Patents Represented by Attorney Greenlee Sullivan P.C.
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Patent number: 8252737Abstract: Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration.Type: GrantFiled: December 15, 2005Date of Patent: August 28, 2012Assignee: The Regents of the University of ColoradoInventors: Robert S. Hodges, Yuxin Chen, Michael Vasil, Robert E. W. Hancock, Susan W. Farmer
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Patent number: 8252898Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: GrantFiled: February 18, 2010Date of Patent: August 28, 2012Assignee: Hexima LimitedInventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
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Patent number: 8245811Abstract: A steering system for a vehicle comprising a steering control to effect mechanical steering of the vehicle, the steering control being mechanically connected via a mechanical steering train, to at least one steerable ground engaging wheel. A power assistor apparatus is present for power assisting the mechanical steering of the vehicle when the operator operates the steering control. The system includes a hydraulic steering actuator which is operable by an electronically controlled hydraulic steering control valve to effect hydraulic power steering of the vehicle independently of the operation of the steering control. The electronically controlled hydraulic steering control valve is operable in response to signals from an electronic controller, the hydraulic steering actuator being supplied with pressurized hydraulic fluid from a supply valve arrangement.Type: GrantFiled: February 19, 2010Date of Patent: August 21, 2012Assignee: JCB Landpower LimitedInventors: Charles David Nicklin, Gregory Peter Fitton, Richard Frederick George Young
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Patent number: 8247412Abstract: The present invention provides compounds of formula (I): in which R1, R?1, R2, R?2, R3, Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.Type: GrantFiled: April 24, 2006Date of Patent: August 21, 2012Assignee: Galapagos SasuInventors: Pierre Deprez, Hélène Jary, Taoues Temal
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Patent number: 8241860Abstract: Provided are rapid and sensitive cell-free assay methods for detecting and/or measuring specific bimolecular or higher order interactions via reassembly of a split monomeric reporter protein, and methods of detecting or identifying modulators of such interactions by the effect on the signal provided by the reassembled split reporter protein. This methodology is adaptable to protein-protein, protein-peptide, protein-nucleic acid, protein-methylated or nonmethylated nucleic acid and other small or large molecule ligands and binding proteins.Type: GrantFiled: November 3, 2008Date of Patent: August 14, 2012Assignee: The Arizona Board of Regents of Behalf of the University of ArizonaInventors: Indraneel Ghosh, Cliff I. Stains, Jason R. Porter, Benjamin Jester, Jennifer Furman
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Patent number: 8242058Abstract: Methods and reagents for site-selective functionalization of peptides and proteins. The methods most generally involve the reaction of a thioester with hydrazine. Reagents include bifunctional reagents of formula: H2N—NH—CH2-M-L-FG and salts thereof where M is a single bond or a chemical group carrying a non-bonding electron pair, such as —C(O)NR?—, where R? is H, or an alkyl or aryl group; L is an optional linker group as described above; and FG is a functional group having reactivity that is orthongonal to that of the hydrazine group. FG can, among others, be an azide, alkenyl, alkynyl, nitrile (—CN) or triazole group and is preferably an azide group (—N3). Methods and reagents can, for example, be combined with intein-mediated protein splicing to link proteins or fragments thereof to various chemical species or to a surface.Type: GrantFiled: July 23, 2007Date of Patent: August 14, 2012Assignee: Wisconsin Alumni Research FoundationInventors: Ronald T. Raines, Jeet Kalia
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Patent number: 8232007Abstract: Subfluorinated carbonaceous materials obtained through direct fluorination of graphite or coke particles are provided. One set of subfluorinated carbonaceous materials has an average chemical composition CFx in which 0.63<x?0.95, 0.66<x?0.95 or 0.7<x?0.95. The subfluorinated carbonaceous materials are capable of electrochemical performance superior to commercial CF at relatively high rates of discharge.Type: GrantFiled: February 21, 2007Date of Patent: July 31, 2012Assignees: California Institute of Technology, Centre National de la Recherche Scientifique (C.N.R.S.), Universite Blaise PascalInventors: Rachid Yazami, André Hamwi
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Patent number: 8227616Abstract: The present invention relates generally to compounds providing antibacterial therapeutic agents and preparations, and related methods of using and making antibacterial compounds. Antibacterial compounds of the present invention include chalcone, alkylpyrimidine, aminopyrimidine and cyanopyridine compounds and derivatives thereof exhibiting minimum inhibitory concentrations (MIC) similar to or less than conventional antibacterial compounds in wide use. For example, the present invention provides chalcone and cyanopyridine compounds, and derivatives thereof, exhibiting high antibacterial activities having multiple electron withdrawing group substituents, such as halogens and fluorinated alky groups, and optionally having hydroxyl and/or alkoxyl groups substituents.Type: GrantFiled: June 14, 2010Date of Patent: July 24, 2012Assignee: Wisconsin Alumni Research FoundationInventors: Helen E. Blackwell, Matthew D. Bowman, Jennifer C. O'Neill, Joseph R. Stringer
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Patent number: 8217381Abstract: In an aspect, the present invention provides stretchable, and optionally printable, components such as semiconductors and electronic circuits capable of providing good performance when stretched, compressed, flexed or otherwise deformed, and related methods of making or tuning such stretchable components. Stretchable semiconductors and electronic circuits preferred for some applications are flexible, in addition to being stretchable, and thus are capable of significant elongation, flexing, bending or other deformation along one or more axes. Further, stretchable semiconductors and electronic circuits of the present invention are adapted to a wide range of device configurations to provide fully flexible electronic and optoelectronic devices.Type: GrantFiled: September 6, 2007Date of Patent: July 10, 2012Assignee: The Board of Trustees of the University of IllinoisInventors: John A. Rogers, Matthew Meitl, Yugang Sun, Heung Cho Ko, Andrew Carlson, Won Mook Choi, Mark Stoykovich, Hanqing Jiang, Yonggang Huang, Ralph G. Nuzzo, Keon Jae Lee, Zhengtao Zhu, Etienne Menard, Dahl-Young Khang, Seong Jun Kang, Jong Hyun Ahn, Hoon-sik Kim
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Patent number: 8208982Abstract: An evanescent catheter system having a tip portion of an optical fiber capable of securely measuring fluorescence intensity or fluorescence spectrum of a substance around a catheter tip, without being hindered by optical absorption of hemoglobin in erythrocytes in blood, and being capable of calculating an existing amount of a fluorescence-emitting substance existing in an evanescent light generating part. A protecting layer 22 and a cladding 23 are removed from an upper semicircular part of a core 24 at a tip of a catheter 21 to expose the core 24. When excitation light 29 is incident, evanescent light 25 is generated on the upper semicircular part of the core 24 and a fluorescent substance generates emits fluorescence 30. An interference filter 26 filters out the excitation light and only the fluorescence 30 reaches the photodiode 28, permitting a measuring device to measure an existing amount of the fluorescent substance.Type: GrantFiled: December 1, 2005Date of Patent: June 26, 2012Assignee: National University Corporation Hamamatsu University School of MedicineInventors: Atsuo Miyakawa, Matsuyuki Doi, Seiji Yamamoto, Susumu Terakawa
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Patent number: 8207216Abstract: Compounds of formula: and pharmaceutically acceptable salts, esters and solvates thereof, where variables are defined in the specification, useful generally as inhibitors of protein kinases and particularly useful for inhibition of GSK-3. Pharmaceutically compositions and medicaments containing a compound of the invention are provided. The invention provides methods of treatment of protein kinase-related disease, disorders or conditions. The invention provides methods of treatment of GSK-3-related diseases, disorders or conditions.Type: GrantFiled: June 19, 2009Date of Patent: June 26, 2012Assignee: The Board of Trustees of the University of IllinoisInventors: Alan P. Kozikowski, Irina Gaysina
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Patent number: 8202717Abstract: Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a particular example, porcine alveolar macrophage cells are described as having a capability of supporting infectivity and reproduction by PRRSV. Cells and cell lines of the invention are disclosed in connection with applications relating to PRRS disease, including vaccine technologies.Type: GrantFiled: January 11, 2008Date of Patent: June 19, 2012Assignee: The Board of Trustees of the University of IllinoisInventor: Federico A. Zuckermann
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Patent number: 8198621Abstract: The present invention provides stretchable, and optionally printable, semiconductors and electronic circuits capable of providing good performance when stretched, compressed, flexed or otherwise deformed. Stretchable semiconductors and electronic circuits of the present invention preferred for some applications are flexible, in addition to being stretchable, and thus are capable of significant elongation, flexing, bending or other deformation along one or more axes. Further, stretchable semiconductors and electronic circuits of the present invention may be adapted to a wide range of device configurations to provide fully flexible electronic and optoelectronic devices.Type: GrantFiled: March 17, 2009Date of Patent: June 12, 2012Assignee: The Board of Trustees of the University of IllinoisInventors: John A. Rogers, Dahl-Young Khang, Yugang Sun, Etienne Menard
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Patent number: 8187795Abstract: Described herein are processing techniques for fabrication of stretchable and/or flexible electronic devices using laser ablation patterning methods. The laser ablation patterning methods utilized herein allow for efficient manufacture of large area (e.g., up to 1 mm2 or greater or 1 m2 or greater) stretchable and/or flexible electronic devices, for example manufacturing methods permitting a reduced number of steps. The techniques described herein further provide for improved heterogeneous integration of components within an electronic device, for example components having improved alignment and/or relative positioning within an electronic device. Also described herein are flexible and/or stretchable electronic devices, such as interconnects, sensors and actuators.Type: GrantFiled: December 9, 2008Date of Patent: May 29, 2012Assignee: The Board of Trustees of the University of IllinoisInventors: Kanti Jain, Kevin Lin
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Patent number: 8182861Abstract: Thin film processing systems and methods are provided having a moving deposition sensor capable of translation and/or rotation in a manner that exposes the sensor to thin film deposition environments in a flux region substantially the same as the deposition environments experienced by one or more moveable substrates during a selected deposition period. In one embodiment, a thin film monitoring and control system is provided wherein one or more moveable substrates and a moveable deposition sensor are moved along substantially coincident trajectories in a flux region of a thin film deposition system for a selected deposition period. Systems and methods of the present invention may include SC-cut quartz crystal microbalance sensors capable of excitation of at least two different resonant modes.Type: GrantFiled: October 12, 2010Date of Patent: May 22, 2012Assignee: Research Electro-Optics, Inc.Inventors: William David Lee, Dale C. Ness, Alan D. Streater
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Patent number: 8181410Abstract: A metal building insulation system and method for by-pass wall girt metal building systems which facilitates the installation of wall insulation applied from the interior of the building for the full depth of the wall girt. Integrally faced vapor barrier blanket insulation combined with vapor barrier extensions installed behind perimeter structural and corner columns before wall girt erection are preferred system components.Type: GrantFiled: December 16, 2008Date of Patent: May 22, 2012Assignee: Armand Holdings, Ltd.Inventor: Michael D. Stensrud
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Patent number: 8184276Abstract: Described herein are devices and methods for making extremely accurate measurements in a medium by continuously measuring the index of refraction of the medium such as water or biological tissue. Also described herein is a device for constantly measuring the index of refraction, and using the index of refraction data to constantly calibrate the optical measurement device. In addition, a primary measurement device (a ladar) that is optimized for data collection in a volume backscattering medium such as water or biological tissue is described, along with data results from the lab.Type: GrantFiled: December 7, 2009Date of Patent: May 22, 2012Inventor: Carl Embry
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Patent number: 8173598Abstract: Provided are methods to enhance healing of wounds and tissue, especially during or pursuant to psychological and/or physical stress and to protect tissue from deleterious effects associated with oxidative, psychological and/or physical stress, including but not limited to extreme exertion, ischemia, infarct, and damage associated with reperfusion of ischemic or transplanted tissues.Type: GrantFiled: April 27, 2011Date of Patent: May 8, 2012Assignee: The Board of Trustees of the University of IllinoisInventor: Herve Y. Sroussi
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Patent number: PP22716Abstract: A new and distinct apricot variety is described. The variety results from the open pollination of the variety ‘Goldstrike’ (U.S. Plant Pat. No. 7,035). Seedlings generated from the open pollination were planted at Clyde, Otago, New Zealand. In 2002 D14/1 was identified as having potential as a new variety, it has since been given the denomination ‘Clutha Summer’. The fruit of ‘Clutha Summer’ have been shown to have a very attractive appearance with between 25 to 85% cover of a deep rose red blush, along with a superb flavour. This variety is also characterised by its firm melting, semi-cling stone flesh, excellent keeping quality, and the timing of harvest.Type: GrantFiled: July 19, 2011Date of Patent: May 8, 2012Assignee: The New Zealand Institute for Plant and Food Research LimitedInventors: Michael T. Malone, Arlene E. Nixon
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Patent number: PP22742Abstract: A new and distinct cultivar of Punica granatum plant named ‘Orange Blossom Special’, characterized by its compact, mounding growth habit, small, lustrous, medium green foliage that turns bright yellow in fall, reddish-orange flowers produced in abundance from spring to fall, greenish-tan to reddish-green fruits, and root/crown cold hardiness to USDA Hardiness Zone 7.Type: GrantFiled: November 1, 2010Date of Patent: May 22, 2012Assignees: Plant Introductions Inc., University of Georgia Research Foundation, Inc.Inventor: Michael Dirr