Abstract: A phase-change memory device includes a first insulator having a hole therethrough, a first electrode that conforms at least partially to the hole, a phase-change material in electrical communication with the first electrode, and a second electrode in electrical communication with the phase-change material. When current is passed from the first electrode to the second electrode through the phase-change material, at least one of the first and second electrodes remains unreactive with the phase change material.

Abstract: A system for providing at least a partially mounted tire and wheel assembly is disclosed. The system includes the steps of using a prime mover to bring a tire and wheel together and using the primer mover to work on at least one of the tire or the wheel to mount the tire and the wheel together, wherein the work performed by the prime mover is the only positive work introduced into the tire/wheel system.

Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Abstract: The present invention relates to therapeutic combinations comprising a protease inhibitor and a polymerase inhibitor for the treatment of HCV. The present invention also relates to therapeutic combinations comprising VX-950 and a polymerase inhibitor. Also within the scope of the invention are methods using the therapeutic combinations of the present invention for treating HCV infection or alleviating one or more symptoms thereof in a patient. The present invention also provides kits comprising the combinations of the present invention.

Abstract: An external-cavity laser module includes a package defining an enclosure, the package including a base having a surface internal to the enclosure, a thermoelectric cooler within the enclosure, the thermoelectric cooler including an upper carrier plate and a lower carrier plate, the lower carrier plate being placed on the internal surface of the base and the thermoelectric cooler (TEC) being configured to stabilize the temperature of the upper carrier plate at a substantially constant temperature. The laser module further includes a laser assembly housed within the enclosure, including a gain medium for emitting an optical beam into the external cavity and an end mirror. Variations of the environmental temperature with respect to the thermally stabilized temperature cause mechanical deformations of the TEC upper carrier plate that is in thermal coupling with the laser assembly. The mechanical deformations in turn induce variations in the optical path length of the laser cavity.

Abstract: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Abstract: A fastener is disclosed. The fastener includes a housing, wherein the housing forms a housing cavity, wherein the housing cavity includes at least one recess; a cage at least partially disposed in said housing cavity, wherein an outer surface of the cage is spaced apart from an inner surface of the housing that forms the housing cavity, wherein the cage defines a cage cavity, and a plurality of passages aligned with said at least one recess; a plurality of retaining members at least partially retained within said plurality of passages; and a plunger at least partially disposed in said cage cavity, wherein said plunger is at least partially movable within said cage cavity between a first position to cause said one or more retaining members to be displaced radially outwardly thereby mechanically coupling said housing to said cage, and a second position to allow said one or more retaining members to be displaced radially inwardly thereby allowing said housing to be uncoupled from said cage.

Abstract: In one aspect, the invention provides compounds of Formula I or pharmaceutically acceptable salts thereof. In another aspect, the invention provides methods for treatment of diseases or disorders mediated by a protein kinase, comprising administering a therapeutically effective amount of a compound of this invention.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

Abstract: A method of fabricating a turning mirror for an optical device includes the steps of depositing on a substrate, which defines a plane in which an optical signal propagates in a propagating direction, a photoresist layer sensitive to electrons and to UV radiation. The material in which the photoresist layer is formed, has a contrast not larger than 3. A first portion of the photoresist layer is exposed to an electron beam, wherein the electron dose of the electron beam exposure is varied within the first portion according to a selected pattern, and wherein the electron does to which a given region in the photoresist is exposed, depends on the resulting photoresist height in the given region after development. A second portion of the photoresist layer is exposed to UV radiation; the first and the second portions are overlapped at least in a third portion.

Abstract: The invention relates to ion channel modulators of formula Ia, pharmaceutical compositions thereof, and to methods of treating diseases using such compounds where activation or hyperactivity of calcium and/or sodium ion channels is implicated in the disease state.

Abstract: A document scanner is disclosed. The document scanner includes a document bed having a surface to position a document. The document bed includes a slot in which a presentment apparatus is positioned. The presentment apparatus includes a first rigid layers a second compressible layer, and a third lower friction layer. A method of use of the document scanner is disclosed as well.

Abstract: Filter media and a method for manufacturing filter media is disclosed. The filter media includes a corrugated porous filter media layer including a top surface and a bottom surface, wherein the corrugated porous filter media layer includes one or more peaks separated by valleys, a second porous filter media layer including a top surface and a bottom surface, the valleys of the corrugated porous filter media proximate the second porous filter media layer, and an ultrasonically weldable material disposed between one or more of the valleys of the corrugated porous filter media layer and the top surface of the second porous filter media layer.

Abstract: A high-temperature, heat-resistant fill material is disclosed. The high-temperature, heat-resistant fill material includes an alumina refractory waste material having one or more of a used alumina-magnesium-carbon material, a used high-alumina material and a used fused-grain alumina material is disclosed. A method for method for manufacturing a material is also disclosed.

Abstract: A sterile, substantially maintenance free disposable dental handpiece is constructed from two shells and a center core, the center core having a flow deflector on one end. The shells are joined around the core with mating protrusions and/or tapered walls to form the body and head of the handpiece. A base is integrally-formed with the center core. The base has conduits that allow entry of light and pressurized air and/or water into the body. The head at the opposite end of the body from the base rotatably mounts an impeller assembly having an impeller shaft. The impeller shaft includes blades driven by the pressurized air. The blades can have cavities to reduce weight.

Abstract: A vehicular storage enclosure comprising a sub-compartment (108) disposed within a passenger compartment (P) of a vehicle (V), wherein the sub-compartment (108) includes a closure panel (106) that provides selective access to the sub-compartment (108), wherein the closure panel (106) includes an outboard surface (116) that is substantially exposed to the passenger compartment (106) and an inboard surface (114) that is substantially exposed to the sub-compartment (108) when the sub-compartment (108) is closed off by the closure panel (106), and a handle (204) that is accessible from within the sub-compartment (108), and wherein one of or both of the handle (204) and an area proximate the handle (204) on the inboard surface (114) includes indicia (G) to conspicuously provide one or more instructions for opening the closure panel (106) from within the sub-compartment (108).

Abstract: A door handle assembly for a door substrate having an aperture, said door handle assembly comprising: a bell crank capable of pivoting about an axis, the bell crank including a first arm, a second arm and a base therebetween; a door handle that operatively engages the second arm of the bell crank, wherein a free end of the second arm extends upward and outward away from the base such that the free end of the second arm sweeps around a generally conical shape as the bell crank pivots about the axis; means for securing the door handle to the bell crank including a pin and notch assembly, wherein the pin is inserted through an aperture in the door handle and engages a notch located on the second arm; and a plurality of ribs formed on one or more surfaces of the bell crank.

Abstract: A tool assembly and method for completing a well are provided. The tool is deployed on tubing string and includes a fluid treatment assembly with cup seals above and below the treatment ports. An equalization valve beneath the fracturing assembly can be opened or closed to control fluid passage between the coiled tubing and treatment zone to the wellbore below.