Patents Represented by Attorney Heller Ehrman White & McAuliffe LLP

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  • Immunotherapy for chronic myelocytic leukemia
    Patent number: 6759045
    Abstract: Immunotherapy utilizing naked anti-granulocyte antibodies provides an effective means for treating chronic myelocytic leukemia (CML). Such antibodies can be administered alone or in combination with other therapies, such as immunoconjugates or chemotherapeutics. In either format, an effective therapy for treating CML is provided, which avoids the toxic side-effects typically associated with cancer therapy. The disclosed immunotherapy also is effective for treating acute myelocytic leukemia (AML) when co-administered with inducing agents which induce expression of antigens minimally displayed on the surface of myeloblasts.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: July 6, 2004
    Assignee: Immunomedics, Inc.
    Inventors: David M. Goldenberg, Hans J. Hansen
  • Vertical cavity apparatus with tunnel junction
    Patent number: 6760357
    Abstract: A vertical cavity apparatus includes first and second mirrors, a substrate and at least first and second active regions positioned between the first and second mirrors. At least one of the first and second mirrors is a fiber with a grating. At least a first tunnel junction is positioned between the first and second mirrors.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: July 6, 2004
    Assignee: Bandwidth9
    Inventors: Julien Boucart, Constance Chang-Hasnain, Michael Jansen, Rashit Nabiev, Wupen Yuen
  • Agonist and antagonist peptides of carcinoembryonic antigen (CEA)
    Patent number: 6756038
    Abstract: The present invention relates to the preparation and use of peptides that act as agonists and antagonists of human carcinoembryonic antigen (CEA). Agonists of the CEA peptide, CAP1, are disclosed and their utility in enhancing immune responses against CEA demonstrated.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: June 29, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jeffrey Schlom, Elene Barzaga, Sam Zaremba
  • Microcup compositions having improved flexure resistance and release properties
    Patent number: 6753067
    Abstract: This invention relates to a novel composition suitable for use in the manufacture of electrophoretic display cells. The mechanical properties of the cells are significantly improved with this composition in which a rubber material is incorporated.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: June 22, 2004
    Assignee: SiPix Imaging, Inc.
    Inventors: Xianhai Chen, Mary B. Chan-Park, Xiaojia Wang, Rong-Chang Liang
  • Insulin-like growth factor agonist molecules
    Patent number: 6750321
    Abstract: Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: June 15, 2004
    Assignee: Genentech, Inc.
    Inventors: Yvonne Man-yee Chen, Ross G. Clark, Andrea G. Cochran, Henry B. Lowman, Iain C. A. F. Robinson, Nicolas J. Skelton
  • Insulin-like growth factor agonist molecules
    Patent number: 6743894
    Abstract: Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: June 1, 2004
    Assignee: Genentech, Inc.
    Inventors: Yvonne Man-yee Chen, Ross G. Clark, Andrea G. Cochran, Henry B. Lowman, Iain C. A. F Robinson, Nicholas J. Skelton
  • Systems and methods for packet filtering
    Patent number: 6735179
    Abstract: Systems and methods are described for converting priority based rules into isomorphic longest match rules. Rules for packet processing may be presented to a networking device in priority order, through an interface such as a Command Line Interface (CLI) or from networking applications which may reside on the networking device. The networking device may include hardware and/or software layers for accelerating packet processing; a forwarding layer may include hardware and/or software designed to perform longest match searches on packets. Prioritized rules may be converted into a data structure for the forwarding layer, so that a longest match search performed by the forwarding layer on the data structure is equivalent to a priority order search on the prioritized rules.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: May 11, 2004
    Assignee: Bivio Networks, Inc.
    Inventor: Yakov Teplitsky
  • Balanced distortion reduction circuit
    Patent number: 6734726
    Abstract: A method and apparatus for utilizing the distortion generated within a portion of a balanced amplifier to cancel the distortion generated within the whole balanced amplifier. Samples of the signal and distortion from part of the balanced amplifier are combined with a reference signal such that the two signals destructively combine leaving the distortion from the sampled part of the balanced amplifier. The gain and phase of the distortion is then adjusted so that when it is coupled into the input of the other part of the balanced amplifier the distortion generated by both parts of the balanced amplifier are cancelled.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: May 11, 2004
    Assignee: Remec, Inc.
    Inventor: Mark Billsberry
  • Determination of endometrial receptivity toward embryo implantation
    Patent number: 6733979
    Abstract: Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for &bgr;3 and detecting &bgr;3 in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: May 11, 2004
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Bruce Lessey
  • Delivery of a composition to the liver by utilizing the portal vein
    Patent number: 6722370
    Abstract: In general, the invention features methods for delivering a composition to the liver in a non-surgical, percutaneous approach by utilizing the portal vein. Also disclosed are methods allowing for the liver-specific delivery of a composition.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: April 20, 2004
    Assignee: Corgentech, Inc.
    Inventor: Michael J. Mann
  • IR MALDI mass spectrometry of nucleic acids using liquid matrices
    Patent number: 6723564
    Abstract: Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported.
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: April 20, 2004
    Assignee: Sequenom, Inc.
    Inventor: Franz Hillenkamp
  • Hand truck provided with a pusher plate for pushing a load off a platform
    Patent number: 6719521
    Abstract: A hand truck is provided with a pusher plate for pushing a load off its platform. In one embodiment, the hand truck comprises a frame to which the platform for accommodating a load and the wheels are attached and the operating construction is hingeably connected to the frame, wherein the pusher plate on one side is hingeably connected to the first end of the operating construction and on the other side is hingeably connected to the frame via an auxiliary arm. The operating construction extends from a first end close to the platform to handles, for grasping the hand truck with the hands. The pusher plate can be moved across the platform, for pushing a load placed on the platform off the platform.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: April 13, 2004
    Inventor: Leonardus Johannes Josephus Van Boxtel
  • Insulin-like growth factor agonist molecules
    Patent number: 6716586
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 6, 2004
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • Derivatives of C2-substituted indan-1-ol compounds, methods for their preparation and use
    Patent number: 6717008
    Abstract: Derivatives of C2-substituted indan-1-ol compounds, processes for their preparation and their use are disclosed. In particular, the invention relates to compounds of the formula I and to their physiologically acceptable salts and physiologically functional derivatives. The compounds are suitable, for example, for use as anorectics.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: April 6, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel
  • Insulin-like growth factor agonist molecules
    Patent number: 6713451
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: March 30, 2004
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • IR-MALDI mass spectrometry of nucleic acids using liquid matrices
    Patent number: 6706530
    Abstract: Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: March 16, 2004
    Assignee: Sequenom, Inc.
    Inventor: Franz Hillenkamp
  • Systems for detecting and compensating for image artifacts while scanning an imagine plate
    Patent number: 6700131
    Abstract: A method of compensating for differences in detective gain between a plurality of different scanning heads in a multiple scanning head imaging plate scanner, comprising: (a) scanning each of the scanning heads across an imaging plate thereby determining the detected signal at successive locations across the imaging plate for each of the scanning heads; (b) calculating an inverse relationship to the detected signal at successive locations across the imaging plate for each of the scanning heads; (c) scanning each of the scanning heads across an imaging plate containing an image thereon, thereby determining an image value at the successive locations across the imaging plate for each of the scanning heads; and (d) applying the inverse relationship to the determined image values at the successive locations across the imaging plate for each of the scanning heads.
    Type: Grant
    Filed: May 2, 2001
    Date of Patent: March 2, 2004
    Assignee: Alara, Inc.
    Inventors: H. Keith Nishihara, Brian P. Wilfley
  • Circularly permuted fluorescent protein indicators
    Patent number: 6699687
    Abstract: The present invention provides polypeptide and polynucleotides encoding fluorescent indicators having inserted within a fluorescent moiety a sensor polypeptide. Also provided are methods of using the fluorescent indicator. Circularly permuted fluorescent polypeptides and polynucleotides are also provided.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: March 2, 2004
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Geoffrey Baird
  • Heterocyclic modulators of nuclear receptors
    Patent number: 6696473
    Abstract: Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: February 24, 2004
    Assignee: X-Ceptor Therapeutics, Inc.
    Inventors: Richard Martin, Brenton Todd Flatt, Jeffrey Dean Kahl, Tie-Lin Wang
  • Low profile gearcover
    Patent number: D492224
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: June 29, 2004
    Assignee: S & S Cycle, Incorporated
    Inventors: Jeffrey J. Bailey, Jason A. Thurow, Scott Sjovall