Abstract: A pharmaceutical composition comprising: (a) a tumor necrosis factor inhibitor; (b) a compound selected from the group consisting of reverse transcriptase inhibitors, protease inhibitor, a gene inhibitor, myristoylation inhibitors, cell-virus binding inhibitors, LTR promoter site inhibitors, ribosome inactivators, platelet aggregation inhibitors and prophylactic and therapeutic HIV vaccines, and (c) a pharmaceutical inert nontoxic carrier are described.

Abstract: This invention relates to the synthesis from PET (virgin, recycled, post consumer, or precursor raw materials) of novel water dispersible or water emulsifiable polyester resins having improved hydrophobicity or non-polar characteristics. These characteristics give the applied film of these dispersions or emulsions much improved water repellency while at the same time retaining their redispersible or reemulsifiable properties. Such resins can be used for many applications in the paper, textile, coatings, paint, construction, and other industries.

Abstract: The invention provides new carrier compositions containing a triglyceridic oil rich in DHA and anti-neoplastic drugs and a DHA-containing phospholipid.

Abstract: The present invention relates to a tube bending apparatus which has a portable size and is easy to handle, with less cost of bending. The bending apparatus comprises a base plate having an elongated frame mounted on it. The frame includes a top support plate and a bottom support plate parallel to each other, a square support tube and four support bars. A pair of lateral rollers are mounted on each side of the two support plates of the frame and a power means, such as a hydraulic or mechanical ram, is mounted to the support tube to provide a reciprocating movement. A mandrel is engaged to one end of the ram and also to a bending die member which has a semi-circular configuration on its front face and grooves extending on the semi-circular face for relieving stress during the bending operation. The ram is loaded with one or two springs for the convenience of changing and accommodating the bending die members when reloading different sizes of tubing.

Abstract: A novel method is proposed for the vegetative propagation of grasses and some dicots comprised first of growing sods of the desired cultivar over plastic sheeting in a sterile medium. When the planting has matured into a sod, it is harvested in strips which are milled and screened into milled turf pieces or plantlets that are approximately 1 to 3 inches long. In comparison to a sprig or stolon, a milled turf piece or plantlet is produced from a complete piece of sod grown over plastic in which the complete root system has been contained. The milled turf product includes plantlets with complete root, stem and leaf tissue all ready to grow. Bushel for bushel, the milled turf product is more dense with more growing points or meristems and per area it provides quicker grow-in.

Abstract: Bacillus licheniformis O.W.U. 138B and 88B and other bacterial strains capable of degrading feathers isolated from wild birds, are disclosed. The strains and the keratinases produced by these strains are useful for degrading waste feathers produced by commercial poultry processing; producing animal feed, fertilizer, or natural gas from poultry waste; and cleaning of certain fabrics.

Abstract: This invention relates to the synthesis from PET (virgin, recycled, post consumer, or precursor raw materials) of novel water dispersible or water emulsifiable polyester resins having improved hydrophobicity or non-polar characteristics. These characteristics give the applied film of these dispersions or emulsions much improved water repellency while at the same time retaining their redispersible or reemulsifiable properties. Such resins can be used for many applications in the paper, textile, coatings, paint, construction, and other industries.

Abstract: The administration of histidine is able to prevent and ameliorate tissue and cellular damage which is caused by damaging levels of cytokines and growth factors. It is shown that histidine, when administered in therapeutic quantities is able to inhibit cytokines and growth factors involved in cell and tissue damage. In addition, the method of administering histidine to inhibit these molecules can prevent and ameliorate tissue, vessel and cell damage from restenosis, burns, surgical procedures and other disorders which cause and result from damaged tissues, vessels and cells.

Abstract: The present invention relates to methods for protecting the eye from degenerative eye conditions by administering prophylactic histidine compositions. The invention also relates to methods for treating ocular inflammation resulting from various causative agents, by administering therapeutic histidine compositions. The invention relates further still to novel histidine compositions for carrying out the present methods.

Abstract: An innovative liquid mulch apparatus for the production of thin, lightweight and fastly growing sod over an impervious surface such as plastic sheeting are provided. The apparatus of the invention includes, among other components, a transportable agitating tank and a trailing planter assembly that facilitates the liquid mulch method of manufacturing sods.

Abstract: A method for treatment of malignant melanoma by administering an effective amount of thalidomide alone or in combination with other anti-melanoma drugs.

Abstract: A method is disclosed for delivering biologically active agents to a mammalian brain by administering a complex of the biologically active agent with a polycationic carrier coupled to 2-20 eicosapentaenoic acid or docosahexaenoic acid moieties and additional eicosapentaenoic acid or docosahexaenoic acid moieties. The polycationic carrier is poly-lysine, poly-arginine or poly-ornithine of 5-50 amino acid residues. The addition of a targeting moiety selected from tetanus toxin C fragrant, .alpha.-bungarotoxin and nerve growth factor to the complex facilitates delivery of the biologically active agent to glial tissue, or to cortical, cholinergic and adrenergic neurons.

Abstract: Histidine has been found to be efficacious in preventing ischemic/reperfusion induced myocardial injury both functionally and ultrastructurally. Isolated perfused rat hearts (n=8/group) were subjected to 30 minutes of global ischemia and 20 minutes of reperfusion. Histidine concentrations ranging from 10 to 50 mM were given throughout the experiment. During ischemia and reperfusion without histidine the contractile function and coronary flow were 59.+-.10% and 78.+-.6% of control, respectively. Perfusion with histidine (25 mM and above) resulted in significant increases in contractility (94.+-.4%) and coronary flow (92.+-.4) levels. The incidence of arrhythmias (ventricular tachycardia and ventricular fibrillation) during reperfusion was 100 percent (8/8) in the ischemic/reperfused group with an average duration of 13.23.+-.4.48 min. The addition of 25 mM histidine to the perfusion medium reduced the incidence and duration of arrhythmias significantly (mean.+-.SEM 2.25.+-.0.98 min) (P<0.01).

Abstract: The present invention describes polymers having high nitrogen content and high cationic charges derived from dicyanimide, dicyandiamide or guanidine and inorganic ammonium salts. The new compositions are useful in the pulp and paper industries as pitch control agents, as well as adjuvants such as in felt cleaner applications. The new materials are also useful in paper sizing, as retention aids, as antistatic agents, and as coagulants and flocculating agents.

Abstract: A treatment modality for infectious diseases and pulmonary conditions that result from the inflammatory responses by tissues to infections by microorganisms, including but not limited to viruses, retroviruses, bacteria, or other microorganisms, or toxins that arise from microorganisms comprises administering an effective amount of histidine to the affected subject to combat the disease or the distress condition resulting therefrom.

Abstract: Methods of treatment for inflammatory and autoimmune dermatoses which comprises topical and/or systemic administration of a therapeutically-effective amount of thalidomide alone or in combination with other dermatological agents.

Abstract: The present invention describes cyclopropylindole cytotoxic prodrugs of formulas (I), (II) and (III) as shown in the specification. The present invention is also directed to a method for the site-specific treatment of neoplastic diseases in a mammal which method includes the following steps: (i) administering to an afflicted mammal an effective amount of a targeting agent- enzyme donor peptide conjugate wherein the targeting agent is selected from the group of antibodies, monoclonal antibodies, adhesion molecules and tumor cell surface binding ligands; (ii) administering to the afflicted mammal an effective amount of an enzyme acceptor dimer thereby forming active enzymatic sites at a tumor cell surface; and (iii) administering to the afflicted mammal a therapeutically effective amount of an enzyme-activateable, cytotoxic pro-drug thereby releasing the cytotoxic drug at the tumor site.

Abstract: In accordance with the present invention, a method is provided for treating reperfusion injury, ischemia and runaway inflammatory conditions with thalidomide alone or in combination with other drugs selected from the group consisting of nitrates, beta-adrenoceptor blocking agents, anti-platelet/thrombolytic drugs, drugs acting as the arachindonic acid cascade and calcium antagonists. Pharmaceutical compositions comprising thalidomide alone or in combination with other drugs are also provided.

Abstract: Compounds of the formula ##STR1## wherein the substituents are as defined in the disclosure. The compounds are particularly useful for inhibiting damage to a variety of mammalian tissue that are jeopardized, for example, during runaway inflammatory conditions due to the damaging presence of singlet oxygen, the hydroxyl radical, cytokines and growth factors. The compounds are also useful in inhibiting damage to cardiac and central nervous system tissues during reperfusion.

Abstract: A novel mulch/medium/matrix method that stabilizes sods grown on a solid base in large rolls in contiguous beds is described. A vegetative or organic mulch is placed over a solid base which is typically plastic sheeting. A suitable growing medium is infiltrated into the mulch, filling the voids and interstices to produce a coherent matrix which is stable in severe thunderstorms. Seed or sprigs are placed into the matrix either before or after the application of the growing medium which is then irrigated, fertilized, and eventually mowed in the conventional manner. The primary rooting of the growing material intertwines the mulch/medium/matrix and binds and knits it into a sod. As the mulch gradually decomposes, it is replaced by primary rooting forming a thin, bona fide sod which can be one half the weight of a conventional mineral sod. The sod is harvested in large rolls, typically four feet wide and comprising 20-50 square yards.