Abstract: The present invention relates to 1-adamantyl-3-(phenylsulfonyl)thioureas of the formula ##STR1## wherein R is lower alkyl, amino or lower alkanoylamino to methods of preparation thereof and to their use in the treatment and prevention of viral infections in mammalian and avian hosts.

Abstract: D-Homopregnanes of the formula ##STR1## wherein X is hydrogen, Y is hydroxy or X and Y taken together denote an oxygen to carbon bond; R.sup.6 is hydrogen, R.sup.7 is hydrogen, lower alkanoylthio or aroylthio, or R.sup.6 and R.sup.7 taken together denote a carbon to carbon bond and the dotted line in the 1,2-position of the A-ring together with the corresponding solid line denotes a single or double carbon to carbon bond or a pharmaceutically acceptable basic addition salt thereof when Y is hydroxy having diuretic activity are disclosed.

Abstract: Method for the determination of an amino benzoic acid or aminosulphonic acid in urine, plasma or serum. The method consists essentially in reacting a urine, plasma or serum sample with a compound of the 4-phenyl-spiro[furan-2(3H)1'-phthalan]-3,3'-dione type or with a compound of the 2-methoxy-2,4-diphenyl-3(2H)-furanone type or with o-phthaldialdehyde and subsequently carrying out a photometric measurement.

Abstract: The present invention is directed to 3-oxo, 6,9-hydro or halo, 11-oxo or (.alpha.--H,.beta.--OH), 17a-alkanoyloxy, 17a.beta.-carboxylate D-homosteroids which are useful as antiinflammatory agents.

Abstract: Control plasma of non-human origin to be utilized in the monitoring of oral anticoagulant therapy in human beings, prepared from blood of stable anticoagulated mammals, is described.

Abstract: The present disclosure is directed to 6-lower alkoxy-25,26-(lower alkyl or lower alkylene)methylene dioxy-3,5-cyclocholest-22-ene derivatives which are useful in the manufacture of 25,26-dihydroxycholecalciferol.

Abstract: An adsorption process for the selective removal of naphthalenic hydrocarbons in the waste water from a petrochemical operation which comprises contacting the effluent waste water for relatively short periods with activated carbon which has become saturated with respect to non-naphthalenic organics. Contact of the waste water streams with the saturated carbon is continued until the breakthrough of naphthalenic compounds in the waste water exceeds a predetermined concentration, such as 2 ppm. It has been found that efficient removal of naphthalenic compounds can be effected by contacting the waste water for relatively short contact times, for example 10 minutes, notwithstanding the fact that the activated carbon has previously become saturated with respect to non-naphthalenic compounds.

Abstract: Benzoxazole derivatives represented by the formula ##STR1## wherein R is in the 5- or 6-position and is hydrogen or an alkyl group containing 1 to 4 carbon atoms and R.sup.1 and R.sup.2 are independently hydrogen, an alkyl group containing 1 to 4 carbon atoms or a group having the formula--(XO).sub.n --H, wherein X is ethylene or ethylene substituted by methyl or ethyl and which contains a total of 2 to 4 carbon atoms and n is an integer of 1 to 10, at least one of R.sup.1 and R.sup.2 being other than hydrogen, or R.sup.1 and R.sup.2, taken together with the nitrogen to which they are attached, form a 5- to 7-membered, saturated heterocyclic ring,and cosmetically acceptable salts thereof. The subject compounds, in combination with a suitable cosmetic carrier, are useful as radiation absorbers, i.e., UV-A filters.

Abstract: The quantity and quality of liquids produced from solid coal can be enhanced by a process comprising a liquefaction zone and a pyrolysis reactor, preferably a fluid coking zone, wherein the heavy liquids obtained in the pyrolysis reactor, e.g., 1000.degree. F.+ materials having a Conradson Carbon content of at least 15 wt. % are recycled to the liquefaction zone, rather than to the pyrolysis reactor, for further treatment under hydrogenation conditions and, consequently, conversion of the heavy liquids to lower boiling liquids which may be removed from the pyrolysis reactor feed by distillation is achieved.

Abstract: A rapid cytopathic effect inhibition assay for interferon is disclosed. The assay can be completed in about 16 hours or less, allowing its use to assist in clinical diagnosis of viral infections and also, in monitoring the production and purification of interferon whether leukocyte or fibroblast.

Abstract: The amino acid 2-amino-4-(2-aminoethoxy)-trans-but-3-enoic acid can be conveniently prepared via novel intermediates from a 2,2'-disubstituted diethyl ether and a dialkyl N-protected amidomalonate starting material using a multi-step process. Preferred starting materials are bis-2-chloroethyl ether and diethyl acetamidomalonate. The process, in a preferred embodiment, proceeds through the key intermediate ethyl-2-acetamido-4-[2-(2-phthalimido)ethoxy]-but-2-enoate.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.

Abstract: The present disclosure is directed to the synthesis and biological activity of [D-Thr.sup.2, .DELTA..sup.3 Pro.sup.5 ]-enkephalinamide. The subject compound is useful as an agent for the inhibition of diarrhea and also exhibits analgesic activity.

Abstract: A multi-step synthesis of chenodeoxycholic acid from 3-keto-bisnorcholenol, a compound readily obtained from the abundant plant sterol .beta.-sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduction of the 7-alpha hydroxy group into 3-keto-bisnorcholenol.

Abstract: The present disclosure relates to a chromatographic device for the simultaneous collection and evaporation of sequential volatile non-aqueous eluates. The device integrates collection and evaporation steps by continuously feeding the collected eluate directly to an evaporation vessel via a column delivery tube. As the solvent is evaporated from the evaporation vessel, eluate is continuously fed to said vessel, thereby eliminating the need for manual transfer and reducing the chances of contamination. The device increases the surface area available for evaporation, allows for the evaporation of volumes of solvent greater than the capacity of the evaporation vessel and allows for as much as a 5-fold reduction in the time necessary to carry out the chromatography and evaporation procedure.

Abstract: This disclosure relates to 3-hemisuccinate or 3-hemiglutarate derivatives of the biologically active metabolites of Vitamin D.sub.3 which possess Vitamin D activities and uses. The subject compounds also are useful as haptens which can be used to prepare immunogens which in turn elicit antibodies selective to said respective Vitamin D.sub.3 metabolites.

Abstract: A fermentation process for the preparation of 7.alpha.-hydroxylated steroids utilizing strains of the genus Mucor is disclosed. The 7.alpha.-hydroxylated steroids are useful intermediates for the synthesis of chenodeoxycholic acid as well as steroidal hormones.

Abstract: D-Homopregnanes of the formula ##STR1## wherein X is hydrogen, Y is hydroxy or X and Y taken together denote an oxygen to carbon bond; R.sup.6 is hydrogen, R.sup.7 is hydrogen, lower alkanoylthio or aroylthio, or R.sup.6 and R.sup.7 taken together denote a carbon to carbon bond and the dotted line in the 1,2-position of the A-ring together with the corresponding solid line denotes a single or double carbon to carbon bondor a pharmaceutically acceptable basic addition salt thereof when Y is hydroxy having diuretic activity are disclosed.

Abstract: D-Homopregnanes of the formula ##STR1## wherein the dotted line in the 1,2-position together with the corresponding solid line denotes a single or double carbon-carbon bond; R.sup.6 is hydrogen, fluoro, chloro or methyl; R.sup.9 is hydrogen, fluoro, chloro or bromo; R.sup.11 is hydroxyl, acyloxy, fluoro or chloro; and R.sup.17a is hydroxyl or acyloxy with the proviso that when R.sup.9 is fluoro, chloro or bromo and R.sup.11 is fluoro or chloro, the atomic number of R.sup.11 is less than or equal to that of R.sup.9 ; and with the further proviso that when R.sup.6 is hydrogen, and R.sup.11 and R.sup.17a are hydroxy or when R.sup.6 is fluoro, R.sup.11 and R.sup.17a are hydroxyl and the dotted line in the 1,2-position together with the corresponding solid line denotes a single carbon-carbon bond, R.sup.9 is fluoro, chloro or bromo and processes for the preparation thereof are disclosed.

Abstract: 14.beta.-Hydroxyandrostanes and processes for the preparation thereof in which the 14.beta.-hydroxy group is fabricated internally by means of a novel cyclization of 8,14-seco-4,6,9(11)-androstatrien-3,14,17-triones is disclosed.The 14.beta.-hydroxyandrostanes are useful as precursors for the synthesis of cardenolides and related products.