Patent number: 5589486
Abstract: The invention relates to novel N-hydroxy-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives of the formula ##STR1## wherein A, B, D, E, G, I and R are as defined in the specification, m is 0, 1 or 2, with the proviso that:m is 0 or 2, or both G and I are hydrogen, when A is benzyl or halogen-monosubstituted benzyl group; andm is 1, when A is 2-picolyl, as well as their pharmaceutically acceptable acid addition salts. The compounds of formula (I) are useful for enhancing the tolerance of mammals (including man) against hypoxic and/or ischaemic states as well as for treating the degenerative and functional disturbances arising from hypoxic and/or ischaemic results.
Type:
Grant
Filed:
January 17, 1995
Date of Patent:
December 31, 1996
Assignee:
Richter Gedeon Vegyeszeti Gyar Rt.
Inventors:
Kalman Harsanyi, Tibor Gizur, Eva Agai-Csongor, Anna Kallai-Sohonyai, Marta Kapolnas-Pap, Eva Csizer, Bela Heged us, Laszlo Szporny, Bela Kiss, Egon Karpati, Eva Palosi, Zsolt Szombathelyi, Adam Sarkadi, Aniko Gere, Mihaly Bodo, Katalin Csomor, Judit Laszy, Zsolt Szentirmai, Erzsebet Lapis, Sandor Szabo, Peter Bod, Attila Csehi