Patents Represented by Attorney, Agent or Law Firm James R. Nelson
  • Mercapto-acylamino acid antihypertensives
    Patent number: 4929641
    Abstract: Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating hypertension are disclosed.
    Type: Grant
    Filed: May 11, 1988
    Date of Patent: May 29, 1990
    Assignee: Schering Corporation
    Inventors: Martin F. Haslanger, Bernard R. Neustadt, Elizabeth M. Smith
  • Naphthyridine derivatives and method for treating allergic reactions
    Patent number: 4916131
    Abstract: 1-Substituted naphthyridines and pyrido-pyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and hyperproliferative skin diseases and in suppressing the immune response in mammals. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: April 10, 1990
    Assignee: Schering Corporation
    Inventors: David J. Blythin, Marvin I. Siegel, Sidney R. Smith
  • Extraction of granulocyte macrophage colony stimulating factor from bacteria
    Patent number: 4912200
    Abstract: A method of extracting granulocyte macrophage colony stimulating factor (GM-CSF) from GM-CSF-expressing bacterial cells comprising treating a suspension of GM-CSF-containing bacterial cells with an acid and an enhancing agent, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, and separating the GM-CSF containing liquid from the suspended cells.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: March 27, 1990
    Assignee: Schering Corporation
    Inventors: Paul Leibowitz, Yair Alroy
  • Transdermal delivery of nicotine
    Patent number: 4908213
    Abstract: A transdermal nicotine patch comprising an antipruritic to counteract pruritis observed with the transdermal administration of nicotine is disclosed. The patch can be any conventional patch type, e.g., reservoir, adhesive or polymeric matrix.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: March 13, 1990
    Assignee: Schering Corporation
    Inventors: Sharad K. Govil, Paul Kohlman
  • Carboxyalkyl dipeptides as antiglaucoma agents
    Patent number: 4906635
    Abstract: Methods and pharmaceutical compositions are disclosed for reducing intraocular pressure. The methods and compositions employ an active ingredient which comprises certain benzothiadiazinyl and quinazolinyl substituted carboxyalkyl dipeptides wherein the benzothiadiazinyl or quinazolinyl portions are joined to the dipeptide portions by an aminocarbonyl group.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: March 6, 1990
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, David R. Andrews, Paul E. McNamara, Robert W. Watkins
  • Antiglaucoma compositions and methods
    Patent number: 4906613
    Abstract: The present invention relates to ophthalmological pharmaceutical compositions comprising a renin inhibitor and to methods for using said composition in the treatment of glaucoma.
    Type: Grant
    Filed: November 5, 1985
    Date of Patent: March 6, 1990
    Assignee: Schering Corporation
    Inventor: Robert W. Watkins
  • Substituted dipeptides as inhibitors of enkephalinases
    Patent number: 4906615
    Abstract: A method for inhibiting the action of enkephalinases in a mannal to thereby elicit an analgesic effect in said mammal is described.Novel compounds and compositions useful for accomplishing the method of the invention are also described.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: March 6, 1990
    Assignee: Schering Corporation
    Inventor: Joel G. Berger
  • Anti-allergic esters, acetal ethers, thioethers and nitrogen substituted derivatives of bicyclic compounds
    Patent number: 4902693
    Abstract: Esters, acetal ethers, thioethers and nitrogen substituted derivatives of certain bicyclic compounds are disclosed which are useful as anti-allergic, anti-inflammatory and/or cytoprotective agents and in treatment of hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: February 20, 1990
    Assignee: Schering Corporation
    Inventors: David J. Blythin, Ho-Jane Shue
  • Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents
    Patent number: 4897397
    Abstract: Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.
    Type: Grant
    Filed: December 16, 1988
    Date of Patent: January 30, 1990
    Assignee: Schering Corporation
    Inventors: Neng Y. Shih, David J. Blythin
  • Process for preparing intermediates for pharmaceutically useful bicyclic compounds
    Patent number: 4897487
    Abstract: Processes for preparing bicyclic compounds useful as anti-allergic, anti-inflammatory and/or cytoprotective agents are described, together with a process for preparing intermediates thereof.
    Type: Grant
    Filed: April 6, 1988
    Date of Patent: January 30, 1990
    Assignee: Schering Corporation
    Inventors: Dinesh Gala, Martin Steinman, Ashit Ganguly
  • Tricyclic anti-allergy, antiinflammatory and anti-hyperproliferative compounds
    Patent number: 4897391
    Abstract: Isoquinolinone and isothiochromone derivatives of the general formula ##STR1## are disclosed. These compounds display anti-allergy, antiinflammatory and anti-hyperproliferative activity, which makes them useful for treating related disorders.
    Type: Grant
    Filed: June 17, 1988
    Date of Patent: January 30, 1990
    Assignee: Schering Corporation
    Inventor: Richard J. Friary
  • Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol
    Patent number: 4885174
    Abstract: Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.
    Type: Grant
    Filed: May 25, 1988
    Date of Patent: December 5, 1989
    Assignee: Key Pharmaceuticals, Inc.
    Inventors: Nicholas Bodor, Thorsteinn Loftsson
  • Antiglaucoma agents
    Patent number: 4885293
    Abstract: Pharmaceutical compositions and a method for reducing intraocular pressure by topically applying a carboxyalkyl dipeptide are disclosed.
    Type: Grant
    Filed: July 30, 1986
    Date of Patent: December 5, 1989
    Assignee: Schering Corporation
    Inventors: David R. Andrews, Federico C. A. Gaeta, Robert W. Watkins
  • Mercapto-acylamino acids as antihypertensives
    Patent number: 4879309
    Abstract: Novel mercapto-acylamino acids useful as analgesic, as well as in the treatment of hypertension and congestive heart failure and combinations of mercapto acylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating hypertension and congestive heart failure are disclosed.
    Type: Grant
    Filed: January 30, 1989
    Date of Patent: November 7, 1989
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Bernard R. Neustadt
  • Novel Aspergillus niveus microorganism used for the chiral reduction of carbonyl groups
    Patent number: 4879233
    Abstract: There is disclosed a novel microorganism Aspergillus niveus, ATCC 20922, and a process for chiral reduction of ketones using said mircoorganisms.
    Type: Grant
    Filed: February 10, 1989
    Date of Patent: November 7, 1989
    Assignee: Schering Corporation
    Inventor: William Charney
  • Pressurized fluorination of hydroxy alkyl groups
    Patent number: 4876352
    Abstract: There is disclosed a high yielding process for converting a hydroxy alkyl oxazolidine compound to the corresponding fluoro derivative by reacting the hydroxy compound with .alpha., .alpha.-difluoroalkylamine under pressure.
    Type: Grant
    Filed: September 14, 1988
    Date of Patent: October 24, 1989
    Assignee: Schering Corporation
    Inventors: Doris P. Schumacher, Jon E. Clark, Bruce L. Murphy
  • 3-phenethyl-2-benzene-amides or aza-derivatives thereof
    Patent number: 4873335
    Abstract: Compounds of the formula: ##STR1## are produced, with the variables as indicated within.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: October 10, 1989
    Assignee: Schering Corporation
    Inventors: Doris P. Schumacher, Bruce L. Murphy, Jon E. Clark
  • Insoluble copper-alpha interferon complex
    Patent number: 4871538
    Abstract: An insoluble copper-alpha interferon complex useful for injectable pharmaceutical compositions is disclosed.
    Type: Grant
    Filed: July 13, 1987
    Date of Patent: October 3, 1989
    Assignee: Schering Corporation
    Inventors: Zachary Yim, Martin Zupon, Imtiaz Chaudry
  • Aryl-substituted naphthyridine and pyridopyrazine derivatives
    Patent number: 4866061
    Abstract: Aryl-substituted naphthyridines and pyridopyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and/or hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
    Type: Grant
    Filed: May 12, 1988
    Date of Patent: September 12, 1989
    Assignee: Schering Corporation
    Inventors: David J. Blythin, Ho-Jane Shue
  • Nasal spray pump
    Patent number: D308100
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: May 22, 1990
    Assignee: Schering Corporation
    Inventors: Keith A. Bishop, William S. Blake