Abstract: A method, system, and apparatus for authenticating transactions and records is disclosed. A nonce stamp is a physical article that is relatively difficult to copy illicitly, and that bears a “nonce” number. The “nonce” is a relatively unique identifier, in that it is chosen from a distribution such that any given user/customer is extremely unlikely to obtain two nonce stamps bearing the same nonce. The method includes: presenting a nonce stamp having a nonce number; presenting a numbered digital certificate derived securely from the nonce number; and authenticating the transaction by comparing the number on the digital certificate and the nonce number. The digital certificate is typically obtained by users/customers in exchange for the purchase price of a desired transaction. The apparatus is an information-based indicium including a nonce stamp, and a digital certificate including a number derived securely from the nonce.

Abstract: Chloride ion and sodium ion determination methods, compositions, and assays are provided which are based on the use of sodium ion as an activator for &agr;-amylase. Chloride ion and sodium ion determination are performed by colorimetry, using measurements of &agr;-amylase activity to indirectly measure the desired ion concentrations. One preferred composition for chloride ion determination comprises &agr;-amylase that is substantially calcium free, sodium ion in higher concentration than the &agr;-amylase, and an &agr;-amylase activity detecting substrate. In the methods, &agr;-amylase is deactivated by a calcium-binding compound, thereby preventing calcium from bonding with the &agr;-amylase. Next, chloride ion and sodium ion stoichiometrically bond with deactivated &agr;-amylase, thereby activating the &agr;-amylase.

Abstract: A durable antifreeze/coolant composition for coolants for the cooling systems of internal combustion engines is disclosed. The composition is excellent in inhibiting corrosion of metal portions, especially iron and aluminum portions and effectively inhibits cavitation damage. The antifreeze/coolant composition includes about 0.1-8.0% by weight of C6-C12 aliphatic dibasic acid and/or an alkali metal salt thereof and about 0.1-10% by weight of p-toluic acid and/or an alkali metal salt thereof.

Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Exemplary peptides of the invention include KWKSFIKKLTSAAKKVVTTAKPLALIS (SEQ ID NO:3) and KGWGSFFKKAAHVGKHVGKAALTHYL (SEQ ID NO:15). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. Such methods are useful for the treatment of respiratory infections, such as in cystic fibrosis patients. Such methods are further useful for accelerating wound healing.

Abstract: In accordance with the invention, A reinforced catheter is provided comprising an inner layer forming a catheter body, the body having a distal end and a proximal end, the distal end having a closed tip end, a middle reinforcing layer extending over the first inner layer to the distal end and an outer layer extending over the middle reinforcing layer. Additionally, a connector for coupling a catheter to an extension tube or afterloader is provided comprising a first half having a housing with at least one pair of opposing cutout portions of a first depth provided thereon, a second half slidably connectable with the first half and a biasing means for securing the second half within the housing.

Abstract: A multiwell plate scanner comprises a detector for measuring an attribute of a sample which is scanned continuously over wells of a multiwell plate. A signal obtained during the scan may be sampled and digitized based on detector position over the multiwell plate. The scanner is also disclosed for scanning microarrays, bio-chips and areas of samples not having physical separations. The scanner may be used in a high throughput screening system comprising a storage and retrieval module, a sample distribution module, a reagent distribution module, and a detector which incorporates the scanner. The screening system may further comprise a transport module and a data processing and integration module for transporting samples between the components of the system and for controlling system operation.

Abstract: Disclosed are TGF-&agr; polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.

Abstract: A phase change memory device, and method of making the same, that includes contact holes formed in insulation material that extend down to and exposes source regions for adjacent FET transistors. Spacer material is disposed in the holes with surfaces that define openings each having a width that narrows along a depth of the opening. Lower electrodes are disposed in the holes. A layer of phase change material is disposed along the spacer material surfaces and along at least a portion of the lower electrodes. Upper electrodes are formed in the openings and on the phase change material layer. Voids are formed into the spacer material to impede heat from the phase change material from conducting through the insulation material. For each contact hole, the upper electrode and phase change material layer form an electrical current path that narrows in width as the current path approaches the lower electrode.

Abstract: A method is provided for deconstructing an integrated circuit package comprising: taking an integrated circuit package comprising a lead frame having a plurality of wire bond pads for placing a die into electrical contact with the lead frame, and an encapsulant encapsulating the wire bond pads; and removing the encapsulant to expose the wire bond pads; wherein at least a portion of the encapsulant is removed by a lapping process.

Abstract: Disclosed is a linear voice coil actuator having a latching feature, the actuator having a coil assembly, a field assembly, a magnetic structure positioned in the coil assembly, and a stop which limits the position of the magnetic structure with respect to the field assembly when the coil is not energized. The coil assembly has a coil base and a coil located in a cavity in the coil base. The field assembly preferably has an axially magnetized cylindrical magnet, a soft pole piece, and a soft magnetic housing. Preferably the magnetic structure is a magnetic plate positioned coaxially with the axis of magnetization of the magnet and having a diameter or a thickness which is selected to set a latching force between the plate and the magnet when the coil is not energized.

Abstract: With an automatic layout method, a first line having a first line width is generated in a prescribed direction. A second line having a second line width and extending at an oblique angle with respect to the first line is generated, so that the second line terminates at an end portion of the first line with an overlapped area. One or more VIA patterns are read out of a database according to the shape of the overlapped area. The VIA patterns are placed in the overlapped area, so that one of the VIA patterns is located at the intersection of the center lines of the first and second lines. The VIA pattern is a combination of parallelograms, including squares and rectangles.

Abstract: Microorganisms of the genus Bacillus that are capable of reducing nitrates and contain chitin and/or chitosan in their cell walls are provided. The microorganism of the invention can be used for improving soil, for treating organic waste by fermentation, for fermenting soybeans, and for reducing bitterness. The microorganism of the invention can also be used as a feed additive or a good additive. Further, the microorganism of the invention has an anti-microbial effect.

Abstract: An improved wave energy converter for use in offshore and deep-sea locations. The wave energy converter is adapted for secure attachment to the bottom of a body of water (e.g., the ocean floor), preferably beyond the breaker zone. The wave energy converter is selectively adjustable in length. A hydraulic power generation system is used to convert the energy present in the waves into hydraulic power that can be use to generate electricity and for other purposes, such as desalinization. The system may include a hydraulic piston assembly, a floatation device that is connected to the piston assembly, high and low pressure hydraulic reservoirs, and a hydraulically driven power generator. The floatation device moves upward in response to rising waves, and downward under the force of gravity in response to falling waves. The system utilizes this downward gravitational force to discharge fluid from the piston assembly, which in turn, drives the power generator.

Abstract: The invention provides methods of identifying one or more nucleic acids in a sample. The nucleic acids, for example, expressed genes in a cell, can be identified by contacting the nucleic acids with oligonucleotides having detector tags, and selector tags to form tagged oligonucleotides. Each nucleic acid can be uniquely identified by mass-spectrophotometric analysis of the detector tag.

Abstract: A logic circuit design equipment and a logic circuit design method include analyzing input states of all of first cells, respectively, analyzing leakage currents of all of first cells in a case where each first cell is high Vth cell showing a small leakage current at a low speed operation and low Vth cell showing a large leakage current at a high speed operation, respectively, and substituting the first cells for second cells within a range satisfying a timing restriction. Herein, a threshold of the second cell is different from a threshold of the first cell.

Abstract: A memory device includes an array of memory cells arranged in rows and columns with a portion of the rows of the memory cells being divided into segments. A global bias circuit generates a plurality of first bias currents. Each of a plurality of local bias networks includes a local bias circuit that generates a plurality of second bias currents in response to a corresponding one of the plurality of first bias currents, and includes a plurality of segment bias circuits that each generates a third bias current. Each segment bias circuit is adjacent to a corresponding segment of the memory cells. Each segment bias circuit provides a ground feedback signal to the local bias circuit, which adjusts the second bias current in response to the ground feedback signal. The segment bias circuits are disposed in geometric positions in the segments.

Abstract: A nonvolatile reprogrammable switch for use in a PLD or FPGA has a nonvolatile memory cell connected to the gate of an MOS transistor, which is in a well, with the terminals of the MOS transistor connected to the source of the signal and to the circuit. The nonvolatile memory cell is of a split gate type having a first region and a second region, with a channel therebetween. The cell has a floating gate positioned over a first portion of the channel, which is adjacent to the first region and a control gate positioned over a second portion of the channel, which is adjacent to the second region. The second region is connected to the gate of the MOS transistor. The cell is programmed by injecting electrons from the channel onto the floating gate by hot electron injection mechanism. The cell is erased by Fowler-Nordheim tunneling of the electrons from the floating gate to the control gate. As a result, no high voltage is ever applied to the second region during program or erase.

Abstract: Glutamate Transporter Associated Proteins and nucleotide encoding Glutamate Transporter Associated Proteins are provided. Also provided is a method for identifying a compound that modulates a cellular response mediated by a Glutamate Transporter Associated Protein. A method is further provided for identifying a compound that inhibits an interaction between a Glutamate Transporter Associated Protein and a glutamate transporter protein. A method is provided for treating a disorder associated with glutamate transport.

Abstract: In accordance with the present invention there is provided a new class of sterically demanding metallo-intercalators. These compounds intercalate between bases in a duplex polynucleotide, but only where the bases are not fully complementary, for example, where there is a base-pair mismatch. The compounds are sufficiently sterically demanding that intercalation between bases in fully complementary duplexes does not occur to a significant degree. These mismatch intercalators are useful for detecting DNA and RNA defects, for diagnosing disorders characterized by the presence or increase in DNA and/or RNA defects, and for treating such disorders. Further, the compounds are capable of catalyzing photolytic cleavage of nucleic acids at relatively long wavelengths, and under normal sunlight.

Abstract: Microfluidic apparatus including integrated porous substrate/sensors that may be used for detecting targeted biological and chemical molecules and compounds. In one aspect, upper and lower microfluidic channels are defined in respective halves of a substrate, which are sandwiched around a porous membrane upon assembly. In another aspect, the upper and lower channels are formed such that a portion of the lower channel passes beneath a portion of the upper channel to form a cross-channel area, wherein the membrane is disposed between the two channels. In various embodiments, one or more porous membranes are disposed proximate to corresponding cross-channel areas defined by one or more upper and lower channels. The porous membrane may also have sensing characteristics, such that it produces a change in an optical and/or electronic characteristic.