Patents Represented by Attorney Janice E. Williams

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  • Antibiotics produced by Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323
    Patent number: 4797280
    Abstract: A novel antibiotic complex of "vancomycin-like" antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.
    Type: Grant
    Filed: June 10, 1986
    Date of Patent: January 10, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Betty A. Bowie, Richard D. Hedde, Thomas O. Lindsey, David J. Newman, Marcia C. Shearer, Robert D. Sitrin, Joseph R. Valenta
  • Process for the preparation of pyrrolidone derivatives
    Patent number: 4797496
    Abstract: Process for preparing pyrrolidinone derivatives of (1) ##STR1## in which R is hydrogen, alkyl or acyl characterized in that a compound of (2) ##STR2## wherein R.sup.1 is hydrogen and R.sup.2 is benzyl or substituted benzyl, or R.sup.1 and R.sup.2 can together form a group ##STR3## where R.sup.4 and R.sup.5 are independently hydrogen, alkyl, phenyl or optionally substituted aryl or together are 1,4-butylene or 1,5-pentylene; R.sup.3 is hydrogen or straight or branched alkyl of 1 to 4 carbon atoms; and X is alkyl subjected to N-deprotection and the deprotected intermediate is cyclized intramolecularly.The deprotected intermediates can be isolated as acid-addition salts.
    Type: Grant
    Filed: March 8, 1988
    Date of Patent: January 10, 1989
    Assignee: I.S.F. Societa Per Azioni
    Inventors: Mario Pinza, Ugo C. Pfeiffer
  • Substituted butanamido acetate compounds for the preparation of pyrrolidone derivatives
    Patent number: 4788300
    Abstract: A process for preparing compounds (1) ##STR1## where Y is NR.sup.1 R.sup.2 or OR, R.sup.1 and R.sup.2 are hydrogen or C.sub.1-3 alkyl, and R is C.sub.1-3 alkyl, which comprises protecting the hydroxy group of a compound (2) ##STR2## cyclizing the product under basic conditions and removing the protecting group.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: November 29, 1988
    Assignee: I.S.F. Societa per Azioni
    Inventors: Mario Pinza, Ugo C. Pfeiffer
  • Viable cell labelling
    Patent number: 4783401
    Abstract: Methods for reproducibly labelling viable cells with cyanine dyes that do not significantly affect cell viability. Applications for labelled cells include using labelled red blood cells to distinguish post-transfusional bleeding from immunologic reaction and using dilution to measure growth rate of cultured cells.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: November 8, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul K. Horan, Bruce D. Jensen, Sue E. Slezak
  • Process for preparing beta-methyl-gamma-oxo-4-(4-oxo-1(4H)-pyridinyl) derivative of benzene butanoic acid
    Patent number: 4782159
    Abstract: A process for the prepartion of 3-[4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid which comprises the reaction of 3-(4-fluorobenzoyl)butanoic acid with 4-hydroxypyridine under aqueous conditions in the presence of a base.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: November 1, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Michael B. Mitchell, Kiritkant D. Pancholi
  • Affinity chromatography sorbent
    Patent number: 4778846
    Abstract: A novel process for the isolation and purification of vancomycin class antibiotics which utilized affinity chromatography by the formation of a sorption complex between the antibiotic and an immobilizing ligand selected from -D-alanyl-D-alanine or -X-D-alanyl-D-alanine, wherein X is an amino acid radical and the novel affinity chromatography sorbent employed therein are disclosed.
    Type: Grant
    Filed: February 4, 1987
    Date of Patent: October 18, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: Robert D. Sitrin, Kenneth M. Snader, Gail F. Wasserman
  • Pyrimidylalkylthio benzimidale compounds, pharmaceutical compositions and use
    Patent number: 4777172
    Abstract: This invention relates to 2- and 4-pyrimidinylmethylsulphinyl(and thio)benzimidazoles in which the pyrimidyl group is substituted by an optionally substituted amino group. These compounds inhibit exogenously and endogenously stimulated gastric acid secretion.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: October 11, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown
  • Leukotriene antagonists
    Patent number: 4775662
    Abstract: The compounds represented by the formula (I) ##STR1## wherein n is 1 or 2; m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; X is hydrogen or hydroxyl; R is hydroxyl or amino; R.sub.1 is hydrogen, amino or ##STR2## and R.sub.2 is hydroxyl, amino, ##STR3## with the proviso that when m is 0, R.sub.1 is hydrogen or pharmaceutically acceptable salts thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: October 4, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: John G. Gleason, Thomas W. Ku
  • 3,4-diamino-1,2,5-thiadiazole-1-oxides having histamine H.sub.1 -antagonist activity
    Patent number: 4771058
    Abstract: The invention relates to a class of 3,4-diamino-1,2,5-thiadiazole-1-oxides which have histamine H.sub.1 -antagonist activity. A preferred compound of the invention is 3-[3-(5-bromo-3-methylpyrid-2-ylamino)-propylamino]-4-amino-1,2,5-thiadiaz ole-1-oxide.
    Type: Grant
    Filed: June 11, 1986
    Date of Patent: September 13, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Imidazolylthioalkenoic acids and -alkenols and leukotriene antagonistic composition containing them
    Patent number: 4769386
    Abstract: The imidazolylthio substituted alkanoic acids represented by the formula (I) or (IA) as defined herein have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.
    Type: Grant
    Filed: October 24, 1986
    Date of Patent: September 6, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: William E. Bondinell, David T. Hill, Barry M. Weichman
  • Tyr-Arg-vasopressin antagonists
    Patent number: 4766108
    Abstract: Vasopressin antagonists which have a dipeptide tail composed of a neutral and basic amino acid unit demonstrate potent V.sub.1 and V.sub.2 -antagonist activity. Two species of this invention, which are prepared by solid phase peptide synthesis, are [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylene propionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-tyrosine-8-arginine-9-desglycine]- vasopressin and [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-tyrosine-9-desglycine]- vasopressin.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: August 23, 1988
    Assignee: Smith Kline Beckman Corporation
    Inventor: Fadia E. Ali
  • Methylamidine compounds
    Patent number: 4766123
    Abstract: The invention relates to cyanoalkanimidamido derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N.sup.2 -cyanoethanimidamido)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: February 10, 1987
    Date of Patent: August 23, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Cyanoamidine compounds and derivatives thereof
    Patent number: 4766122
    Abstract: The invention relates to cyanoalkanimidamido derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N.sup.2 -cyanopropanimidamido)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: March 26, 1986
    Date of Patent: August 23, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Pyridyl and pyridazinyl substituted thyronine compounds having selective thyromimetic activity
    Patent number: 4766121
    Abstract: This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinylmethyl]-thyronine.
    Type: Grant
    Filed: January 14, 1986
    Date of Patent: August 23, 1988
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: David Ellis, John C. Emmett, Anthony H. Underwood, Paul D. Leeson
  • 3-hydroxypyridines
    Patent number: 4764519
    Abstract: The disclosure relates to a class of 2-(pyridylalkylamino)-3-hydroxypyridines which are active as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: May 1, 1987
    Date of Patent: August 16, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, Peter D. Miles, Rodney C. Young
  • 1,6-dicarba-vasopressin compounds
    Patent number: 4760052
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: April 28, 1987
    Date of Patent: July 26, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • Pyridine derivatives and use as histamine H.sub.2 antagonists
    Patent number: 4758576
    Abstract: This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylallyl group. The compounds have histamine H.sub.2 -antagonist activity.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: July 19, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David G. Cooper, George S. Sach
  • Process for preparing 6-amino-3-hydrazinopyridazine derivatives
    Patent number: 4757142
    Abstract: A novel process for preparing 6-amino-3-hydrazinopyridazine derivatives comprising reacting a 3-amino-6-chloropyridazine derivative with ethyl carbazate under aqueous conditions.
    Type: Grant
    Filed: May 13, 1986
    Date of Patent: July 12, 1988
    Assignee: ISF Societa per Azioni
    Inventors: Mario Pinza, Riccardo Monguzzi, Riccardo Colombo
  • Tricyclic pyridazinone compounds
    Patent number: 4755511
    Abstract: This invention relates to tricyclic pyridazinone compounds, pharmaceutical compositions containing the compounds, and a method of stimulating cardiac activity in a mammal by administering an effective amount of the compound. A compound of the invention is 7-carboxamido-4,4a-dihydro-4a-methyl-[5H]-indeno[1,2-c]-pyridazin-3[2H]-on e.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: July 5, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Brian H. Warrington
  • Inhibition of the 5-lipoxygenase pathway
    Patent number: 4751310
    Abstract: Compounds having the formula ##STR1## wherein n is 0 or 1, R.sup.2 through R.sup.9 are H or C.sub.1-2 alkyl, and X is pyridyl or mono- or disubstituted phenyl are useful in the preparation of the compounds which inhibit the 5-lipoxygenase pathway.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: June 14, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul E. Bender, Nabil Hanna