Patents Represented by Attorney Greenlee Sullivan P.C.
  • Patent number: 8062898
    Abstract: Application of a reference mixture of natural products for systematic analysis and comparison of the properties of biphasic solvent systems in counter-current/partition chromatography. Because the reference mixture is comprised of compounds with varying polarities, functional groups, and structural features it provides a rational method for mapping the optimal resolution polarity range of a particular solvent system. The mapping of optimal resolution polarity ranges of solvent systems provided for the description of the overall optimal resolution polarity range of a solvent system family, comprised of the same solvents in different proportions. By comparing the reference mixture performance in the individual members of a solvent system family, the solvent system that best functions as the representative of, or portal to, the solvent system families is determined. Use of the reference mixture also afforded a method to compare the overall optimal resolution polarity ranges of solvent system families.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: November 22, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Guido F. Pauli, John Brent Friesen
  • Patent number: 8061419
    Abstract: A wellhead connection for connecting and sealing to a casing, including an upper head housing accommodating the upper end of the casing in its central bore, a stop shoulder in the central bore to allow the upper head housing to rest on the upper end of the casing, and a seal profile section formed at the lower end of the central bore below the stop shoulder. The wellhead connection is configured such that, first connecting the slip housing and bottom ring with a bottom connector energizes slip connectors into gripping engagement with the casing and locks the slip housing and bottom ring around the casing, while thereafter connecting the upper head housing and the bottom ring with a top connector energizes the metal seal ring so as to radially compress the metal seal ring against the casing to form a metal seal.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: November 22, 2011
    Assignee: Stream-Flo Industries Ltd.
    Inventors: Abram Khazanovich, Irina Khazanovich
  • Patent number: 8044186
    Abstract: Provided are nucleic acid molecules comprising at least a functional fragment of the capreomycin biosynthetic gene cluster, polypeptides encoded by the cluster and recombinant host cells transformed with any of the nucleic acid molecules disclosed herein. Various methods using any of the vectors or expression cassettes that encode one or more of the gene products of the cluster are provided for heterologous production of capreomycin and capreomycin derivatives.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: October 25, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael George Thomas, Elizabeth Anne Felnagle, Michelle Renee Rondon, Andrew David Berti
  • Patent number: 8039847
    Abstract: The present invention provides a high yield pathway for the fabrication, transfer and assembly of high quality printable semiconductor elements having selected physical dimensions, shapes, compositions and spatial orientations. The compositions and methods of the present invention provide high precision registered transfer and integration of arrays of microsized and/or nanosized semiconductor structures onto substrates, including large area substrates and/or flexible substrates. In addition, the present invention provides methods of making printable semiconductor elements from low cost bulk materials, such as bulk silicon wafers, and smart-materials processing strategies that enable a versatile and commercially attractive printing-based fabrication platform for making a broad range of functional semiconductor devices.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: October 18, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Ralph G. Nuzzo, John A. Rogers, Etienne Menard, Keon Jae Lee, Dahl-Young Khang, Yugang Sun, Matthew Meitl, Zhengtao Zhu, Heung Cho Ko, Shawn Mack
  • Patent number: 8034928
    Abstract: Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more molecules of interest, such as proteins, peptides or nucleic acids. The blocking group(s) is released from the latent fluorescent compound by reaction with a trigger, forming the fluorescent molecule which can be detected. Also provided herein are methods of using latent fluorescent compounds to detect triggers.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: October 11, 2011
    Assignees: Wisconsin Alumni Research Foundation, The Penn State Research Foundation
    Inventors: Ronald T. Raines, Sunil S. Chandran, Timothy E. Glass, Luke D. Lavis
  • Patent number: 8030364
    Abstract: The present invention relates to a preparing method of polyols, polyurethane and polyurethane foams using the same. Polyester, polyamide and polyurethane are depolymerized with the polymeric fatty acid mono(polyhydroxyl alcohol)ide composition and additionally reacted with the polybasic acid, polyol and amine to prepare acid value of 05-˜1 mgKOH/g, hydroxyl value of 10˜500 mgKOH/g, and amine value of 1˜50 mgKOH/g in polyol. This is to transform the double bond of the unsaturated fatty acid from the component of the oils and fats into a conjugated double bond to induce the Diels-Alder reaction, and with the improvement of the reactivity to form a stable combination in the chemical structure to prevent the separate leaching appearance of fat and fatty oil from the final product. In particular, by recycling waste edible oil and waste synthetic resin that can be employed as industrially useful material, the invention provides environment advantages.
    Type: Grant
    Filed: October 10, 2005
    Date of Patent: October 4, 2011
    Inventors: Do Gyun Kim, Hyosung Kim
  • Patent number: 8027035
    Abstract: Described herein is a particle detection system capable of spatially resolving the interaction of particles with a beam of electromagnetic radiation. Using a specific electromagnetic beam cross sectional shape and orientation, the detection sensitivity of a particle detection system can be improved. Also provided are methods for detecting and sizing particles in a manner that has low background signal and allows for spatially resolving the scattering or emission of electromagnetic radiation from particles.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: September 27, 2011
    Assignee: Particle Measuring Systems, Inc.
    Inventors: John Mitchell, Jon Sandberg, Karen R. Sandberg, Legal Representative, Dwight A. Sehler
  • Patent number: 8025932
    Abstract: Ta2O5 and Al2O3 thin films were fabricated by pulsed plasma-enhanced chemical vapor deposition (PECVD) with simultaneous delivery of O2 and the metal precursor. By appropriately controlling the gas-phase environment self-limiting deposition at controllable rates (˜1 ?/pulse) was obtained. The process was insensitive to substrate temperature, with a constant deposition rate observed from 90-350° C. As-deposited Ta2O5 films under these conditions displayed good dielectric properties. Performance improvements correlate strongly with film density and composition as measured by spectroscopic ellipsometry and Fourier transform infrared spectroscopy. Pulsed PECVD eliminates the need for gas actuation and inert purge steps required by atomic layer deposition.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: September 27, 2011
    Assignee: Colorado School of Mines
    Inventors: Colin Wolden, Michael T. Seman
  • Patent number: 8026049
    Abstract: The invention is methods and related kits for diagnosing a disease state of cachexia by measuring biomarker profiles from a biological sample. Rapid measurement of early onset or progression of the disease in a subject is determined by measuring biomarker levels from the subject and optionally comparing the biomarker levels to a standard biomarker profile or metabolome phase portrait for the disease. The biomarkers measured in the assay and related kit for cachexia progression include biomarkers selected from the group consisting of lactate, citrate, formate, acetoacetate, 3-hydroxy butrate, alanine, glutamine, glutamate, valine, isoleucine leucine, thrionine, lysine, arginine, tyrosine, phenyl alanine, histidine and tryptophan.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: September 27, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Fariba Masoumeh Assadi-Porter, Mark E. Cook, Hamid Reza Eghbalnia, Marco Tonelli, Warren Paul Porter, Daniel Elmer Butz
  • Patent number: 8025963
    Abstract: A nanoporous filter comprises a porous support having an essentially flat surface on which is deposited a nanoporous layer having a substantially regular pore structure and uniform pore size within the range from 1 to 50 nm.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: September 27, 2011
    Assignee: Nanotecture Ltd
    Inventors: Mamdouh Abdelsalam, Elizabeth Tull, Philip Nigel Bartlett, Phillip Andrew Nelson
  • Patent number: 8020556
    Abstract: Respiratory apparatus comprising a ventilation mask (10) and means for supplying breathable gasses, under pressure, thereto and means for exhausting gases therefrom, is wherein the pressuring means is provided substantially at the inlet of the mask (10), thereby substantially reducing the length of the air supply hose to a ventilation mask (10), so that problems associated with high pressures and large volumes of dead space can be alleviated.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: September 20, 2011
    Inventor: Shahar Hayek
  • Patent number: 8022177
    Abstract: Calcium channels in a variety of tissues may contain different subunits, including several different ? (gamma) subunits. We report studies regarding structural features of certain gamma subunits, for example the N-terminal first transmembrane domain (TM1) of the subunit ?6. We disclose that certain structural motifs, for example a GxxxG-like structural motif as described herein, can mediate subunit function for calcium channels. A particular peptide motif that has been identified as significant for the ability to mediate a decrease in calcium current is GxxxA. Compositions and methods are disclosed which are useful in modifying calcium regulation in mammalian cells. In various embodiments, calcium current is modified.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: September 20, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Philip M. Best, Janice Jones, Jared P. Hansen, Zuojun Lin, Karen E. Weis, Po-Ju Chu
  • Patent number: 8022050
    Abstract: The present invention relates to a TRPA1 activation inhibitor, more precisely a TRPA1 activity inhibitor containing isopentenyl pyrophosphate and a method for inhibiting pain containing the step of administering isopentenyl pyrophosphate to a subject. Isopentenyl pyrophosphate of the present invention can regulate pain caused by TRPA1, so that it can be effectively used for the development of a pain inhibitor which is effective but has less side effects.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: September 20, 2011
    Assignee: Korea University Industry and Academic Collaboration Foundation
    Inventors: Sun Wook Hwang, Sang-Soo Bang
  • Patent number: 8021145
    Abstract: A gas burner comprising a gas supply element having an outlet, and a gas deflector disposed adjacent the outlet, the position of the deflector, relative to the outlet, being adjustable so as to allow the extent of deflector-induced aeration to be altered.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: September 20, 2011
    Assignee: Neat Gas Burners Limited
    Inventors: Anthony Lawrence Alfred Pompe, Kallis Haralambous
  • Patent number: 8012949
    Abstract: The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: September 6, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Eric Oldfield, Yonghui Zhang, Fenglin Yin
  • Patent number: 8003300
    Abstract: This invention provides processing steps, methods and materials strategies for making patterns of structures for electronic, optical and optoelectronic devices. Processing methods of the present invention are capable of making micro- and nano-scale electronic structures, such as T-gates, gamma gates, and shifted T-gates, having a selected non-uniform cross-sectional geometry. The present invention provides lithographic processing strategies for sub-pixel patterning in a single layer of photoresist useful for making and integrating device components comprising dielectric, conducting, metal or semiconductor structures having non-uniform cross-sectional geometries. Processing methods of the present invention are complementary to conventional microfabrication and nanofabrication platforms, and can be effectively integrated into existing photolithographic, etching and thin film deposition patterning strategies, systems and infrastructure.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: August 23, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kanti Jain, Uttam Reddy
  • Patent number: 7998330
    Abstract: Disclosed herein are electrochemical fabrication platforms for making structures, arrays of structures and functional devices having selected nanosized and/or microsized physical dimensions, shapes and spatial orientations. Methods, systems and system components use an electrochemical stamping tool such as solid state polymeric electrolytes for generating patterns of relief and/or recessed features exhibiting excellent reproducibility, pattern fidelity and resolution on surfaces of solid state ionic conductors and in metal. Electrochemical stamping tools are capable high throughput patterning of large substrate areas, are compatible with commercially attractive manufacturing pathways to access a range of functional systems and devices including nano- and micro-electromechanical systems, sensors, energy storage devices, metal masks for printing, interconnects, and integrated electronic circuits.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: August 16, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Nicholas X. Fang, Placid M. Ferreira, Keng Hao Hsu, Peter Lee Schultz, Kyle E. Jacobs, Anil Kumar
  • Patent number: 7998475
    Abstract: Undesirable genetic traits, such as resistance to toxin, can be inhibited or reversed by introducing sexually compatible individuals substantially homozygous for the sensitive allele, such as the wild type, into the target population.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: August 16, 2011
    Assignee: Oxitec Limited
    Inventor: Luke Alphey
  • Patent number: 7989649
    Abstract: The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of ?-aminoisobutyric acid (AIB) analogs namely, their rapid uptake and prolonged retention in tumors with the properties of halogen substituents, including certain useful halogen isotopes such as fluorine-18, iodine-123, iodine-124, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77, bromine-82, astatine-210, astatine-211, and other astatine isotopes. In addition the compounds can be labeled with technetium and rhenium isotopes using known chelation complexes. The amino acid compounds disclosed herein have a high specificity for target sites when administered to a subject in vivo. The labeled amino acid compounds are useful as imaging agents in detecting and/or monitoring tumors in a subject by Positron Emission Tomography (PET) and Single Photon Emission Computer Tomography (SPECT).
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: August 2, 2011
    Assignee: Emory University
    Inventors: Mark M. Goodman, Jonathan McConathy
  • Patent number: 7988766
    Abstract: Provided herein are adsorbents and methods of using the adsorbents to at least partially remove one or more adsorbates. In an aspect, an adsorbate within a phase is at least partially removed by providing an adsorbent material and contacting the adsorbent material with the phase having an adsorbate, to at least partially remove the adsorbate. Various adsorbents are disclosed having the chemical formula RE1-x-y-zBxB?yB?zOw, where RE is RE is a rare earth metal, B is a trivalent metal ion, B? is a transition metal ion or an alkaline earth element, B? is a transition metal ion, 0?x?0.25, 0?y?0.95, 0?z?0.75, w is a number which results in charge balance, and x+y+z<1.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: August 2, 2011
    Assignee: Eltron Research & Development Inc.
    Inventors: James H. White, Jesse W. Taylor