing the second member at one end of the first member; and overlapping the junction between the first member and the second member with a piece of material smoothing a surface at the junction.

Abstract: Methods, uses, agents and compositions useful for the diagnosis, prevention and/or treatment of inflammatory conditions, such as neuroinflammatory conditions such as multiple sclerosis, and for the identification and selection of inflammatory cytokine-secreting T cell or a precursor thereof, based on the expression and/or modulation of melanoma cell adhesion molecule (MCAM) are disclosed.

Abstract: A supplementary power supply and method for powering a portable electrical device such as a flashlight having a positive terminal and a negative terminal and battery compartment adapted to receive a standard battery therein. The supply comprises a cap adapted for installation on the battery compartment, an electrical circuit comprising a generator and a positive output and a negative output, and an actuator in mechanical communication with the generator and capable of actuation when the power supply is within the compartment and the cap is installed on the compartment, wherein the electrical circuit is sized and shaped to be received within the battery compartment and interconnect the positive output with the positive terminal and the negative output with the negative terminal, and actuation of the actuator operates the generator to provide an electrical current between the positive output and the negative output. There is also disclosed a kit comprising a plurality of replacement caps.

Abstract: A valve assembly for controlling the flow of pressurized fluid supplied to an actuating cylinder having a piston driven by the pressurized fluid along a stroke path therewithin, the pressurized fluid being applied to alternative driving sides of the piston. The valve assembly comprises a first and a second valve pistons, which cooperate to block the supply of pressurized fluid to the current driving side of the piston when the piston reaches the end of its stroke path, thereby limiting the pressure of the pressurized fluid supplied to the driving side to a level reduced compared to a pressure level applied to drive said piston. If a leak occurs within the actuating cylinder at the end of the stroke path of the piston, it will be at the reduced pressurized fluid pressure.

Abstract: There is disclosed a system and method for enabling transmission of data between an application pair, a first one of the applications in a nomadic/mobile subsystem and a second one of the applications in a ground subsystem comprising a first router within the nomadic/mobile subsystem, the first router interconnected with the first application, a second router within the ground subsystem, the second router interconnected with the second application, and a secure data transfer tunnel established between the first router and the second router, the tunnel comprising a plurality of communication pipes, each one of the plurality of pipes having associated therewith one of a plurality of different communication networks and at least one filtering rule dictating circumstances under which the pipe can be used to transmit data.

Abstract: A method and a system for fabricating a macroscopic object, comprising, in an environment at least one energy source; at least one hollow cathode separated from an anode by a bias potential; and a support; a flow of gas through the hollow cathode generating a hollow cathode discharge, particles emitted by the hollow cathode being assembled on the support under action of energy from the energy source.

Abstract: A system and method are presented to provide radio and GPS coverage versatility in a location-based service (LBS) system, such as an automatic vehicle location (AVL) system. A mobile client in communication with one or more servers of an LBS system includes one or more mobile communication devices and one or more GPS devices for establishing a position of the client. The client is configured to determine whether none of the one or more GPS devices provide the server access to the position through a wireless protocol implemented therewith, or whether the position should be communicated to the server using the one or more communication devices.

Abstract: A method for making a porous material, includes melt-blending two or more non-miscible polymers to obtain a co-continuous melt, solidifying the melt to obtain a solid mass consisting of two co-continuous polymer phases, and selectively extracting one of the co-continuous phases thereby creating within the solid mass an essentially continuous pore network having an internal surface. The method further includes replicating the internal surface of the pore network within the solid mass by coating the internal surface with successive layers of materials, and selectively extracting the solid mass without extracting the layers of materials, to thereby yield the product porous material, formed of the layers of materials. The material has a void fraction higher than about 75%, and mainly having essentially fully interconnected sheath-like non-spherical pores and essentially non-fibrous walls.

Abstract: An illuminating device for attachment to a translucent/transparent surface is disclosed. The device comprises a suction cup comprising an inner adhering surface; and a light source positioned towards a center of the suction cup such that when the inner adhering surface is pressed against the translucent surface, light emitted by the light source propagates through the translucent/transparent surface. There is also disclosed a method for attaching a light-emitting device to a translucent/transparent non-porous surface by developing a suction force.

Abstract: An instrumented ball for collecting data in an industrial mill comprising a durable sphere defining an enclosed cavity and having a substantial thickness, the sphere manufactured from a resilient material able to withstand pressures exerted by a working industrial mill, electronics disposed in the cavity comprising: a plurality of devices for sensing physical conditions inside the mill, wherein each of the sensing devices outputs a series of sensed values, the devices comprising at least an accelerometer, a gyroscope, a thermocouple, a microphone and a wear sensor, a memory for storing the sensed values, and a communication port for transmitting the sensed values to an external device located outside of the mill, and a power source disposed in the cavity for powering the electronics.

Abstract: There is disclosed a protective head gear comprising a helmet having a brim positioned above the eyes of the wearer, a face protector covering at least a portion of the face of the wearer, and an adapter comprising an elongate cross member for securing the face protector to the helmet along the brim. There is also disclosed an adapter for attaching a face protector having a pair of strap receiving slots molded therein to a helmet, comprising a cross member secured to the helmet, and a pair of support arms for insertion into the strap receiving slots. Additionally, there is disclosed face protective gear for use with a helmet having a brim positioned above the eyes of the wearer, comprising a cross member comprising a lip molded along an upper edge, and a pair of goggles depending from the cross member When the cross member is secured to the helmet, the lip overlaps the brim.

Abstract: A system for real-time maintaining an inventory of services and associated resources of a client company. A product component communicates with feeds receiving inventory data from the client company. A transactional component communicates with the product component for managing transactional records, processing responses related thereto and updating the inventory records accordingly. An expert engine component evaluates the transactional records against corresponding ones of the inventory records stored in the product component to identify eventual changes to be made to the inventory records as determined by set conditions, and controls generation of service orders articulated on action parameters of the transactions and the inventory records concerned by the transactions.

Abstract: A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.