Abstract: The present invention describes novel soluble variants of type I membrane protein GA733-2 and methods of making and using them. In addition, the present invention describes a method of converting type I membrane proteins into secretory proteins which may be used for active immunotherapy against carcinomas and as reagents in the detection of GA733-2 expression on tumor cells.

Abstract: A copper foil with excellent laser drilling property, having a layer containing any one or more substances selected from indium, tin, cobalt, zinc, cobalt alloys, and nickel alloys on the face of the copper foil to be radiated with laser beams. A copper foil easy to be laser-processed and suitable for forming through hole and via hole with a small diameter at the time of manufacturing a printed circuit board and a method for manufacturing such a copper foil are achieved by improving the surface of a copper foil.

Abstract: Stable pluripotent trophoblast stem (TS) cell lines and uses of the cell lines are described. The cell lines comprise cells that (i) are capable of indefinite proliferation in vitro in an undifferentiated state, and (ii) are capable of differentiation into cells of the trophoblast lineage in vivo.

Abstract: At least one blow-molded plastic container and one compression molded lid are simultaneously produced in a blow mold. Preferably, the method and apparatus utilize a mold capable of simultaneously receiving a pair of extruded parisons. One of the parisons is utilized to produce a pair of aligned container bodies and the other of the parisons is utilized to form a pair of aligned closures. In this manner, a container and closure combination can be manufactured having perfect color matching and can be readily recycled in its entirety. In addition, the method and apparatus according to the present invention significantly reduces tooling costs and required machine capitol.

Abstract: Methods of measuring free and total chlorine content in solutions are provided without lowering the pH of the solution to the acid range by modifying a solution containing chlorine and water to contain a proton donating compound and electrochemically measuring the concentration of the chlorine in the solution. An additional potassium iodide reagent is added when total chlorine content is measured. Stable aqueous reagent solutions useful in automated chlorine analyzers which contain sodium bicarbonate, a base, and water or borax, water, and acid are also described. Finally, apparatuses for detecting the level of chlorine in water samples utilizing an automated chlorine detector, a cartridge having a solid proton donating compound, and optionally a standpipe are discussed.

Abstract: A process for vitrifying waste material containing environmentally hazardous metals or metal compounds includes drying a waste material using a flash dryer, where the drying is carried out at a temperature low enough to prevent volatilization of hazardous metals and metal compounds contained in the waste material. Preferably, more than about 95% of the water is removed form the waste material. The dried waste material is transferred from the flash dryer into a melting vessel, melted, collected and cooled to form a vitrified mass of waste material. Gases produced during the process of the invention are filtered, treated, and released into the atmosphere.

Abstract: This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.

Abstract: A valve comprises an assembly of elastomeric elements confined in a cylindrical space, with one end of the assembly engageable with a valve seat at one end of the cylindrical space. The valve is constructed to provide three successive converging and diverging sections in the fluid flow path, the intermediate section being provided by the valve element and seat. The restrictions exerts a choking for maintaining pressure in a steam system when the valve is used as a steam trap. A rigid, abrasion-resistant element, may be incorporated into one of the elastomeric elements, and a thermally responsive wax may be incorporated into one of the elements to alter its expansion characteristics. A plunger may be incorporated into the valve to exert a force on the elastomeric elements, allowing adjustment of the degree of subcooling when the device is used as a steam trap.

Abstract: A blow molded container having a multi-functional base which enables use of the container in both hot-fill operations and pasteurization/retort operations and enables efficient vertical stacking of like containers. To this end, a portion of the base is capable of flexing upwardly and/or downwardly in response to variations in pressures in a filled and sealed container. Structurally, the base has a discontinuous concave outer annular wall forming a discontinuous standing ring and an inner annular wall functioning as a flex panel. The inner annular wall connects outwardly to a plurality of radial webs extending at an elevation above the standing ring and connects inwardly to an anti-inverting, upwardly-projecting dome. Preferably, a shoulder extends radially inward on the inward facing side of the outer annular wall above a level of the standing ring to facilitate vertical stacking of containers having like bases.

Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described.

Abstract: Nucleic acid and amino acid sequences of the Omp85 proteins of N. gonorrhoeae and N. meningitidis, and fragments thereof are useful in vaccine compositions, therapeutic compositions and diagnostic compositions for use in the prevention, treatment and diagnosis of non-symptomatic gonococcal infection or symptomatic disease and non-symptomatic meningococcal infection and symptomatic disease. Antibodies are developed to these proteins and also useful in the compositions and methods described herein.

Abstract: This invention relates to substituted indoline derivative compounds which are antagonists of the progesterone receptor, their preparation and pharmaceutical utility, particularly including contraception and treatment of benign or malignant neoplastic diseases, having the general structure: wherein R1 and R2 may be single substituents or fused to form spirocyclic rings.

Abstract: An acoustic guitar having a soundboard and a head-plate made of a sheet of metal, such as a sheet of aluminum. The outward facing surfaces of the soundboard and head-plate are provided with a decorative appearance such as by etching or sanding a pattern thereon. The metal soundboard and head-plate provide the acoustic guitar with a unique appearance and enhance durability without adversely affecting the tonal qualities of the guitar.

Abstract: A liquid vaporizing and feeding apparatus, having high heat transfer efficiency and capable of producing a large flow of vaporized gas from a small amount of liquid, utilizes an inclined vaporization plate which is held at a set temperature by a heater. Liquid, discharged by a nozzle in the vicinity of the upper end of the vaporization plate, is vaporized as it flows down an inclined upper face of the vaporization plate. When the volume of the liquid collected on the vaporization plate 20 reaches a designated amount, a level sensor 40 stops the inflow of liquid through the nozzle. Then, as vaporization continues, and the liquid level falls, the sensor causes inflow of liquid to resume. The cycle of stopping and resuming flow of liquid is repeated to maintain a constant liquid level.

Abstract: A ballast block deck system includes a plurality of ballast blocks (12) laterally positioned to form an elevated deck (14) on an existing roof structure. Each block (12) has a predetermined thickness and multiple corner portions (22). A pedestal assembly (30) is located directly beneath the corner portions (22) of adjacent ballast blocks (12) to space and support the blocks (12) a spaced distance above the existing roof surface. The pedestal assembly (30) includes a support plate (34) having a support surface (40) for supporting the corner portions (22) thereon, a cornercap (42) which overlies the corner portions (22), and a fastener (44) which removably attaches the cornercap (42) to the support plate (34). When installed, the corner portions (22) of adjacent ballast blocks (12) are captured between the support plate (34) and cornercap (42) of the pedestal (30).

Abstract: An insulated concrete wall assembly having an embedded anchor plate which enables reliable mounting of fixtures, such as curtain rod brackets and the like, to an exposed surface of an interior wall of a building. The anchor plate is preferably an expanded metal plate having securement apertures of a size to receive and positively engage a fastener extending through wallboard and the anchor plate thereby permitting the fixture to be drawn into tight engagement with the wallboard by positive engagement of the fixture mounting fastener with the anchor plate. In addition, the anchor plate preferably has integrally formed securement projections, or spikes, which enable the anchor plate to be pressed into engagement with the rigid foam insulation before wallboard, such as drywall, is applied over the insulation. The invention also relates to a method of assembling an insulated concrete wall.

Abstract: The invention pertains to a method for examining a series of objects that are symmetrical in reference to a rotational axis, e.g., circular disks, during or after the manufacturing process of the disks. In particular, the invention pertains to the optical examination of circular data carriers, e.g., CD, DVDs, CD-Rs or the like. The invention proposes that each object contains at least one marking or is provided with at least one marking. The marking makes it possible to unequivocally determine the angular position of each object about the rotational axis in reference to the marking for objects manufactured in the same manufacturing process. At least one section of the objects is scanned by at least one scanning element, and the marking is detected during the examination process.

Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.

Abstract: A dyestuff capable of undergoing a clearly visible colour change when contacted with a color-developing material is dispersed in the body of a plastics film and used in the identification of goods. The film can be used for packaging of the goods or as a label or seal affixed to the goods. When testing the authenticity of packaging goods, the plastics film is marked with the color-developing chemical to produce a colored mark on the package. The dyestuff is preferably a latent dyestuff which is colorless and invisible to the eye under ambient conditions for use of the film but which forms a clearly visible color when contacted with the color-developing material.

Abstract: A roll-form spacer product providing air space and drainage passageways within a building structure. Preferably, the spacer product is a corrugated web of material having undulating front and rear faces and serpentine-shaped longitudinally extending edges. The faces include alternating arrays of grooves and ridges which extend perpendicular to the side edges and parallel to an axis of a spiral roll of the spacer. Thus, when the spacer is unrolled and applied to a building structure in a plurality of horizontally extending rows, the ridges and grooves are substantially vertically-disposed to form a plurality of unobstructed passageways for the drainage of moisture. Preferably, the web is made of an openwork mat of randomly convoluted polymeric filaments, and thus, enables ready circulation of air.