Patents Represented by Attorney Howard C. Stanley
  • Patent number: 5352605
    Abstract: In one aspect the present invention relates to the use of viral promoters in the expression of chimeric genes in plant cells. In another aspect this invention relates to chimeric genes which are capable of being expressed in plant cells, which utilize promoter regions derived from viruses which are capable of infecting plant cells. One such virus comprises the cauliflower mosaic virus (CaMV). Two different promoter regions have been derived from the CaMV genome and ligated to heterologous coding sequences to form chimeric genes. These chimeric genes have been shown to be expressed in plant cells. This invention also relates to plant cells, plant tissue, and differentiated plants which contain and express the chimeric genes of this invention.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: October 4, 1994
    Assignee: Monsanto Company
    Inventors: Robert T. Fraley, Robert B. Horsch, Stephen G. Rogers
  • Patent number: 5254801
    Abstract: A class of heterologous dominant conditional lethal genes is disclosed. The gene is useful in genetically modifying plant cells and plants to selectively induce cellular lethality for purposes such as inducing male sterility for hybrid seed production, cell ablation and counter-negative selection.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: October 19, 1993
    Assignee: Monsanto Company
    Inventors: Stanton B. Dotson, Ganesh M. Kishore
  • Patent number: 5250515
    Abstract: A method for potentiating the insecticidal activity of a protein toxin of Bacillus thuringiensis bacteria is disclosed. A potentiating amount of trypsin inhibitor is co-administered to the insect along with the toxin. Improved insecticidal compositions are also disclosed which contain an insecticidal amount of a protein toxin of Bacillus thuringiensis and a potentiating amount of a trypsin inhibitor.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: October 5, 1993
    Assignee: Monsanto Company
    Inventors: Roy L. Fuchs, Ganesh M. Kishore, Susan C. MacIntosh
  • Patent number: 5223419
    Abstract: A transacting DNA binding factor is disclosed. The ASF 1 protein factor specifically binds to the sequence motif TGACG found upstream of the promoter in many plant genes. Coexpression of this protein factor augments the level of expression of the up-regulated promoter containing the TGACG motif.
    Type: Grant
    Filed: February 1, 1991
    Date of Patent: June 29, 1993
    Assignee: The Rockefeller University
    Inventors: Fumiaki Katagiri, Eric Lam, Nam-Hai Chua
  • Patent number: 5223526
    Abstract: Novel N-[2-(cyclic alkyl)phenyl]pyrazole-4-carboxamides useful as fungicides, methods of using said compounds, and fungicidal compositions containing them.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: June 29, 1993
    Assignee: Monsanto Company
    Inventors: Jim I. McLoughlin, Suzanne Metz
  • Patent number: 5219824
    Abstract: Disclosed herein are herbicidal pyridine compounds substituted at the 3- and/or 5-position with a carboxylic acid-derived heterocyclic moiety, as well as herbicidal compositions and use of these compounds.
    Type: Grant
    Filed: October 21, 1991
    Date of Patent: June 15, 1993
    Assignee: Monsanto Company
    Inventors: Yuen-Lung L. Sing, Len F. Lee
  • Patent number: 5206369
    Abstract: An improved process for dehydrating dialkyl 2,6-bis(trifluoromethyl)-2,6-dihydroxy-4-(alkyl)-3,5-piperidinedicarboxyla tes using concentrated sulfuric acid essentially in the absence of a solvent to prepare the corresponding dialkyl 2,6-bis(trifluoromethyl)dihydro-4-(alkyl)-3,5-pyridinedicarboxylates.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: April 27, 1993
    Assignee: Monsanto Company
    Inventor: William H. Miller
  • Patent number: 5196045
    Abstract: A compound having the structural formula ##STR1## wherein: Y is selected from O and S;R.sub.1 and R.sub.4 are independently selected from fluorinated methyl, chlorofluorinated methyl, and C.sub.1 -C.sub.4 alkyl, provided that not both R.sub.1 and R.sub.4 may be C.sub.1 -C.sub.4 alkyl;R.sub.2 is selected from hydrogen, lower alkyl, haloalkyl, alkenyl, alkynyl, haloalkenyl, and a cation;R.sub.3 is selected from C.sub.1 -C.sub.5 alkyl, cycloalkyl, cycloalkylalkyl, hydroxy, and alkoxy; andX is selected from ##STR2## in which R.sub.8 is selected from H, alkyl and CF.sub.3 and R.sub.10 is selected from F, Cl, --OR.sup.1, --SR.sup.1, --NHR.sup.1, --N(R.sup.1).sub.2, phenyl, substituted phenyl, and --P(OR.sup.1).sub.2where R.sup.1 is as defined above; ##STR3## wherein R.sup.1 is as defined above; ##STR4## wherein R.sub.14 and R.sub.15 are independently selected from hydrogen and alkyl; and --N.dbd.C.dbd.O and their use as herbicides.
    Type: Grant
    Filed: March 20, 1991
    Date of Patent: March 23, 1993
    Assignee: Monsanto Company
    Inventors: Len F. Lee, Mark G. Dolson
  • Patent number: 5188642
    Abstract: This invention involves a cloning or expression vector comprising a gene which encodes 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) polypeptide which, when expressed in a plant cell contains a chloroplast transit peptide which allows the polypeptide, or an enzymatically active portion thereof, to be transported from the cytoplasm of the plant cell into a chloroplast in the plant cell, and confers a substantial degree of glyphosate resistance upon the plant cell and plants regenerated therefrom.The EPSPS coding sequence may be ligated to a strong promoter, such as the 35S promoter from cauliflower mosaic virus, to create a chimeric gene. Such genes can be inserted into plant transformation vectors, and subsequently introduced into plant cells. Plant cells transformed using such genes and plants regenerated therefrom have been shown to exhibit a substantial degree of glyphosate resistance.
    Type: Grant
    Filed: February 12, 1990
    Date of Patent: February 23, 1993
    Assignee: Monsanto Company
    Inventors: Dilip M. Shah, Stephen G. Rogers, Robert B. Horsch, Robert T. Fraley
  • Patent number: 5185025
    Abstract: The present invention relates to certain novel substituted 3-phenoxypyrazoles and their use as herbicides.
    Type: Grant
    Filed: October 13, 1989
    Date of Patent: February 9, 1993
    Assignee: Monsanto Company
    Inventors: Kurt Moedritzer, Michael D. Rogers
  • Patent number: 5185253
    Abstract: Transgenic plants are disclosed which are resistant to virus infection by Potato Virus X and Potato Virus Y. Plant genes and transformation vectors are also disclosed. Potato plants, for example, Russet Burbank variety, are made resistant to dual infection by Potato Virus X and Potato Virus Y by transforming the plant to express the coat proteins of the two viruses.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: February 9, 1993
    Assignee: Monsanto Company
    Inventor: Nilgun E. Tumer
  • Patent number: 5169432
    Abstract: Substituted pyridines having at the 3 or 5 position a carbonyl oxy(thio)ester or a heterocyclocarbonyl and at the other a substituted alkyl group, herbicidal compositions and methods of use thereof.
    Type: Grant
    Filed: May 23, 1991
    Date of Patent: December 8, 1992
    Assignee: Monsanto Company
    Inventors: Susan M. Auinbauh, Len F. Lee, Karey A. Van Sant
  • Patent number: 5169429
    Abstract: A method of inducing male sterility in a dicotyledonous plant which comprises treating the plant prior to, during or post meiosis with an amount of a substituted 4-oxo-1-phenyl-1,4-dihydropyridazine, which is effective to produce male sterility in the plant.
    Type: Grant
    Filed: July 5, 1991
    Date of Patent: December 8, 1992
    Assignee: Monsanto Company
    Inventors: Harlow L. Warner, Gerard Sutra
  • Patent number: 5162536
    Abstract: Described herein is a process for dehydration of substituted piperidine dicarbothioate compounds and a novel compound obtained thereby.
    Type: Grant
    Filed: October 28, 1991
    Date of Patent: November 10, 1992
    Assignee: Monsanto Company
    Inventors: Sherrol L. Baysdon, Helen L. Janoski
  • Patent number: 5156670
    Abstract: Fully substituted pyridines having a cyclic alkylidene substituent, useful as herbicides, compositions and methods of use thereof.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: October 20, 1992
    Assignee: Monsanto Company
    Inventors: Len F. Lee, Kathleen K. Smith, Karey A. Van Sant
  • Patent number: 5145783
    Abstract: Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate (EPSP) synthases, DNA encoding glyphosate-tolerant EPSP synthases, plant genes encoding the glyphosate-tolerant enzymes, plant transformation vectors containing the genes, transformed plant cells and differentiated transformed plants containing the plant genes are disclosed. The glyphosate-tolerant EPSP synthases are prepared by substituting an alanine residue for a glycine residue in a conserved sequence found between positions 80 and 120 in the mature wild-type EPSP synthase.
    Type: Grant
    Filed: July 9, 1990
    Date of Patent: September 8, 1992
    Assignee: Monsanto Company
    Inventors: Ganesh M. Kishore, Dilip M. Shah
  • Patent number: 5142055
    Abstract: Processes for production of 2,6-substituted-3,5-pyridinedicarboxylic acids, esters, salts, amides, halides, and cyano compounds, useful as herbicides and as intermediates which provide herbicides.
    Type: Grant
    Filed: October 4, 1990
    Date of Patent: August 25, 1992
    Assignee: Monsanto Company
    Inventor: Len F. Lee
  • Patent number: 5129943
    Abstract: Disclosed herein are 2- or 6-fluoromethyl-3-pyridinecarboxylate derivatives with 5-[(heterocyclic)ylidene]amino substitution useful as herbicides and herbicide intermediates.
    Type: Grant
    Filed: May 20, 1991
    Date of Patent: July 14, 1992
    Assignee: Monsanto Company
    Inventors: Shridhar G. Hegde, Len F. Lee, Robert D. Bryant
  • Patent number: 5125961
    Abstract: Substituted pyridines characterized by having been substituted in the 3-position with an isoxazolyl or isothiazolyl radical. A method of using such pyridines as herbicides and herbicidal compositions containing such pyridines are described. Methods of preparing such substituted pyridines are also disclosed.
    Type: Grant
    Filed: August 12, 1991
    Date of Patent: June 30, 1992
    Assignee: Monsanto Company
    Inventors: Susan M. Auinbauh, Len F. Lee, Lisa L. McDermott
  • Patent number: 5125956
    Abstract: Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR.sub.2 moiety where R.sub.2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and herbicidal use of these compounds.
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: June 30, 1992
    Assignee: Monsanto Company
    Inventors: Donald E. Korte, Len F. Lee