Abstract: A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.
Type:
Grant
Filed:
November 6, 1995
Date of Patent:
August 3, 1999
Assignee:
Abbott Laboratories
Inventors:
David A. Riley, Ashok V. Bhatia, Steven A. Chamberlin, Gregg E. Robinson
Abstract: Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R.sup.1, R.sup.2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibiting neurotransmitter release; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to activate or inhibit neurotransmitter release in mammals.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
June 22, 1999
Assignee:
Abbott Laboratories
Inventors:
Nan-Horng Lin, Mark W. Holladay, Melwyn A. Abreo, David E. Gunn, Suzanne A. Lebold, Richard L. Elliott, Yun He
Abstract: The invention relates to a novel substance with activity against insect pests of the order Diptera. The invention further relates to the substance which acts together with a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties. The invention further relates to a novel strain(s) of Bacillus thuringiensis which produces such a substance. The invention further relates to pesticidal compositions comprising the substance and a pesticidal carrier, or the substance and a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties as well as methods of using the pesticidal compositions to control a pest.
Type:
Grant
Filed:
May 27, 1997
Date of Patent:
June 15, 1999
Assignee:
Abbott Laboratories
Inventors:
Chi-Li Liu, William D. Lidster, Carmen Sanchez Lopez
Abstract: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.
Type:
Grant
Filed:
November 21, 1997
Date of Patent:
April 6, 1999
Assignee:
Abbott Laboratories
Inventors:
Michael D. Meyer, Robert J. Altenbach, Fatima Z. Basha, William A. Carroll, Irene Drizin, James F. Kerwin, Jr., Michael D. Wendt
Abstract: The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular weight of about 130,000 daltons and a rhomboidal crystal consisting essentially of two delta-endotoxins, each having a molecular weight of about 33,000 daltons, as well as spores, crystals, delta-endotoxins and/or mutants thereof. The invention also relates to insecticidal compositions obtainable therefrom. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) from the order Lepidoptera and/or Coleoptera. The invention also relates to isolated DNA sequences encoding the delta-endotoxins.
Type:
Grant
Filed:
November 10, 1994
Date of Patent:
March 9, 1999
Assignee:
Abbott Laboratories
Inventors:
Chi-Li Liu, Lee Fremont Adams, Patricia A. Lufburrow, Michael David Thomas
Abstract: A process of protecting a 1,2- or 1,3-aminoalcohol for reductive amination coupling is provided. The alcohol is protected with trimethylsilyl chloride. Trimethylsilyl protected norepinephrine derivatives useful in the preparation of arbutamine are also provided.
Abstract: The invention relates to a mutant of Bacillus thuringiensis which produces a larger amount of crystal delta-endotoxin with a greater pesticidal activity as compared to the corresponding parental strain. The mutant may also have a larger crystal size as compared to the corresponding parental strain. The crystal delta-endotoxin produced by the mutant Bacillus thuringiensis will have an activity directed towards the same pest(s) as its parental Bacillus thuringiensis crystal delta-endotoxin. The invention further relates to a method for producing such a mutant, compositions comprising such a mutant as well as methods for controlling a pest(s) using these compositions.
Type:
Grant
Filed:
August 28, 1997
Date of Patent:
February 23, 1999
Assignee:
Abbott Laboratories
Inventors:
Chi-Li Liu, Pamela G. Marrone, Jewel M. Payne, Hanne Gurtler, Annette S. Petersen
Abstract: The invention relates to a novel substance with activity against insect pests of the order Diptera. The invention further relates to the substance which acts together with a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties. The invention further relates to a novel strain(s) of Bacillus thuringiensis which produces such a substance. The invention further relates to pesticidal compositions comprising the substance and a pesticidal carrier, or the substance and a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties as well as methods of using the pesticidal compositions to control a pest.
Type:
Grant
Filed:
July 11, 1994
Date of Patent:
January 12, 1999
Assignee:
Abbott Laboratories
Inventors:
Chi-Li Liu, William D. Lidster, Carmen Sanchez Lopez
Abstract: The present invention relates to novel compositions of and methods of manufacture of controlled release formulations obtained by mixing molten drugs with molten additives to produce homogeneous drug-additive composites.
Type:
Grant
Filed:
June 20, 1997
Date of Patent:
September 15, 1998
Assignee:
Abbott Laboratories
Inventors:
Howard Cheskin, Thomas J. Hale, Kurt G. Van Scoik, Ji Zhou
Abstract: Novel bacterial isolates of B. thuringiensis are disclosed which have enhanced toxicity with respect to previously resistant or insufficiently susceptible insect species, including, but not limited to, Plutella xylostella, Spodoptera frugiperda and Spodoptera exigua, as well as certain secondary pests such as Trichoplusia ni. Such isolates may be characterized by their possession of a particular subset of the genes coding for the various B. thuringiensis .delta.-endotoxin proteins and by a characteristic plasmid profile, or array, known to be associated therewith.
Type:
Grant
Filed:
February 10, 1995
Date of Patent:
September 1, 1998
Assignee:
Abbott Laboratories
Inventors:
David R. Wilcox, Robert A. Smith, Terry A. Benson
Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.
Type:
Grant
Filed:
December 13, 1996
Date of Patent:
September 1, 1998
Assignee:
Abbott Laboratories
Inventors:
Patricia A. Oliver-Shaffer, Bikshandarkoil A. Narayanan, James E. Resek, Pulla Reddy Singam
Abstract: The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular weight of about 130,000 daltons and a rhomboidal crystal consisting essentially of two delta-endotoxins, each having a molecular weight of about 33,000 daltons, as well as spores, crystals, delta-endotoxins and/or mutants thereof. The invention also relates to insecticidal compositions obtainable therefrom. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) from the order Lepidoptera and/or Coleoptera. The invention also relates to isolated DNA sequences encoding the delta-endotoxins.
Type:
Grant
Filed:
May 3, 1995
Date of Patent:
June 23, 1998
Assignee:
Abbott Laboratories
Inventors:
Chi-Li Liu, Lee Fremont Adams, Patricia A. Lufburrow, Michael David Thomas
Abstract: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
Type:
Grant
Filed:
May 30, 1995
Date of Patent:
June 16, 1998
Assignee:
Abbott Laboratories
Inventors:
Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen
Abstract: A method for the systematic and efficient synthetic preparation and identification of metabolites of a pharmaceutical product in order to study possible toxic and/or otherwise biologically-active metabolites of such pharmaceutical products as early and conveniently as possible in the very expensive drug development process, comprising adding samples of the pharmaceutical product to a series of combinations of a synthetic metalloporphyrin (SMP) with a synthetic metalloporphyrin-co-oxidizing reagent in the presence of a suitable solvent, under specified conditions, in a manner such that each sample of pharmaceutical product is reacted with a different combination of synthetic metalloporphyrin, SMP-co-oxidizing reagent and solvent, followed by separation and isolation of the resulting oxidative products, then confirmation of the identity of metabolites from the pre-identified oxidative products by appropriate animal model studies, and subjecting the actual metabolites prepared in larger quantities by the above m
Type:
Grant
Filed:
September 12, 1995
Date of Patent:
June 2, 1998
Assignee:
Abbott Laboratories
Inventors:
Mukund S. Chorghade, David H. Dolphin, David R. Hill, Fumio Hino, Elaine C. Lee
Abstract: A process for the crystallization of an iron-dextran complex in readily-filterable form comprising adding slowly, with stirring, an acidified aqueous iron-dextran solution to a vessel containing a water miscible organic solvent such as methanol, as well as crystalline iron-dextran complexes so prepared.
Abstract: A prefilter bag for insertion into a standard filtration bag apparatus, having a filtration assembly comprising a seamless filter membrane having uniform pore openings preselected within the range of between about 2 and about 50 microns (.mu.) and a linearly channeled, non-deformable, semi-rigid liquid transport thermoplastic sheet in the form of a molded webbing or netting in contact with the upper surface of the filter membrane; said webbing having marginal edges which are coextensive with those of the membrane; said assembly adapted to be shaped by continuous winding of the assembly upon itself for 2 to 5 complete convolutions around a tubular mandrel so as to form a cylindrical tube or cone; the bottom of said cylinder being sealed to prevent liquid leakage and the top of said cylinder, forming a liquid inlet opening, being sealed to a retaining ring adapted to be inserted in, attached to or sealed to an outer, retaining ring of a non-wrapped filter bag.
Type:
Grant
Filed:
November 26, 1996
Date of Patent:
May 26, 1998
Assignee:
ISP Investments Inc.
Inventors:
Moshe Gershenson, Robert S. Elliott, John Pearson, Edward G. Malawer
Abstract: A method of stabilizing an aqueous solution of an acid copolymer of maleic acid and a C.sub.1 -C.sub.5 alkyl vinyl ether against degradation in viscosity or molecular weight upon storage for an extended period of time in aqueous solution at ambient conditions, with a single stabilizing agent, which comprises forming the acid copolymer directly from a slurry of corresponding anhydride in an organic solvent by hydrolysis in water, and adding including ethylenediamine tetraacetic acid (EDTA), or salt thereof, as the single stabilizing agent to the solution either before or after hydrolysis.
Type:
Grant
Filed:
September 13, 1995
Date of Patent:
April 14, 1998
Assignee:
ISP Investments Inc.
Inventors:
Chi-San Wu, James Curry, James P. Cullen, John S. Mc Ewan
Abstract: This invention relates to a coprecipitated binder composition used for the compression of pharmaceutically and agriculturally active components to provide a non-friable pill or tablet of increased hardness with remarkably improved rate of dissolution and improved stability in aqueous solution. The invention also relates to the process for preparing the binder and to its incorporation in a formulation with the active ingredient.