Patents Represented by Attorney, Agent or Law Firm Jonathan Myers
  • Recombinant poxvirus comprising at least two compox ATI promoters
    Patent number: 7300658
    Abstract: Recombinant poxvirus are disclosed comprising in the viral genome at least two expression cassettes, each comprising a cowpox ATI promoter according to SEQ ID NO:1, a polynucleotide sequence in which not more than 6 nucleotides are substituted, deleted, and/or inserted into SEQ ID NO:1 and still active as an ATI promoter, or a polynucleotide comprising at least 10 nucleotides including nucleotides 22 to 29 of SEQ ID NO: 1 and still active as an ATI promoter and a coding sequence, wherein the expression of the coding sequence is regulated by said promoter or said polynucleotides. The recombinant poxviruses are useful as pharmaceutically active ingredients in the preparation of vaccines.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: November 27, 2007
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer
  • Nucleic acid encoding pyruvate carboxylase from coryneform glutamicum
    Patent number: 7267967
    Abstract: A pyruvate carboxylase gene having SEQ ID NO:1 as well as an amino acid sequence having SEQ ID NO:2 expressed by the pyruvate carboxylate gene are disclosed. Also disclosed is a method for microbial production of amino acids of the aspartate and/or glutamate family in which the pyruvate carboxylase activity is increased by genetically changing the pyruvate carboxylase gene having SEQ ID NO:1 through expression of a microorganism which produces the corresponding amino acid having SEQ ID NO:2.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: September 11, 2007
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Bernd Eikmanns, Petra Peters-Wendisch, Hermann Sahm
  • Reactor for gasifying granular fuels that form a fixed bed
    Patent number: 7258841
    Abstract: The inventive reactor contains a fixed bed into whose lower area an oxygen-containing gasifying agent is introduced. Said gasifying agent moves upwards in the fixed bed. Product gas containing hydrogen and carbon monoxide is guided out of the reactor over the fixed bed, through a discharge channel. At least one cyclone is located in the reactor for separating solids from the product gas. Said cyclone has an inlet for the dust-laden product gas coming from the fixed bed, a discharge line for product gas and a solids removal line leading into the fixed bed. Said cyclone discharge line is connected to the discharge channel of the reactor.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: August 21, 2007
    Assignee: Metallgesellschaft Aktiengesellschaft
    Inventor: Gerhard Schmitt
  • Composition and process for improving the combustibles combustion, process and device for obtaining such composition
    Patent number: 7241320
    Abstract: The invention relates to a composition and process for improving the combustion of any kind of combustible. Also the invention relates to a process and device for obtaining such composition. The variant destined to the firing installations using common liquid/gaseous combustible as well as those ones using solid combustibles and, simultaneously liquid/gaseous combustibles for enhancing the combustion contain ?20% of 6% watery solution of potassium dichromate, treated with monochromatic light having/=480?490. 10?9 m; 0.02 ammonia; 0.3% non-additivated mineral oil and ?80% demineralized water. The variant destined to the firing installations using solid combustibles ?10% of 5% watery solution of potassium permanganate, treated with monochromatic light having/=595?625. 10?9 m; 0.05% urea 0.3% non-additivated mineral oil and ?90% de-mineralized water.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: July 10, 2007
    Inventor: Mihai Suta
  • Method for the manufacture of polyesters
    Patent number: 7241855
    Abstract: A method is described for the manufacture of polyesters of aromatic dicarboxylic acids with aliphatic and/or cycloaliphatic dials, in which an aromatic dicarboxylic acid in the presence of a monocarboxylic acid or a mixture of a monocarboxylic acid present in a saturated solution with water or another suitable solvent is converted with an aliphatic or cycloaliphatic dial to a dicarboxylic acid alkanediolestercarboxylate and/or its oligomers, which are polycondensed in further process steps to the polyester.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: July 10, 2007
    Assignee: Zimmer Aktiengesellschaft
    Inventors: Stefan Deiss, Michael Reisen, Karl-Heinz Heldmann, Eckhard Seidel
  • Process for the synthesis of N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide
    Patent number: 7199257
    Abstract: A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: April 3, 2007
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Bela Sörös, Zoltan Tuba, György Galik, Adam Bor, Adam Demeter, Ferenc Trischler, Janos Horvath, Janos Brlik
  • Fuel cell stack with circuit
    Patent number: 7183015
    Abstract: In a direct-methanol fuel cell stack with an at least partial circulation (7, 9) of the fuel, according to the invention a means is arranged in this circulation for reducing the concentration of an undesired byproduct. This means is comprised especially of a further electrochemical cell (8) to which electric current is applied and which at least partly transforms the byproducts by an electrochemical reduction reaction again to methanol and water. Since the concentration of byproducts is small, the loss in electric current required for the additional reduction reaction has no noticeable effect on the efficiency of the fuel cell stack.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: February 27, 2007
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Detlef Stolten, Hendrik Dohle, Jürgen Mergel, Helmut Baltruschat
  • Vector for integration of heterologous sequences into poxviral genomes
    Patent number: 7150874
    Abstract: A new DNA vector is disclosed comprising a nucleic acid sequence useful for inserting heterologous sequences into the genome of poxviruses by homologous recombination. Also disclosed are recombinant poxviruses carrying heterologous coding sequences transferred by the DNA vector.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: December 19, 2006
    Assignee: GFS Forschungszentrum fur Umwelt und Gesundheit GmbH
    Inventors: Stefan Wintersperger, Robert Baier, Gerd Sutter, Marion Ohlmann, Volker Erfle
  • Method of cleaning industrial gases
    Patent number: 7097671
    Abstract: A methanol/water scrubbing solution containing colloidal metal sulfides formed from metal carbonyls and resulting from the scrubbing of industrial gases, such as synthesis gas, is subjected to agglomeration of the metal sulfides before the scrubbing solution to be separated enters the separating column which separates the methanol from the water containing precipitated metal sulfides. The agglomeration is carried out in a precipitation vessel and the scrubbing liquid is diluted before it enters the precipitation vessel. The result is minimal encrustation of the trays or other parts of the cleaning plant for the scrubbing solution.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: August 29, 2006
    Assignee: Lurgi AG
    Inventors: Manfred Meyer, Ulrich Wagner, Hans Kammerer
  • Process for preparing monohydrate and crystal modifications of fluconazole
    Patent number: 7094904
    Abstract: A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) ?wherein R2 is hydrogen, or a C1 to C10 alkyl or phenyl group, R3 and R4 independently of each other are a C1 to C10 alkyl or phenyl group in an aqueous solution, preferably at a pH below 3 or above 8.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: August 22, 2006
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Jánosné´ Kreidl née Regina Hegedus, legal representative, Laszlo Czibula, Csaba Szantay, Jenone Farkas, Ida Deutschne Juhasz, Istvan Hegedus, Eva Werkne Papp, Judit Nagyne Bagdy, Agnes Piller, Janos Kreidl, deceased
  • Method and device for producing polyesters, copolyesters and polycarbonates
    Patent number: 7084234
    Abstract: In a process for producing polyester, the esterification of dicarboxylic acids and diols is carried out in at least one reaction stage, the prepolycondensation of the esterification product in at least one reaction stage and the polycondensation of the prepolycondensation product in at least one reaction stage. To increase the capacity of the apparatus forming one or more of the reaction stages in the production of the polyesters, at at least one of the reaction stages the supplied product system before it enters the reaction stage or within the reaction stage is divided into at least two partial streams and the partial streams entirely or partially separate from one another are passed through the reaction stage.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: August 1, 2006
    Assignee: Zimmer Aktiengesellschaft
    Inventors: Fritz Wilhelm, Michael Reisen
  • Expression of heterologous genes from an IRES translational cassette in retroviral vectors
    Patent number: 7056730
    Abstract: The present invention relates to a retroviral vector which expresses a gene, e.g. for therapeutic use and/or of viral origin, under the translational control of an internal ribosomal entry site (IRES) resulting in the efficient translation of said gene.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: June 6, 2006
    Assignee: Aarhus University
    Inventors: Finn Skou Pedersen, Thomas Jesperson, Mogens Duch
  • Phytopharmaceutical food products or integrators
    Patent number: 6797284
    Abstract: Phytopharmaceutical food products which contain plant extracts and aminoacids and which can be used in order to reduce tobacco smoke addiction.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: September 28, 2004
    Inventor: Ursula Mariah Rothlin
  • Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid
    Patent number: 6765114
    Abstract: The invention relates to a new process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid of formula (I) via the new intermedier 1-(nitromethyl)cyclohexyl-acetic acid derivative of formula (II), wherein R represents hydrogen, benzyl group, diphenylmethyl group or C1-C4 alkyl or alkoxy aromatic ring substituted derivatives thereof.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: July 20, 2004
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Tibor Gizur, Zoltanné Lengyel, Krisztina Szalai
  • Process for the synthesis of a known tetrazol derivative
    Patent number: 6710183
    Abstract: A Process is disclosed for preparing a compound of the Formula (I) which comprises the steps of: (a) detritylating a compound of the Formula (III)  with 0.1 to 1 equivalent of potassium hydroxide in a C1 to C4 straight chain alcohol solvent to obtain a reaction mixture containing the compound of the Formula (I), (b) changing the C1 to C4 straight chain alcohol solvent in the reaction mixture to an aprotic solvent or a weakly protic solvent, and (c) following step (b) crystallizing out the compound of the Formula (I) from the reaction mixture.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: March 23, 2004
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Janos Fischer, Ildiko Ballo, Endrene Petenyi, Janos Kreidl, Laszlo Czibula, Andras Nemes, Ida Deutschne Juhasz, Eva Werkne Papp, Judit Nagyne Bagdy, Istvan Hegedüs, Jenöme Farkas
  • Vector for integration of heterologous sequences into poxviral genomes
    Patent number: 6682742
    Abstract: The present invention provides a DNA vector comprising a nucleic acid sequence useful for inserting heterologous sequences into the genome of poxviruses by homologous recombination. The present invention relates also, inter alia, to recombinant poxvirses carrying heterologous coding sequences transferred by the vector according to the present invention.
    Type: Grant
    Filed: December 26, 2001
    Date of Patent: January 27, 2004
    Assignee: GSF Forschungszentrum fur Unwelt und Gesundheit GmbH
    Inventors: Stefan Wintersperger, Robert Baier, Gerd Sutter, Marion Ohlmann, Volker Erfle
  • Altered strain of the modified vaccinia virus ankara (MVA)
    Patent number: 6682743
    Abstract: The invention provides new strains of the Modified Vaccinia Virus Ankara (MVA) that have a strongly reduced virulence for most mammals, especially humans, but nevertheless grows in cells of a continuous cell line approved for the production of a therapeutic agent such as a vaccine. The invention also provides a method for producing said adapted MVA strains. The adapted MVA can be used e.g. for parenteral immunization, as a vector system, or in the active or inactivated from as an adjuvant or as a regulator of the unspecific components of the immune system.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: January 27, 2004
    Assignee: Bavarian Nordic A/S
    Inventor: Anton Mayr
  • Use of zinc hyaluronate against peptic ulcer
    Patent number: 6656921
    Abstract: The invention relates to pharmaceutical compositions against peptic ulcer as well as to a method of treating peptic ulcer. The compositions contain and the method of treatment employs zinc hyaluronate as an active ingredient having a molecular weight in the range of 500,000 to 1,200,000 daltons.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: December 2, 2003
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Janos Illes, Judit Matuz, Erzsabet Neszmelyi, Gaborne Forrai, Bela Stefko, Katalin Saghy, Laszlo Szporny
  • Cosmetic composition for stressed skin under extreme conditions
    Patent number: 6649178
    Abstract: A cosmetic composition is provided effective against stresses of climate extremes. The composition includes hot, cold and dry climate treatment portions. The hot climate treatment portion has a first botanical ingredient to impart a cool sensation, and a sunscreen agent. The cold climate treatment portion has a second botanical ingredient to combat skin inflammation, and a silicone fluid or hydrocarbon for retaining moisturize. The dry climate treatment portion has a third botanical ingredient to impart moisturization and an ester.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: November 18, 2003
    Inventors: Fatemeh Mohammadi, Anthony Vargas
  • Polymer composition, the production and further processing thereof into receptacles
    Patent number: 6610763
    Abstract: A process for preparing a container for handling a household waste material which involves molding a household waste container from a plastic batch material containing 0.1 to 10% by weight of at least one phenol biocide selected from the group consisting of 5,5′-dichloro-2,2′-dihydroxydiphenyl methane, 3,5,3′,5′-tetrachloro-4,4′-dihydroxydiphenyl methane, 3,5,6,3′,5′,6′-hexachloro-2,2′-dihydroxydiphenyl methane, 5,5′-dichloro-2,2′-dihydroxydiphenyl sulfide, 2,4,5,2′,4′,5′-hexachloro-dihydroxydiphenyl sulfide, 3,5,3′,5′-tetrachloro-2,2′-dihydroxydiphenyl sulfide, and 2,4,4′-trichloro-2′-hydroxydiphenyl ether to form the container with an inner and an outer co-extruded layer wherein the phenol is applied on a co-extruded layer forming the surface of the inner co-extruded layer.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: August 26, 2003
    Assignee: Gebr. Otto GmbH & Co. KG
    Inventor: Ulrich Beese