Patents Represented by Attorney, Agent or Law Firm Jonathan Myers
  • Patent number: 5981300
    Abstract: A test kit is disclosed for analyzing a patient's saliva to determine the patient's risk of tooth decay, which contains: (a) a support; (b) an absorbent material in contact with said support and capable of removing saliva from the mouth and of absorbing the saliva; (c) a composition coated on said absorbent material, said composition soluble in saliva and capable of reaction inside the mouth of the patient with the saliva to reduce the pH of the saliva; and (d) a color scale for determining outside of the mouth of the patient the pH of the saliva absorbed by the absorbent material in which the composition is dissolved to measure the reaction of the composition with the saliva in the patient's mouth to determine the patient's risk of tooth decay.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: November 9, 1999
    Assignee: M & M Dental-Medizin GmbH
    Inventors: Claus-Jurgen Moll, Theodor Paessens, Jorg Althoff
  • Patent number: 5965391
    Abstract: The invention concerns a DNA fragment located in front of the malate synthase gene of a coryne-form bacterium and isolated from the latter. Any structural gene which codes for a protein can be inserted after this DNA fragment. After transformation of such a construct into a coryne-form bacterium, expression of the structural gene inserted after the DNA fragment is regulated. The invention also concerns a process for synthesizing any protein by culturing a transformed coryne-form bacterium. A bacterium of this type contains in replicable form a DNA fragment isolated from the malate synthase gene of a coryne-form bacterium, and after which the structural gene which codes for the protein to be synthesized is inserted. Since expression of the structural gene which codes for the protein to be synthesized is regulated by the DNA located in front of it, the structural gene is expressed and the desired protein synthesized as soon as a suitable inducing agent is added to the medium.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: October 12, 1999
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Dieter Reinscheid, Bernhard Eikmanns, Hermann Sahm
  • Patent number: 5962576
    Abstract: A water-based adhesive is disclosed which contains an aqueous dispersion of one or more phenol resins stabilized by one or more polyacrylates, one or more latexes with one or more halogenated polyolefins and one or more cross-linking agents. The invention also includes a method of priming a substrate in which the substrate is coated with the adhesive as a primer and then with a cover cement and finally bonded to rubber under vulcanization.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: October 5, 1999
    Assignee: Metallgesellschaft Aktiengesellschaft
    Inventors: Stefan Dehnicke, Ernst List, Helmut Rullmann, Adolf Zellner
  • Patent number: 5948479
    Abstract: In accordance with the method according to the invention, for the production of the plastics overlay, first of all a paste is made of a plastics dispersion and fillers. This paste is free of organic solvents and is applied to a sintered porous metal layer. The multilayer material thus produced is then sintered. Since the use of organic solvents is dispensed with, health risks and the risk of fire are reduced. Moreover, the composite materials produced according to the invention exhibit excellent cavitation resistance. In addition to conventional lubricant-free applications, such as bearings, these composite materials may consequently be used in particular in gear pumps and shock absorbers.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: September 7, 1999
    Assignee: Glyco-Metall-Werke Glyco B.V. & Co.KG
    Inventors: Achim Adam, Horst Mann, Stefan Fuchsberger
  • Patent number: 5906940
    Abstract: Stem cells or other organ-function cells are cultivated in a fluidized bed system on macroporous glass carrier bodies treated with a structure protein such as gelatin and an extracellular matrix protein such as fibronectin, and coated with a stroma cell layer. Glass carriers coated with gelatin are added to a fluidized bed reactor, and a culture medium containing an extracellular matrix protein is added to bind the protein to the gelatin. Stromal cells are then added and the cells are cultured to immobilize the cells on the carriers containing the bound protein. Immature organ-function cells are added to the reactor, and while generating a fluidized bed of the carriers in the culture medium, the culture medium is recirculated from and to the reactor in a recirculation loop. Bubble-free aeration of the culture medium is effected to cultivate the immature organ-function cells on the carriers to obtain both mature differentiated organ-function cells and progenitor organ-function cells.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: May 25, 1999
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Christian Wandrey, Manfred Biselli, Bernd Schroder, Hans-Joachim Schmoll
  • Patent number: 5882400
    Abstract: The invention concerns a method of producing a surface layer structure by doping a matrix with metal ions. The aim of the invention is to provide a method of this kind in which the depth distribution of the metal ions in the substrate can be regulated, thus optimumizing the doping without incurring any of the disadvantages inherent in the prior art methods. This is achieved by first depositing matrix material on a suitable substrate by laser ablation in an atmosphere of oxygen, thus forming a on surface of the substrate a first layer a matrix material. Dopant is then deposited on the surface of the first layer, followed by more matrix material. The result is a uniform doping of the deposited matrix at a defined depth in the surface layer structure.
    Type: Grant
    Filed: May 10, 1996
    Date of Patent: March 16, 1999
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Stefanie Bauer, Martin Fleuster, Willi Zander, Jurgen Schubert, Christoph Buchal
  • Patent number: 5858727
    Abstract: The invention relates to a process for producing outer membrane proteins of gram-negative bacteria by gram-positive host cells. To this end, a gene structure containing a gene coded for an outer membrane protein is constructed; in front of this gene there is a pro-gene sequence which codes for a propeptide of an export protein of a gram-positive bacterium. In front of the pro-gene sequence there is a pre-gene sequence which codes for a signal peptide of an export protein of a gram-positive bacterium. After the cloning of a gene structure thus constructed into a vector and transformation into a gram-positive bacterium, the outer membrane protein is expressed with a signal peptide and propeptide, transported through the membrane of the gram-positive host cell and released into the test of the culture.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: January 12, 1999
    Assignee: Forschungszentrum Julich GMBH
    Inventors: Jochen Meens, Michael Klose, Hermann Sahm, Roland Freudl
  • Patent number: 5846397
    Abstract: An apparatus is disclosed for obtaining inhibitively active "I" water and stimulatively activated "S" water which comprises:a parallelipipedic column having an open top;a support for said column;a cover closing said top of said column;at least one electrode assembly in said column and including:a pair of spaced apart mutually parallel porous membranes defining between inner surfaces thereof a supply space receiving water to be separated into inhibitively activated "I" water and stimulatively activated "S" water,respective porous electrodes spaced from outer surfaces of said membranes and parallel thereto, anda respective spacer between each of said electrodes and the respective outer surface whereby water flows outwardly from said supply space through said membranes and said electrodes;means for electrically connecting one of said electrodes as a positive electrode and the other of said electrodes as a negative electrode;means in said column for forming a first storage space adjacent said positive electrode f
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: December 8, 1998
    Assignee: S. C. Tehman
    Inventors: Ioan Manzatu, Vasile Ionita-Manzatu
  • Patent number: 5837262
    Abstract: A pharmaceutical composition is disclosed for the treatment against several herpes virus infections or atherosclerotic plaques in a mammalian subject suspectible thereto which comprises: (a) 10 to 30% by weight of the peptide of SEQ ID 2; (b) 10 to 30% by weight of the peptide of SEQ ID 4; 10 to 30% by weight of the peptide of SEQ ID 6; and (d) 10 to 30% by weight of the peptide of SEQ ID 8; in combination with a pharmaceutically acceptable inert carrier.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: November 17, 1998
    Assignee: Bio-Virus Research Incorporated
    Inventors: Daniel Golubev, Alexander Chaihorsky
  • Patent number: 5833756
    Abstract: A process for decontaminating a solid material contaminated with an organic pollutant wherein the solid material contains grains with a particle size of up to 60 microns, which includes the steps of:(a) extracting the organic pollutant from the solid material containing grains with the particle size up to 60 microns by using a microemulsion which includes a thermodynamically stable, macroscopically homogeneous and optically transparent mixture of water, an apolar hydrophobic solvent, and a surfactant to form a cleaned solid material and a pollutant-containing microemulsion;(b) separating the cleaned solid material from the pollutant-containing microemulsion; and(c) splitting the pollutant-containing microemulsion into a surfactant-rich phase and a pollutant-containing phase.
    Type: Grant
    Filed: August 29, 1996
    Date of Patent: November 10, 1998
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Franz-Hubert Haegel, Wolfgang Clemens, Milan Schwuger, Carl-Johannes Soeder, Katrin Stickdorn, Leslie Webb
  • Patent number: 5824429
    Abstract: A boundary layer structure, useful in a fuel cell, includes a solid electrolyte and an electrode. The electrode consists essentially of a perovskite base material and a platinum group metal oxide addition, along the boundary between the perovskite and the electrolyte. Iridium oxide is a preferred metal oxide addition material, while a preferred perovskite is lanthanum ferrite, which contains Sr and either Co or Mn.
    Type: Grant
    Filed: October 29, 1996
    Date of Patent: October 20, 1998
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Dasarathi Das, Jimmie Edwards, Lutz Kindermann, Klaus Hilpert, Gunther Putz
  • Patent number: 5804423
    Abstract: A method is disclosed for preparing 5-ketogluconate, which comprises the steps of:(a) genetically modifying a microorganism capable of microbiologically producing 5-ketogluconate to increase gluconate NADP.sup.+ -5-oxidoreductase gene expression of said microorganism;(b) culturing said microorganism in a medium to produce 5-ketogluconate; and(c) recovering 5-ketogluconate from said medium.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: September 8, 1998
    Assignees: Forschungszentrum Julich GmbH, Rhein Biotech GmbH
    Inventors: Ralf Klasen, Stephanie Bringer-Meyer, Hermann Sahm, Cornelies Petrus Hollenberg
  • Patent number: 5804150
    Abstract: The ore which contains gold and at least one of the metals silver, copper, nickel, zinc or iron is calcined at temperatures in the range from 500.degree. to 900.degree. C. with the addition of oxygen-containing gas, thereby producing a metal-oxide-containing solids mixture and a SO.sub.2 -containing exhaust gas. The SO.sub.2 containing exhaust gas is brought in contact with aqueous solution, thereby producing a sulfite-containing solution. The solids mixture from the calcination is cooled to temperatures in the range from 50.degree. to 300.degree. C. and is stirred up with the sulfite-containing solution. Metal oxides are dissolved, and a sulfate-containing solution os formed. In a first separating zone, the sulfate-containing solution is separated from the solids, and either the solids are supplied to a gold leaching or the sulfate-containing solution is subjected to a further treatment for the separation of nonferrous metals.
    Type: Grant
    Filed: February 24, 1997
    Date of Patent: September 8, 1998
    Assignee: Metallgesellschaft Aktiengesellschaft
    Inventors: Michael Tacke, Walter Pierson, Eberhard Stolarski
  • Patent number: 5783158
    Abstract: The ore which contains gold and/or silver and as accompanying metal at least iron is calcined at temperatures in the range from 500.degree. to 900.degree. C. with the addition of oxygen-containing gas. There is obtained a metal-oxide-containing solids mixture and a SO.sub.2 -containing exhaust gas. The solids mixture from the calcination is cooled, the temperature being reduced by at least 50.degree. C. The cooled solids mixture is added to a fluidized-bed reactor, and SO.sub.2 -containing exhaust gas is introduced into the fluidized-bed reactor. In the reactor, metal sulfate is produced in the solids mixture, so that at least 10% of the sulfur content are bound in the exhaust gas. Solids mixture containing metal sulfate is withdrawn from the fluidized-bed reactor, is stirred up with an aqueous acid solution, thereby dissolving metal sulfate. The remaining solids are supplied to a recovery of gold and/or silver.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: July 21, 1998
    Assignee: Metallgesellschaft Aktiengesellschaft
    Inventors: Michael Tacke, Walter Pierson, Eberhard Stolarski
  • Patent number: 5770578
    Abstract: The use of triterpensaponins, like notoginsenoside R1 (NR1) and/or astragaloside (ASIV) for the production of medicaments for stimulating the fibrinolytic activity and blocking the endotoxin effect, especially for the treatment of patients and animals which suffer from endotoxin shock or to limit the endotoxin shock. Corresponding medicaments are also suitable prophylactive and therapeutic treatment of patients of coronary heart disease, peripheral arterial disease for patients who suffer from angina pectoris and for the prevention of such diseases in healthy persons.
    Type: Grant
    Filed: January 4, 1996
    Date of Patent: June 23, 1998
    Assignee: Bergi GmbH
    Inventors: Bernd Binder, Weijian Zhang, Johann Wojta
  • Patent number: 5767332
    Abstract: In the production of aromatic hydrocarbon from coking crude by-product benzene after a vaporization stage in which the crude benzene is evaporated to leave a residue, the crude benzene is subjected to pressure refining in the presence of hydrogen. The residue is distilled to form high and low boiling fractions and at least the gas pressure and temperature of the distillation stage is controlled so that the sump product apart from styrene is substantially free from aromatic hydrocarbons with less than 9 carbon atoms. The rate of withdrawal of the vaporization residue from the vaporizing column is controlled, depending upon the concentration of polymer formers in the crude benzene to be in the range of 6 to 40% of the rate of feed of the coking by-product benzene to the vaporizing column.
    Type: Grant
    Filed: August 29, 1995
    Date of Patent: June 16, 1998
    Assignee: Krupp Koppers GmbH
    Inventors: Hans-Jurgen Vollmer, Uwe Ranke, Reiner Wieczorkowski, Thottakudi Ramanuja Narasimhan
  • Patent number: 5760175
    Abstract: A peptide is disclosed for detection of a herpe4s virus infection in an animal subject susceptible thereto, wherein the peptide comprises a compound of the Formula: ##STR1## designated Sequence ID 1.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: June 2, 1998
    Assignee: Bio-Virus Research Incorporated
    Inventors: Daniel B. Golubev, Alexander Chaihorsky
  • Patent number: 5750389
    Abstract: Nucleotide sugars, especially UDP, ADP, CDP or TDP saccharoses can be enzymatically obtained by the reaction of nucleoside diphosphates with di or trisaccharides with a saccharose synthase in which the virtual absence of nucleoside phosphatases (0.1% or less) can be ensured by special purification methods and sensitive detection. The purification of the raw extract, obtained preferably from rice grains, comprises especially the application of the ultra-filtered extract containing 50 mM KCl with a pH 8 on a sepharose Q column and a gradient elution out of the column at a pH 8 with 50 to 500 mM KCl.
    Type: Grant
    Filed: January 6, 1995
    Date of Patent: May 12, 1998
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Lothar Elling, Maria-Regina Kula
  • Patent number: 5723522
    Abstract: The present invention relates to a plastic material which is modified with fiber fillers. Particularly thermoplastic material with melting point above 200 degrees Celsius are selected for this plastic material. As fiber fillers particularly cellulose fibers and/or modified cellulose fibers in practical concentrations of approximately 20% are used.
    Type: Grant
    Filed: March 22, 1996
    Date of Patent: March 3, 1998
    Assignee: Color Plastic Chemie, Albert Schleberger GmbH
    Inventor: Franz Bergmann
  • Patent number: 5723026
    Abstract: The production of high purity benzene and high purity toluene is obtained by utilizing the initial gas separating column for the treatment of the aromatic containing starting material as a separating column for separating a benzene rich from a toluene rich component. The benzene rich component is subject directly to distillation while the toluene is subject to predistillation to separate high boiling components and only then to extractive distillation is distilled to separate the high purity benzene from the high purity toluene.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: March 3, 1998
    Assignee: Krupp Koppers GmbH
    Inventors: Martin Leisse, Hans-Jurgen Vollmer, Uwe Ranke