Patents Represented by Attorney Greenlee Sullivan P.C.
  • Patent number: 8110503
    Abstract: Various processes and related systems are provided for making structures on substrate surfaces. Disclosed are methods of making a structure supported by a substrate by providing a substrate having a receiving surface and exposing at least a portion of the receiving surface to output from a remote plasma of an inert gas. The remote plasma has an energy low enough to substantially avoid etching or sputtering of the receiving surface but sufficient to generate a treated receiving surface. The treated surface is contacted with a deposition gas, thereby making the structure supported by the substrate.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: February 7, 2012
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Navneet Kumar, Angel Yanguas-Gil, Gregory S. Girolami, John R. Abelson
  • Patent number: 8112144
    Abstract: Since cerebral atrophy does not occur only in a specific cross-section and reaches the brain in its entirety or arises prominently in a specific lobe (for example temporal lobe), for the assessment of cerebral atrophy, not only atrophy assessment for the frontal lobe but also an assessment also including atrophy of the temporal lobe, the parietal lobe and the occipital lobe is more desirable. The intracranial volume, the volume of the grey matter and the volume of the white matter are respectively extracted, computed and converted into numbers by image processing from a plurality of MRI slice images and the like. Ratios of these values from the conversions into numbers are taken to calculate the ratio of the grey matter and the ratio of the white matter with respect to the entire brain. Through comparison of a multitude of measurement data obtained by this automated computation, and a case, an objective cerebral atrophy assessment is carried out.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: February 7, 2012
    Assignees: National University Corporation Shizuoka University, National University Corporation Hamamatsu University School of Medicine
    Inventors: Seiji Yamamoto, Baigalmaa Tsagaan, Keiichi Abe
  • Patent number: 8106674
    Abstract: Provided is a method for measuring one or more properties of liquid crystals in an automated manner. Also provided is a liquid crystal analysis instrument (LCAS) that automatically measures one or more properties of liquid crystals.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: January 31, 2012
    Assignee: LC Vision, LLC
    Inventor: Michael Wand
  • Patent number: 8101718
    Abstract: The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provide more effective protection to such patients during non-bleeding periods. This invention is based on the discovery that the recombinant B-domainless porcine fVIII, termed OBI-1, has greater bioavailability compared to the natural porcine fVIII partially purified from porcine plasma, termed HYATE:C. Therefore, the inventive method employs lower unit doses of OBI-1, including, alternatively, omission of antibody-neutralizing dosage, or has longer intervals between the administration, compared to HYATE:C, to provide equivalent protection in patients having fVIII deficiency.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: January 24, 2012
    Assignees: Emory University, Ipsen Biopharm Limited
    Inventors: John S Lollar, Garrett E. Bergman
  • Patent number: 8097348
    Abstract: Pi-conjugated organoboron polymers for use in thin-film organic polymer electronic devices. The polymers contain aromatic and or unsaturated repeat units and boron atoms. Pi-conjugated organoboron polymers which are end capped, derivatized with solubilizing groups or both exhibit improved solubility and handling properties beneficial for the formation of thin films useful for device fabrication. The vacant p-orbital of the boron atoms conjugate with the pi-conjugated orbital system of the aromatic or unsaturated monomer units extending the pi-conjugation length of the polymer across the boron atoms. The pi-conjugated organoboron polymers are electron-deficient and, therefore, exhibit n-type semiconducting properties, photoluminescence, and electroluminescence.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: January 17, 2012
    Assignee: TDA Research, Inc.
    Inventors: Silvia DeVito Luebben, Shawn Sapp
  • Patent number: 8097277
    Abstract: The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: January 17, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David M. Lynn, Adam D. Miller
  • Patent number: 8092800
    Abstract: This invention relates to domain antibodies. In particular, it relates to domain antibodies (dAbs) that recognize virulence traits of Candida spp. and confer passive protection against candidiasis.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: January 10, 2012
    Assignee: Istituto Superiore di Sanita
    Inventors: Antonio Cassone, Flavia de Bernardis, Steven Grant, Haiqun Liu
  • Patent number: 8088969
    Abstract: The invention relates to methods of selecting and maintaining a population of pigs having a low copy number of porcine endogenous retrovirus, and the use of such pigs as a source of cells, tissue and/or organs suitable for xenotransplantation. The invention further relates to methods for selecting cells, tissue and/or organs from such pigs for suitability for use in xenotransplantation.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: January 3, 2012
    Assignee: Living Cell Products Pty Ltd.
    Inventors: Robert Bartlett Elliott, Olga Garkavenko, Alexander Burns Ferguson
  • Patent number: 8088262
    Abstract: Provided are a low impedance gold electrode, which has increased surface area, and can improve a bonding force with other materials, an apparatus for and a method of fabricating the low impedance gold electrode, and an electrolyte solution for use in the fabrication of the low impedance gold electrode. The gold electrode has a surface roughness that is increased through electrolysis using an acid electrolyte solution, has an impedance that is less than 1/10 of an impedance before the electrolysis and is higher than 0? when the low impedance gold electrode is disposed in the acid electrolyte solution or another electrolyte solution, and has a single-layered structure whose thickness is less than that before the electrolysis.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: January 3, 2012
    Assignee: Marveldex, Inc.
    Inventors: Seh Jin Choi, Myung Ki Choi
  • Patent number: 8084399
    Abstract: The present invention relates to a screening method of an amphiphilic peptide specifically binding to hairpin RNA, more precisely a screening method of an amphiphilic peptide having specificity and strong binding strength to target hairpin RNA using peptide library comprising those peptides having modifications of both hydrophilic face and hydrophobic face. The method of the present invention provides a screening method of an amphiphilic peptide which is specific to hairpin RNA. So, the peptide selected by the method of the present invention can be effectively used for the study of hairpin RNA functions and for the production of a novel drug using an artificial peptide binding to a hairpin RNA target.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: December 27, 2011
    Assignee: SNU R&DB Foundation
    Inventors: Jaehoon Yu, Jeffrey Kieft, Su Jin Lee
  • Patent number: 8082799
    Abstract: A method is provided for determining the extent of cyclic stress fatigue suffered by a component comprising the steps of: (i) obtaining a gauge material which undergoes a continued progressive/cumulative and quantifiable change in at least one of its physical properties in response to repeated strain cycles applied to the gauge material, the quantifiable change being indicative of both degree of strain and number of cycles incurred during the repeated strain cycles; (ii) determining a correlation between an extent of the quantifiable change in the gauge material and an effect on said component of a corresponding number and degree of strain cycles; (iii) affixing the gauge material to said component to subject the gauge material to any strain encountered by an adjacent portion of the component; (iv) at least periodically determining the extent of said quantifiable change to the gauge material to determine the extent of cyclic stress fatigue undergone by the component.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: December 27, 2011
    Assignee: Paradigm Shift Technologies Inc.
    Inventor: Alexandre Oudovikine
  • Patent number: 8083894
    Abstract: The present invention relates to a method for manufacturing a security paper, for security or value documents, that exhibits at least one through opening (12) having characteristic irregularities (14) in the edge region. According to the present invention, a paper web having thin sites in the form of the outline of the desired shape of the at least one through opening (12) is formed on a paper mold, and the paper web dewatered after sheet formation, the region delimited by the thin sites being removed from the paper web by the occurring forces.
    Type: Grant
    Filed: July 3, 2006
    Date of Patent: December 27, 2011
    Assignee: Giesecke & Devrient GmbH
    Inventors: Uwe Gruszczynski, Thomas Bodendieck
  • Patent number: 8080377
    Abstract: The present invention relates to a method for confirming the exposure on chrysene using a DNA fragment whose expression is increased or decreased specifically when it is exposed to chrysene. The method of the present invention is effective in determination of risk by chrysene and monitoring the chrysene exposure, so that it can be effectively used as a tool for examining the mechanism of chrysene induced toxicity.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: December 20, 2011
    Assignee: Korea Institute of Science and Technology
    Inventors: Jae-Chun Ryu, Youn-Jung Kim, Mi-Kyung Song, Hee-Kyung Jeon
  • Patent number: 8075879
    Abstract: Certain attenuated mutants of Brucella, especially B. melitensis, B. abortus, B. suis and B. ovis, when administered to a human or animal trigger a protective immune response such that subsequent challenge with virulent Brucella of the same species does not result in disease or results in much less severe symptoms. Functional inactivation of galE, a virB gene or the operon (ORFs 1087-1090) comprising the gene encoding ?-hexosaminidase (BMEI1087) and a lytic murein transglycosylase gene (BMEI1088). A specific example of the attenuated galE mutant which produces a protective immune response is B. melitensis GR024. The specific example of an inactivated ORF1087-1090 operon is B. melitensis GR026; it has an insertion mutation in the promoter region upstream of ORF 1090. Vaccination with live cells of either or both of these mutants results in a T cell response which protects the human or animal against challenge with virulent B. melitensis.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: December 13, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Gireesh Rajashekara, Gary Splitter
  • Patent number: 8076617
    Abstract: Provided is a tunable radiation emitting structure comprising: a nanoamorphous carbon structure having a plurality of relief features provided in a periodic spatial configuration, wherein the relief features are separated from each other by adjacent recessed features, and wherein the nanoamorphous carbon comprises a total of from 0 to 60 atomic percent of one or more dopants of the dopant group consisting of: transition metals, lanthanoids, electro-conductive carbides, silicides and nitrides. In one embodiment, a dopant is selected from the group consisting of: Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, La and other lanthanides, Hf, Ta, W, Rh, Os, Ir, Pt, Au, and Hg. In one embodiment, a dopant is selected from the group consisting of: electro-conductive carbides (like Mo2C), silicides (like MoSi2) and nitrides (like TiN).
    Type: Grant
    Filed: April 7, 2008
    Date of Patent: December 13, 2011
    Inventors: Robert A. Norwood, Terje Skotheim
  • Patent number: 8071210
    Abstract: In one aspect, described herein are ultrathin films comprising an azlactone functionalized polymer and a primary amine functionalized polymer. Also described herein are ultrathin films including reactive, nonreactive, partially reactive/nonreactive, hydrophobic, hydrophilic, and mixed hydrophobic/hydrophilic ultrathin films. In another aspect, described herein are methods for making surface attached and freestanding ultrathin films.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: December 6, 2011
    Assignee: Wiscousin Alumni Research Foundation
    Inventors: David M. Lynn, Maren E. Buck, Jingtao Zhang
  • Patent number: 8070920
    Abstract: The invention provides methods for sharpening the tip of an electrical conductor. The methods of the invention are capable of producing tips with an apex radius of curvature less than 2 nm. The methods of the invention are based on simultaneous direction of ionized atoms towards the apex of a previously sharpened conducting tip and application of an electric potential difference to the tip. The sign of the charge on the ions is the same as the sign of the electric potential. The methods of the invention can be used to sharpen metal wires, metal wires tipped with conductive coatings, multi-walled carbon nanotubes, semiconducting nanowires, and semiconductors in other forms.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: December 6, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Joseph W. Lyding, Scott W. Schmucker
  • Patent number: 8071573
    Abstract: Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: December 6, 2011
    Assignee: The Board of Trustees of the University of Illinois, a Body Corporate and Politic of the State of Illinois
    Inventors: John M. Sanders, Yongcheng Song, Julian M. W. Chan, Eric Oldfield, Yonghui Zhang
  • Patent number: 8066061
    Abstract: A reusable metal seal for a wellhead provides a metal-to-metal seal and includes upper and lower tapered sealing flanks which may be deflected by tapered wall surfaces on the wellhead engaging the taper sealing flanks, and the seal may have a plurality of annular relief grooves.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: November 29, 2011
    Assignee: Stream-Flo Industries Ltd.
    Inventors: Keith D. Farquharson, Tianle Guo, Heinrich Lang, Tony Lam, Kevin Paul Schneider
  • Patent number: 8067327
    Abstract: The present invention provides modified molecular sieve membranes with improved CO2/CH4 separation selectivity and methods for making such membranes. The molecular sieve membranes are modified by adsorption of a modifying agent, such as ammonia, within and/or on the membrane.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: November 29, 2011
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Shiguang Li, Sara A. Arvidson, John L. Falconer, Richard D. Noble