Abstract: A fluid transport/containment apparatus includes a fluid-bearing module and an actuation module. The fluid-bearing module includes a substrate and fluid transport/containment elements distributed therein, with one or more of the fluid transport/containment elements having microfluidic dimensions. The actuation module is detachably secured to the fluid-bearing module such that the actuation elements are operatively interfaced with the fluid transport/containment elements.
Abstract: The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.
Type:
Grant
Filed:
July 23, 2009
Date of Patent:
August 21, 2012
Assignees:
AC Immune S.A., Genentech, Inc.
Inventors:
Andrea Pfeifer, Maria Pihlgren, Andreas Muhs, Ryan Watts
Abstract: An electronic communication device includes a buffer and a controller. The buffer stores characters as they are being input by a user. The controller transmits the stored characters over a network when the number of characters stored exceeds a threshold. The controller also dynamically adjusts the threshold time period.
Abstract: In a helmet according to this invention, a recess-projection fitting mechanism to attach a blockish inside pad on a head protecting cap portion side includes a male hook or female hook on the blockish inside pad side, and a female hook or male hook on the head protecting cap portion. When pulling the inside pad outward from inside the head protecting cap portion at least partly, a recess-projection fitting disengaging slant surface causes one hook to relatively levitate from the other hook, thus relatively disengaging the male hook from the female hook. This invention can provide the helmet which, when worn by a head of a helmet wearer, can be removed with a comparatively small force, and the detaching operation of which can be performed easily and reliably with a comparatively simple arrangement.
Abstract: The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.
Type:
Grant
Filed:
April 30, 2009
Date of Patent:
August 14, 2012
Assignee:
Genomatica, Inc.
Inventors:
Anthony P. Burgard, Mark J. Burk, Robin E. Osterhout, Priti Pharkya
Abstract: Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of isoindoline based PDE 4 modulators.
Abstract: The present disclosure is directed to a micromachined rotary actuator constructed of a central portion and an outer portion at least partially surrounding the central portion and separated from the central portion by an in-plane gap. A plurality of arms are each connected at one end to the central portion and at another end to the outer portion so as to span the in-plane gap. The arms are constructed of a plurality of horizontally stacked materials positioned to enable the arms to bend in-plane when heated. Conductors are positioned within the actuator for heating the arms. Because of the rules governing abstracts, this abstract should not be used to construe the claims.
Type:
Grant
Filed:
June 20, 2007
Date of Patent:
August 14, 2012
Assignee:
Carnegie Mellon University
Inventors:
William C. Messner, James A. Bain, Gary K. Fedder
Abstract: A valve apparatus includes a substrate, a main flow channel formed in the substrate, a control channel formed in the substrate such that the main flow channel and the control channel meet at a junction, a bi-phase material within the control channel, a heating element adjacent the control channel and the junction, the heating element being controllable to generate sufficient energy to cause the bi-phase material to transition from a solid phase to a liquid phase, and a pumping mechanism for forcing the bi-phase material either into or out of the junction when the bi-phase material is in the liquid phase.
Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
Abstract: A method is disclosed for the generation of triacylglycerols from gums that have been separated from an oil product. The gums are treated with an enzyme having PLC activity, which results in the formation of diacylglycerols and phosphates, and treated with an enzyme having PLA activity, which results in the formation of lyso-phospholipids and free fatty acids. The diacylglycerols and the free fatty acids from these two separate reactions then combine in the presence of the enzymes to generate new triacylglycerol molecules.
Abstract: A system and method for transporting user-requested framed data from a gateway device to a handheld viewing device includes an information source, a gateway device, a relay network and a handheld viewing device. The gateway device includes a fetch and cache component, storage, and a wireless transport layer. The wireless transport layer delivers content from the gateway to the handheld viewing device. The user of the handheld device is then graphically presented with a representative form of the data and is thus able to manually select certain frames of data through a user interface.
Abstract: Systems and methods are provided for adapting a text, for example, for generating a text appropriate for the proficiency level of a language learner, are described. An original text is received and at least one portion of the original text to adapt is identified, where the adapted text will facilitate reader comprehension. An adaptation to be applied to the at least one portion of the original text is determined. The at least one portion of the original text is analyzed based on the adaptation, the adaptation is applied to the at least one portion of the original text, and the adapted text is provided.
Type:
Grant
Filed:
March 20, 2007
Date of Patent:
August 7, 2012
Assignee:
Educational Testing Service
Inventors:
Jill C. Burstein, John Sabatini, Jane Shore, Matthew Ventura
Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl) -N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
Type:
Grant
Filed:
April 6, 2011
Date of Patent:
August 7, 2012
Assignee:
ACADIA Pharmaceuticals Inc.
Inventors:
Mikkel Boas Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jörg Berghausen
Abstract: New methods and compositions are disclosed that comprise the phytochemical Diindolylmethane, alone or in combination with immune potentiating steroids. These methods and compositions are utilized to treat subjects suffering from common cutaneous warts (verrucae) and Human Papilloma Virus (HPV) related conditions of the oropharynx, larynx, genitalia, and uterine cervix.
Abstract: The present invention relates to a process for preparing a compound comprising an ?,? amide linkage between a cysteine moiety and a glutamic acid moiety, such as ?-glutamylcysteine or a ?-glutamylcysteine derivative, the process comprising providing a cysteine derivative, a ?-glutamyl donor and an enzyme capable of transferring the ?-glutamyl group to said cysteine derivative in a reaction environment promoting transfer of the ?-glutamyl group to said cysteine derivative. The invention also relates to compounds comprising an ?,? amide linkage between a cysteine moiety and a glutamic acid moiety, such as ?-glutamylcysteine or a ?-glutamylcysteine derivative, when obtained by processes of the invention, and uses thereof.
Abstract: The present invention is directed to methods and apparatus for decreasing pressure in the left atrium of a patient by implanting a valved shunt through the atrial septum, whereby a volume of blood sufficient to reduce pressure in said left atrium is released to the right atrium.
Abstract: Systems and methods for downhole formation testing based on the use of one or more elongated sealing pads capable of sealing off and collecting or injecting fluids from elongated portions along the surface of a borehole. The modified sealing pads increase the flow area by collecting fluids from an extended portion along the surface of a borehole, which is likely to straddle one or more layers in laminated or fractured formations. A tester device using the elongated sealing pads can be deployed and withdrawn using an extendible element pressing the pads to the borehole. Various designs and arrangements for use with a fluid tester, which may be part of a modular fluid tool, are disclosed in accordance with different embodiments.
Type:
Grant
Filed:
January 18, 2010
Date of Patent:
August 7, 2012
Assignee:
Halliburton Energy Services, Inc.
Inventors:
Philip Edmund Fox, Michael E. Shade, Gregory N Gilbert, Mark A. Proett
Abstract: There is provided a medicine dispensing system configured such that a medicine dispensing device includes a sub unit having a function to dispense medicine that is connected to a medicine dispensing device that includes a main unit having a function of packing medicines. There is also provided a medicine dispensing device that can be appropriately integrated with such a medicine dispensing system. The medicine dispensing system includes, in some embodiments a main unit, a sub unit and a transfer device connecting the main unit and the sub unit. The medicine dispensing system transfers the medicine dispensed in the sub unit to the main unit by means of a transfer device and dispenses the medicine at a medicine packing part together with the medicine dispensed from a main storage part in the main unit.
Abstract: An abdominal training apparatus provides focused training on the abdominal muscles using a resistance provided by a resistance device. The user may be supported in an elevated position by a seat support. A cable may transfer the resistance from the resistance device to the user. One or more pulleys may guide the resistance such to the user such that a force vector below and away from the user is provided to the user. In use, the user may perform abdominal training by engaging or grasping the cable to engage the resistance. The user may also support or secure one or both legs using a leg support of the apparatus. The force vector of the resistance is highly beneficial in that it allows the resistance to target and strengthen the abdominal muscles.