Patents Represented by Attorney Heller Ehrman White & McAuliffe LLP

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  • Sulfonamides and derivatives thereof that modulate the activity of endothelin
    Patent number: 6632829
    Abstract: Thienyl-, furyl- and pyrrolyl-sulfonamides, formulations of pharmaceutically-acceptable salts thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides, formulations thereof and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit the activity of endothelin are also provided.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: October 14, 2003
    Assignee: Texas Biotechnology Corp.
    Inventors: Chengde Wu, Bore Gowda Raju, Timothy Kogan, Natalie Blok, Patricia Woodard
  • Self-crosslinking compositions based on fluorine-containing polycondensates
    Patent number: 6630205
    Abstract: The invention relates to a method for coating a substrate according to which a self-crosslinking coating composition is produced on the basis of a) at least one hydrolysable silane with at least one nonhydrolysable substituent, said silane having one or more electrophilic groups X on at least one nonhydrolysable substitutent, b) at least one hydrolysable silane with at least one nonhydrolysable substituent, said silane having one or more nucleophilic groups Y on at least one nonhydrolysable substituent, c) at least one hydrolysable silane with at least one nonhydrolysable carbonic group that has an average of 2 to 30 fluorine atoms that are bound to one or more aliphatic carbon atoms that are separated from the silicon atom by at least two atoms.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: October 7, 2003
    Assignee: Institut für Neue Materialien gem. GmbH
    Inventors: Stefan Brueck, Christoph Lesniak, Hermann Schirra, Helmut Schmidt
  • Anti-transforming growth factor Beta (TGF-&bgr;) treated stem cell composition and method
    Patent number: 6627191
    Abstract: The invention relates to stem cell compositions comprising anti-TGF-&bgr; treated stem cells which are viable for at least 14 days in culture without replication or differentiation and methods for rapid and long term in vitro hematopoiesis and in vivo hematopoietic reconstitution using such anti-TGF-&bgr; treated stem cells.
    Type: Grant
    Filed: January 25, 2000
    Date of Patent: September 30, 2003
    Assignee: Seattle Biomedical Research Institute
    Inventors: Stephen H. Bartelmez, Ewa Sitnicka, Frank Ruscetti
  • Fluorescent protein sensors for measuring the pH of a biological sample
    Patent number: 6627449
    Abstract: Disclosed are fluorescent protein sensors for measuring the pH of a sample, nucleic acids encoding them, and methods of use. The preferred fluorescent protein sensors are variants of the green fluorescent protein (GFP) from Aequorea victoria. Also disclosed are compositions and methods for measuring the pH of a specific region of a cell, such as the mitochondrial matrix or the Golgi lumen.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: September 30, 2003
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Atsushi Miyawaki, Juan Llopis
  • Long wave length absorbing bacteriochlorin alkyl ether analogs
    Patent number: 6624187
    Abstract: Novel compounds that either preferentially absorb into hyperproliferative tissue and absorb light efficiently at a wavelength of between about 700 and about 850 nm or act as intermediates for such absorbing compounds.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: September 23, 2003
    Assignee: Health Research, Inc.
    Inventors: Ravindra K. Pandey, Thomas J. Dougherty, William R. Potter
  • Insulin-like growth factor agonist molecules
    Patent number: 6620789
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: September 16, 2003
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C.A.F. Robinson
  • Nanostructured forms and layers and method for producing them using stable water-soluble precursors
    Patent number: 6620514
    Abstract: A process for preparing a composition for producing nanostructured mouldings and layers comprises contacting an aqueous and/or alcoholic sol of a compound of an element selected from silicon sand metals of the main groups and transition groups of the Periodic Table with species possessing hydrolysable alkoxy groups and comprising at least one organically modified alkoxysilane or a precondensate derived therefrom, under conditions which lead to (further) hydrolysis of the species, and subsequent removal of the alcohol formed and any alcohol already present originally. The process is characterized in that the alcohol is removed in an amount such that the residual alcohol content of the composition is not more than 20% by weight.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: September 16, 2003
    Assignee: Institut für Neue Materialien gem. GmbH
    Inventors: Ertugrul Arpac, Gerhard Jonschker, Hermann Schirra, Helmut Schmidt
  • Semi-solid delivery vehicle and pharmaceutical compositions
    Patent number: 6613355
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: September 2, 2003
    Assignee: A.P. Pharma, Inc.
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
    Patent number: 6613804
    Abstract: Biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, bicyclic or tricyclic carbon or heterocyclic ring biphenylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: September 2, 2003
    Assignee: Encysive Pharmaceuticals, Inc.
    Inventors: Ming Fai Chan, Timothy Kogan, Erik Joel Verner, Adam Kois, Vitukudi Narayanaiyengar Balaji
  • Immunogenic conjugates comprising a group B meningococcal porin and an H. influenzae polysaccharide
    Patent number: 6613336
    Abstract: Disclosed is an H. influenzae type b polysaccharide-meningococcal outer membrane protein conjugate, pharmaceutical compositions thereof, and the use thereof to induce an immune response to H. influenzae in an animal.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: September 2, 2003
    Assignee: Baxter International Inc.
    Inventors: Milan S. Blake, Francis Michon, Peter C. Fusco, Iver Heron
  • Methods of enhancing cognitive function using an AL-1 neurotrophic factor immunoadhesin
    Patent number: 6610296
    Abstract: The present invention provides methods of enhancing cognitive function in mammals by administering intracerebrally a homo-multimeric immunoadhesin molecule that contains the extracellular domain of AL-1, also known as ephrin-A5.
    Type: Grant
    Filed: January 2, 1996
    Date of Patent: August 26, 2003
    Assignee: Genentech, Inc.
    Inventors: Ingrid W. Caras, John W. Winslow
  • Process for making ice pops
    Patent number: 6610336
    Abstract: A process for making confection compositions such as ice pops of gel consistency, in the absence of heat treatment which takes advantage of a chemical reaction between an alginate salt, other than calcium alginate, or a low methoxy pectin and free calcium provides a homogeneous gel product which can be subsequently depositing into a mold pocket and converted into a desired product such as an ice pop by traditional steps.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: August 26, 2003
    Assignee: Ice Cream Partners USA, LLC
    Inventor: Mike Poorman
  • Fluorescent protein sensors for measuring the pH of a biological sample
    Patent number: 6608189
    Abstract: Disclosed are fluorescent protein sensors for measuring the pH of a sample, nucleic acids encoding them, and methods of use. The preferred fluorescent protein sensors are variants of the green fluorescent protein (GFP) from Aequorea victoria. Also disclosed are compositions and methods for measuring the pH of a specific region of a cell, such as the mitochondrial matrix or the Golgi lumen.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: August 19, 2003
    Assignee: University of California
    Inventors: Roger Y. Tsien, Juan Llopis, Rebekka M. Wachter, S. James Remington
  • Insulin-like growth factor agonist molecules
    Patent number: 6608031
    Abstract: Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: August 19, 2003
    Assignee: Genentech, Inc.
    Inventors: Ross G. Clark, Henry B. Lowman, Iain C. A. F. Robinson
  • Cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion proteins in E. coli
    Patent number: 6602688
    Abstract: The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli. In particular, antibody fragment fusion molecules having an antibody moiety which is directed against tumors and an enzyme moiety which cleaves a nontoxic prodrug to give the toxic drug can be advantageously prepared in this way while retaining their respective functional properties.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: August 5, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Martin Opper, Klaus Bosslet, Joerg Czech
  • Targeted transcutaneous cancer therapy
    Patent number: 6602274
    Abstract: The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, using a light source that preferably transmits light to a treatment site transcutaneously. The method provides for administering to the subject a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent, or a photosensitizing agent delivery system, or a targeted prodrug. This targeted substance preferably selectively binds to the target tissue. Light at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The light intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted photosensitizing agent or targeted prodrug product.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: August 5, 2003
    Assignee: Light Sciences Corporation
    Inventor: James Chen
  • Needle spin for medical instrument
    Patent number: 6599232
    Abstract: A medical instrument includes a distal frame portion that accepts a needle cam. The needle cam has helical slots for accepting a collar, whereby the collar rides up and down the needle cam, to thereby cause the needle cam to rotate. Spin movement of the needle is caused by movement of the collar, to thereby achieve a proper seed implantation during a medical procedure by having the needle spin between seed implant locations.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: July 29, 2003
    Assignee: Integrated Implant Systems, LLC
    Inventors: Edward J. Kaplan, Diego Y. Fontayne, Robert A. Joachim
  • Benzene tricarboxylic acid derivatives as insulin receptor activators
    Patent number: 6600069
    Abstract: Compounds of Formula I, and pharmaceutical compositions containing these compounds, activate the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, and are therefore useful for the treatment of animals, especially humans, with hyperglycemia, especially for the treatment of type 2 diabetes. Processes for preparation of the compounds, and their use in assays, are also disclosed.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: July 29, 2003
    Assignee: Telik, Inc.
    Inventors: Louise Robinson, Prasad V. V. S. V. Manchem, Nicolas Cairns, Steven R. Schow
  • Methods of destruction of cyanide in cyanide-containing waste
    Patent number: 6596916
    Abstract: Methods of treatment of cyanide-containing waste are provided. In particular, methods for treatment of spent potliner prior to landfill disposal are provided. These methods, which involve treatment of the waste with a mixture containing an aqueous oxidizing solution and an agent, such as magnesium chloride, that increases the oxidation potential of the solution, can be performed at ambient temperature and pressure.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: July 22, 2003
    Assignee: Waste Management, Inc.
    Inventor: Gary Fisher
  • Refrigerator thermometer
    Patent number: D477541
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: July 22, 2003
    Assignee: B & H Liquid Crystal Devices Ltd.
    Inventor: W. J. Stephen Barker