Patents Represented by Attorney Heller Ehrman White & McAuliffe LLP
  • Patent number: 6864246
    Abstract: The invention concerns more particularly dodecylthio-phenylacetanilide derivative complexes such as (S)-2?,3?,5?-trimethyl-4?-hydroxy-?-dodecylthio-phenylacetanilide or related derivatives thereof and cyclodextrins.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: March 8, 2005
    Assignee: Pierre Fabre Medicament
    Inventors: Joël Bougáret, Elie Leverd, Marie-Dominique Ibarra, Alexandre Gil
  • Patent number: 6865120
    Abstract: The present invention discloses a ferroelectric random access memory having a multi-bit line structure. The ferroelectric random access memory includes a plurality of cell array blocks for storing cell data, a common data bus unit for transmitting read/write data, and a timing data register array unit for sensing the read data and outputting the write data to the common data bus unit. The timing data register array unit senses the read data by using timing of a sensing voltage of the common data bus unit to reach the sensing threshold voltage. As a result, the ferroelectric random access memory improves a sensing margin in a low voltage and increases a sensing speed.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: March 8, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventor: Hee Bok Kang
  • Patent number: 6863826
    Abstract: Animal waste such as fecal material from swine, chicken, turkey, and cattle is converted into useful forms such as fertilizer, other types of soil builders, and even nutrient feed additives. Devices, systems, and methods are provided that allow economical conversion and in many instances, alleviate the production and release of undesirable gases such as sulfide and ammonia. In one embodiment, undesirable anaerobic and facultative anaerobic bacteria are killed at a greater rate than desirable soil compatible aerobic bacteria. The use of low temperature killing diminishes off gassing commonly associated with other techniques, and the use of gas trapping additives such as zeolites provides enhanced soil building qualities such as slow release of nitrogen and slow release of moisture to soil. The methods allow convenient adjustment of composition, allowing conversion of waste into tailored designer fertilizer suited for particular soils.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: March 8, 2005
    Inventor: Richard G. Sheets
  • Patent number: 6862111
    Abstract: This invention relates to a color image dithering method and apparatus for producing an output point in an output color space corresponding to a selected vertex in a tetrahedron of a three-dimensional cubic subinterval of a pixel point in a source color space.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: March 1, 2005
    Assignee: PictoLogic, Inc.
    Inventors: Frederick Lin, Shultz Chan
  • Patent number: 6861068
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: March 1, 2005
    Assignee: A.P. Pharma, Inc.
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • Patent number: 6862231
    Abstract: A repair circuit of a semiconductor memory device features a fuse box unit, a fuse stop unit and a repair control circuit unit. The fuse box unit outputs a first control signal to command a failed cell to be substituted with a spare cell when inputted address information is identical with address information programmed in a fuse. The fuse stop unit outputs a third control signal to command the spare cell to be substituted in response to the first control signal and a second control signal for representing if the spare cell is normal or not. The repair control circuit unit substitutes the failed cell with the spare cell in response to the third control signal. As a result, the repair circuit of the present invention substitutes a failed cell with a normal spare cell when a space cell is normal, without performing a repair operation when a spare cell fails.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: March 1, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventor: Bon Seong Koo
  • Patent number: 6861244
    Abstract: The invention relates to nasal or oral administration of a compound containing inactivated influenza virus antigen and aluminum as adjuvant for the prophylaxis of influenza virus infections. Said vaccine is especially suitable for inducing a mucosal IgA immune response and systemic IgG immune response.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: March 1, 2005
    Assignee: Baxter Healthcare S.A.
    Inventors: Noel Barrett, Otfried Kistner, Marijan Gerencer, Friedrich Dorner
  • Patent number: 6858705
    Abstract: Methods are described for conjugating radioiodinated non-metabolizable peptides to proteins and antibodies with improved yields and qualities of conjugates. Radioiodinated residualizing antibody conjugates comprising any aminopolycarboxylate-appended peptide, or any carbohydrate-appended peptide, are also provided. Additionally, methods are described for conjugating radioiodinated aminopolycarboxylates to proteins and antibodies, as well as for conjugating radioiodinated non-metabolizable carbohydrates to proteins and antibodies by a variety of chemical approaches. The instant radioiodinated residualizing antibody conjugates are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: February 22, 2005
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam V. Govindan, Gary L. Griffiths
  • Patent number: 6858544
    Abstract: A method for forming a bit line of a semiconductor device wherein a first opening in an interlayer insulation film is formed in a P+ S/D (source/drain) region, a post etch treatment (PET) for stabilizing the resistance in the P+ S/D opening is performed, followed by the subsequent formation of a second opening in the N+ S/D region, such that any increase of the resistance of the N+ S/D opening by the PET is thereby prevented.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: February 22, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventors: Sung Gon Jin, Jai Sun Roh
  • Patent number: 6852849
    Abstract: Non-oligomerizing fluorescent proteins, which are formed by operatively linking two or more monomers of a fluorescent protein, or which are derived from a fluorescent protein having at least one mutation that reduces or eliminates the ability of the fluorescent protein to oligomerize, are provided. The non-oligomerizing fluorescent proteins can be derived from a naturally occurring green fluorescent protein, a red fluorescent protein, or other fluorescent protein, or a fluorescent protein related thereto. Also provided is a fusion protein, which includes a non-oligomerizing fluorescent protein linked to at least one polypeptide of interest. In addition, a polynucleotide encoding a non-oligomerizing fluorescent protein is provided, as is a recombinant nucleic acid molecule, which includes polynucleotide encoding a non-oligomerizing fluorescent protein operatively linked to at least a second polynucleotide.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: February 8, 2005
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Robert E. Campbell
  • Patent number: 6853567
    Abstract: The present invention relates to a pumping voltage generator configured to effectively generate a pumping voltage VPP depending on voltage variation. The pumping voltage generator of the present invention comprises a detector, a cycle selecting unit, an oscillator, a control driver and a pumping unit. The detector detects a plurality of pumping voltage levels, and outputs a plurality of enable signals in response to the detected voltage levels. The cycle selecting unit outputs an oscillation cycle selecting signal for controlling an oscillation cycle of a pumping voltage in response to the plurality of enable signals. The oscillator enabled by one of the plurality of enable signals outputs an oscillation signal corresponding to the oscillation cycle selecting signal. The control driver outputs a pumping control signal for controlling the pumping operation in response to the oscillation signal. The pumping unit outputs the pumping voltage in response to the pumping control signal.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: February 8, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventor: Myeong Ju Kwon
  • Patent number: 6852493
    Abstract: The invention provides a method for increasing the hybridization rate of nucleic acids in a nucleic acid assay by labeling nucleic acid molecules with paramagnetic labels and activating a magnetic field inducing rapid migration of the labeled molecules to a solid support, where the labeled molecule hybridizes with its complementary pair. The paramagnetic label may be present on the target nucleic acid or the probe nucleic acid, depending upon whether the target or probe are the immobile phase.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: February 8, 2005
    Assignee: Iris Biotechnologies, Inc.
    Inventors: Jaime E. Ramirez-Vick, Simon Chin
  • Patent number: 6852848
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: February 8, 2005
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Austin L. Gurney, William I. Wood
  • Patent number: 6852559
    Abstract: A semiconductor device and a method for forming the same are disclosed. The semiconductor device includes an epitaxial source/drain junction layer having an insulating film thereunder. The method comprises the step of forming a under-cut under an epitaxial source/drain junction layer so that an insulating film filling the under-cut can be formed.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: February 8, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventors: Byung Il Kwak, Kyung Jun Ahn
  • Patent number: 6849710
    Abstract: A fragment condensation process for the synthesis of analogs of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), in which amino acid residues (22-31) form a synthetic amphipathic ?-helix, is provided.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: February 1, 2005
    Assignee: F. Hoffmann-La Roche AG
    Inventor: Humberto Arzeno
  • Patent number: 6850447
    Abstract: A nonvolatile ferroelectric memory device having a multi-bit control function performs read/write operations by selecting a plurality of cells simultaneously, thereby improving the operation speed of a chip. In the nonvolatile ferroelectric memory device, a plurality of cells are selected at the same time, and stable sensing values of data having a small distribution can be obtained by using average characteristics of a plurality of selected cells. Accordingly, since two or more cells are simultaneously selected and a plurality of bits are read/written in the cells depending on stabilized charge, the operation speed of a chip can be improved.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: February 1, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventor: Hee Bok Kang
  • Patent number: 6842060
    Abstract: The present invention discloses a digital control logic circuit having a characteristic of time hysteresis for controlling transition of a digital control signal for a predetermined period, comprising a first time hysteresis unit, a second time hysteresis unit and an inverter. The first time has the characteristic of time hysteresis when an input signal transits from a first level to a second level. The second time hysteresis unit has the characteristic of time hysteresis connected to the first hysteresis in series when the input signal transits from the second level to the first level.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: January 11, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventor: Sang Sic Yoon
  • Patent number: 6838439
    Abstract: The present invention relates to compounds of the formula I which are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention also relates to processes for the preparation of formula I, pharmaceutical compositions containing compounds of formula I, and the treatment or prophylaxis of various diseases caused by or are associated with excess leucocyte adhesion and/or leucocyte migration, as well as diseases associated with cell-cell or cell-matrix interactions, which on interactions of VLA-4 receptors with their ligands play a part of, for example, inflammatory processes, rheumatoid arthritis or allergic disorders.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: January 4, 2005
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Hans Ulrich Stilz, Volkmar Wehner, Christoph Huls, Dirk Seiffge
  • Patent number: 6838050
    Abstract: Methods of providing anti-infective activity to a medical device including the steps of exposing the medical device to an anti-infective oxidant, and transferring the anti-infective oxidant into a wall of the medical device. One embodiment includes the step of exposing a medical device that is at least in part within a patient to the anti-infective oxidant. Another embodiment includes the steps of exposing a medical device to an aqueous solution which produces the anti-infective oxidant and transferring a sufficient amount of the anti-infective oxidant into the medical device wall to provide the medical device with anti-infective activity. Also provided is an oxidant releasing member that has anti-infective oxidant releasably contained therein and that is configured to be disposed adjacent to the medical device.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: January 4, 2005
    Assignee: Oxibio, Inc.
    Inventors: Terrence R. Green, Jack Fellman
  • Patent number: 6838369
    Abstract: A method for forming a contact hole of a semiconductor device, wherein a polymer residual on a bottom surface of the contact hole is treated with plasma of mixture gas containing oxygen to convert the polymer residual into a pure silicon oxide film free of carbon and fluorine for easy removal in a subsequent washing process is disclosed. The method comprises (a) sequentially forming a capping layer and a planarized interlayer insulating film on a semiconductor substrate having a predetermined lower structure; (b) selectively etching the interlayer insulating film to expose a predetermined region of the capping layer; (c) removing the exposed capping layer; (d) subjecting the resulting structure to a plasma treatment using a mixture gas containing oxygen; and (e) performing a cleaning process.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: January 4, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventors: Ho Seok Lee, Dong Sauk Kim, Jin Woong Kim