Abstract: A wavelength tuneable external-cavity laser module comprises a gain medium in thermal contact with a thermally stabilized substrate; an end mirror, and a phase element for controlling the phase of the optical beam and being positioned within the external cavity between the gain medium and the end mirror, wherein said phase element comprises a material having a refractive index that varies in response to changes in temperature and has a transmissivity substantially independent of wavelength across said predetermined wavelength range. The thermally-controllable phase element is configured so as to induce a phase variation that compensates the drop in the output power due to ageing or to external temperature variation. A heating element is placed in thermal contact to the phase element. By thermally controlling an intra-cavity phase element it is possible to vary continuously the output power as a function of the injection current.

Abstract: A factory layout including a track circuit, one or more wheeled carts for traversing the track circuit and a tire/wheel assembly carried by the wheeled cart. One or more work stations can be positioned at locations along the track circuit. Various wheeled cart embodiments are disclosed and various work station configurations are disclosed.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: A method for treating a subject having an inflammatory or auto-immune disease with a substituted isoxazolo pyridinone. Also, a method for administering a substituted isoxazolo pyridinone to a cell to retain or increase glucocorticoid receptor transrepression activity with only minimal glucocorticoid receptor transactivation activity.

Abstract: The invention relates to a method of assessing airway variability in airway responsiveness or asthma by measuring the variation of resistance (Rrs) by a forced oscillation technique utilizing either a single or a plurality of input frequencies during a plurality of respiratory cycles of a patient; calculating the statistical variability of the Rrs for the patient; and, correlating the statistical variability of the Rrs of the patient to a standard curve to quantify the degree of asthma of the patient. The invention also enables the effectiveness of a bronchoactive agent to be measured.

Abstract: A toy-holding apparatus for securely holding at least two playground toys, such as hoops or wands, in a predetermined relationship to one another includes a first hoop grip adapted to releasably grip a first playground hoop and a second hoop grip adapted to releasably grip a second playground hoop. A connecting element is disposed between the first and second hoop grips. A friction-inducing insert is disposed on at least one of the hoop grips to minimize unintended movement between the hoop grips and the hoops.

Abstract: A power generation system is disclosed. The power generation system includes an electrical converting device and a repowered portion connected to the electrical converting device. The repowered portion includes a reciprocating internal combustion engine and a gearbox. The reciprocating internal combustion engine is connected to the gearbox by a first connecting structure. The gearbox is connected to the electrical converting device by a second connecting structure.

Abstract: An apparatus for assembling a tire and a wheel is disclosed. The apparatus includes a single-cell workstation including a device that retains a wheel, and a plurality of sub-stations. The device moves the wheel to each of the plurality of sub-stations, without releasing the wheel, to assemble a tire-wheel assembly. A method is also disclosed.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.

Abstract: An inflator device is disclosed. The inflator device includes a seal assembly that maintains, while sealing from ambient pressure, an open air passageway between a tire bead and wheel bead seat during an inflation procedure. A seal for the inflator device is also disclosed. The seal includes a ring-shape having a flexible inner periphery that is adapted to maintain, while sealing from ambient pressure, an open air passageway between a tire bead and wheel bead seat during an inflation procedure.

Abstract: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.

Abstract: Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections.

Abstract: Decorative paper for decorative coating materials comprising a base paper and an ink receiving layer dyed in such a way that the decorative paper has after impregnation with impregnating resins and pressing as laminate the same coloring as the coloring of a laminate of a decorative paper that does not comprise an ink receiving layer.