Patents Represented by Attorney J. Ward
  • Patent number: 5932774
    Abstract: A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: August 3, 1999
    Assignee: Abbott Laboratories
    Inventors: David A. Riley, Ashok V. Bhatia, Steven A. Chamberlin, Gregg E. Robinson
  • Patent number: 5914328
    Abstract: Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R.sup.1, R.sup.2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibiting neurotransmitter release; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to activate or inhibit neurotransmitter release in mammals.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 22, 1999
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Mark W. Holladay, Melwyn A. Abreo, David E. Gunn, Suzanne A. Lebold, Richard L. Elliott, Yun He
  • Patent number: 5912162
    Abstract: The invention relates to a novel substance with activity against insect pests of the order Diptera. The invention further relates to the substance which acts together with a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties. The invention further relates to a novel strain(s) of Bacillus thuringiensis which produces such a substance. The invention further relates to pesticidal compositions comprising the substance and a pesticidal carrier, or the substance and a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties as well as methods of using the pesticidal compositions to control a pest.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: June 15, 1999
    Assignee: Abbott Laboratories
    Inventors: Chi-Li Liu, William D. Lidster, Carmen Sanchez Lopez
  • Patent number: 5905134
    Abstract: Polymers can be prepared in solution by continuously distilling solvent from a solution of diacid prepolymers.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: May 18, 1999
    Assignee: Abbott Laboratories
    Inventors: John J. Hufnagel, Ashok V. Bhatia, David A. Riley, Greg E. Robinson
  • Patent number: 5891882
    Abstract: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: April 6, 1999
    Assignee: Abbott Laboratories
    Inventors: Michael D. Meyer, Robert J. Altenbach, Fatima Z. Basha, William A. Carroll, Irene Drizin, James F. Kerwin, Jr., Michael D. Wendt
  • Patent number: 5879676
    Abstract: The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular weight of about 130,000 daltons and a rhomboidal crystal consisting essentially of two delta-endotoxins, each having a molecular weight of about 33,000 daltons, as well as spores, crystals, delta-endotoxins and/or mutants thereof. The invention also relates to insecticidal compositions obtainable therefrom. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) from the order Lepidoptera and/or Coleoptera. The invention also relates to isolated DNA sequences encoding the delta-endotoxins.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: March 9, 1999
    Assignee: Abbott Laboratories
    Inventors: Chi-Li Liu, Lee Fremont Adams, Patricia A. Lufburrow, Michael David Thomas
  • Patent number: 5874601
    Abstract: A process of protecting a 1,2- or 1,3-aminoalcohol for reductive amination coupling is provided. The alcohol is protected with trimethylsilyl chloride. Trimethylsilyl protected norepinephrine derivatives useful in the preparation of arbutamine are also provided.
    Type: Grant
    Filed: April 5, 1996
    Date of Patent: February 23, 1999
    Assignee: Abbott Laboratories
    Inventors: William T. Monte, Aline C. Lindbeck
  • Patent number: 5874289
    Abstract: The invention relates to a mutant of Bacillus thuringiensis which produces a larger amount of crystal delta-endotoxin with a greater pesticidal activity as compared to the corresponding parental strain. The mutant may also have a larger crystal size as compared to the corresponding parental strain. The crystal delta-endotoxin produced by the mutant Bacillus thuringiensis will have an activity directed towards the same pest(s) as its parental Bacillus thuringiensis crystal delta-endotoxin. The invention further relates to a method for producing such a mutant, compositions comprising such a mutant as well as methods for controlling a pest(s) using these compositions.
    Type: Grant
    Filed: August 28, 1997
    Date of Patent: February 23, 1999
    Assignee: Abbott Laboratories
    Inventors: Chi-Li Liu, Pamela G. Marrone, Jewel M. Payne, Hanne Gurtler, Annette S. Petersen
  • Patent number: 5859235
    Abstract: The invention relates to a novel substance with activity against insect pests of the order Diptera. The invention further relates to the substance which acts together with a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties. The invention further relates to a novel strain(s) of Bacillus thuringiensis which produces such a substance. The invention further relates to pesticidal compositions comprising the substance and a pesticidal carrier, or the substance and a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties as well as methods of using the pesticidal compositions to control a pest.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: January 12, 1999
    Assignee: Abbott Laboratories
    Inventors: Chi-Li Liu, William D. Lidster, Carmen Sanchez Lopez
  • Patent number: 5807574
    Abstract: The present invention relates to novel compositions of and methods of manufacture of controlled release formulations obtained by mixing molten drugs with molten additives to produce homogeneous drug-additive composites.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: September 15, 1998
    Assignee: Abbott Laboratories
    Inventors: Howard Cheskin, Thomas J. Hale, Kurt G. Van Scoik, Ji Zhou
  • Patent number: 5801046
    Abstract: Novel bacterial isolates of B. thuringiensis are disclosed which have enhanced toxicity with respect to previously resistant or insufficiently susceptible insect species, including, but not limited to, Plutella xylostella, Spodoptera frugiperda and Spodoptera exigua, as well as certain secondary pests such as Trichoplusia ni. Such isolates may be characterized by their possession of a particular subset of the genes coding for the various B. thuringiensis .delta.-endotoxin proteins and by a characteristic plasmid profile, or array, known to be associated therewith.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: September 1, 1998
    Assignee: Abbott Laboratories
    Inventors: David R. Wilcox, Robert A. Smith, Terry A. Benson
  • Patent number: 5801250
    Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: September 1, 1998
    Assignee: Abbott Laboratories
    Inventors: Patricia A. Oliver-Shaffer, Bikshandarkoil A. Narayanan, James E. Resek, Pulla Reddy Singam
  • Patent number: 5770431
    Abstract: The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular weight of about 130,000 daltons and a rhomboidal crystal consisting essentially of two delta-endotoxins, each having a molecular weight of about 33,000 daltons, as well as spores, crystals, delta-endotoxins and/or mutants thereof. The invention also relates to insecticidal compositions obtainable therefrom. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) from the order Lepidoptera and/or Coleoptera. The invention also relates to isolated DNA sequences encoding the delta-endotoxins.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: June 23, 1998
    Assignee: Abbott Laboratories
    Inventors: Chi-Li Liu, Lee Fremont Adams, Patricia A. Lufburrow, Michael David Thomas
  • Patent number: 5767144
    Abstract: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: June 16, 1998
    Assignee: Abbott Laboratories
    Inventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen
  • Patent number: 5760216
    Abstract: A method for the systematic and efficient synthetic preparation and identification of metabolites of a pharmaceutical product in order to study possible toxic and/or otherwise biologically-active metabolites of such pharmaceutical products as early and conveniently as possible in the very expensive drug development process, comprising adding samples of the pharmaceutical product to a series of combinations of a synthetic metalloporphyrin (SMP) with a synthetic metalloporphyrin-co-oxidizing reagent in the presence of a suitable solvent, under specified conditions, in a manner such that each sample of pharmaceutical product is reacted with a different combination of synthetic metalloporphyrin, SMP-co-oxidizing reagent and solvent, followed by separation and isolation of the resulting oxidative products, then confirmation of the identity of metabolites from the pre-identified oxidative products by appropriate animal model studies, and subjecting the actual metabolites prepared in larger quantities by the above m
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: June 2, 1998
    Assignee: Abbott Laboratories
    Inventors: Mukund S. Chorghade, David H. Dolphin, David R. Hill, Fumio Hino, Elaine C. Lee
  • Patent number: 5756715
    Abstract: A process for the crystallization of an iron-dextran complex in readily-filterable form comprising adding slowly, with stirring, an acidified aqueous iron-dextran solution to a vessel containing a water miscible organic solvent such as methanol, as well as crystalline iron-dextran complexes so prepared.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: May 26, 1998
    Assignee: Abbott Laboratories
    Inventors: William T. Monte, Laurie Scaggs
  • Patent number: 5755962
    Abstract: A prefilter bag for insertion into a standard filtration bag apparatus, having a filtration assembly comprising a seamless filter membrane having uniform pore openings preselected within the range of between about 2 and about 50 microns (.mu.) and a linearly channeled, non-deformable, semi-rigid liquid transport thermoplastic sheet in the form of a molded webbing or netting in contact with the upper surface of the filter membrane; said webbing having marginal edges which are coextensive with those of the membrane; said assembly adapted to be shaped by continuous winding of the assembly upon itself for 2 to 5 complete convolutions around a tubular mandrel so as to form a cylindrical tube or cone; the bottom of said cylinder being sealed to prevent liquid leakage and the top of said cylinder, forming a liquid inlet opening, being sealed to a retaining ring adapted to be inserted in, attached to or sealed to an outer, retaining ring of a non-wrapped filter bag.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: May 26, 1998
    Assignee: ISP Investments Inc.
    Inventors: Moshe Gershenson, Robert S. Elliott, John Pearson, Edward G. Malawer
  • Patent number: 5739183
    Abstract: A method of stabilizing an aqueous solution of an acid copolymer of maleic acid and a C.sub.1 -C.sub.5 alkyl vinyl ether against degradation in viscosity or molecular weight upon storage for an extended period of time in aqueous solution at ambient conditions, with a single stabilizing agent, which comprises forming the acid copolymer directly from a slurry of corresponding anhydride in an organic solvent by hydrolysis in water, and adding including ethylenediamine tetraacetic acid (EDTA), or salt thereof, as the single stabilizing agent to the solution either before or after hydrolysis.
    Type: Grant
    Filed: September 13, 1995
    Date of Patent: April 14, 1998
    Assignee: ISP Investments Inc.
    Inventors: Chi-San Wu, James Curry, James P. Cullen, John S. Mc Ewan
  • Patent number: 5734006
    Abstract: This invention relates to a coprecipitated binder composition used for the compression of pharmaceutically and agriculturally active components to provide a non-friable pill or tablet of increased hardness with remarkably improved rate of dissolution and improved stability in aqueous solution. The invention also relates to the process for preparing the binder and to its incorporation in a formulation with the active ingredient.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: March 31, 1998
    Assignee: ISP Investments Inc.
    Inventor: Kolazi S. Narayanan
  • Patent number: 5731463
    Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: March 24, 1998
    Assignee: Abbott Laboratories
    Inventors: Xiu C. Wang, Ashok V. Bhatia, Steven Chamberlin, Luping Liu