Abstract: A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain substituted quinoline, naphthyridine and pyrido-pyrazine derivatives.
Abstract: Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic peptides useful for treating hypertension are disclosed.
Type:
Grant
Filed:
March 27, 1987
Date of Patent:
January 31, 1989
Assignee:
Schering Corporation
Inventors:
Martin F. Haslanger, Bernard R. Neustadt, Elizabeth M. Smith
Abstract: Novel compounds and compositions which inhibit SRS--A in mammals are disclosed. Methods for preparing said compounds and compositions and methods for their use for treating allergic reactions, inflammation and for reducing the severity of myocardial infarction resulting from heart attack are disclosed.Useful intermediates for preparing said compounds are also disclosed.
Type:
Grant
Filed:
November 17, 1987
Date of Patent:
January 17, 1989
Assignee:
Schering Corporation
Inventors:
Anil K. Saksena, Jesse K. Wong, Pietro Mangiaracina
Abstract: Esters, acetal ethers, thioethers and nitrogen substituted derivatives of certain bicyclic compounds are disclosed which are useful as anti-allergic, anti-inflammatory and/or cytoprotective agents and in treatment of hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
Abstract: The invention relates to an antifungal compound of the following structural formula ##STR1## which is isolated from the AFC complex elaborated by the microorganism Actinomadura sp: nov SCC 1838, ATCC 53656.
Type:
Grant
Filed:
August 25, 1987
Date of Patent:
November 29, 1988
Assignee:
Schering Corporation
Inventors:
Vinod R. Hegde, Mahesh G. Patel, Ann C. Horan, Ingrid-Agneta Gunnarsson
Abstract: The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular pressure, e.g., in the treatment of glaucoma.
Type:
Grant
Filed:
April 4, 1986
Date of Patent:
November 8, 1988
Assignee:
Schering Corporation
Inventors:
Robert Watkins, Ronald J. Doll, Bernard R. Neustadt, Elizabeth M. Smith, Charles V. Magatti, Elijah H. Gold
Abstract: Zwitterionic bicyclic compounds are disclosed which are useful as anti-allergic, anti-inflammatory and/or cytoprotective agents and in the treatment of hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
Abstract: Methods and pharmaceutical compositions are disclosed for reducing intraocular pressure. The methods and compositions employ an active ingredient which comprises certain benzothiadiazinyl and quinazolinyl substituted carboxyalkyl dipeptides wherein the benzothiadiazinyl or quinazolinyl portions are joined to the dipeptide portions by an aminocarbonyl group.
Type:
Grant
Filed:
September 3, 1986
Date of Patent:
October 18, 1988
Assignee:
Schering Corporation
Inventors:
Bernard R. Neustadt, David R. Andrews, Paul E. McNamara, Robert W. Watkins
Abstract: 1-Substituted naphthyridines and pyrido-pyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and hyperproliferative skin diseases and in suppressing the immune response in mammals. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
Type:
Grant
Filed:
December 18, 1986
Date of Patent:
October 4, 1988
Assignee:
Schering Corporation
Inventors:
David J. Blythin, Marvin I. Siegel, Sidney R. Smith
Abstract: An antifungal vaginal suppository is disclosed comprising cis-2-(1H-imidazolylmethyl)-3-(2',6'-difluorobenzyloxy)-2,3-dihydro-5-fluo robenzo[b]thiophene in a suppository base containing biocompatible polymers, a surfactant and an absorbent in a vegetable oil phase.
Abstract: Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.
Abstract: There is disclosed the compound (5R,6S,8R)-6-(1-hydroxyethyl)-2-(3R-pyrrolidin-2-one-3-yl)thiopenem-3-carb oxylic acid, and pharmaceutically acceptable salts and esters as well as compositions containing them and methods for their use.
Abstract: A skin moisturizing preparation, such as a skin cream, face cream, lotion or ointment containing a combination of a phosphatide such as soy lecithin and one or more C.sub.10 -C.sub.30 carboxylic acid sterol esters. The preparation preferably also contains a caprylic/capric acid triglyceride for enhanced moisturization. There is also described a method of treating dry skin by topical application of such moisturizing preparations.
Abstract: A method, reagents, and kit for determining the levels of D-1 receptor antagonistic activity of neuroleptic drugs. The method correlates competition between analyte and tritiated R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol for binding to D-1 receptors in mammalian brain tissue.
Type:
Grant
Filed:
November 19, 1984
Date of Patent:
July 26, 1988
Assignee:
Schering Corporation
Inventors:
Allen Barnett, William Billard, Louis Iorio