Abstract: This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: wherein R1 and R2 may be single substituents or fused to form spirocyclic or hetero-spirocyclic rings; R3 is H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 allyl C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, or substituted alknyl, CORC; RC is H, C1 to C3 alkyl, substituted C1 to C3 alkyl, aryl, substituted aryl, C1 to C3 alkoxy, substituted C1 to C3 alkoxy, C1 to C3 aminoalkyl, or substituted C1 to C3 aminoalkyl; R4 is H, halogen, CN, NO2, C1 to C6 alkyl, substituted C1 to C6 alkyl alkynyl, or substituted alkynyl, C1 to C6 alkoxy, substituted C1 to C6 alkoxy, amino, C1 to C6 aminoalkyl, or substituted C1 to C6 aminoalkyl; and R5 is selected from a trisubstituted benzene ring of a five or six membered ring with 1, 2, or 3 heteroatoms from the group including O, S, SO, SO2 or NR6 and

Abstract: Hot-fillable, blow molded, wide-mouth plastic containers having a pair of flex panels (11, 111, 211) for accommodating thermally induced volumetric and pressure variations while affording easy contents scoopability, and desirable labeling features. The containers are capable of being blow-molded from injection molded preforms or from extruded parisons. The containers may be hot-filled and retorted. A desirable base (27, 127, 227) for a retortable container is also disclosed.

Abstract: This invention provides compounds of the formula: wherein A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N; and A and B cannot both be CH; and when A and B both equal N, one N may be optionally substituted with an C1 to C6 alkyl group; R1 and R2 are independent substituents selected from the group of H, C1 to C6 alkyl, substituted C1 to C6 alkyl, C2 to C6 alkenyl, substituted C2 to C6 alkenyl, C2 to C6 alkynyl, substituted C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, substituted aryl, heterocyclic, substituted heterocyclic, CORA, or NRBCORA; or R1 and R2 are fused to form optionally substituted 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic ring, the heterocyclic ring containing one to three heteroatoms selected from the group of O, S and N; or pharmaceutically useful salts thereof.

Abstract: The present invention provides compounds which are agonists of the progesterone receptor and have the structures: wherein R1 and R2 are independent substituents selected from the group of H, optionally substituted C1 to C6 alkyl, alkenyl, alkynyl, or alkynyl groups C3 to C8 cycloalkyl, aryl, substituted aryl, or heterocyclic groups, or CORA or NRBCORA; or R1 and R2 are fused to form an optionally substituted 3 to 8 membered Spiro cyclic alkyl or alkenyl ring or a Spiro cyclic ring containing one to three heteroatoms selected from O, S and N; RA is selected from H, amino, or optionally substituted C1 to C3 alkyl, aryl, C1 to C3 alkoxy, or C1 to C3 aminoalkyl groups; RB is H, C1 to C3 alkyl, or substituted C1 to C3 alkyl; R3 is H, OH, NH2, CORC, or optionally substituted C1 to C6 alkyl, C3 to C6 alkenyl, or alkynyl groups; RC is selected from H or optionally substituted C1 to C3 alkyl, aryl, C1 to C3 alkoxy, or C1 to C3 aminoalkyl groups; Q1 is S, NR7, or CR8R9; R5 is an optionally trisubstitu

Abstract: A biostimulating substance, useful in agriculture, horticulture and microbial processes, is composed of acetic acid and a fossil humic substance containing solid humins and humic acid. A method for improving the biostimulating properties and stability of dispersions of fossil humic substances containing peat or lignite includes the step of mixing a fossil humic substance with acetic acid in an amount sufficient that the resulting suspension contains at least about 5 to about 25% by weight organic solids. The modified humic substance can be used as a biostimulant for enhancing plant growth and health and for increasing digestion of organic solids by microorganisms in sewage plants and similar facilities.

Abstract: Methods for efficient production of recombinant AAV are described. In one aspect, three vectors are introduced into a host cell. A first vector directs expression of cre recombinase, a second vector contains a promoter, a spacer sequence flanked by loxP sites and rep/cap, and a third vector contains a minigene containing a transgene and regulatory sequences flanked by AAV ITRs. In another aspect, the host cell stably or unducibly expresses cre recombinase and two vectors carrying the other elements of the system are introduced into the host cell.

Abstract: A stand having pedestals for providing a support for a pumpkin being carved and/or displayed. The stand also protects an underlying surface from juices and debris discharged from the pumpkin.

Abstract: A fail-safe fluid actuator comprising a piston slidably disposed within a cylinder. In the event of a pressure loss, the piston is urged to a fail-safe position by a plurality of externally mounted constant force spring mechanisms. In one embodiment the mechanisms are located at one end of the cylinder with a telescoping cover for protecting them from exposure and damage. In another embodiment the mechanisms are located at the side of the cylinder whereby the overall length of the actuator is significantly shortened. The fail-safe force applied to the piston by the spring mechanisms is externally adjustable, and they are readily accessible fur replacement or repair.

Abstract: This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: wherein: A is O, S, or NR4; B is a bond between A and C═Q, or the moiety CR5R6; R4, R5, R6 are independently selected from H or optionally substituted C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, or heterocyclic groups, or cyclic alkyl constructed by fusing R4 and R5 to from a 5 to 7 membered ring; R1 is selected from H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, substituted alkynyl, —COH, or optionally substituted —CO(C1 to C3 alkyl), —CO(aryl), —CO(C1 to C3 alkoxy), or —CO(C1 to C3 aminoalkyl) groups; R2 is selected from H, halogen, CN, NO2, or optionally substituted C1 to C6 alkyl C1 to C6 alkoxy, or C1 to C6 aminoalkyl gro

Abstract: A neck for an acoustic guitar made from a plywood material which is glued with and at least partially impregnated with a phenolic resin. The plywood neck is stronger and more durable than conventional neck structures and requires no further finishing steps during manufacture other than sanding and buffing. Preferably, a fingerboard made of a high pressure laminate material is adhesively secured to the neck. In addition, a bridge made of the same type of high pressure laminate as the fingerboard is preferably attached to the soundboard of the guitar body.

Abstract: A retractor having a retractable tether and a spring biased reel providing a retracting force throughout the full extension of the tether to take up any slack in the tether and to return the tether to its normal wound storage position on the reel. The retractor having a housing and a swivel attachment component extending from the housing which enables the housing of the retractor to pivot relative to the surface to which the retractor is connected. The general structure of the swivel attachment component permits ready assembly of any one of various configured swivel attachment components to the retractor housing.

Abstract: The present invention provides Bin1 genomic sequences and proteins encoded thereby. Also provided are compositions and methods utilizing these sequences and proteins in the diagnosis and treatment of cancers and hyperplastic disease states. Further provided are oligonucleotides derived from sequences encoding Bin1, as well as compositions and methods utilizing same for diagnostic and therapeutic purposes.

Abstract: A blow-molded plastic container (10) providing enhanced top loading capability. The container (10) has an inner peripheral surface (24) on which a plurality of integral, solid, inwardly and longitudinally extending ribs (26) are formed. Preferably, the ribs (26) extend throughout the entire container inner surface (24) from the top edge of the finish (20) to a mold parting line (28) on the base (14). A method and apparatus for making the container (10) is also disclosed.

Abstract: This invention provides a progesterone receptor antagonist of formula 1 having the structure wherein T is O, S, or absent; R1, and R2 are each, independently, hydrogen, alkyl, substituted alkyl; or R1 and R2 are taken together form a ring and together contain —CH2(CH2)nCH2—, —CH2CH2CMe2CH2CH2—, —O(CH2)pCH2—, —O(CH2)qO—, —CH2CH2OCH2CH2—, or —CH2CH2NR7CH2CH2—; n=1-5; p=1-4; q=1-4; R3 is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or CORA; RA is hydrogen, alkyl, substituted alky, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R4 is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R5 is hydrogen, allyl, or substituted alkyl; R6 is hydrogen, alkyl, substituted alkyl, or CORB; RB is hydrogen, alkyl, substituted alkyl, alko, substituted alkoxy, amino

Abstract: A sealing ring and rim assembly for use with an outer curing envelope to retread a tire casing. The assembly includes a rigid annular rim having a fixed diameter and a resiliently expandable elastomeric annular sealing rim captured on the rim. An inflatable bladder is located between the rim and the sealing ring so that, when the bladder is inflated, the sealing ring expands into uniform sealing engagement with an inner peripheral bead of the tire casing. The use of an inflatable bladder ensures that sealing pressure will be uniformly exerted so that an endless band of seal is created about the entire circumference of the tire bead. In addition, one particular size of the assembly is capable of use on a variety of tires having a tire bead circumference within a range of circumferences.

Abstract: A composition which elicits antibodies to multiple known variants of Tat protein of HIV-1 of both the B and non-B clades contains the peptide R1-Asp-Pro-Asn-Leu-Asp-Pro-Trp-Asn-R2 SEQ ID NO: 23, and preferably an additional at least two variants of a peptide or polypeptide of the formula: R1-Asp-Pro-Y7-Leu-Glu-Pro-Trp-Z12-R2 SEQ ID NO: 8. In this composition, at least one of the two variants contains Arg at Y7 and Lys at Z12, and in at least a second of the two variants Y7 is Asn and Z12 is Asn. Vaccinal and pharmaceutical compositions can contain one or more such peptides associated with carrier proteins, associated in multiple antigenic peptides, or as part of recombinant proteins. Diagnostic compositions and uses are described for assessing the immune status of vaccinated patients.

Abstract: This invention concerns cyclic combination therapies using progestational agents and indoline derivatives which are progesterone receptor antagonists of the general structure: wherein: A, B and D are N or CH, though not all can be CH; R1 and R2 are H, CORA, NRBCORA, or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, or aryl groups; or R1 and R2 form a spirocyclic ring; RA is H or optionally substituted alkyl aryl, alkoxy, or aminoalkyl; RB is H, alkyl alkyl; R3 is H, OH, NH2, alkyl, alkenyl, or CORC; RC is H, alkyl, aryl, alkoxy, or aminoalkyl; R4 is benzene or a 5 or 6 membered heteroaromatic ring; RF is H, alkyl, aryl, alkoxy, or aminoalkyl; RG is H or alkyl; R5 is H or alkyl; W is O or a chemical bond; or a pharmaceutically acceptable salt thereof. These methods may be used for contraception.

Abstract: A rapid method for modifying a viral capsid or envelope protein with a polyethylene glycol (PEG) is described. Also provided are methods of delivering a molecule using the PEG-modified viruses of the invention. Compositions containing the PEG-modified viruses of the invention, are characterized by improved gene expression, reduced neutralizing antibody and CTL production. Also provided are viral compositions having enhanced physical stability, in which the viruses are lyophilized in a formulation having a 1:1 ratio of sucrose and mannitol are provided.

Abstract: A process for blow-molding and coating plastic containers under conditions of positive control in a close-coupled, compact machine to enhance operational efficiency. According to one of the preferred methods, the containers are coated promptly after the containers are discharged from hot molds to take advantage of the residual heat of the freshly blown containers to enhance curing/drying of the coating and to enhance bonding of the coating to the container surface. According to another one of the preferred methods, the containers are aseptically filled and capped either before or after the containers are coated. Alternatively, the process can include hot-filling and capping of containers in which the containers are coated promptly after being hot-filled to take advantage of the elevated temperature of the hot-filled containers.