Abstract: The present invention provides antisense compounds and methods for modulating the expression of target genes expressed in the kidney. In particular, this invention provides antisense oligonucleotide compounds optimized for targeting nucleic acid molecules expressed in the kidney. Such compounds are shown herein to efficiently modulate the expression of target genes SGLT2 and connective tissue growth factor (CTGF) in the kidney.

Abstract: Apparatus and methods for identifying and counting objects having identifiers entering and exiting a surgical field are provided. In one embodiment, the apparatus has an entry scanner, a hand held scanner and an exit scanner for generating a detection field and for receiving data which identifies said objects. In another embodiment, the apparatus has a plurality of lower antennas and an upper antenna for generating a detection field and for receiving data which identifies said objects. Various surgical devices with identifiers and methods for preventing electromagnetic coupling between and protecting objects and identifiers are also provided. The invention further provides apparatus and methods comprising a handheld scanner and a mat adapted to underlie a patient during a surgical procedure.

Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.

Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.

Abstract: There is provided a medicine packaging apparatus, which is capable of rapidly coping with errors occurring during processes.

Abstract: A system and method for thermal regulation, the system comprising a bedding element that is configured to enclose at least a part of a living being or other object. The system further comprising a temperature regulation element that is included in the bedding element and that includes a phase change material which changes between a liquid phase and a solid phase within the desired temperature range.

Abstract: Interventional catheters are disclosed for use in performing diagnostic and therapeutic procedures in vessels that are accessed retrograde to blood flow. The catheters include an elongated shaft slidably disposed within a sheath, a distal region having an end effector and a filter disposed proximal to the end effector to capture emboli liberated during the diagnostic or therapeutic procedure. The filter includes a plurality of struts that cooperate with an exterior surface of the catheter to define a reservoir to retain captured emboli, the reservoir configured so that advancement of the sheath contracts the filter without squeezing or dislodging captured emboli beyond a distal end of the filter.

Abstract: Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.

Abstract: A system is for encoding information on a passive surface acoustic wave (SAW) device. The system includes a requesting unit configured to wirelessly transmit an impulse signal. The impulse signal is a signal that includes only a single pulse. A SAW device has an interdigital transducer (IDT) configured to physically store coded data. The SAW device is configured to receive the impulse signal. In response to receiving the impulse signal, the SAW device excites the IDT to generate a coded signal that includes the stored coded data and frequency components at a fundamental frequency.

Abstract: A metal leading edge of a turbine fan blade is manufactured by cutting and shaping an elongated metal part. The metal part has front and rear edges extending lengthwise of the part, and has a generally wedge-shaped transverse cross-section with opposite sides diverging from the front edge toward the rear edge. A cavity is cut inward from the rear edge toward the front edge. This provides the part with a generally V-shaped transverse cross-section having opposite side walls diverging rearwardly from the front edge. A mandrel is inserted into the cavity, and the side walls of the V-shaped part are deflected toward each other to constrict the cavity into the configuration of the mandrel. The part is then mounted as a metal leading edge by inserting a turbine fan blade component into the constricted cavity and fastening the part to the component.

Abstract: Fluid containers are disclosed which have fluid reservoirs in their closures. These reservoirs are advantageous to hold sacrificial fluid which lessens the loss of the fluid of interest to the outside through evaporation. The reservoirs may have openings to the inside or outside of the container, or to both. Reservoirs with openings to the outside serve to reduce evaporative loss by raising the partial pressure of fluid in the vicinity of the contact between the closure and the remainder of the container. The reservoirs may be refillable without opening the container. In one embodiment a fluid reservoir allows the zone of contact between the closure and the remainder of the container to be immersed in fluid, so that gases seeking to escape the interior of the container must pass through fluid.

Abstract: A system and method for obtaining a frequency error estimate representing the difference between a reference frequency and the frequency of a space-time transmit diversity signal is disclosed herein. The method includes taking the correlation of total sums, comprised of partial sums taken in defined first and second intervals, to represent the frequency error as the imaginary component of the correlation function.

Abstract: The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

Abstract: The present invention provides systems and methods for protecting wounds, such as surgical incisions. In one embodiment, a dressing for protecting a wound includes: a support cushion configured to surround the wound, the support cushion having sidewalls defining a major axis and a minor axis, the support cushion including at least two perforations that traverse the sidewalls at offset locations; a reservoir configured to be suspended over and in engagement with the support cushion; and a cover configured to be positioned over the reservoir. The at least two perforations may define first and second interlocking J-shaped portions. The support cushion may include a wicking portion configured to surround the wound and a hydrophobic portion configured to surround the hydrophobic portion. The wicking portion may be configured to transfer fluid from the wound to the reservoir. Methods of applying the dressing, and kits including the dressing, also are provided.

Abstract: Systems and methods are provided for monitoring the deterioration of a rechargeable battery. A battery monitoring system may be used to store charging information, discharge information and storage information for a rechargeable battery to a data store. The charging information may include a number of charge cycles incurred by the rechargeable battery. The discharge information may include a number discharge cycles incurred by the rechargeable battery. The storage information may include information relating to periods when the rechargeable battery is not being actively charged or discharged. The battery monitoring system may be further used to determine an amount of deterioration of a battery performance characteristic based on the stored charging information, discharge information and storage information.

Abstract: A system and method are provided for implementing a web server on a mobile station. A first mobile station may include a database of information. A network address for the first mobile station may be transmitted to a second mobile station to enable the second mobile station to communicate with the first mobile station directly over a wireless network. The second mobile station may then be provided access to the database of information by communicating directly over the wireless network with the first mobile station, wherein the first mobile station operates as the wireless server for the second mobile station.

Abstract: A keyboard includes a plurality of keys associated with alphanumeric characters including the letters A-Z. The keys are split into a left side section and a right side section. The left side section is oriented at least partially above the right side section, or the right side section is oriented at least partially above the left side section. The keyboard is stationary. A mobile communication device includes the keyboard.

Abstract: Embodiments of the invention provide high power waveguide polarizers with broad bandwidth and low loss, and methods of making and using the same. Under one aspect of the present invention, a waveguide polarizer includes a hollow waveguide body having an interior surface; a first ridge disposed on the interior surface of the hollow waveguide body and having an inward-facing surface; and a first plurality of projections disposed on the inward-facing surface of the first ridge. The projections may have a width that is narrower than that of the ridge, and a length that is tunable. The length of the projections may be selected to induce about a 90-degree phase delay in a first mode propagating in a plane parallel to the first ridge relative to a second mode propagating in a plane perpendicular to the first ridge.